How long can I run DNP?

[mrsloppyboo]

I’m on week 3. Did 5 days 250, 7 days 400mg and finishing it off with 500mg powder DNP. I’m exhausted. Lethargy and water weight are real. The heat sucks but is manageable. I want to extend my cycle and get even leaner. Does the body build a tolerance to DNP? I hear different things from different people

 

[xrayphoton13]

I’m on week 3. Did 5 days 250, 7 days 400mg and finishing it off with 500mg powder DNP. I’m exhausted. Lethargy and water weight are real. The heat sucks but is manageable. I want to extend my cycle and get even leaner. Does the body build a tolerance to DNP? I hear different things from different people

There is some good information here from our very own @Type-IIx
https://ampouletude.com/~type-iix/DNP-risk_reward.html

 

[explodingHeart]

Wouldn't it help to post your bodyfat % and your end goal?

 

[Deadpool99]

There is some good information here from our very own @Type-IIx
https://ampouletude.com/~type-iix/DNP-risk_reward.html

I can't seem to find @Type-IIx DNP risk - reward document/notes, getting a 404 error. Is there any way to view, rly interested in his take and analysis on DNP

 

[xrayphoton13]

I can't seem to find @Type-IIx DNP risk - reward document/notes, getting a 404 error. Is there any way to view, rly interested in his take and analysis on DNP

I think it's all gone for now. Hopefully he'll repost it one day on his Substack page

 

[ChemBB]

7 days 400mg and finishing it off with 500mg powder DNP. I’m exhausted. Lethargy and water weight are real.

I've run DNP likely more times than most people here.
7-8 times, at dosages from 200mg -> 800mg

Here is my anecdotal experience:
High-dose DNP is counterproductive.

Anything much over 200-250mg and the carb cravings often cause you to binge at the end of the day, undoing any progress.

And the increasing lethargy + general malaise from escalating dosages mean that your drive to exercise and NEAT activity tend to decrease, again offsetting any increase in BMR.

Every time, I wound up losing more weight by doing 200-250mg for a longer period, than trying to short-cut and do 400-800mg for a brief 2-3 week burst.

Does the body build a tolerance to DNP?

No, not physiologically possible with mitochondrial uncouplers.

I used to have a lengthy DNP guide that was fairly popular on an old, defunct forum called FitMisc. Unfortunately it's gone without any archives =/

 

[Sampei]

I’m on week 3. Did 5 days 250, 7 days 400mg and finishing it off with 500mg powder DNP. I’m exhausted. Lethargy and water weight are real. The heat sucks but is manageable. I want to extend my cycle and get even leaner. Does the body build a tolerance to DNP? I hear different things from different people

Until you die works well

 

[ChemBB]

Forgot to mention, I've seen a few comments over the years online from people running 75-125mg chronically for mitochondrial/metabolic health.

There are a few papers talking about chronic low-dose DNP use, and some threads with anecdotal experiences

2,4 Dinitrophenol as Medicine - PMC

In the sanctity of pure drug discovery, objective reasoning can become clouded when pursuing ideas that appear unorthodox, but are spot on physiologically. To put this into historical perspective, it was an unorthodox idea in the 1950’s to suggest ...

pmc.ncbi.nlm.nih.gov

https://www.mdpi.com/1422-0067/26/16/7740

https://portlandpress.com/biochemj/article-abstract/481/23/1831/235328/Biochemical-basis-and-therapeutic-potential-of?redirectedFrom=fulltext

https://hal.science/hal-03035300v1/file/2020-11-17_DNP_lifespan.pdf

https://www.uk-muscle.co.uk/threads/dnp-125mg-daily-test.224511

 

[OmL]

The first day you really ‘feel’ DNP go grab a clean piece of kitchen roll, the really absorbent shit, and wipe your face and head. Then look at the colour of it.

 

[quarter]

The first day you really ‘feel’ DNP go grab a clean piece of kitchen roll, the really absorbent shit, and wipe your face and head. Then look at the colour of it.

I hate that i want to try this now

 

[eery]

No, no tolerance.

 

[eery]

The first day you really ‘feel’ DNP go grab a clean piece of kitchen roll, the really absorbent shit, and wipe your face and head. Then look at the colour of it.

i never got any yellow bodily fluids tbh, not even my cum

 

[xrayphoton13]

I've run DNP likely more times than most people here.
7-8 times, at dosages from 200mg -> 800mg

Here is my anecdotal experience:
High-dose DNP is counterproductive.

Anything much over 200-250mg and the carb cravings often cause you to binge at the end of the day, undoing any progress.

And the increasing lethargy + general malaise from escalating dosages mean that your drive to exercise and NEAT activity tend to decrease, again offsetting any increase in BMR.

Every time, I wound up losing more weight by doing 200-250mg for a longer period, than trying to short-cut and do 400-800mg for a brief 2-3 week burst.



No, not physiologically possible with mitochondrial uncouplers.

I used to have a lengthy DNP guide that was fairly popular on an old, defunct forum called FitMisc. Unfortunately it's gone without any archives =/

Completely agree with this. 200mg is manageable for me and I can stay on track with the diet. Every time I pushed to 400mg or 600mg not only am I miserable in the evenings but I'm also starving. Sadly even on tirzepatide when I run 400mg+ DNP I don't lose weight bc I end up outeating it.

 

[mrsloppyboo]

Hello gentlemen I’m the original poster. I’m still alive lmao. My 750mg run for 2 weeks was awful and the cravings were the worst it didn’t even work just awful.

Currently I’m on retatrutide and cutting again. Did 300-450mg daily for a couple weeks. Cravings under control. Great progress. Took a 2 days break off it to mentally feel okay. Currently doing 600-750mg daily for a week and a half to lose a bit extra fat.

RETATRUTIDE IS A GAME CHANGER

Yesterday was my 2nd day of 600mg (I took an extra before bed so 750mg). Yesterday I literally ate UNDER my deficit goal. I ate 900cal yesterday and was satisfied. 900 calories on 750mg DNP and I was satisfied.

Retatrutide +DNP is the best stack for fat loss it’s incredible. I was 179, then 177 after a couple days off the initial DNP run. Now 2 days into the 2nd run I’m 173.4. My goal was 170 lol. I’ll probably get down to 169 and stall then when water weight drops from DNP see where I’m at. I estimate I lose 6-9lbs in this next week

 

[ChemBB]

Retatrutide +DNP is the best stack for fat loss it’s incredible.

The best stack for fatloss is actually amphetamine/methamphetamine and DNP -- but sure, I'll give GLP-1's + DNP a close second.

(Not being facetious)

 

[Banana Joe]

I ate 900cal yesterday and was satisfied. 900 calories on 750mg DNP and I was satisfied.

Retatrutide +DNP is the best stack for fat loss it’s incredible. I was 179, then 177 after a couple days off the initial DNP run. Now 2 days into the 2nd run I’m 173.4. My goal was 170 lol. I’ll probably get down to 169 and stall then when water weight drops from DNP see where I’m at. I estimate I lose 6-9lbs in this next week

900kcal with Reta+DNP?
Is 160lbs the weight where you estimate to have successfully burned off all your muscles?

How about making a proper intro in the introduction section? I'd be curious about your diet approach and steroid cycles.

 

[Banana Joe]

.

 

[sionnach]

Fitmisc

 

[QuadFather]

Wouldn't it help to post your bodyfat % and your end goal?

That username holy shit

 

[mrsloppyboo]

900kcal with Reta+DNP?
Is 160lbs the weight where you estimate to have successfully burned off all your muscles?

How about making a proper intro in the introduction section? I'd be curious about your diet approach and steroid cycles.

For me 165lbs is stage lean (before I carb up). Diet is essentially fasting until 2-3pm then all my calories are from protein and I eat as much pickles and sauerkraut as I want which ends up not being much bc reta makes me so full. Also lots of diet Cola. I train fasted. No cardio on this dose of DNP