BamaCrazy
Banned
I believe that is what this study indicates also.
MESO-Rx
Anabolic Steroids
HGH Sensitivity Discussion
- Thread starter Wrangel7
- Start date
Ateam2023
Member
Greatttt , more AGGREGATE bs, "Damned if you do, Damned if you don't", , might as well save a little $ and just skip the filtering , so much controversy over the filtering, i asm just to lazy to comply, Guess im NOT missing out on anything eh?
BamaCrazy
Banned
I’m just going to upgrade my medical insurance just in case I get a hole in my butt and not worry about it. Hahaha
AlexDavis43
Member
The entire history of GH use, both clinically & by bodybuilders, suggests you aren't "damned if you don't filter"
Ateam2023
Member
I Agree 100% , i've been using non-filtered peptides/hgh for alot of years outta my life and i honestly, Will NOT be filtering in the future, all the "bubble boys" can schoff, and roll there eyes , but its just a fact,,
clearheaded
Member
yes ghoul conflates alot of things. papers suggest filtering for hospital use to prevent infection in aids patients vs actually testing aggregate prevention.
logically one can work out not only size wise but also the mechanical destruction and smashing of peptides through small holes. think about anything moving through a sieve and remember syringes can cause cavitation so just because u aren't using high powered machine there is alot of "pressure", charges of filter media ph of the solution temp and concentration all will factor in.
also I dont believe any evidence for aggregates SOOO huge ie larger than 2micrometers are bioactive never mind present never mind broken up into smaller aggregates.. but again we do know aggregates FORM from filtration, how much I dunno..
if insist on filtration use proper buffered bad water, dilute 3x normal amount (made that # up but more dilute the better) will help prevent further aggregation aswell as loss.
logically one can work out not only size wise but also the mechanical destruction and smashing of peptides through small holes. think about anything moving through a sieve and remember syringes can cause cavitation so just because u aren't using high powered machine there is alot of "pressure", charges of filter media ph of the solution temp and concentration all will factor in.
also I dont believe any evidence for aggregates SOOO huge ie larger than 2micrometers are bioactive never mind present never mind broken up into smaller aggregates.. but again we do know aggregates FORM from filtration, how much I dunno..
if insist on filtration use proper buffered bad water, dilute 3x normal amount (made that # up but more dilute the better) will help prevent further aggregation aswell as loss.
AlexDavis43
Member
Nonfiltered GH has been used successfully in the clinic and by bodybuilders for decades
Where are all the problems that were supposed to be caused by misfolding or sticky icky whatever? (the ones that filtering would've prevented ofc)
clearheaded
Member
AlexDavis43
Member
Fuck it I'm just gonna start saying "dimmer" and profess with confidence that that is what causes water retention from UGL GH
Take the W you bastards
Take the W you bastards
These are good references. Thank you for sharing. That's my concern with using these syringe filters for anything that isn't absolutely critical from sterility standpoint. What's the net-net effect?
We don't have the means to characterize what's coming off these cheap syringe filters from Amazon or even the Tisch filters.
I have a confession to make. Nah, I better not lol.
BamaCrazy
Banned
I think the amount of compound passed through a single filter increases the risks. I don’t know much about brewing but I believe that’s an environment where quality filters and filter swaps would be most beneficial.
Ateam2023
Member
oh "do tell" now what have you done ?? Confess your sins ,,
Ghoul
Member
That study is deeply flawed. I suggest you read the entire paper.
1. PES is a solid membrane with pores. It's not made from fibers. It doesn't shed.
2. The filters used were bulk packaged in a cardboard box. Not individually packaged as all sterile filters are. Of course they were filled with dust.
3. The PES filters without fiberglass pre filters, or fiberglass mesh layered onto the membrane reduced, not increased particle count in the reconstituted protein. No one's made fiberglass containing PES syringe filters for proteins in over a decade. .
4. KGF-2 is uniquely fragile, the most easily denatured protein used in medicine. It's *never* filtered unless attached to a carrier protein like albumin for stability. Of course filtering it causes it to unfold and aggregate. rHGH is orders of magnitude stronger, is filtered through .22um multiple times during manufacture, and we have clear data showing it's not damaged by syringe filtration. .
The same braindead clowns who insist particulate contamination and aggregation are nonissues campaign against filtration by claiming it causes particulate contamination and aggregation, lol.
If you use a sterile .22um PES filter from a reputable brand it's not going to introduce more particulates than it removes. We have high quality evidence of that. It's not going to denature rHGH either. We know that for a fact.
Even Cobetter 50¢ filters meet the standard. A large multinational filter company that supplies the science industry, not PED users, where adding contaminants would ruin experiments, clog HPLC columns and quickly be out of business.
Don't give idiots oxygen.
clearheaded
Member
it does cause aggregation, I've shared papers on this... again, logically even braindead can imagine smashing together paticals flying through a sieve under pressure that may not be best thing for delicate things 
if want to do a resin filter like in manufacturing that may be helpful for u though!
also ghoul, stop posting chat gpt.
quick question, do u think syringe filters are the same thing as what used in biotech? just curious
if want to do a resin filter like in manufacturing that may be helpful for u though!
also ghoul, stop posting chat gpt.
quick question, do u think syringe filters are the same thing as what used in biotech? just curious
BamaCrazy
Banned
So you cut off your oxygen right after writing this, correct?
BamaCrazy
Banned
And some PES pre-filters contain borosilicate microglass prefilters.it does cause aggregation, I've shared papers on this... again, logically even braindead can imagine smashing together paticals flying through a sieve under pressure that may not be best thing for delicate things
if want to do a resin filter like in manufacturing that may be helpful for u though!
also ghoul, stop posting chat gpt.
quick question, do u think syringe filters are the same thing as what used in biotech? just curious
Syringe filter type SYKG-S have Polyethersulfone (PES) membrane filter and a binder free Borosilicate microglassfiber prefilter in polypropylene housing.
AlexDavis43
Member
Please provide a reference for this.
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