MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
Just appetite changes over about a month after stopping. If you're using it to control blood sugar/insulin response you should monitor that more carefully when stopping though
Ghoul
Member
Rebound appetite, sugar cravings, can be brutal. It's not uncommon to overshoot the baseline weight started with. But this is dependent on how long you've used and how much lost. 90%+ regain all weight lost within a year or two.
RAW95
Member
Two days ago, I did my 3rd pin of Tirzepatide at 2.5mg.
I haven’t needed to increase the dose after the second week, and I’d even say that during this third week, the appetite suppression is at its strongest.
I couldn’t binge eat even if I wanted to.
Sugar and carb cravings completely disappeared from the very first dose.
There are times during the day when I do feel hungry, but after a moderate amount of food, I feel full.
There are also meals where I eat simply because too many hours have passed since the last one.
I always consume carbs before training, while the rest of my meals are mostly protein-based.
To reach my goal, I don’t think I’ll need to go above 5mg.
I also haven’t experienced dizziness or fatigue.
The only downside is that it’s made me drink significantly less water, which is something I need to fix.
I haven’t needed to increase the dose after the second week, and I’d even say that during this third week, the appetite suppression is at its strongest.
I couldn’t binge eat even if I wanted to.
Sugar and carb cravings completely disappeared from the very first dose.
There are times during the day when I do feel hungry, but after a moderate amount of food, I feel full.
There are also meals where I eat simply because too many hours have passed since the last one.
I always consume carbs before training, while the rest of my meals are mostly protein-based.
To reach my goal, I don’t think I’ll need to go above 5mg.
I also haven’t experienced dizziness or fatigue.
The only downside is that it’s made me drink significantly less water, which is something I need to fix.
Ghoul
Member
That's normal. Blood serum concentrations increase during the first four weeks of use before leveling off. Second dose especially often takes people by surprise since it feels much stronger than the first,
Sounds like you're a good responder. Many guys feel nothing until 5, 7.5, or even 10mg. Generally the higher initial dose someone needs to feel an effect, the less weight is ultimately lost.
Care2Play
New Member
I found lots of anecdotal data on forums based on obese people who get their cravings back after months of usage, but I can’t find data for amateur (natural) bodybuilders.
I have been cutting for the 8 weeks (700 kcal a day below TDEE) and it is getting harder to get rid of the last few %. The idea is to use it for 4 weeks as part of my prep cut, to reach a goal.
I don’t want to mess up my hormones and get cravings I naturally never had after I stopped Tirz.
Ghoul
Member
There's no evidence of any permanent changes to your incretin hormones (glp, gip, glucagon, insulin) or sensitivity. It's just that removing the exogenous hormones is like an ending a cycle of other hormones abruptly. A brutal return to baseline. In this case, after artificially suppressing appetite it's not a slow return of hunger, but a rubber band snapping back.
This rapid return of intense appetite puts on pressure that can lead to bad choices. That's the worst case scenario.
It doesn't matter whether you're obese or not, the more you crush your hunger with these hormones, the further away from your homeostasis weight / body fat you go, once you return to normal levels of the appetite regulating hormones, the more your body will think you're starving and use every trick to make you eat enough to get back to your "natural weight" asap.
Starving people find everything irresistibly appetizing, and have been known to eat anything, even other people lol.
The sugar cravings were wild on I’ve never had a sweet tooth before I was aware of
Ghoul
Member
Protein first, everything else will take care of itself.
Just think in terms of eating in a way that maximizes protein. The primary limit with GLPs is *volume*, not calories. So something that seems healthy, like vegetables, is using up a lot of your limited capacity for volume while providing insufficient nutrition.
A good multivitamin will help cover trace elements you may be missing from the lower volume of food.
CubanQuentin
Member
"Your Honor, in my defense, I ate those 2 dudes because I ran out of tirz"
fit2beking
New Member
Curious as to why you suggested this? Was it something in his test results? Or just a general suggestion? I use mag glycinate and thereonmate
Eddie.
Member
His ALP is borderline low, that correlates with magnesium deficiency. ALP is not like AST and ALT where lower is better.
oldmanwilliams
Member
What do you guys do when traveling and keeping Semaglutide or Tirzepatide stable? How long is the stability of both of these when unconstituted? I don't want to freeze and then defrost them that's probably bad. I am wondering how long I get away with them being unrefridgerated without them degrading too much.
CubanQuentin
Member
If you're going on a short vacation I would either skip it altogether if it's a week or less or take a dose the day before traveling and resume regular dose schedule after returning. If you're planning to move somewhere, I'd say it should be stable for a few hours, so just make sure it's the last thing you pack and you can stick it in the fridge as soon as you get to your new residence. After all, it's not like the shipping companies refrigerate it while it's in the hands of the postman
If you're moving somewhere far away enough that you're taking a plane, however... I would just forfeit the doses I have and order more after moving. I would not want to be caught dead with contraband in my luggage
my Tirz finally came in so I can up the dose. About filtering it, should I filter it injection by injection or do the whole vial? thing is I have some small vials left so basically 1dose would be a whole vial (10mg).
(I got 40mg vials but still have 10mg and 5mg vials left so I wanna finish those first)
Also I am at 5mg rn and feel no appetite suppression anymore. Do I go to 7.5 and then 10 or could I go straight to 10mg?
Also do I filter it back in the vial and then inject or do I filter right as I inject it?
Last thing, I wanna add metformin for it's health and longevity benefits, is doing Tirz + Metformin an issue or is it fine (I'm not diabetic and not on HGH)
(I got 40mg vials but still have 10mg and 5mg vials left so I wanna finish those first)
Also I am at 5mg rn and feel no appetite suppression anymore. Do I go to 7.5 and then 10 or could I go straight to 10mg?
Also do I filter it back in the vial and then inject or do I filter right as I inject it?
Last thing, I wanna add metformin for it's health and longevity benefits, is doing Tirz + Metformin an issue or is it fine (I'm not diabetic and not on HGH)
Thinking of switching from Tirz to Ozempic…
Then this pops up and suddenly I’m like: “For science, of course.”
Then this pops up and suddenly I’m like: “For science, of course.”
Ghoul
Member
Don't filter as you inject.
You should be filtering into new sterile vials. But filtering back into the original is still preferable to not filtering.
I'd advise going to 7.5mg for 2 weekly doses before deciding if you want to progress to 10mg. This is particularly important since you're starting metformin, since the combination can lead to hypoglycemic effects. Be conscious of any dizziness or vision changes, and drop the dose of(or eliminate) metformin if they occur. You likely won't have this happen, but it can be serious if it does.
For longevity don't forget to pluck the low hanging fruit by getting your bp and cholesterol into ideal ranges, choosing the longevity enhancing options if you need pharmaceuticals to address those biomarkers.
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CubanQuentin
Member
Obligatory nerd comment clarifying that this is most likely due to losing fat around the penis which makes it reveal previously hidden inches
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