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dinfar1337 said:
for muscle building effects these drugs arent worth more than the insulin sensitivty, dont look into the glucagon effect its not even gonna feel like 0.01% of aas
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Brooo I feel like the influencers are getting to me.

I think the glucagon effects is like 150 calories a day or something. (Don't quote me).

I wonder why Survodutide never got any traction? Not as cool of a name?
 
bananafeet said:
Brooo I feel like the influencers are getting to me.

I think the glucagon effects is like 150 calories a day or something. (Don't quote me).

I wonder why Survodutide never got any traction? Not as cool of a name?
Click to expand...

The other GLPs are alot more expensive to be dosed at doses used in clinical trials. Since it's not cost effective, there's no demand for it and no reason to produce more, thus the price will never drop.
 
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bananafeet said:
Brooo I feel like the influencers are getting to me.

I think the glucagon effects is like 150 calories a day or something. (Don't quote me).

I wonder why Survodutide never got any traction? Not as cool of a name?
Click to expand...
yup, my answer was to muscle building effects.

the glucagon is gonna help you preserve lean mass and have better lipolysis on paper right? but no studies as of yet, and hgh is just much better. use reta to get insulin sensivity up if you're looking for it to build "muscle" aka being semi anabolic.

and the 2nd best effect could be better health overall so u can blast longer. but for providing an edge thats about it
 
Ghoul said:
Me too, 15mg slow titration (pharma protocol, 4 weeks per level) and zero sides . Don't "feel" anything at all, which is the normal experience for those who reach a stable maintainance dose.
Click to expand...

I remember you did stack for awhile, are you still stacking glps?
I keep thinking of adding Tirz due to the proclaimed "reduction in inflammation benefits".
 
bananafeet said:
What do you think about the GIP and glucagon activation at higher doses of Tirz/Reta?

Do the higher doses confer any benefit?

I looked at the binding data and it seems at lower doses Tirz favours GIP and higher doses is when you get the glucagon activation with reta.

So my thinking is micro dosing Tirz is fine to get the GIP but bolus would be better for reta to get the glucagon activation.
Click to expand...

If you can get to a high clinical dose of Reta (8mg or 12mg) the benefits of glucagon are major, as you'll experience continuously enhanced fat metabolism. Almost like using clenbuterol. Below 8mg glucagon's impact is minor.

At low doses biggest advantage of Reta is good glucose control with minimal appetite suppression. But if someone wants appetite suppression to lose weight, Tirz may be a better place to start.

I went from 2.4mg Sema maintainance, to 10mg Tirz before feeling anything, Since you're at 15 Tirz, I'd think you should be able to get to 8mg Reta or more pretty quickly.

You'll have to see how Reta affects RHR for you. That seems to hit some people hard. Other glucagon agonizing GLP combo drugs failed in early trials because RHR was out of control.
 
Photon said:
I remember you did stack for awhile, are you still stacking glps?
I keep thinking of adding Tirz due to the proclaimed "reduction in inflammation benefits".
Click to expand...

Given the way these drugs work I think a higher dose of a single GLP is the best way to go. The only exception might be if you reach max dose on one, like Tirz, and still can't reach goal weight, then careful use of a Sema add on might be make sense. But for weak or non responders, the pharma cos will be releasing larger doses. Tirz has been proven safe up to 25mg, and Sema up to 7.2mg in clinical trials, so stacking is even less necessary.

With Reta especially the balance between GLP/GIP/Glucagon is critical, and I don't think you want Tirz GIP (1x binding strength, like natural GIP), competing with Reta GIP (7x binding strength vs natural GIP) for the same receptor site.
 
Ghoul said:
If you can get to a high clinical dose of Reta (8mg or 12mg) the benefits of glucagon are major, as you'll experience continuously enhanced fat metabolism. Almost like using clenbuterol. Below 8mg glucagon's impact is minor.

At low doses biggest advantage of Reta is good glucose control with minimal appetite suppression. But if someone wants appetite suppression to lose weight, Tirz may be a better place to start.

I went from 2.4mg Sema maintainance, to 10mg Tirz before feeling anything, Since you're at 15 Tirz, I'd think you should be able to get to 8mg Reta or more pretty quickly.

You'll have to see how Reta affects RHR for you. That seems to hit some people hard. Other glucagon agonizing GLP combo drugs failed in early trials because RHR was out of control.
Click to expand...
I'm currently on 3mg Tirz single dose per week and it's plenty at the moment. I went up to 1.5mg twice a week of semaglutide.

What do you think of the GLP4 drugs that are proposed? I think it's called bioglutide and it will have igf1 as well.

Isn't being on a replacement dose of HGH or 1-2mg of tesamorelin functionally the same thing?

I haven't found any info about the quadruple agonists yet. I'm not talking about cagri-sema. I'm talking about an anti catabolic agent being added.

Crazy aside the new PT141 weightloss drugs might be a winner if they can get people horny and slimmer at the same time
 
Ghoul said:
Pharma Tirz.

I'm also on rHGH, which provides a far greater increase in lipolysis and resting energy expenditure than even high dose Reta could so I see no reason to switch from Tirz.
Click to expand...
I see. I stalled on 15mg, so instead of going up to 20/25 mg I made a switch to Reta
 
Ghoul said:
If you can get to a high clinical dose of Reta (8mg or 12mg) the benefits of glucagon are major, as you'll experience continuously enhanced fat metabolism. Almost like using clenbuterol. Below 8mg glucagon's impact is minor.

At low doses biggest advantage of Reta is good glucose control with minimal appetite suppression. But if someone wants appetite suppression to lose weight, Tirz may be a better place to start.

I went from 2.4mg Sema maintainance, to 10mg Tirz before feeling anything, Since you're at 15 Tirz, I'd think you should be able to get to 8mg Reta or more pretty quickly.

You'll have to see how Reta affects RHR for you. That seems to hit some people hard. Other glucagon agonizing GLP combo drugs failed in early trials because RHR was out of control.
Click to expand...
Hi Ghoul, about Sema, do you know if it’s possible that some people just don’t respond to it?
I remember when i ran it, and i barely felt any effects, even at a 2.4 dose, i switched to Tirz, and at just 5 mg i already started feeling the effects
 
Anyone experience PIP from their oils? So far the test e 250, 300 and test c 250 have all resulted in inflamed/sore injection sites. I’ve been a pin cushion for a long time and used QSC exclusively for years prior to switching to SSA - never had an issue?
 
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