Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[Jesintn]

How is glps, tirz, sema, combined with Dnp, 250 mgs e3d then eod, then maybe every day? I’d say dose dependent but any difficulty with sitting in the stomach ?

 

[Luke391]

How is glps, tirz, sema, combined with Dnp, 250 mgs e3d then eod, then maybe every day? I’d say dose dependent but any difficulty with sitting in the stomach ?

why not push with mitochondrial efficiency peptides before going to DNP? it would be much safer and still very effective.
I've heard people say Mirabegron is as strong as Clen when it comes to fat burning.
For me even just L-Carnitine at a good 500mg a day keeps me noticably leaner, diet and training being equal.

Also, if you're used to getting lean withour GLPs, with some Tirz or Reta you might find yoi can maintain 10% bodyfat or less without too much struggle

 

[Luke391]

Try Reta, I still have a large appetite but can’t eat close to as much !!!

thanks for the input but I've seen many people say that Reta doesn't supress appetite as much as Sema/Tirz. I'm used to Tirz so I don't wanna mess around with it too much. I'll go to 15mg tirz since it makes more sense than switching to a different drug, and if it's still not enough at 15mg I'll try stacking some Cagrilintide or Metformin on top of it

 

[Alex2000]

Hello, has anyone used 10 mg semaglutide? How long can it last once reconstituted if I start with doses of 0.5? I’ve calculated about 3 months… but I suppose it won’t last that long in the fridge.

 

[Luke391]

Hello, has anyone used 10 mg semaglutide? How long can it last once reconstituted if I start with doses of 0.5? I’ve calculated about 3 months… but I suppose it won’t last that long in the fridge.

better if yoi get smaller vials. ideally you'd kepp it reconstituted for no more than 4 week. Some have reported using sema for 6-8 weeks and it was fine, other say it loses potency after 4 weeks

 

[Onit]

Perhaps someone can advise me on the following.

I’m currently cutting with 5 weeks left until a photoshoot. So far, everything has gone well. During the day, I have no problem sticking to my diet. However, once I get home, I experience strong cravings for snacks. After training, I have my post-workout meal, but I still feel hungry afterwards.

At the moment, I’m on 10 mg reta. I do notice that I feel full a bit quicker, but overall it has hardly any effect on my appetite. Meanwhile, some people on just 2 mg can barely eat anything. I could increase the dose, or add tirzepatide to help suppress my hunger. However, I’m not sure if tirzepatide would still be useful with only 5 weeks to go (due to the time needed to build a baseline).

Yes, this is a mental game. But every little bit that helps is a welcome bonus.

What would be the best approach here?

 

[Ghoul]

Perhaps someone can advise me on the following.

I’m currently cutting with 5 weeks left until a photoshoot. So far, everything has gone well. During the day, I have no problem sticking to my diet. However, once I get home, I experience strong cravings for snacks. After training, I have my post-workout meal, but I still feel hungry afterwards.

At the moment, I’m on 10 mg reta. I do notice that I feel full a bit quicker, but overall it has hardly any effect on my appetite. Meanwhile, some people on just 2 mg can barely eat anything. I could increase the dose, or add tirzepatide to help suppress my hunger. However, I’m not sure if tirzepatide would still be useful with only 5 weeks to go (due to the time needed to build a baseline).

Yes, this is a mental game. But every little bit that helps is a welcome bonus.

What would be the best approach here?

You could take Reta to the max dose, 12mg, sometimes once GLPs cross a threshold dose, effects become much more pronounced.

If you are going to add something to get immediate results, Sema would be more effective and avoid unintended consequences of Tirz. A very tiny dose of Sema, .25mg, would significantly increase appetite suppression within a day of administration.

 

[Onit]

You could take Reta to the max dose, 12mg, sometimes once GLPs cross a threshold dose, effects become much more pronounced.

If you are gong to add something to get immediate results, Sema would be more effective and avoid unintended consequences of Tirz. A very tiny dose of Sema, .25mg, would significantly increase appetite suppression within a day of administration.

Thanks for your reply. Since July 21, I’ve been on 9 mg, having been on 6 mg before that. Since last week, I’ve increased it to 10 mg. I could try dosing 12 mg.

Initially, I was also considering sema (which I’ve had good experiences with) or cagri. However, I still have a prepared vial of tirzepatide, assuming it’s still good (prepared last year). I also have a tirzepatide kit. So I wouldn’t need to order anything or wait for delivery. A single vial of sema is quite expensive if I order it locally.

 

[Ghoul]

Thanks for your reply. Since July 21, I’ve been on 9 mg, having been on 6 mg before that. Since last week, I’ve increased it to 10 mg. I could try dosing 12 mg.

Initially, I was also considering sema (which I’ve had good experiences with) or cagri. However, I still have a prepared vial of tirzepatide, assuming it’s still good (prepared last year). I also have a tirzepatide kit. So I wouldn’t need to order anything or wait for delivery. A single vial of sema is quite expensive if I order it locally.

I would increase the dose of reta, even slightly beyond the clinical trial max, up to 15mg, instead of adding tirz.

 

[Onit]

I would increase the dose of reta, even slightly beyond the clinical trial max, up to 15mg, instead of adding tirz.

Since I’m eager to learn, I’m curious about your reasoning.

I read that the dose can indeed be increased beyond 12 mg. Would you go straight to 15 mg, or take the intermediate step of 12 mg first?

Edit:
Maybe it’s good to mention that I dose Monday, Thursday, and Saturday (3 times a week). Could dosing once every 5 to 6 days possibly have better appetite-suppressing effects?

I could try it, but I’m worried that the single higher dose might cause side effects.

 

[phenominal34]

Thanks for your reply. Since July 21, I’ve been on 9 mg, having been on 6 mg before that. Since last week, I’ve increased it to 10 mg. I could try dosing 12 mg.

Initially, I was also considering sema (which I’ve had good experiences with) or cagri. However, I still have a prepared vial of tirzepatide, assuming it’s still good (prepared last year). I also have a tirzepatide kit. So I wouldn’t need to order anything or wait for delivery. A single vial of sema is quite expensive if I order it locally.

You have a reconstituted vial of Reta from last year just sitting in fridge ?

Send it off for testing lol

 

[Luke391]

Since I’m eager to learn, I’m curious about your reasoning.

I read that the dose can indeed be increased beyond 12 mg. Would you go straight to 15 mg, or take the intermediate step of 12 mg first?

Edit:
Maybe it’s good to mention that I dose Monday, Thursday, and Saturday (3 times a week). Could dosing once every 5 to 6 days possibly have better appetite-suppressing effects?

I could try it, but I’m worried that the single higher dose might cause side effects.

better if you stick to once a wrrk dosing like the phrma protocols. Going above the max approved dose for any one GLP tends to have significant diminishing results, so it's just not worth it. if you're on Reta 12mg the best thing would be to stack sema 0.25mg

 

[phenominal34]

better if you stick to once a wrrk dosing like the phrma protocols. Going above the max approved dose for any one GLP tends to have significant diminishing results, so it's just not worth it. if you're on Reta 12mg the best thing would be to stack sema 0.25mg

I assume you’re referring to diminishing returns by the graphs thru the studies Of most ppl who were way out of shape and obese ?

 

[Bigmike806]

So pros and cons of running reta and micro dosing tirz. Thanks,not running it yet just weighing out all options.

 

[Eddie.]

So pros and cons of running reta and micro dosing tirz. Thanks,not running it yet just weighing out all options.

Well, you have 243 pages of info right here. Just start with the recent 50 and you ll find all the answers you need.

 

[Ghoul]

.l

So pros and cons of running reta and micro dosing tirz. Thanks,not running it yet just weighing out all options.

Post in thread 'Reta vs Tirz'

Jun 12, 2025

I've used all Tirz for a cut 2 years ago, Nuked my appetite, found it hard to hit my protein goals.

Using Reta currently, not as suppressive but I'm losing the weight and I'm able to hit my 200g of protein a day.

maybe try a mix of the two? I know someone doing 6mg Reta and .25 Sema and says the appetite suppression is better, I might try this too tbh

I'm not a fan of mixing GLPs, but adding sema to either is probobly a better choice if you do, than mixing reta and tirz.

This way you're only boosting GLP agonism, the primary appetite suppression mechanism. Tirz and Reta bind...

• Ghoul

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[Jesintn]

If you are going to add something to get immediate results, Sema would be more effective and avoid unintended consequences of Tirz. A very tiny dose of Sema, .25mg, would significantly increase appetite suppression within a day of administration.

what unintended consequences of tirz is meant?

 

[Ghoul]

what unintended consequences of tirz is meant?

These are not simple compounds like steroids. It's retarded to just mix these things randomly.

EVERY other glucagon agonist GLP drug trial was stopped early and the drugs abandoned because of the threat to health of the subjects was too high.

A safe balance between GIP and Glucagon was very difficult for Eli Lily to find.

Tirz GIP is normal strength. Reta GIP is 9x strength. They did that on purpose. Altering that balance by mixing 1x GIP and 9x GIP is foolish.

 

[The Answ3r]

Pinned 15 mg Tirz before bed last night and woke up feeling like I got the absolute shit beaten out of me with a bat for eight hours straight. No idea what the hell that was, but I’m still in shock. After vacation I’m definitely dropping the dose. Any smart way to do it? Should I play nice and taper down, or just say “fuck it” and jump straight from 15 to 5 mg and call it a fresh start?

 

[phenominal34]

Pinned 15 mg Tirz before bed last night and woke up feeling like I got the absolute shit beaten out of me with a bat for eight hours straight. No idea what the hell that was, but I’m still in shock. After vacation I’m definitely dropping the dose. Any smart way to do it? Should I play nice and taper down, or just say “fuck it” and jump straight from 15 to 5 mg and call it a fresh start?

Did you work your way up to 15mgs ?