Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[Ghoul]

yeah , they made reta to not effect appetite, i forgot about that

Reta is great for giving benefits without significant appetite suppression. Which is great for BB. or any others wanting the non-weight loss benefits, but it makes me wonder how successful it'll be as an actual weight loss med, since Tirz is so

nope, still relying on my balls for the time being. only Tirz and L-Carnitine. the Carnitine is a nice fat burner but doesn't really give me more energy. Also I probably have hypothyroidism, once my my paycheck hits I'll get bloodwork to check a bunch of stuff.
Once I finish the Tirz I got I might consider switching to Reta

If your issue is a ferocious appetite , switching to Reta isn't going to help. Have you read of many people saying "Wow, tirz wasn't doing much. but Reta sure cut back on my appetite!"?

It's the opposite. Reta is appreciated by BBs precisely because it doesn't kill appetite like Sema or Tirz. The ones needing more appetite suppression are always stacking something else with it.

All it's going to do is drain your wallet and boost your food intake.

 

[SnowyMiami]

Reta is great for giving benefits without significant appetite suppression. Which is great for BB. or any others wanting the non-weight loss benefits, but it makes me wonder how successful it'll be as an actual weight loss med, since Tirz is so

If your issue is a ferocious appetite , switching to Reta isn't going to help. Have you read of many people saying "Wow, tirz wasn't doing much. but Reta sure cut back on my appetite!"?

It's the opposite. Reta is appreciated by BBs precisely because it doesn't kill appetite like Sema or Tirz. The ones needing more appetite suppression are always stacking something else with it.

All it's going to do is drain your wallet and boost your food intake.

Do you believe once the hype cycle fades Tirz will remain most people's best option?

 

[BigDadd7]

Do you believe once the hype cycle fades Tirz will remain most people's best option?

That entirely depends on your goals. If your goal is to control blood sugar, reta is the go to. If you also want to control food cravings and/or lose weight, tirz is the go to.

 

[Almoister]

That entirely depends on your goals. If your goal is to control blood sugar, reta is the go to. If you also want to control food cravings and/or lose weight, tirz is the go to.

Reta gives extra energy in cut tho atleast i feel absurd difference to Trizz

 

[Sera]

Reta is great for giving benefits without significant appetite suppression. Which is great for BB. or any others wanting the non-weight loss benefits, but it makes me wonder how successful it'll be as an actual weight loss med, since Tirz is so

If your issue is a ferocious appetite , switching to Reta isn't going to help. Have you read of many people saying "Wow, tirz wasn't doing much. but Reta sure cut back on my appetite!"?

It's the opposite. Reta is appreciated by BBs precisely because it doesn't kill appetite like Sema or Tirz. The ones needing more appetite suppression are always stacking something else with it.

All it's going to do is drain your wallet and boost your food intake.

Reta is strong as fuck in my experience. 1mg giving me equivalent appetite suppression as 5mg tirz.

The suppression is qualitatively different between the two so it’s a little difficult to compare.

But it doesn’t make food seem repulsive to me like tirz does.

I guess everyone reacts differently.

Also way less fatigue.

Although gotta be careful with it to avoid increasing your RHR.

 

[Ghoul]

Reta is strong as fuck in my experience. 1mg giving me equivalent appetite suppression as 5mg tirz.

Also way less fatigue.

Although gotta be careful with it to avoid increasing your RHR.

I'm speaking in generalities of course. Some people say they can't eat on .5mg Reta. But mostly, it's "I can choose to eat or not" or some variation on that theme. Again, not a negative for most users here, but for Luke, based on his unusually potent appetite, he is one of those who needs the "brute force" appetite reduction vs the gentle "just quiets the food noise." type.

Honestly, if it weren't for the additional health benefits of Tirz, I'd say Sema is probably the best in that circumstance.

The main thing the addition of GIP to GLP does is suppress nausea GLP would normally induce, making the experience less unpleasant. Unlike Sema, which has nothing subtle about it. It's like a spiked club. "Eating too much despite me reducing food noise? I'll let you finish eating beyond your appetite, and reward you with some intense nausea so you can hug the toilet for a while. I'll keep doing that until you learn to listen to your appetite, and stop eating when you're no longer hungry.".

On the other hand, very very few are getting to 8mg and 12mg top doses of Reta, where the glucagon benefits actually manifest and burn fat faster than the caloric deficit alone would. If Luke can get to those levels, and accepts the cost of those doses of Reta, he might get the appetite suppression he needs and a bonus of a couple hundred calories burning off each day effortlessly, But that's a maybe and Tirz is working for him for sure, he just needs to increase the dose.

 

[ineffectual]

Do you believe once the hype cycle fades Tirz will remain most people's best option?

My opinion just from messing with Sema, then Tirz and eventually I will play with reta and whatever else becomes popular.... They hit everyone a little different. From sides and effectiveness. More options, affordable, the better. Then it may depend on what insurance covers or even what the pcp likes and wants to push.

 

[Ghoul]

My opinion just from messing with Sema, then Tirz and eventually I will play with reta and whatever else becomes popular.... They hit everyone a little different. From sides and effectiveness. More options, affordable, the better. Then it may depend on what insurance covers or even what the pcp likes and wants to push.

Sad irony that despite greatly expanded coverage by insurance, many who would qualify have disqualified themselves by lowering weight via DIY GLP's.

Even if you go the do it yourself route, it's a good idea to get one prescription from a doc while you still qualify via BMI. Even if you don't fill it. Because once that's in your medical record, you continue to qualify for "maintenance" coverage even after you drop below the minimum BMI 27 most require. It's nice to have the option to swap over to pharma, and be able to keep switching to new GLPs as they become available.

 

[Almoister]

Is here anyone who knows how much time off glps would one roughly neeed to almost reset dose to base line from like 10mg ? Dont like how high doses make me feel reta/trizz ofc

 

[BigDadd7]

Sad irony that despite greatly expanded coverage by insurance, many who would qualify have disqualified themselves by lowering weight via DIY GLP's.

Even if you go the do it yourself route, it's a good idea to get one prescription from a doc while you still qualify via BMI. Even if you don't fill it. Because once that's in your medical record, you continue to qualify for "maintenance" coverage even after you drop below the minimum BMI 27 most require. It's nice to have the option to swap over to pharma, and be able to keep switching to new GLPs as they become available.

Damn it. Thats really good thinking!

 

[Ghoul]

Is here anyone who knows how much time off glps would one roughly neeed to almost reset dose to base line from like 10mg ? Dont like how high doses make me feel reta/trizz ofc

That's not how it works. You don't build tolerance.

To get the same response at the same dose, you have to be roughly the same weight / bodyfat you were when you initially took it. As you lost weight / fat, a given dose becomes less appetite suppressive. When you regain, the same dose becomes stronger in appetite suppression effects.

 

[Almoister]

Sel

That's not how it works. You don't build tolerance.

To get the same response at the same dose, you have to be roughly the same weight / bodyfat you were when you initially took it. As you lost weight / fat, a given dose becomes less appetite suppressive. When you regain, the same dose becomes stronger in appetite suppression effects.

Well fuck… gonna do tren for 2yrs straight i guess

 

[Luke391]

I'm speaking in generalities of course. Some people say they can't eat on .5mg Reta. But mostly, it's "I can choose to eat or not" or some variation on that theme. Again, not a negative for most users here, but for Luke, based on his unusually potent appetite, he is one of those who needs the "brute force" appetite reduction vs the gentle "just quiets the food noise." type.

Honestly, if it weren't for the additional health benefits of Tirz, I'd say Sema is probably the best in that circumstance.

The main thing the addition of GIP to GLP does is suppress nausea GLP would normally induce, making the experience less unpleasant. Unlike Sema, which has nothing subtle about it. It's like a spiked club. "Eating too much despite me reducing food noise? I'll let you finish eating beyond your appetite, and reward you with some intense nausea so you can hug the toilet for a while. I'll keep doing that until you learn to listen to your appetite, and stop eating when you're no longer hungry.".

On the other hand, very very few are getting to 8mg and 12mg top doses of Reta, where the glucagon benefits actually manifest and burn fat faster than the caloric deficit alone would. If Luke can get to those levels, and accepts the cost of those doses of Reta, he might get the appetite suppression he needs and a bonus of a couple hundred calories burning off each day effortlessly, But that's a maybe and Tirz is working for him for sure, he just needs to increase the dose.

thank you for always going in depth with your responses. Can definetly relate to the Sema experience lol. I tried 0.25mg Ozempic before the UGL Tirz and I felt no appetite suppresion, hungry as usual, then if I ate too much 4-6hours later I'd get the most painfull stomach cramps and nausea of my life that would have bed bound for 1 day. only used it 3 weeks and the let it rot in my fridge forna year.
Also I am genetically prone to heart problems and have been hospitalized for a heart problem once when I was a kid, so the increased heart rate of Reta kinda makes me reluctat to use it. Like you said for me it's the "brute force appetite suppresion" I'm looking for.
Guess just more Tirz and maybe Cagri

 

[Luke391]

Sad irony that despite greatly expanded coverage by insurance, many who would qualify have disqualified themselves by lowering weight via DIY GLP's.

Even if you go the do it yourself route, it's a good idea to get one prescription from a doc while you still qualify via BMI. Even if you don't fill it. Because once that's in your medical record, you continue to qualify for "maintenance" coverage even after you drop below the minimum BMI 27 most require. It's nice to have the option to swap over to pharma, and be able to keep switching to new GLPs as they become available.

so if I get jacked enought to have a BMI of 27 I can get prescrpibed Mounjaro? interesting

 

[Ghoul]

Damn it. Thats really good thinking!

The good news is even below the minimum BMI, there is an ever increasing list of conditions you can get it prescribed for. IE, fatty liver or sleep apnea.

Alternatively, you could just get a telehealth appointment someplace like Sesame, lie about your weight, and get a prescription.

thank you for always going in depth with your responses. Can definetly relate to the Sema experience lol. I tried 0.25mg Ozempic before the UGL Tirz and I felt no appetite suppresion, hungry as usual, then if I ate too much 4-6hours later I'd get the most painfull stomach cramps and nausea of my life that would have bed bound for 1 day. only used it 3 weeks and the let it rot in my fridge forna year.
Also I am genetically prone to heart problems and have been hospitalized for a heart problem once when I was a kid, so the increased heart rate of Reta kinda makes me reluctat to use it. Like you said for me it's the "brute force appetite suppresion" I'm looking for.
Guess just more Tirz and maybe Cagri

I think you're on the right GLP for your slightly unusual circumstances. I may have missed your Tirz dose if you mentioned it. I've been on 15mg or over a year, and feel nothing, but I don't gain any weight either nor do I overeat, so it's working exactly as it should.

I did decide to be in a calorie deficit to cut BF % down while on GH for a recomp, and bumped up to 20mg/wk to make that easier (I accumulated a surplus of 10mg Zepbound pens). It's working like a charm. I'm easily maintaining a very slight deficit, and managing to lose fat while increasing muscle mass. Once I'm back on 15mg, my normal prescribed maintainance dose, and appetite increases slightly, I'll do a slow, lean bulk.

You can safely increase Tirz up to 25mg, and I'd recommend staying on one compound if you can make it work before adding another. Because remember, when you get to goal, you need to stay on to maintain that. Easier to do for the long term with a single compound, especially Tirz, which should become increasingly cheaper and easy to source no matter what happens with the Chinese counterfeit supply,

 

[Ghoul]

so if I get jacked enought to have a BMI of 27 I can get prescrpibed Mounjaro? interesting

If you have even halfway decent insurance coverage, yes. 27bmi is the lower cutoff with a comorbidity. IE, high blood pressure, cholesterol, sleep apnea. Otherwise it's 29 BMI. Then you'll need to show "response". Generally more than. 5% weight loss within 16 weeks.

After that you're home free.

CVS/Caremark is the largest prescription plan handler for insurance policies and they recently dropped zepbound in favor of wegovy (sema) as a negotiating tactic to force Eli Lilly to drop the price of Zepbound, so that will change in the future, but the main thing is to get any GLP prescription as soon as you can before forcing yourself up to 27 becomes too difficult or insurance raises the bmi requirement (a couple plans have, to save money). Once you're in, you're in. No matter what happens to your weight, it'll always be assumed you require a GLP to avoid obesity. It's defined as a chronic disease like diabetes, not a "one and done" thing to be cured.

If you tell me who your insurance provider is (they probably cover millions of people so it's not an opsec issue, you can dm if you prefer), I can give you the specifics of coverage and what to tell your doctor to get a prescrip.

 

[Luke391]

The good news is even below the minimum BMI, there is an ever increasing list of conditions you can get it prescribed for. IE, fatty liver or sleep apnea.

Alternatively, you could just get a telehealth appointment someplace like Sesame, lie about your weight, and get a prescription.

I think you're on the right GLP for your slightly unusual circumstances. I may have missed your Tirz dose if you mentioned it. I've been on 15mg or over a year, and feel nothing, but I don't gain any weight either nor do I overeat, so it's working exactly as it should.

I did decide to be in a calorie deficit to cut BF % down while on GH for a recomp, and bumped up to 20mg/wk to make that easier (I accumulated a surplus of 10mg Zepbound pens). It's working like a charm. I'm easily maintaining a very slight deficit, and managing to lose fat while increasing muscle mass. Once I'm back on 15mg, my normal prescribed maintainance dose, and appetite increases slightly, I'll do a slow, lean bulk.

You can safely increase Tirz up to 25mg, and I'd recommend staying on one compound if you can make it work before adding another. Because remember, when you get to goal, you need to stay on to maintain that. Easier to do for the long term with a single compound, especially Tirz, which should become increasingly cheaper and easy to source no matter what happens with the Chinese counterfeit supply,

I'm on 10mg. Thank you for always being available on here. yeah I have seen Tirzepatide's price drop significantly since I started buying it. Kinda feel like I got ripped off now that prices are so low lol.
Your consideration of the protocol being easier to maintain off just 1 compound is definetly right, something I didn't think of.
It's not like I have a ton of weight left to loose, just another 5-7lbs to reach 10% bf and I'll be good to maintain, as long as my appetite is under control. If I was to then start bulking would it be fine to jump around the Tirz dose? If I loose more weight I think that even on 15mg I could eat in a surplus no problem, even enjoy it. But depending on how long I push the bulk and if I add some other drugs in the future I maybe will find myself having to lower the dose to eat enough. Would it be an issue to bounce between 12.5-20mg let's say or is it fine?

 

[Luke391]

If you have even halfway decent insurance coverage, yes. 27bmi is the lower cutoff with a comorbidity. IE, high blood pressure, cholesterol, sleep apnea. Otherwise it's 29 BMI. Then you'll need to show "response". Generally more than. 5% weight loss within 16 weeks.

After that you're home free.

CVS/Caremark is the largest prescription plan handler for insurance policies and they recently dropped zepbound in favor of wegovy (sema) as a negotiating tactic to force Eli Lilly to drop the price of Zepbound, so that will change in the future, but the main thing is to get any GLP prescription as soon as you can before forcing yourself up to 27 becomes too difficult or insurance raises the bmi requirement (a couple plans have, to save money). Once you're in, you're in. No matter what happens to your weight, it'll always be assumed you require a GLP to avoid obesity. It's defined as a chronic disease like diabetes, not a "one and done" thing to be cured.

If you tell me who your insurance provider is (they probably cover millions of people so it's not an opsec issue, you can dm if you prefer), I can give you the specifics of coverage and what to tell your doctor to get a prescrip.

Unfortunately Mounjaro is not yet prescribed in my country. Some Doctors will give ozempic for diabetics but nor for weight loss

 

[ineffectual]

Sad irony that despite greatly expanded coverage by insurance, many who would qualify have disqualified themselves by lowering weight via DIY GLP's.

Even if you go the do it yourself route, it's a good idea to get one prescription from a doc while you still qualify via BMI. Even if you don't fill it. Because once that's in your medical record, you continue to qualify for "maintenance" coverage even after you drop below the minimum BMI 27 most require. It's nice to have the option to swap over to pharma, and be able to keep switching to new GLPs as they become available.

Its something I never even considered when I first bought a few bottles to see what the fuss was about. There is no way I ever want to go back to the sugar monster I was before. Hopefully grey will always be around in some form.

 

[CHIEF M]

250mg EOD right at the start? Seems quite high as a starting dose, from what I’ve read.

He put mcg not mg lol