Ghoul
Member
I need all my vials replaced my fear has been mongered I’ve been blowing spit bubbles and hissing at people all morning
When you pop the stopper off, give it a good sniff.
Liberated butyl rubber oligomers smell Iike a brand-new inflatable pool toy, rubber garden hose, that strong “new plastic-rubber” smell, then add a faint hint of antiseptic medicine cabinet, like Band-Aid.
By the way, it’s not the BA or BB that’s responsible for leaching this out of raw bromobutyl and chlorobutyl, it’s oil.
Raw rubber stoppers are Type I, suitable for water based injectable drugs, oil based injectables are supposed to use Type II, either coated or special formulations designed not to release oligomers.
“Under the accelerated extraction conditions, extractables from oil-based vehicle tests were appreciably higher than those from aqueous vehicles.”
Comprehensive Determination of Extractables from Five Different Brands of Stoppers Used for Injectable Products
Five commonly used stopper formulations were tested for extractables using three different vehicles (pH 3 citrate buffer with 20% w/v sulfobutylether-β-cyclodextrin, pH 8 phosphate buffer and 50/50 v/v polyoxyethylated castor oil/dehydrated alcohol). The stoppers, made from butyl and halobutyl...



