Objection! Assumes facts not in evidence. In the US of A, those assertions about a drug are not true until the FDA says they're true. Practically speaking.
MESO-Rx
Anabolic Steroids
Blood Pressure
- Thread starter gilmarpersonal
- Start date
Ghoul
Member
Oh, the FDA has already given the initial green light to it, as an "orphan drug" to treat "Systemic Sclerosis", a very rare disease that Cilnidipine reduces the symptoms of.
FDA Grants Orphan Drug Status to AISA-021 for Systemic Sclerosis
Aisa Pharma, Inc., a clinical-stage biopharmaceutical company based in Boston, has announced that the U.S. Food and Drug Administration (FDA) has gran
So Cilnidipine will be available shortly in the US with a different name, as a new branded drug, for Systemic Sclerosis only, with a cost likely to be thousands, if not tens of thousands a month as most "orphan drugs" are priced.
But not as a BP med, which it was intended for.
The maker can always pony up the cash to prove its safety and efficacy, and bring it to market, and then try to recoup that investment when competing against a cheap, effective, and relative safe generic CCB that every doctor knows and trusts.
I wouldn’t invest my money in that endeavor personally, but maybe they will someday.
It’s a crappy process but it’s what we got. Beats having flipper babies, I guess.
AllGoodThings
Member
I'm trying to get my hypertension under control, but I'm dealing with hyperkalemia which started years ago, before any BP meds were introduced, so they don't want me on any ARB's or ACE inhibitors, which really sucks. I'm currently on Nebivolol 10mg ED and Clonidine 0.1mg 2x/day. I just realized recently through my own research that Nebivolol also has the potential to cause/exasperate hyperkalemia, so I'm going to need to address this with my nephrologist. He tried me on Amlodipine, but I got insane, INTENSE low back and hip pain, to the point of being entirely bedridden and in agony for days. I've never experienced anything like it in my life. Has anyone experienced or even heard of this kind of a reaction to amlodipine? My hypertension is still well managed, and I need more options. My pre-existing hyperkalemia (along with chronically low sodium) is really limiting my options.
BamaCrazy
Banned
If I go above 20mg Telmisartan my potassium gets out of range fast. I tested this twice with before and after labs on a dosage increase to 40mg. But 5-10mg Nebivolol does not give me issues at all. So I’m on 20mg Telmisartan, 10mg Cilnidipine and 5mg Nebivolol right now.
And Amlo didn’t give me body pains. It gave me edema in my hands while sleeping. That’s why I switched to Cilnidipine.
AllGoodThings
Member
Thank you for sharing, I appreciate it. Unfortunately, being in the US, Cilnidipine isn't an option for me. I'm going to see if my Dr will try low dose Telmisartan and monitor my blood work. I believe my hypertension is angiotensin driven, so it should help considerably
BP_6
Member
Just a note, Cinidipine is very easy and inexpensive to get, even if you are in the US from overseas. Might be worth getting some to see if it helps you.
Photon
Member
Will probably require prior authorization too..which no doctor will do..
Last edited:
Just came off cycle and transitioned to cruise + HGH - blood pressure dropped back to normal, no more headaches, resting heart rate stabilized, and overall I feel great. I ran 20mg telmisartan daily throughout the cycle to keep BP in check, and it definitely did the job.
Also added ivabradine during the cycle, and it turned out to be a great addition. Big thanks to the smart guys on this forum who recommended it - made a real difference keeping my resting heart rate in check.
That said, as the years go by, even moderate doses hit harder. The body doesn’t bounce back like it used to in my 20s. These days, cruising feels like a well-earned vacation - not just for the body, but for the mind too.
Also added ivabradine during the cycle, and it turned out to be a great addition. Big thanks to the smart guys on this forum who recommended it - made a real difference keeping my resting heart rate in check.
That said, as the years go by, even moderate doses hit harder. The body doesn’t bounce back like it used to in my 20s. These days, cruising feels like a well-earned vacation - not just for the body, but for the mind too.
Bumpygooch
Member
please pardon my pedantism in advance……..exacerbate
Did you see any HR ceiling from ivabradine? I was using nebivolol for a while but no matter how hard I lifted or peloton’d, it was nearly impossible to break 125 bpm.
Yeah, I definitely noticed a ceiling with ivabradine. On 10mg, my heart rate would barely hit 105 bpm during steady-state cardio, even if I tried to push it. To go higher, I basically had to do HIIT - not really my thing, so I stuck with incline walking or cycling for 60–75 mins around 100–105 bpm.
Before ivabradine, I’d easily be in the 120–130 range. The only time I hit 150–160 while on it was during heavy leg days. So yeah, it keeps HR low - great for resting control, but it does cap your training intensity.
AllGoodThings
Member
Thank you, I always appreciate corrections, they never make me exasperated
Bumpygooch
Member
Tried 20 last night, since I don’t have the cuff. Got readings of anywhere between 125-138/75-85. So, reduced for sure. Now I’ll get a cuff as well. Thank you, sir.
Ghoul
Member
You may notice feeling somewhat more chill in stressful or aggravating situations. It's not your imagination. Cilnidipine partially blocks the physical stress response to psychological stress, and since you don't "feel" the stress via increased BP and muscle tension, psychological stress is reduced. Without any feelings of sedation or tiredness. It only "kicks in" when the central nervous system tries to boost blood pressure and muscle tension in preparation for "fight or flight".
I noticed this effect much more at 20mg than 10mg.
This study reported the case of a 72-year-old hypertensive man whose blood‐pressure spikes under acute psychological stress were markedly blunted by switching to cilnidipine. It's been confirmed by tests intentionally inducing psychological stress and measuring BP response. Some folks are much more susceptible to this BP spike when aggravated than others, and Ciln is perfect for them.
One other thing, anyone in the US considering Ciln should consider getting it now. The ending of de minimus on 8/29 and the FDA's planned increased involvement in enforcement at international mail facilities *may* make it much harder in the near future. If you buy smart it's under $30 for a year's supply, and has a very long shelf life. It can easily remain good for 7+ years kept refrigerated.
malfeasance
Member
Is this going to slow down your ability to kill predators when attacked?
Ghoul
Member
Yes, but since "flight" is also blunted you don't try to run, making you appear to be a badass, so they look for a softer target.
So to report back. I actually have my bp at like 122/74 on a good day. 130/80 on a bad one. With no cardio. So I’m going to add cardio in soon. Diet has been good. Training good. And I’m taking 30mg telimisartan. And amlodipine 5mg. My question now is can I add 5mg cialis on workout days. Used to take it has a pre workout loved it. Stopped for a while but looking to add it back in. Also at what point would you drop a medication. Say I start the cardio and get down to like 115/65. At that point should I drop the teli or amlodipine? Just looking for some feed back guys. Overall bp looking a lot better.
Starting with drugs and no cardio is already stupid asf…
Ghoul
Member
]
After lifestyle change and BP is consistantly below 120/80, for at least 3 months (some say 6, some 12), either lower dose by 50% or remove one med from combo, check bp again in 2 weeks, and if still below 120/80 you can try stopping completely, otherwise check again every 2 weeks.
After lifestyle change and BP is consistantly below 120/80, for at least 3 months (some say 6, some 12), either lower dose by 50% or remove one med from combo, check bp again in 2 weeks, and if still below 120/80 you can try stopping completely, otherwise check again every 2 weeks.
