ineffectual
Member
Why are you always trying to sell me on new drugs?
MESO-Rx
Anabolic Steroids
Operation Pangea XVII: Record 769 arrests and USD 65 million in illicit pharmaceuticals seized in global bust
- Thread starter kain
- Start date
IndividualMan
Member
he is secretly indian and is trying to ship more product
LGOP528
Member
You are clearly very new here.
SnowyMiami
Member
If your wife is even a little chubby before kids just wait until after. 
ineffectual
Member
That usually goes away when they start banging the best friend.If your wife is even a little chubby before kids just wait until after.
BigDadd7
Member
I like em a little thickIf your wife is even a little chubby before kids just wait until after.
5mg a day oral? It’s metabolised into levomethamphetamine right
sionnach
Banned
Ateam2023
Member
also levoamphetemine,
Ghoul
Member
Yep. It metabolizes into enough of the L forms of amphetamine and methamphetamine it could rival the weakest cup of coffee you've ever had in your life. If you're particularly sensitive to it.
There's a reason it's not a controlled substance despite those metabolites.
On the other hand, if you're subject to routine drug tests it might be awkward failing the initial test. You'll need to tell them you used a Vicks Vapor inhaler (otc), and request confirmatory enantiomer testing. Vicks metabolizes into 10-20x as much of the L form of methamphetamine as selegeline does.
There's a reason it's not a controlled substance despite those metabolites.
On the other hand, if you're subject to routine drug tests it might be awkward failing the initial test. You'll need to tell them you used a Vicks Vapor inhaler (otc), and request confirmatory enantiomer testing. Vicks metabolizes into 10-20x as much of the L form of methamphetamine as selegeline does.
Thanks for providing more information about it. You piqued my interest about this substance as I used to take ADHD meds (stims) but had to stop using them as I felt they were burning me out and were unsustainable over the long term. So a non stim option that increases dopamine etc sounds really useful.
Currently using low dose sertraline (ssri) so I think I would have to stop that to try it, or it might risk serotonin syndrome.
I asked about route of administration because theoretically you could maybe sublingual it for 100% bioavailability to skip the metabolites issue and stretch a supply further. But if you say it’s not really that stimulating or a problem maybe it would be easier to use it orally.
Ghoul
Member
FYI they shouldn't ever be used together. You're supposed to allow a 14 day washout between them.
Sertraline has a bunch of different effects, a whole mess of sides (like most SSRIs), and isn't always very effective. But if it works I wouldn't discontinue it to start with this.
Selegeline is a much simpler drug. It only preserves dopamine from prematurely being broken down. It is sometimes used successfully for treatment resistant depression, or off label to overcome tolerance to ADHD meds (tolerance is sometimes caused by excess amount dopamine breakdown, by adding selegeline, ADHD med doses can often be cut in half).
Anyway, as always with any drug, check for interactions with everything you're taking and do your homework. I just wanted to confirm you defiantly don't want to combine them.
The "Why" not to use them together is this:
Low dose selegeline, under 10mg, inhibits MAO-b, which breaks down dopamine. This preserves dopamine, and takes a load off the cells that produce it (this is seen as an anti-aging benefit). Mao-b inhibition is safe, and essentially free of dangerous side effects. The younger you are the less MAO-b you have killing your dopamine, and lower doses of selegeline are just as effective, down to 1mg in your 20s.
The risk is that at higher doses, 10mg+ it also inhibits MAO-a, which breaks down serotonin.
Sertraline increases serotonin. With MAO-a inhibition levels can rise too high and cause serotonin syndrome.
So while 5mg selegeline is comfortably below the level that inhibits MAO-a, it's best to keep these two drugs clear of each other.
ineffectual
Member
Pct24x7 carries selgin. I wonder if they can get Selerin for about the same price. Hopefully shipping resumes soon and successfully.
Ghoul has converted me to become an Indian...
@Ghoul In other posts you say you take 200mg of moda and 50mg of amoda a day (I'm guessing normally). Do you take Selegiline daily and if so do you half the dose of the moda?
Ghoul
Member
I dropped Moda / Armoda ) dosage when I optimized thyroid levels, and again after starting Selegiline.
I've long "modulated" based on waking time (since dose determines duration).
Standard for me is now is 50mg Armodafinil at 7:30 AM wake up or 100mg if 5:30 AM.
Coffee also had to be reduced by 1/3rd.
Modafinil blocks the transporter that moves dopamine back into the neurons it originates from for reuptake, where it goes into storage for reuse later. This means dopamine stays in areas related to wakefulness (the striatum) longer than it would otherwise, increasing levels and therefore "wakefulness".
MAO-B, sits inside the neurons breaking down a portion of the dopamine that's taken back up. This process creates oxidants, and forces the neurons to make new dopamine because it doesn't have enough stored to meet the brain's requirements. These stresses are what cause the dopamine producing neurons to "burn out" over time, leading to age related demotivation, depression, and eventually parkinson's disease, where you can't produce enough dopamine to turn thoughts into muscle movement.
Selegeline inhibits MAO-B from breaking down dopamine, reducing the oxidative byproducts, allowing more of the reuptaken dopamine to go into storage for reuse, which means neurons aren't as stressed since they don't have to make as much replacement dopamine, preserving their function long term and preventing decline of dopamine production capacity.
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