MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
I went from sema to reta last shot was 1mg to 2mg reta still had apetite supression just not the same and also insane energy boost i was also over 1000kcal in deficit so i could really feel the change but maybe it was couse of the glp1
Ah man I really hope that it's the same experience for me. As mentioned, I really like the effects for my health and I can eat at 2,5mg, but don't have to. But like the first time, I'm in week 2 and the lethargy is ridiculous. I've tried to split the dose this time into 2 shots but it doesn't matter. Looking forward to Reta so bad
TheBeast1
New Member
Funny enough, I drink about a gallon plus of water a day.
But so far today, I haven't had any symptoms of the issue after taking 5g of salt last night. Sort of crazy I need to add it to my supplement list now but here we are!
Over 4mg i think i saw all of the gurus that sell overpriced reta claim the glucagon(part that should give u the energy boost) works the best and also saw people talk about loading phase takes 4weeks to saturate ? Not sure if there is any Truth to those claims
Interesting, first time I heard that. Thank you, will see if it's true
Ghoul
Member
It takes 4-5 half lives to reach stable serum (blood) concentration levels. For Sema/Tirz/Reta that's about 4 weeks.
We don't have solid info regarding glucagon activation with reta, but if you extrapolate the weight loss impact of different doses from the clinical trials, it suggests glucagon effects aren't very significant until 8mg+, when baseline metabolic rate appears to exceed pre-weight loss BMR. With other GLPs, BMR keeps going down with calorie deficit and weight loss, the way metabolic adaptation usually works as it tries to conserve energy in response to a perceived food shortage.
Daaaang, makes sense but dang. I'm glad you pointed that out because I have been eyeballing a kit but it is a bit pricey compared to Tirz. I may just go back to low dose Tirz. I was running 2mg for a bit (4mg was too much) and I think it gave me just enough help without the added issues.
I'm in a bulk right now so just going to work on discipline. I thought 4mg was a good idea to keep food noise down on a bulk and i have to choke down my protein every morning and force the meals down, with excessive bloating afterwards.
Not a good combo lol.
bananafeet
Member
Yes exactly this. Reta is GIP first, then GLP1 and then GCCR.
I'm gonna trial some mazdutide. I'm a bit concerned about how it will interact with HGH that produces IGF1 at SD+1 so I'm considering adding in some semaglutide for BG control.
What do you think @Ghoul
Looking to stack something on top of Tirz for a bit more appetite control/less cravings. Would Metformin (for the leptin receptor agonism) or Cagrilintide (Amyelin receptor agonism) be better? I'm on 10mg Tirzepatide, I don't want to up the Tirz further because I belive my GLP1 and GIP receptors are fully saturated or close to, because at first going from 2.5mg to 5mg destroyed my appetite, after loosing some weight going from 5mg to 10mg made a tiny difference but it wasn't enough, so I'm getting diminiscing returns
Give me a source for this. People keep saying this with no evidence and it doesn’t jive with the results. There was no energy expenditure measurement in the trials, so we don’t have direct data. And there is no reason to believe glucagon is not activated in a meaningful way at lower doses, especially since even 4mg produces high % weight loss. Further there is barely a difference in total loss between the 8mg and 12mg groups, which doesn’t support the idea that glucagon impact and EE are accelerating at higher doses.
bananafeet
Member
Don't worry mate I'm no longer worried about hypothetical fibrils!! I am the proud new owner of mobile gallstones haha
Been on 15mg Tirz for about 2–3 weeks now, and funny enough, it’s easier to handle than 12.5mg. I’m eating without any issues, hitting my calories, and the weight is still dropping - even though I cut back on cardio and eased up on training. The other day I tried to out-eat Tirz - almost managed it. Had a big meal at a restaurant and then went solo on a full 1lb tiramisu. Mission accomplished… but man, the night was rough, and by morning I was 0.5lbs lighter on the scale.
you sure it's Tirz and not Clen or DNP
Real talk tho, it might have improved your insulin sensitivity to the point your nutrient partitioning is way better than before. I noticed the same going from 5mg to 10mg, didn't get much additional appetite suppression (only a teeny tiny bit) but I got leaner and I look fuller (especially the legs) my guess is better nutrient partitioning.
I binged a bit yesterday (my fault) and today I looked vascular and fuller, instead of flabby (little water retention yes, but it went away my mid day)
I’ve never tried pharma Tirz, only UGL. I’ve run Tirz from three different vendors here and they all worked the same for me. I know India is selling pharma Tirz now, but in my opinion it’s not worth the price.
SnowyMiami
Member
Just seems sus that you are maxing out the dosage and not getting wrecked by it.
I’ve mentioned it in this thread before whenever I adjusted the dose. I’ve been on Tirz for over a year now. The body adapts, and appetite suppression was never my main goal. After each shot I do feel some fatigue for 2–3 days, but it’s manageable. If I’m not mistaken, a couple of guys here are on pharma Tirz at this dose and feel fine, so I don’t see anything unusual about it.
not everyone gets recked, especially after being on these drugs for a longer time. I'm on 10mg and feel zero appetite suppresion by now (tho I'm maintaining 30lbs lighter than when I started)
bananafeet
Member
I just started Tracy's 10mg Retatrutide. 7 days in.. I feel nothing and I've taken 4mg over 6 days. Going to finish the vial and give up and try the mazdutide.
I've only had sensitive skin and a pounding heart as an "effect". Tirz and sema were much more powerful
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