The Lobster International, AU, CANADA and EU Domestic HGH, PEPTIDES and Turkish Pharmacy

[Kralteramon]

"Clown" huh? Do I know you?

It's not my "conclusion" that's the comedy here, it's deciding to put your ignorance on public display.

Every batch of pharma rHGH is tested for potency, separate from "purity", because not all rHGH is active.

“For somatropin-containing medicinal products, the biological activity (potency) shall be determined using a validated bioassay and expressed relative to the WHO International Standard in International Units (IU), in order to ensure comparability with the reference product.”

Similar medicinal products containing somatropin (Annex to guideline on similar biological medicinal products containing biotechnology-derived proteins as active substance: non-clinical and clinical issues) - Scientific guideline | European Medicines

www.ema.europa.eu

"“Accurate determination of biological activity is essential in the development, registration, and quality control of rhGH pharmaceutical products…"

An improved reporter gene assay for evaluating the biological activity of recombinant human growth hormone - PMC

pmc.ncbi.nlm.nih.gov

Nice one. I didn't fully read everything yet but I will. Really interesting.

What we can replicate by ourselves:
PK studies focussed on IGF1 response
IGF-1 is the
preferred pharmacodynamic marker for the activity of somatropin and is recommended to be used in
comparative pharmacodynamic studies.

What I don't understand:
In order to compare differences in biological activity between the similar and the reference medicinal
product, data from comparative bioassays should be provided, including receptor-binding studies and
functional assays (e.g. cell proliferation assays in human cell lines). Wherever possible, analytical
methods should be standardised and validated according to relevant guidelines.

How would one conduct a receptor binding study or test for receptor binding? And functional assays?

 

[AlexDavis43]

How would one conduct a receptor binding study or test for receptor binding? And functional assays?

It's nerd shit in cell culture studies - 30000 foot view:

The growth hormone receptor is expressed in a cell line and they see if/how the new GH compound binds (&/or competes with native GH if it's supposed to do that)

Functional assay would be measuring something that activating the receptor is supposed to do (this would be their example of a proliferation assay)

Something could bind the wrong spot and pass the binding assay but since it's the wrong spot, it wouldn't activate downstream signaling

 

[Spaceman Spiff]

Nice one. I didn't fully read everything yet but I will. Really interesting.

What we can replicate by ourselves:
PK studies focussed on IGF1 response
IGF-1 is the
preferred pharmacodynamic marker for the activity of somatropin and is recommended to be used in
comparative pharmacodynamic studies.

What I don't understand:
In order to compare differences in biological activity between the similar and the reference medicinal
product, data from comparative bioassays should be provided, including receptor-binding studies and
functional assays (e.g. cell proliferation assays in human cell lines). Wherever possible, analytical
methods should be standardised and validated according to relevant guidelines.

How would one conduct a receptor binding study or test for receptor binding? And functional assays?

NO point of fully dissecting all of this shit if no one is going to perform the test or even put money down for it.

Nor if one doesn't do any basic testing.

At this point its talking about how to be a fucking iron chef when one can't even make cereal.

Its stupid.

Then goes silent when we talk about putting money down but when someone talks about aggregates or filters he is first one to post.

 

[Kralteramon]

I'm impartial in all this. I'm just looking for answers. But judging from your feedback it's an impossible undertaking and certainly not a standard test. In that case I'm going to focus on GH and IGF responses in my bloodwork to find some of the answers I'm looking for. And I will accept that some things will have to remain unknown. Thanks all.

 

[Spaceman Spiff]

I'm impartial in all this. I'm just looking for answers. But judging from your feedback it's an impossible undertaking and certainly not a standard test. In that case I'm going to focus on GH and IGF responses in my bloodwork to find some of the answers I'm looking for. And I will accept that some things will have to remain unknown. Thanks all.

I hate to say I go off feels a bit.

Was on serostim for a year plus. Can't handle it cause of the cost out of pocket. Just starts building up too much.

It felt like serostim did have less sides.


IGf1 testing from serostim and QSC HGH was nearly identical.

Ultimately, the cost effectiveness of UGL is great.

 

[cousinmuscles]

"Clown" huh? Do I know you?

It's not my "conclusion" that's the comedy here, it's deciding to put your ignorance on public display.

Every batch of pharma rHGH is tested for potency, separate from "purity", because not all rHGH is active.

“For somatropin-containing medicinal products, the biological activity (potency) shall be determined using a validated bioassay and expressed relative to the WHO International Standard in International Units (IU), in order to ensure comparability with the reference product.”

Similar medicinal products containing somatropin (Annex to guideline on similar biological medicinal products containing biotechnology-derived proteins as active substance: non-clinical and clinical issues) - Scientific guideline | European Medicines

www.ema.europa.eu

"“Accurate determination of biological activity is essential in the development, registration, and quality control of rhGH pharmaceutical products…"

An improved reporter gene assay for evaluating the biological activity of recombinant human growth hormone - PMC

pmc.ncbi.nlm.nih.gov

And what are you going to do then, forget the fact that you can do serum somatropin and IGF tests because they mean nothing, and hope a miracle happens and UGLs quality control matches pharma grade?

Bringing this bullshit up in this thread, when you have a serious source who delivers and sells real product, is extremely disrespectful and has gone lightyears away from where it should be. I won't even begin to describe how I started my journey of hoping to get legit stuff, let alone whatever compound I desire, let alone at a super competitive price, and you are here bashing this source trying to make it seem like they don't deserve business because you don't like them personally?

If it is about leveling up how sources should conduct testing, why not make a thread about to have a relevant discussion?

 

[cousinmuscles]

I hate to say I go off feels a bit.

Was on serostim for a year plus. Can't handle it cause of the cost out of pocket. Just starts building up too much.

It felt like serostim did have less sides.


IGf1 testing from serostim and QSC HGH was nearly identical.

Ultimately, the cost effectiveness of UGL is great.

Same reasons here. I can afford to do it with pharma GH, however my mind which helped me come to this point where I have that kind of money, tells me there is no reason to overpay for the same result.

I'm impartial in all this. I'm just looking for answers. But judging from your feedback it's an impossible undertaking and certainly not a standard test. In that case I'm going to focus on GH and IGF responses in my bloodwork to find some of the answers I'm looking for. And I will accept that some things will have to remain unknown. Thanks all.

He posted that not with conscious thoughts of helping the community, but in a emotional state defending his ego. Why did you have to look up what those methods consist of instead of him explaining it in one or two sentences and making everyone see why it is necessary? Because he doesn't understand what he's talking about.

 

[TheLobster]

EU domestic products are sold out
Thank you for your interest
We will notify you once the stock is replenished

Wishing you a great day

 

[Mariafitness]

What happend to the guy that said lobster ghosted him after his shippment got stuck?

Still nobody talking about how he double the EU pricing to 180 dollar instead of 70

 

[Eddie.]

Still nobody talking about how he double the EU pricing to 180 dollar instead of 70

I don't know where you see this, last time i checked before he goes OOS he had 5 kits for 420. Share a screenshot pls. He raised the prices but it's nowhere near what you're saying.

 

[TheLobster]

What happend to the guy that said lobster ghosted him after his shippment got stuck?

Still nobody talking about how he double the EU pricing to 180 dollar instead of 70

180$ woah i wish haha. Lobster get crazy

i sell EU domestic

420$ for 5 kits
790$ for 10 kits

 

[TheLobster]

What happend to the guy that said lobster ghosted him after his shippment got stuck?

Still nobody talking about how he double the EU pricing to 180 dollar instead of 70

I never ghosted someone because of shipping problems. Not my style

 

[CharlesV]

What happend to the guy that said lobster ghosted him after his shippment got stuck?

all that i documented here. if it was the same situation i’m thinking of, dude was hyper paranoid and sounding alarms for no reason. he still worked out out amicably with Lobster.

 

[Spaceman Spiff]

What happend to the guy that said lobster ghosted him after his shippment got stuck?

Still nobody talking about how he double the EU pricing to 180 dollar instead of 70

Even if he did, go buy from someone else you moron.

No one is making you buy 10 kits from lobster.

Go to SSA or another source to buy 9 kits so you wont go to prison or whatever you were bitching about before.

You act spoiled and entitled.

 

[MyNameIsJeff]

What happend to the guy that said lobster ghosted him after his shippment got stuck?

Still nobody talking about how he double the EU pricing to 180 dollar instead of 70

He's quickly out of stock at current prices. Hence he adjusts the prices upwards. It's called balancing supply and demand, retard.

 

[Spaceman Spiff]

He's quickly out of stock at current prices. Hence he adjusts the prices upwards. It's called balancing supply and demand, retard.

it looks like this user just did his first injection of HGH at 2.5iu. Shortly after they are complaining of water retention.

ROFL

 

[CharlesV]

it looks like this user just did his first injection of HGH at 2.5iu. Shortly after they are complaining of water retention.

i thought you were joking. “very bloated” after 2.5mgs of growth?

oh boy. better dial that way back to a more reasonable dose.

 

[Mariafitness]

Even if he did, go buy from someone else you moron.

No one is making you buy 10 kits from lobster.

Go to SSA or another source to buy 9 kits so you wont go to prison or whatever you were bitching about before.

You act spoiled and entitled.

"entitled" due to asking how a vendor can TRIPPLE the price, are you joking? why dont you go and by pharma you cheap cunt if you feel so great about paying top price. This is price i pay in france, without risking any customs. To not even question how a vendor can TRIPPLE the price is absurd

 

[GreatOak]

"entitled" due to asking how a vendor can TRIPPLE the price, are you joking? why dont you go and by pharma you cheap cunt if you feel so great about paying top price. This is price i pay in france, without risking any customs. To not even question how a vendor can TRIPPLE the price is absurd

Supply & Demand my friend!

 

[TheLobster]

Supply & Demand my friend!

I didn’t triple the price. This guy clearly has no idea what he’s talking about. Don’t be too hard on him he’s probably not someone who sees things normally. We accepted you as you are, my friend. You’re right