Hiccup Hell

[BigDadd7]

I dated a girl that had hiccups for over a year. When I met her shed kicked the issue less than a week before. Aside from the how'd you give head during that time curiosity I had, I also had a bunch of questions about it for her. It was a misalignment with the nerves in her diaphragm that medication couldn't fix.

She was able to get rid of it and keep it at bay for several weeks by going to holotropic breathing meditation class. It was 2 or 3 hours of sitting in this chair you make of out of yoga pillows and just breathing as deeply as you could until the end of class. I did it once, it was difficult and weird. It helped her though, they'd start to come on and shed make it to the next class and they would go away.

Best of luck.

They would be like a Jake brake on a cock sucker!

 

[HeatherSwanson]

Just laying a marker down for future reference.

My partner in this, who arranged the test, reluctantly agreed to allow an anonymized copy of the result to be posted here. Remember, this was done through a commercial account connected to his profession. "Private testing" groups don't even share their results here.

10 seconds after I posted the usual knuckle draggers here attacked, making me instantly regret the wasted effort so I had Millard nuke the thread.

I'll communicate with Jano and provide him with the details to see if he can arrange an NMR protocol to test for lipid linker substitution and correct conjugation site for anyone interested in having it done. I'll bet it's wrong in every UGL copy of Tirz, Reta, and Sema.

Funny thing is I found out after the fact Novo Nordisk told the FDA in a recent letter that getting the lipid linker step in Sema (and all GLPs) was so difficult they expected unauthorized manufacturers wouldn't get it right. Since no one outside of FDA pharma companies would ever test for it, and HPLC wouldn't catch it, they expected it wouldn't be discovered, compromising efficacy and safety.

How fucking dare you put extra effort into the scientific method trying to understand something to the fullest extent. This is the internet! Good day sir!

 

[Ghoul]

How fucking dare you put extra effort into the scientific method trying to understand something to the fullest extent. This is the internet! Good day sir!

It's kinda sad, because it would've been a wake up call about the unseen hazards of UGL produced peptides, the limits of "purity" tests, and the false reassurance those who don't understand those limits take from the results.

We've just recently seen an example of those limits coming to light with the peptide damaging / mildly toxic antimicrobial excipients found in a couple of SRYs products. More than just being about those two products, it pulled back the curtain on yet another aspect of what we don't know, since excipients are routinely identified and removed from purity calculations, but aren't disclosed in test results.

The good news is it was shared with a few interested, serious people, including some Meso members. who are using it as a template for advanced testing of other compounds commonly used by this community. I assume they'll share how they got it done and post the test results here, so it wasn't a complete waste of effort and may raise the bar on the type of testing we expect vendors to provide.

 

[readalot]

It's kinda sad, because it would've been a wake up call about the unseen hazards of UGL produced peptides, the limits of "purity" tests, and the false reassurance those who don't understand those limits take from the results.

We've just recently seen an example of those limits coming to light with the peptide damaging / mildly toxic antimicrobial excipients found in a couple of SRYs products. More than just being about those two products, it pulled back the curtain in what we don't know, since excipients are routinely identified and removed from purity calculations, but aren't disclosed in test results.

The good news is it was shared with a few interested, serious people, including some Meso members. who are using it as a template for advanced testing of other compounds commonly used by this community. I assume they'll share how they got it done and post the test results here, so it wasn't a complete waste of effort and may raise the bar on the type of testing we expect vendors to provide.

Very pitiful to see that response to your work. But who's the fool when you are trying to share this type of data/analysis with the likes of P34, etc?

I'm definitely done and was pretty stupid of me to get involved.

Maybe better luck somewhere like this for anonymous citizen science...

In Novo’s Own Words: Degradation of Amylin Analogs Such as Cagrilintide (and How to Test For It)

In Novo’s Own Words: Degradation of Amylin Analogs Such as Cagrilintide (and How to Test For It) “A hallmark of the pancreatic hormone amylin is its high propensity toward the formation of amyloid fibrils, which makes it a challenging drug design effort.” So begins Novo Nordisk’s excellent...

glp1forum.com

See the refs therein. All of this discussion of the potential dangers of aggregation is right there for anyone to read and study. Cagri provides a very compelling example. Nota bene.

I still wish you would have offered to pitch in on the GH testing but it ain't my place to plead. Some communities are probably past the point of repairing.

This ain't the place to invest your time. Move on.

 

[readalot]

It's kinda sad, because it would've been a wake up call about the unseen hazards of UGL produced peptides, the limits of "purity" tests, and the false reassurance those who don't understand those limits take from the results.

We've just recently seen an example of those limits coming to light with the peptide damaging / mildly toxic antimicrobial excipients found in a couple of SRYs products. More than just being about those two products, it pulled back the curtain on yet another aspect of what we don't know, since excipients are routinely identified and removed from purity calculations, but aren't disclosed in test results.

The good news is it was shared with a few interested, serious people, including some Meso members. who are using it as a template for advanced testing of other compounds commonly used by this community. I assume they'll share how they got it done and post the test results here, so it wasn't a complete waste of effort and may raise the bar on the type of testing we expect vendors to provide.

Then other piece I seem to have sorely missed is that this is the UG. When I first joined I got some great advice that I discounted. Lets just say there is quite a bit of diversity in the forum membership here.

Trying to run an R&D program remotely while trying to collaborate with resellers and those that have a vested interest in destructively interfering with analytical testing progress was plain dumb. HPLC testing is the commmunity optimum. The sellers can show the customers they are getting their anabolic API. Done.

Making a buck rules the day and very little honor even among thieves here. Take the $1250 outstanding debt by Lobster. You think $1250 means anything to me? Haha. Sure, it means $1250 of testing that could go into the pot. But you got members here rationalizing and even counseling Lobster not to pay what he owes. Lobster told me himself he had Meso vets / "OGs" counseling him to ignore me.

Long story short, Millard's lofty goals are a fool's errand. All that matters is not interfering with that bottom line.

@Millard, for your review. Naked self interest on the part of member's here will never be compatible with the vision you laid out.

 

[BamaCrazy]

Very pitiful to see that response to your work. But who's the fool when you are trying to share this type of data/analysis with the likes of P34, etc?

I'm definitely done and was pretty stupid of me to get involved.

Maybe better luck somewhere like this for anonymous citizen science...

In Novo’s Own Words: Degradation of Amylin Analogs Such as Cagrilintide (and How to Test For It)

In Novo’s Own Words: Degradation of Amylin Analogs Such as Cagrilintide (and How to Test For It) “A hallmark of the pancreatic hormone amylin is its high propensity toward the formation of amyloid fibrils, which makes it a challenging drug design effort.” So begins Novo Nordisk’s excellent...

glp1forum.com

See the refs therein. All of this discussion of the potential dangers of aggregation is right there for anyone to read and study. Cagri provides a very compelling example. Nota bene.

I still wish you would have offered to pitch in on the GH testing but it ain't my place to plead. Some communities are probably past the point of repairing.

This ain't the place to invest your time. Move on.

In the end it makes no difference just like the other crusades he shits out. If those “mildly toxic antimicrobial excipients” have always been there or are occasionally present but nothing happens to the users, then it doesn’t really matter.

 

[readalot]

In the end it makes no difference just like the other crusades he shits out. If those “mildly toxic antimicrobial excipients” have always been there or are occasionally present but nothing happens to the users, then it doesn’t really matter.

The observation you shared was spot on as well. Perhaps some of the goals are worthy but the right "face" has to do the selling. I wish you health and be well.

 

[gnxclone]

One single dose of 0.5mg of reta and now I have hiccups that will not go away. FML! I really wanted to use the reta to for its other benefits, like fixing blood markers. I had this happen before when I accidentally grabbed and used my wife's sema at 2mg. I blamed thew sema 100%.

Do I abandon the reta altogether? Wait for the hiccups to go away then restart at 100mcg? I must be a super-hyper-responder. I guess that means if I can find a tolerable dose, a full course won't be as expensive.

 

[naps_for_gains]

I had a similar reaction from a high dose of pharma tirz. For me it lasted a week and the hiccups were triggered by eating ~700 calorie meals. They would last about 10 hours after eating and made it difficult to concentrate on anything.

 

[gnxclone]

About 20 minutes after posting, I tried the peanut butter trick. I ate about a tablespoonful of peanut butter. That’s all. It worked!! The hiccups went away and haven’t returned. I even ate dinner later without them coming back.

I didn’t believe peanut butter would really work but tried it anyway out of desperation. Shocked, but very happy.