BigDadd7
Member
You're thinking that iu is a volumetric measurement, it's not.
MESO-Rx
Anabolic Steroids
HGH potency --- How is this determined?
- Thread starter Max Magnus
- Start date
You didn't read.
CC == cubic centimeter which is also the equivalent of a milliliter or ml
The units on a diabetic insulin syringe are not IU or CC, they are units; There's several options, but the most common is 100U insulin syringes. 10 units on these is the equivalent of 0.1cc or 0.1ml. cc and ml can be used interchangeably for clarity sake, pick one and stick with it for consistency.
IU is International Units, and this is a dosing/bioavailability unit and what this represents will vary wildly from compound to compound; i.e. 5,000IU of Vitamin D is a miniscule volume vs 500 IU of Vitamin E. This is only used as a bioavailability thing and is not representative of anything on the syringe or a measure of mg or ml or cc. It's compound specific.
Please do some research and get up to speed on what the units mean, it will simplify your questions and understanding of things and make it easier for us to help you when you do have questions.
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Read this (in the search list you ignored)...
Anyone worked with this lab in Germany?
bioassay-online.com
@janoshik
Any recommendation if they need a legit entity to order the Nb2 cell line assay?
Yourbioanalytical services powerhouse | Development Validation and Routine testing of biologics and drug products
We are a contract service organization specialized in the development and validation of bioassays for pharmaceutical potency testing. Our services are performed under GMP and GLP certification to meet regulatory guidance for pre-market and on-market products.
bioassay-online.com
@janoshik
Any recommendation if they need a legit entity to order the Nb2 cell line assay?
Ghoul
Member
The confusion is understandable.
An IU is a measure of POTENCY aka bioactivity.
First, let's knock insulin syringes out of the way.
1ml=1cc=100 units (aka iu).
That's because insulin only comes as a liquid and is manufactured to have 100iu of insulin bioactivity per ml. This has nothing to do with rHGH bioactivity iu (which is measured against dry mg, not ml of liquid, since you can dilute a mg of rHGH to whatever liquid concentration and it'll still contain the same amount of bioactivity).
The gold standard bioactivity measure of rHGH involves removing the pituitary from a bunch of cloned rats, injecting rHGH for 7 days, and measuring the amount of weight gain to calculate iu per mg.
Now they use cells to do the same thing without needing rats (a cruel, time consuming process). In one method, they use lab grown human liver cells, expose them to the rHGH, and measure how much IGF-1 they produce.
The reference standard set by the World Health Organization defines rHGH as having 3iu of bioactivity per milligram. It can vary from 2.7-3.1iu/mg of bioactivity and be within acceptable limits per the FDA.
Modern methods of production can actually produce rHGH with 4iu+ / mg potency, and it has to be diluted to get closer to 3iu/mg so it complies with the standard.
This way no matter what pharma brand you get, they're all roughly 3iu/mg so they're interchangeable.
UGL doesn't test this at all. It's just assumed every UGL is 3iu/mg.
On a Jano test: if the rHGH content in a vial is 5mg, it's called 15iu.
So in effect, for UGL, IU has become a measure of weight, not bioactivity, and lost all meaning.
1mg or 3iu, it's the same thing for UGL rHGH. It's the quantity of rHGH in the vial, though actual bioactivity per mg certainly varies and we don't know what it is. It may explain why we see comments that one brand produced side effects like carpal tunnel (normal for rHGH btw) at 9iu, while another "cleaner" brand didn't at the same dose.
Sure, they're both 3mg ("9iu") doses, but the "clean" one may actually have 6iu of bioactivity and "low quality side effect inducing" brand has 12iu of activity, bringing on stronger side effects at what appears to be the same dose.*
*What the community has attributed to side effects caused by undiscovered "impurities" are all normal effects of GH and individual sensitivity to it. GH causes general water retention, and IGF causes water retention in connective tissues (leading to nerve compression that causes transient carpal and joint pain symptoms, that usually stop happening over time). This happens to patients being treated with pharma rHGH too, it's spelled out right on the boxes, and has nothing to do with contaminants.
An IU is a measure of POTENCY aka bioactivity.
First, let's knock insulin syringes out of the way.
1ml=1cc=100 units (aka iu).
That's because insulin only comes as a liquid and is manufactured to have 100iu of insulin bioactivity per ml. This has nothing to do with rHGH bioactivity iu (which is measured against dry mg, not ml of liquid, since you can dilute a mg of rHGH to whatever liquid concentration and it'll still contain the same amount of bioactivity).
The gold standard bioactivity measure of rHGH involves removing the pituitary from a bunch of cloned rats, injecting rHGH for 7 days, and measuring the amount of weight gain to calculate iu per mg.
Now they use cells to do the same thing without needing rats (a cruel, time consuming process). In one method, they use lab grown human liver cells, expose them to the rHGH, and measure how much IGF-1 they produce.
The reference standard set by the World Health Organization defines rHGH as having 3iu of bioactivity per milligram. It can vary from 2.7-3.1iu/mg of bioactivity and be within acceptable limits per the FDA.
Modern methods of production can actually produce rHGH with 4iu+ / mg potency, and it has to be diluted to get closer to 3iu/mg so it complies with the standard.
This way no matter what pharma brand you get, they're all roughly 3iu/mg so they're interchangeable.
UGL doesn't test this at all. It's just assumed every UGL is 3iu/mg.
On a Jano test: if the rHGH content in a vial is 5mg, it's called 15iu.
So in effect, for UGL, IU has become a measure of weight, not bioactivity, and lost all meaning.
1mg or 3iu, it's the same thing for UGL rHGH. It's the quantity of rHGH in the vial, though actual bioactivity per mg certainly varies and we don't know what it is. It may explain why we see comments that one brand produced side effects like carpal tunnel (normal for rHGH btw) at 9iu, while another "cleaner" brand didn't at the same dose.
Sure, they're both 3mg ("9iu") doses, but the "clean" one may actually have 6iu of bioactivity and "low quality side effect inducing" brand has 12iu of activity, bringing on stronger side effects at what appears to be the same dose.*
*What the community has attributed to side effects caused by undiscovered "impurities" are all normal effects of GH and individual sensitivity to it. GH causes general water retention, and IGF causes water retention in connective tissues (leading to nerve compression that causes transient carpal and joint pain symptoms, that usually stop happening over time). This happens to patients being treated with pharma rHGH too, it's spelled out right on the boxes, and has nothing to do with contaminants.
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Max Magnus
New Member
Appreciate the help... (although, I gotta say, this has little to do with the OP). --- So lets beat the horse to death (shall we)? --- Who knows, maybe we'll all learn something?
PS. IU measured for vitamins,
Here's a simply search AI results; (do you own if not satisfied with this one).
Yes, the "units" marked on a diabetic insulin syringe are an internationally standardized measure of insulin's biological activity, known as International Units (IU). This was implemented because the potency of insulin can vary by type, batch, and formulation, making a simple weight or volume measurement unreliable for consistent dosing.
How the International Unit works
Instead of measuring insulin by mass (like milligrams), an International Unit measures its biological effect on the body. This system was established by the World Health Organization (WHO) to ensure that a dose of one unit of insulin has the same effect, regardless of its source.
So far so good... Now, read this !
The term "IU" (International Unit) is a measure of biological activity used for vitamins, biologics, and certain medications, but it is not a direct measure of mass like milligrams (mg) or micrograms (mcg). This unit allows for the comparison of different forms of a substance based on their potency, which is crucial for vitamins like A, D, and E that exist in multiple forms with varying biological effects. While IU is used for both vitamins and certain medications (such as hormones, vaccines, and blood products), the key difference lies in the context: for vitamins, it standardizes potency across different molecular forms (e.g., retinol vs. beta-carotene for vitamin A), whereas for medications, it ensures consistent biological effect across different preparations, especially those derived from biological sources.
NOTE: When you get right down to it, --- mixing and measuring doses, comes down to 'Parts' ---- and 'Percentages.'
1 part GH, 10 parts BAC. ---- Easy. ---- But this not the OP question.
Thanks !
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Type-IIx
Member
Straight to your question: HGH potency depends on purity, and low/no dimer
Max Magnus
New Member
Low Dimer... ???
A
Anonymous member 154437
Guest
You’re a retard. How are you calling a 1ml syringe a 3ml syringe
Ateam2023
Member
gotta have low % of dimer to know its real hgh , haha
Max Magnus
New Member
You sound like a Farm Boy... We're talking 'Measurements' DUMB-ASS... Not Needle Size!
YOU couldn't do a 2 stage math problem to save your life. Now get out back and feed the Pigs Goober ... !
Your inability or unwillingness to admit your units errors above while doubling and tripling down gives a strong troll vibe. I am hopeful the Mod takes the appropriate action using his best judgement. You don't sound like you are here to learn. Sure hope I am wrong.
Max Magnus
New Member
I don't know chief... Although I've been doing AAS for 20yrs, I'm fairly new to buying UL ---- Never had to test for 'Garbage product' before ---gotta have low % of dimer to know its real hgh , haha
You seem to be the Expert in this area, but YOU got no answers' --- I've always gotten mine from US Pharma (because I can afford it).
BigDadd7
Member
We got this guy trolling here. We've got the schizo in the primo thread, isn’t there a third guy somewhere arguing and not making sense?
Ateam2023
Member
Then other unfortunate part of these threads is the time in good faith people waste to try and help out. The thread gets deleted and that time cant be replaced.
Congrats OP.
Max Magnus
New Member
Read,
'You're are judging yourself' - While I've agreed with you on many points, On this one, you're wrong. ---- Thanks for 'digging up' that obscure info.
NOCTURNALDEATH
New Member
No if you want to make sure you get 3.6 iu you would reconsitute with 3ml and would do 30 units. 30x10=300units=3ml
