MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
explodingHeart
Member
That you in the profile pic? that's damn lean. I'm using GLPs to stay around single digit bf. Will stay around here for as long as I can and hope it will killl off fat cells or permanently change my set point.
Boomer gatekeeping mentality, drawing a line on what's acceptable right in front of them.
- tren, steroids, trt, whatever = good
- kidney protective BP drugs or GLPs = bad
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Meh
Trusting pharma=bad
They have been thoroughly proven to have no concern for people's health as long as the bottom line isn't interrupted.
explodingHeart
Member
Who is "they"? Are they in the room with you right now?
anon55
Member
Thanks. Yes it is me, after a huge meal while being a little bit dehydrated. Veins where popping out like crazy everywhere. Tirzepatide works well unfortunately I currently have a lot of digestive sides on it because I eat to much. Mostly constipation, sometimes nausea, burping, and when I really can't poop, an explosive diarrhea is coming. To be honest I'm going back to 5mg soon.
I feel you there. Digestion issues suck. Trying to get myself in order as well. But I'm on a cut. Wouldn't be fun to be on this stuff in a surplus.
anon55
Member
Yes it's hell. Blending food helps. Sometimes everything goes well for weeks then digestive issues go back. I have suspicion for helicopter pylori but haven't done the test yet.
Are you taking the glp one for other benefits besides control of diet?
anon55
Member
For long term health too! -that's why i also use cholesterol meds for example!-
Not calling anybody out in particular, but I'm seeing both in this thread and my friends that are new to glp-1s but using them in the attempt to lose a large amount (>10lbs) a tendency to try to moderate dosage rapidly in the short term by feels -- specifically perceived hunger control or perceived gastro sides.
Don't. This is gonna result in weird unpleasant yo-yoing, massive mis(over and under) dosing, and generally a bad time. If you want to do a feedback-based dosage, weigh yourself every day and take a long-term (>1week) average. If number go down, (down 0.5-1.5 lbs/wk is on-track) it's working, even (especially) if you don't feel anything. When in doubt just do the standard dosage schedule for the drug you're on -- probably a small dosage increase every 4 weeks -- you probably aren't special.
"I get hungey on day 6" or "i still want to eat a whole-ass pizza even though it wrecks my guts now" or "I don't feel nauseous every morning like I used to" are not good reasons to adjust your dosage or dosing schedule. They might be a good reason to adjust your diet (you will have to adjust your diet on glp-1s, that's how they work) or take some miralax or drink more water or have small amounts of sugar on hand to compensate for hypoglycemia.
obvious disclaimer: None of this applies if you're some kinda athlete doing a crash cut right before competition, but hopefully you know what you're doing and don't need me to tell ya.
Don't. This is gonna result in weird unpleasant yo-yoing, massive mis(over and under) dosing, and generally a bad time. If you want to do a feedback-based dosage, weigh yourself every day and take a long-term (>1week) average. If number go down, (down 0.5-1.5 lbs/wk is on-track) it's working, even (especially) if you don't feel anything. When in doubt just do the standard dosage schedule for the drug you're on -- probably a small dosage increase every 4 weeks -- you probably aren't special.
"I get hungey on day 6" or "i still want to eat a whole-ass pizza even though it wrecks my guts now" or "I don't feel nauseous every morning like I used to" are not good reasons to adjust your dosage or dosing schedule. They might be a good reason to adjust your diet (you will have to adjust your diet on glp-1s, that's how they work) or take some miralax or drink more water or have small amounts of sugar on hand to compensate for hypoglycemia.
obvious disclaimer: None of this applies if you're some kinda athlete doing a crash cut right before competition, but hopefully you know what you're doing and don't need me to tell ya.
25mm 0.22um filter and 1.5ml of bac water. I ended up getting more bac water and flushing it out that way. I think I still lost about 1/3 of the vial content.
It was only 1.5ml because the whole vial was only 1 and a half doses
I am actually interested in this...In a few days I am planning to reconstitute and filter a vial of tirz, and I will need to use similar amounts (it is a 10 mg vial so I will be using 2 ml of BAC water). I already have 4 mm PES filters coming. They are small, but on paper they should be enough for these small volumes of solution.
yeah a 4mm filter should be good, I tought the 25 mm were fine but apparently not. I ended up flushing out with like another 2.5ml of bac water and as a result I had to inject like 3.5ml to get my dose. Still it seemed fine. I went up to 10mg today (altough it probably was a bit less since I lost some in the filter, maybe 8mg).
I actually felt quite sick afterwards but I had to eat something because yesterday I fasted (only water, coffee and some supplements), so I forced myself to eat and it actually made the nausea go away. feeling alright now.
the~club~bro
New Member
Ive jumped ship from sema to tirz. (Sigma Audley TR30)
I wasn't sure where to begin with the Tirz so I compared the dosing schedule and decided to jump in at 7.5mg.
Took first shot on Monday morning. I'm already struggling to finish my meals. I can *feel* the difference. Just looking at my boxed up food for the day kinda makes me feel a bit sick.
I had been running ~1.5mg of UGL sema per week (first selliza and then deus, if anyone cares) and was finding its potency on the wane and feeling like I was having to escalate the dose even further to get the same effects. The physical sensation of feeling full just wasn't there anymore like it once was.
I honestly do wonder about the quality of the UGL sema product. I had previously ran genuine novo pens and felt the dose escalation required with the UGL was not in keeping with my experience with the novo pens. Thats just my gut intuition.
However, there are also other mitigating factors, such as ~7 weeks ago I began 250mg test a week, which coincides with my novo pens drying up, so it's interesting to consider if this has had an effect of resetting things to a different level due to the increased metabolic demands.
Anyone else with experience of using a GLP1 as a natural and then transitioning onto gear? Would be curious to know if anyone else experienced something similar.
I wasn't sure where to begin with the Tirz so I compared the dosing schedule and decided to jump in at 7.5mg.
Took first shot on Monday morning. I'm already struggling to finish my meals. I can *feel* the difference. Just looking at my boxed up food for the day kinda makes me feel a bit sick.
I had been running ~1.5mg of UGL sema per week (first selliza and then deus, if anyone cares) and was finding its potency on the wane and feeling like I was having to escalate the dose even further to get the same effects. The physical sensation of feeling full just wasn't there anymore like it once was.
I honestly do wonder about the quality of the UGL sema product. I had previously ran genuine novo pens and felt the dose escalation required with the UGL was not in keeping with my experience with the novo pens. Thats just my gut intuition.
However, there are also other mitigating factors, such as ~7 weeks ago I began 250mg test a week, which coincides with my novo pens drying up, so it's interesting to consider if this has had an effect of resetting things to a different level due to the increased metabolic demands.
Anyone else with experience of using a GLP1 as a natural and then transitioning onto gear? Would be curious to know if anyone else experienced something similar.
CubanQuentin
Member
One thing to understand about pharma is that, yes, it is true that being a bunch of big corpos is reason enough to be distrustful of them. But nothing brings down stock prices and gets shareholders' panties in a bunch more than people dropping dead. You can't trust them to care about the health of the people but you can trust them to want to avoid bad publicity like the plague
There's always gonna be risk with any drugs, "the only drug without side effects is the one that doesn't work" and all that, but so long as studies prove something does actually what it's intended to and so long as people aren't dropping like flies from it it's probably "safe enough"
Ghoul
Member
Yes. Test will boost appetite, though the biggest reason for a drop off in appetite suppression is usually weight loss, which is how GLP hormone therapeutics work.
I has a similar thing with tirz. First on 2.5mg I felt nothing, went to 5mg and holy fuck I barely ate for 6weeks and lost 25lbs. Then the appetite suppresion started to fade and I regained about 15lbs in 12 weeks or so. Now I went to 10mg and I'm starting to feel it a bit again but still 10mg doesn't feel as strong as 5mg used to. And I am a bit fatter than what 5mg initially got me to. I do think that after some time some people experience loss off effectivness to some degree. I don't know if it is because of the quality or if it's the body wanting to go back at a higher weight
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Ghoul
Member
Significant weight regain at the same dose of pharma is almost unheard of, but is reported with UGL fair often.
It's not normal. 10,000+ subjects in extended phase IV GLP trials going out 3-4 years and overwhelmingly weight is maintained in a tight range.
Slipping back at the same dose getting close to starting weight is either a sign of reduced quality of the vials being used or a sign of immunogenicity developing.
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