Steroid Profile Primobolan

[HUGE McBIGLARGE]

Does the aromatase inhibiting effect of primo differ in its mechanism of action to an actual AI?

I ask because my e2 is quite high, and while AIs do lower my e2, I need borderline breast cancer treatment doses to get my e2 in range.

If I can take 200mg of primo and get an equal or greater aromatase inhibiting effect as 3.5mg of anastrozole, I’d prefer to do so.

 

[Deltaaaaxxxx]

Does the aromatase inhibiting effect of primo differ in its mechanism of action to an actual AI?

I ask because my e2 is quite high, and while AIs do lower my e2, I need borderline breast cancer treatment doses to get my e2 in range.

If I can take 200mg of primo and get an equal or greater aromatase inhibiting effect as 3.5mg of anastrozole, I’d prefer to do so.

The test/primo ratio needed to maintain correct levels of e2 depends on everyone, just try different ratios, do you blooodwork and once you’ve found the correct one, stick with it.

Unfortunately primo is really expensive, but it will be healthier to regulate your e2 with primo than with any AI

 

[HUGE McBIGLARGE]

Unfortunately primo is really expensive, but it will be healthier to regulate your e2 with primo than with any AI

Thanks for the reply. Do you know how the mechanism differs to those of AIs?

I figure if it binds to aromatase and makes it inert, then it is mechanistically identical to an AI. It is to my understanding that the pharmacological effects of aromatase inhibitors are almost entirely limited to aromatase inhibition, so any substance that inhibits aromatase should have the same side effects.

So I’m left scratching my head wondering how primo actually differs to an AI.

I’d still prefer 200mg primo to 3.5mg anastrozole, because in my mind a moderate dose of steroids is safer than a fat dose of an AI, but I am aware that this is just bias.

 

[Deltaaaaxxxx]

Thanks for the reply. Do you know how the mechanism differs to those of AIs?

I figure if it binds to aromatase and makes it inert, then it is mechanistically identical to an AI. It is to my understanding that the pharmacological effects of aromatase inhibitors are almost entirely limited to aromatase inhibition, so any substance that inhibits aromatase should have the same side effects.

So I’m left scratching my head wondering how primo actually differs to an AI.

I’d still prefer 200mg primo to 3.5mg anastrozole, because in my mind a moderate dose of steroids is safer than a fat dose of an AI, but I am aware that this is just bias.

To be honest I don’t really how primo lowers the E2 levels, it wasn’t created for that purpose initially. But I can ensure you that primo really lowers E2 and not only blind the receptors.

I don’t really know in details what are the side effects of AI but they can block your veins at the end of day. Initially it’s a medication for cancer so….

Primo is safe in that way but you will probably need more than 200mg of primo if you need a high dose of AI

 

[OldGHGuy]

To be honest I don’t really how primo lowers the E2 levels, it wasn’t created for that purpose initially. But I can ensure you that primo really lowers E2 and not only blind the receptors.

I don’t really know in details what are the side effects of AI but they can block your veins at the end of day. Initially it’s a medication for cancer so….

Primo is safe in that way but you will probably need more than 200mg of primo if you need a high dose of AI

By what mechanism does Primo lower E2 and how similar/different is this to how an AI works? Its a good question that I bet @Type-IIx knows the answer to...

 

[Deltaaaaxxxx]

By what mechanism does Primo lower E2 and how similar/different is this to how an AI works? Its a good question that I bet @Type-IIx knows the answer to...

I think that the AI are just killing the enzymes that converts the testosterone into E2, concerning primo I don’t know

 

[ve79]

The test/primo ratio needed to maintain correct levels of e2 depends on everyone, just try different ratios, do you blooodwork and once you’ve found the correct one, stick with it.

Unfortunately primo is really expensive, but it will be healthier to regulate your e2 with primo than with any AI

Expensive and a bit painful

 

[Deltaaaaxxxx]

Expensive and a bit painful

Yes, and it’s even worse if you pin highly concentrated primo, for example, the pip with a 100mg/ml primo will be less painful than a 200mg/ml, etc etc

 

[ve79]

Yes, and it’s even worse if you pin highly concentrated primo, for example, the pip with a 100mg/ml primo will be less painful than a 200mg/ml, etc etc

Yup I got the 200mg and the pips are like golf balls

 

[Deltaaaaxxxx]

Yup I got the 200mg and the pips are like golf balls

I’ve heard that they are also selling 300mg/ml primo lol

 

[Nidus]

Yup I got the 200mg and the pips are like golf balls

I’ve heard that they are also selling 300mg/ml primo lol

Get 175mg Primo in MCT. Does wonders, for 200mg Primo, just dilute it by mixing it with other oils i.e. your Test shot.

 

[dasking]

I think that the AI are just killing the enzymes that converts the testosterone into E2, concerning primo I don’t know

If im not mistaken my interpretation dumbed down is most AI are working by blocking then Aromasin by destroying the aromatase enzymes. If memory serves primo likely activates and holds space in that receptor. Sort of like the meds for opiate addiction some block the receptors and others hold onto the receptor and cannot be pushed out easily by said opiates.

In my experience it takes a few weeks for primo to impact my estrogen to any meaningful capacity and I have to stay on my AI for atleast the first 1.5 weeks. Vs if I take aromasin it's days and I'm beginning to feel it's effects.

 

[dasking]

Thanks for the reply. Do you know how the mechanism differs to those of AIs?

I figure if it binds to aromatase and makes it inert, then it is mechanistically identical to an AI. It is to my understanding that the pharmacological effects of aromatase inhibitors are almost entirely limited to aromatase inhibition, so any substance that inhibits aromatase should have the same side effects.

So I’m left scratching my head wondering how primo actually differs to an AI.

I’d still prefer 200mg primo to 3.5mg anastrozole, because in my mind a moderate dose of steroids is safer than a fat dose of an AI, but I am aware that this is just bias.

Im no dr or expert but the more updated research I've come across leans towards AI only being problematic if estrogen is too low. Or pre existing medical conditions.

Only major thing i can note as a negative of using primo for estrogen, is my HDL but that's about it at replacment doses. As far as the AIs other then taking too much or the e2 rebound from dropping Adex suddenly I've had little issue either.

 

[espresso123]

Regarding E2. I am not aware of the mechanism on how it lowers the levels. I did my bloodwork and know by my ratio and injection frequency what it did on paper, and also on how I felt mentally and also regarding my joints during cutting.

Regarding PIP: It is painful and I can somewhat agree on it being more painful if injected by itself. I cannot explain why whatsoever. But I remember being on a higher dose of TRT or a very low dose "cycle" on SC test and Primo IM. And it was way more painful than just pinning it mixed up together.

 

[TRENdy07]

I’m taking 800 mg of primo. 200/ml. I mix my weekly test/primo/ deca doses all in one vial. Then I’ll heat it on my coffee warmer for 7 minutes and I pin 3ml mon/wed/fri. I’d be lying if I told you I couldn’t feel it for a couple days, but it isn’t bad.

 

[Nidus]

I’m taking 800 mg of primo. 200/ml. I mix my weekly test/primo/ deca doses all in one vial. Then I’ll heat it on my coffee warmer for 7 minutes and I pin 3ml mon/wed/fri. I’d be lying if I told you I couldn’t feel it for a couple days, but it isn’t bad.

I do the same, daily shots, insulin syringe. Test/Primo, warm it up a bit and then shoot it. 0 Pip.

 

[Torin0815]

I do the same, daily shots, insulin syringe. Test/Primo, warm it up a bit and then shoot it. 0 Pip.

Sounds good !

 

[Zc7219]

I do the same, daily shots, insulin syringe. Test/Primo, warm it up a bit and then shoot it. 0 Pip.

What ratio are you doing that’s pip free?

 

[Nidus]

What ratio are you doing that’s pip free?

350 Test 250 Primo
0.2ml Test 0.25 primo

 

[Zc7219]

350 Test 250 Primo
0.2ml Test 0.25 primo

You’re lucking out in the estrogen department. That would ruin me.