Future Project: Brewing Injectable Oxandrolone -Seeking Community Input-

[readalot]

what about the half life or clearance similar to injectable winstrol?

you'd like to minimize half life? Rapid clearance?

gonna be hard to best this....

R

Post in thread 'Nandrolone no ester source'

Oct 13, 2023

Imagine a PK profile like this for nandrolone / boldenone / trenbolone...



I guess the subscribers can donate my royalty stream to MesoRx. I am sure @Millard will find a great use for it. Thanks for the great site Sir.

• readalot

No nasty solvents needed.

 

[Sicsemptyran]

I do sincerely appreciate OP’s thinking and goals with the injectable anavar and as a huge fan of anavar, I am sympathetic to the idea of an Anavar+. As a few people have called out though, Anavar is extraordinarily bioavailable to the point of rounding error differences, and its effect on the liver/lipids will likely be little adjusted.

I think there’s been a lot of promotion of the idea that injection is always better when oftentimes it just doesn’t matter frankly.

 

[Excel.exe]

you'd like to minimize half life? Rapid clearance?

or the opposite or however injectable winstrol works. i have read that injectable starts showing results by the time you are ready for third injection compared to oral winstrol which takes 2 weeks.

 

[readalot]

or the opposite or however injectable winstrol works. i have read that injectable starts showing results by the time you are ready for third injection compared to oral winstrol which takes 2 weeks.

Which? The old suspension or the newer UG stanozolol solution equivalent to what's termed by many as TNE?

They will have different PK profiles.

The oxandrolone and stanozolol troches I've used kick in rapidly; you are transferring the active drug I to the in the bloodstream via the buccal mucosa.

 

[Excel.exe]

Which? The old suspension or the newer UG stanozolol solution equivalent to what's termed by many as TNE?

that i do not know, sorry. just read it elsewhere and was curious about it.

 

[readalot]

that i do not know, sorry. just read it elsewhere and was curious about it.

The solution sometimes found on the UG was never available as a pharma product. The only pharma products IIRC were oral tabs and the Winstrol-V aqueous suspension.

I'm not a fan of the solvents often used to make 17-aa AAS soluble in an oil based formulation.

 

[Excel.exe]

The only pharma products IIRC were oral tabs

i know it was prescribed for angioedema in humans

the Winstrol-V aqueous suspension.

but what was it prescribed for in animals? i see mixed answers. some say for chronic kidney failure and some say for amenia.

I'm not a fan of the solvents often used to make 17-aa AAS soluble in an oil based formulation.

you mean solvents like eo?

 

[readalot]

i know it was prescribed for angioedema in humans


but what was it prescribed for in animals? i see mixed answers. some say for chronic kidney failure and some say for amenia.


you mean solvents like eo?

EO, guiacol, whatever other crap UGLs throw in to get the 17-AA AAS into solution.

Oxandrolone and stanozolol were never formulated by Pharma to be an oil based injectable solution.

 

[readalot]

but what was it prescribed for in animals? i see mixed answers. some say for chronic kidney failure and some say for amenia.

Now days some vets use for wasting, poor appetite.

 

[Country Club Hero]

I read your comment and no reason to use injectable "var". Retarded. Injectable var, not you.

Recipe? Solvents?

Idk because I never ordered it. I think it’s dosed at 50mg per ml. But not sure on the solvents.

I’ve found that all oral steroids cause heartburn and more importantly they turn the oil glands in my face on full blast. Like oily like a teenager!

However, if I use the injectable version I don’t get the increase in oil production. So I rarely use orals.

Proviron is the worst at cranking up oil production. It’s horrible. But all others do it too. Just slightly less oil production.

I do like orals turned in to injectable oil or water based for preworkout use. I get significant results from them. I wish I could use orals more. Especially Proviron because it makes me feel great minus the shiny, oily face.

 

[Anonymous35]

It will crashed anavar is very hard to brew with oils even with DMSO it crashed
Maybe at 20mg/ml but thats not very interesting at that low dose …

 

[Anonymous35]

If you want to brew some orals there is some
Dianabol, superdrol, anadrol, methyltrienolone

Letrozole too is not complicated

 

[Jaxino]

The issue with injectable orals lies in the fact that a significant number of metabolites, which would normally be produced through hepatic processing, are bypassed. Essentially, compounds like Anadrol or Superdrol etc etc undergo a fundamentally different pharmacokinetic profile when administered via injection.

For instance, take Anadrol—it undergoes conversion into a highly potent DHT derivative. However, when administered via injection, it remains uncertain whether this metabolic transformation will still occur in the same manner.

What I have observed, however, is that when taking oral steroids alongside oral BPC-157, I experience absolutely no gastrointestinal discomfort.

 

[xrayphoton13]

The issue with injectable orals lies in the fact that a significant number of metabolites, which would normally be produced through hepatic processing, are bypassed. Essentially, compounds like Anadrol or Superdrol etc etc undergo a fundamentally different pharmacokinetic profile when administered via injection.

For instance, take Anadrol—it undergoes conversion into a highly potent DHT derivative. However, when administered via injection, it remains uncertain whether this metabolic transformation will still occur in the same manner.

What I have observed, however, is that when taking oral steroids alongside oral BPC-157, I experience absolutely no gastrointestinal discomfort.

I'm really curious about the differences here between oral and injectable anadrol. @Type-IIx do you have any insight into this? I'm sure injectable anadrol hasn't really been used enough to have much info on but if you know anything maybe you could include it in your upcoming article

 

[Pez'sAnabolicJunta]

Hi everyone,

I’ve been thinking about taking on a new project: creating an injectable oxandrolone solution at 20 mg/mL. I wanted to run my initial idea and recipe by the community "filter" before moving forward to ensure it’s viable, safe, and optimized. This is purely in the planning phase for now, and I won’t start until I’ve gathered enough information, feedback and made necessary adjustments based on the community expertise.


The reason why i'm interested in an injectable form of oxandrolone is because I hope is likely to have a reduced impact on the lipid panel compared to the oral form due to differences in metabolism:

Oral oxandrolone undergoes first-pass metabolism in the liver. This contributes to its significant effect on lowering HDL ("good cholesterol") and raising LDL ("bad cholesterol").This hepatotoxicity is a major reason oral oxandrolone has a more pronounced impact on lipids.


Injectable form bypass the liver during initial metabolism, potentially reducing the strain on hepatic function and lipid metabolism.
The direct impact on lipid profiles may be milder.


If the community agrees this is a worthwhile project and provides some guidance, I’d love to proceed under your advice.


Proposed Recipe

For 100 mL of solution at 20 mg/mL:

Oxandrolone raw: 2,000 mg (2 g)

MIG 812: Primary solvent (~40–50 mL initially)

Benzyl Alcohol (BA): 1% (1 mL)

Benzyl Benzoate (BB): 15% (15 mL)

MCT Oil: Carrier oil to adjust the total volume to 100 mL


Planned Steps


Weigh 2 g of oxandrolone powder and add to 40 mL of MIG 812, stirring continuously.

Apply gentle heat (below 40°C) if necessary to help dissolve the powder.


Mix in 1 mL of BA as a preservative and 15 mL of BB to enhance solubility and stability.


Gradually add MCT oil while stirring until the total solution reaches 100 mL.


Filter the solution through a 0.22-micron sterile syringe filter into sterile vials.


Are there any critical improvements or changes you’d suggest for this recipe?


If this project gets a green light from the community and the recipe is refined with your help, I’d love to document the entire process and share results here. My goal is to learn and ensure the final product is safe, effective, and aligned with best practices.


I want to clarify that I’m open to constructive criticism and am here to learn from the experienced brewers in this community. My goal is to have an informed and productive discussion. If at any point I come across in pointless or nonsensical debates, I sincerely apologize in advance—that’s absolutely not my intention.

Thanks in advance !

Well thought out. I have a few cautions, life lessons, and a question or 2. Keep in mind 75% of my knowledge is self-taught or look & learn so keep that in mind.
Why Mig-812? I tried Mig-840 as a carrier with test prop & test phenyliprop and it hurt pretty bad while in MCT or EO (I don't reccomend this) it never hurt. 2) Have you thought about checking with an Uber Org Chem geek? Wouldn't Ethyl Lactate (Animal's original super solvent) or the stinky Guiacol which are proven to work or esterless compound possibly be better choices? 3) I was going to suggest prefiltering but this is so small scale.

 

[Pez'sAnabolicJunta]

Yeah I made it too long. You missed my point. If you want to go to more trouble then buccal troche/admin is better than IM. Straight into bloodstream. Eliminates first pass but 2nd, 3rd, ... fourth passes still present.

Formulating oxandrolone for IM injection is PITA and inefficient plus many vendors use solvents that are ASS.

My pleasure.

I had a compounding book that showed making troches. Never thought I'd use it so I ebayed that book. Books like it are a few hundred bucks. Easier to go online and ask an organic chemist online (if he is legit pay em) if they can help you with that or more than a onsie for making test susp or winnie perhaps.

 

[Banana Joe]

The issue with injectable orals lies in the fact that a significant number of metabolites, which would normally be produced through hepatic processing...

For instance, take Anadrol—it undergoes conversion into a highly potent DHT derivative. However, when administered via injection, it remains uncertain whether this metabolic transformation will still occur in the same manner.

What I have observed, however, is that when taking oral steroids alongside oral BPC-157, I experience absolutely no gastrointestinal discomfort.

Anecdotally, people seem to be very happy with injectable Anadrol, IFBB Pro Roman Fritz sings its praise in every second podcast.
So, even if some metabolites are bypassed it *seems* to work fine, or even better than oral.
That being said, what would make it interesting for me is bypassing the strong appetite suppression I get even from a low dose of from orals, so I would try it at a lower concentration of let's say 20-30mg/ml.

BUT now that you mention oral BPC to counter that side effect, I must read into that. This is the first time I am hearing about this.

I'm really curious about the differences here between oral and injectable anadrol. @Type-IIx do you have any insight into this? I'm sure injectable anadrol hasn't really been used enough to have much info on but if you know anything maybe you could include it in your upcoming article

Would be curious as well, from what I gathered, there doesn't seem much data to extrapolate from, as none of these oral compounds seem to have been looked into as injectables.

 

[AlexDavis43]

Anecdotally, people seem to be very happy with injectable Anadrol, IFBB Pro Roman Fritz sings its praise in every second podcast.
So, even if some metabolites are bypassed it *seems* to work fine, or even better than oral.
That being said, what would make it interesting for me is bypassing the strong appetite suppression I get even from a low dose of from orals, so I would try it at a lower concentration of let's say 20-30mg/ml.

BUT now that you mention oral BPC to counter that side effect, I must read into that. This is the first time I am hearing about this.

It was interesting to learn users of injectable anadrol experience similar appetite suppression. Further calls into question the role of "first-pass liver metabolism" in this effect.

 

[Banana Joe]

It was interesting to learn users of injectable anadrol experience similar appetite suppression.

It has been a while since I (admittedly rather superficially) looked into injectable Oxy, but my impression was that it does not, or at least to a much lesser extent suppress appetite.

If appetite suppression is similar, what advantage of injectable orals are there actually? Lipids will be skewed more or less equally, and I doubt anyone will care about bioavailability in this particular case.

 

[AlexDavis43]

If appetite suppression is similar, what advantage of injectable orals are there actually? Lipids will be skewed more or less equally, and I doubt anyone will care about bioavailability in this particular case.

People think it's easier on the liver and more bioavailable.

I'm not saying any of that is true or false, but that is the perceived advantage.

My overall impression is the compound is toxic either way. Maybe it is a few percent more or less toxic with different administration methods.