Loving my first go at tesamorelin

[Proud Pangolin]

The weight gain was observed with Ipamorelin in isolation and does make sense, even though it's counterintuitive at first.

The likely problem with Ipamorelin is that while it boosts GH pulse levels, they're much shorter than Tesa. 20-30 mins vs 2-3 hours. This leads to lower IGF increases, and IGF helps overcome GH induced insulin resistance allowing muscles to burn off the free fatty acids liberated by GH. Higher insulin resistance from any cause tends to increase fat storage.

Maybe this can be overcome with a GLP.

It probably works in conjunction with Tesa since Tesa provides a reliable IGF boost to burn FFAs. I just wouldn't go below the known effective 2mg dose when adding Ipa.

View attachment 336631

Do you have some source (study) about the lenght of the GH peaks caused by Tesa? I have found exact numbers in studys that would support such a long pulse of 2-3 considering a naturall pulse is only 20-30mins.

And whats with that chatpgt generated graph?
Dont get me wrong i dont want to be cocky or something, but i simply only draw conclusions from empiric evidence.

Also in just realised: if the shorter pulse results in lower igf-1 (which is plausible) this also means insulin sensitivity wont be even nearly as high as with a longer pulse so this wouldnt explain the findings.

 

[benfrankparkway]

You understood me wrong. Im currently taking CJC no dac + GHRP-2. And i want to switch CJC with another GHRH-> Tesamorelin.

The GHRP-2 im.primarly taking to inhibit the Soma.

I also thought of switching GHRP-2 with Ipamorelin as im getting somewhat of a cortisol reaction from it (starting to get a rash in my face after like 4 weeks and im guessing this is due to cortisol)

When you refer to "soma" I am guessing you are referring to somatostatin inhibitors? I am not trying to pull the kitchen sink approach, but how do you feel about natural somatostatin inhibitor claiming supplements, green tea, huperzine A, choline?

 

[songsofpyramids]

but @5 ius of hgh daily i doubt any amount of tesa would make an impact, may make it worse,,

You’d have to adopt some ridiculous injection schedule with a fasted shot 16-18 hours after the hgh because the action from the gh keeps working so long. You might get other downstream benefits of ghrh beyond igf1 even while shutdown but I don’t know if Tesa worth the financial cost to do that. I’m thinking of ditching ipamorelin because even at 2.1iu hgh and ipa 13-15 hours later it feels blunted. Still getting small sleep gains I can see on the tracker but not to the same extent as pre hgh.

Hgh really revs my system I’ve been forced to understand and embrace, so maybe I’m a poor sample and others will get better returns. I have to take my hgh when I wake up to pee first thing am or my sleep gets messed up.

 

[bananafeet]

No that won't work. 2mg Tesa amplifies endogenous GH pulses (and baseline GH) by 50-75%. So if your natural level is 100ug it's increased to 150ug-175ug.

At 2iu+ endogenous production is knocked out, so 50% more of 0 is still 0. 100mg of Tesa wouldn't do anything when there's no existing GH production.

 

[Proud Pangolin]

When you refer to "soma" I am guessing you are referring to somatostatin inhibitors? I am not trying to pull the kitchen sink approach, but how do you feel about natural somatostatin inhibitor claiming supplements, green tea, huperzine A, choline?

I only have experiences with.huperzine A. I took.it because its a ascetylcholinesterase inhibitor so i tried it as a nootropic.

Im telling you: terrible stuff, besides depressive mood it totally fucked up my sleep and made me sweat like crazy. I really cant imagine how people would tolerate the dosages needed for its soma inhibiting effect.

Leaving the general.effectivity of these inhibitors aside (whivh is absolutely questionable) my problem.with this would be timing. Absorbtion time will vary depending on your fasted state. I inject the first time right in tge morning before fasted cardio. I would have to wait half an hour till its obsorbed and maybe i.wont tolerate it on an empty stomache (i do not with high dosages of green tea extract)

So simply not very practical

 

[benfrankparkway]

I only have experiences with.huperzine A. I took.it because its a ascetylcholinesterase inhibitor so i tried it as a nootropic.

Im telling you: terrible stuff, besides depressive mood it totally fucked up my sleep and made me sweat like crazy. I really cant imagine how people would tolerate the dosages needed for its soma inhibiting effect.

Leaving the general.effectivity of these inhibitors aside (whivh is absolutely questionable) my problem.with this would be timing. Absorbtion time will vary depending on your fasted state. I inject the first time right in tge morning before fasted cardio. I would have to wait half an hour till its obsorbed and maybe i.wont tolerate it on an empty stomache (i do not with high dosages of green tea extract)

So simply not very practical

"questionable" I understand. I take huperzine A before i train for bjj/muay thai. I do feel it helps with my focus and head noise. For the other supposed soma inhibitors, my hopes the would lower soma, but feel there are also other benefits to those supplements. Then it goes back to is it worth it for the money. Hard to measure results if not impossible with the efficacy of supplements

 

[Mushy404]

Probably just a price drop + free ship.

Where did you find out about the sale?

Or more importantly, how do I find out about their sales on my own?
I was just about to order some Tesa and Ipa, but sounds like I should hold off for 2 weeks.

 

[Mushy404]

For the last 2 weeks I have been taking 1mg of Tesa + 250mcg of Ipa before bed. And then taking 250mcg of Ipa upon waking. I am also half way through my first week of Reta (GLP-3) 2mg/week.

Based on this thread, and other things I've been reading, I am going to increase my Tesa to 2mg before bed, but in your opinion, should I keep dosing my Ipa the same? Or should I increase it? Do you think the morning dose is beneficial?

Thanks

 

[rxr260]

I haven't tried Tesa yet, but Tirz/Reta works wonders for the visceral fat burning....Melanotan II also works as well.

Second this, tirz has all but eradicated my visceral fat.

 

[Photon]

Where did you find out about the sale?

Or more importantly, how do I find out about their sales on my own?
I was just about to order some Tesa and Ipa, but sounds like I should hold off for 2 weeks.

I asked about in their thread.

Post in thread 'Sigma Audley Inc. - Your source for peptides, ancillaries, AAS, and more!'

Jul 13, 2025

Any upcoming TSM5/TSM10 promo?
Last promo was Dec 2024.

We overlooked this product in this promotion. We will bring this product to the next promotion.

• SigmaAudley China Peptide

• 

 

[OIuerhojdiew]

I used GH, then Tesa for a year, That's what Tesa is optimized for. Punching through visceral fat that's become resistant to hormone signaling so it doesn't release its fat. This happens with age, the longer visceral fat sits there the less responsive it becomes, and eventually fibrosis develops making it rock hard. It's also really bad for your health. Much more dangerous than subcutaneous.

The FDA indication for Tesa is specifically to counteract the psychological distress otherwise fit men experience from using anti-HIV drugs that cause rapid growth of visceral fat deposits. Otherwise lean guys with big guts.

Even though it boosts IGF like GH, the visceral fat reduction is Tesa's main effect, and the other GH like effects, better skin, nails, etc, are present but less pronounced and slower to come on than GH,

GH also reduces stubborn visceral fat, but takes large doses (and sides) to get the same rapid effect as Tesa.

Something about Tesa keeping natural pulsatile GH release that makes it so good at visceral fat annihilation. Tesa itself doesn't cause lose weight, the visceral fat just gets redistributed to areas it's
easier to lose with diet and exercise,

Since sides are minimal with Tesa, it's very safe, and timing of the dose is irrelevant (it just amplifies your natural GH release keeping the GH axis intact), it's a good starter for 35+ year olds. 6 months daily injections will almost effortlessly recomp a hardened gut, improve skin and hair, then transition to GH to maintain the visceral fat loss and expand benefits to other areas.

Funny thing is those visceral fat inducing anti-HIV drugs aren't really even used any more, but the pharmaceutical company keeps coming out with new, more concentrated (for easier injections)versions of Tesa (Egrifta). I suspect a lot of people are getting this prescribed off label, since it's illegal to prescribe rHGH for anything other than short children and adults with GH deficiency or muscle wasting.

Combined with Tirz or Reta, and TRT it's the most potent visceral fat reduction stack there is.

https://www.theratech.com/news-releases/news-release-details/theratechnologies-receives-fda-approval-egrifta-wrtm-tesamorelin

Damn...what a wonderful comment. Very thorough. I've been on TRT (currently 175mg/wk EOD dosing, 12mg Tz/wk) and Tz for about a year with great results. Really happy with the recomp from 6'1 265 fat to 240 strong but still some gut (but lot less). Really considering Tesa, my turnoff was is this a forever peptide like Tz? Can I just do a cycle and get some recomp in my abdomen area and then keep on with the tz and trt? or will it come right back after discontinuation?

 

[songsofpyramids]

should I keep dosing my Ipa the same? Or should I increase it? Do you think the morning dose is beneficial?

The official ceiling for ipamorelin in science is 300mcg, but you can find dudes on other forums banging 1mg+ of it with testing to show positive impact. I do 300mcg of ipamorelin for sleep hygiene while on am hgh injections. The morning dose will be marginally beneficial, but not close to as much as your pm dose with ghrh.

 

[bubba618]

Damn...what a wonderful comment. Very thorough. I've been on TRT (currently 175mg/wk EOD dosing, 12mg Tz/wk) and Tz for about a year with great results. Really happy with the recomp from 6'1 265 fat to 240 strong but still some gut (but lot less). Really considering Tesa, my turnoff was is this a forever peptide like Tz? Can I just do a cycle and get some recomp in my abdomen area and then keep on with the tz and trt? or will it come right back after discontinuation?

Tesamorelin gains (losses) are relatively permanent in that unless you have some underlying issue which causes abnormal visceral adiposity or you have a shit lifestyle regarding eating and exercise.

Tirzepatide and the other related weight loss compounds operate as temporary hormone modulators to help you control your eating. Those changes generally go away once the compounds are stopped, but if you have embraced a healthier lifestyle and/or managed to change your metabolic set point, those changes may stick around for a while.

 

[Vicki]

The official ceiling for ipamorelin in science is 300mcg, but you can find dudes on other forums banging 1mg+ of it with testing to show positive impact. I do 300mcg of ipamorelin for sleep hygiene while on am hgh injections. The morning dose will be marginally beneficial, but not close to as much as your pm dose with ghrh.

Any benefit to ipa at night if you're taking gh in the morning? I have a lot of ipa in the freezer so wondering if it would be useful to add

Mostly for sleep specifically

 

[Ghoul]

Tesamorelin gains (losses) are relatively permanent in that unless you have some underlying issue which causes abnormal visceral adiposity or you have a shit lifestyle regarding eating and exercise.

Tirzepatide and the other related weight loss compounds operate as temporary hormone modulators to help you control your eating. Those changes generally go away once the compounds are stopped, but if you have embraced a healthier lifestyle and/or managed to change your metabolic set point, those changes may stick around for a while.

That isn't borne out by that stats.

Is exogenous testosterone via TRT for hypogonadal men a temporary crutch?

Is exogenous Insulin for diabetics a temporary crutch?

Why would exogenous GLP be a temporary crutch if there's a deficiency in production, or sensitivity to that hormone?

 

[songsofpyramids]

Any benefit to ipa at night if you're taking gh in the morning?

Yes, mostly sleep benefits, as I doubt the actual gh boost does much with hgh on board. I do my ipamorelin like 14-16 hours after my hgh am im injection and I get sleep benefits I can see on my health tracker (longer sws and rem). I also had a bunch laying around and decided to throw it in and I do not regret it.

 

[bubba618]

That isn't borne out by that stats.

Is exogenous testosterone via TRT for hypogonadal men a temporary crutch?

Is exogenous Insulin for diabetics a temporary crutch?

Why would exogenous GLP be a temporary crutch if there's a deficiency in production, or sensitivity to that hormone?

I think you misunderstand me. It's temporary in that the effects wane once the compound is no longer applied. I don't see any of it as a crutch whether GLP-1, TRT, etc. Instead, they are treatments which must be maintained at some level in order to maintain the benefits. You've said as much as I recall.

Tesamorelin effects do not fall into that same temporary category unless there is some underlying issue such as medicine-induced lipodystrophy such as with HIV medications, or perhaps a genetic disorder causing an ongoing lipodystrophy. Again... I believe you have said as much yourself in the past.

 

[OIuerhojdiew]

Tesamorelin gains (losses) are relatively permanent in that unless you have some underlying issue which causes abnormal visceral adiposity or you have a shit lifestyle regarding eating and exercise.

Tirzepatide and the other related weight loss compounds operate as temporary hormone modulators to help you control your eating. Those changes generally go away once the compounds are stopped, but if you have embraced a healthier lifestyle and/or managed to change your metabolic set point, those changes may stick around for a while.

Thank you, yes I was full on metabolic syndrome with a fatty liver before my TRT and Tz a year ago. Have made holistic changes to my lifestyle that definitely show up in my bloodwork and liver enzymes, and all the markers for metabolic syndrome (including waist size). The belly is much smaller but still there. I'm going to get some tesa ordered.

 

[Heretolearn]

So I’ve been researching Tesa for my wife and we are both very new I am confused about dosing reconstituting etc. some info I read says 2 mg daily , something else I read said 300 mcg for 6 days a week. If I mix 2 ml of bac water for a 2 mg vial of Tesa that only gives me 1 dose of 2 mg correct? How do I figure mcg to ml doses or am I totally wrong with my thoughts ?

 

[sionnach]

If I mix 2 ml of bac water for a 2 mg vial of Tesa that only gives me 1 dose of 2 mg correct?

Well 2mg can't be anything other than 2mg until you divide it. Slow down with your headmath bruh.