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HYB (Best Service and Product - International Shipping)

Itsthejuice said:
Decided to give yura a go, small order, 300 or so, but man he's only asked for proof of payment. Paid on the 27th, sent transaction ID, sent bank record, even sent a bank statement. Literally nothing left I can send as proof. If he was just stalling for time because he has lots of back orders I'd rather he just tell me.

Well maybe on Monday, after a full week, I'll have progress.
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Surely you don't expect him to ship before the bank transfer lands in his account? You could just be a scammer using photOshop. International bank transfers take a while.

In future, use crypto. It lands instant and he can then ship it faster
 
Ghoul said:
I went down a deep rabbit hole on this today.

I asked about his IGF, which was really low as well, and he mentioned his low Leptin level, so it got me curious. I had been looking at studies of AIDS muscle wasting patients who get enormous doses of serostim, 15-18iu a day for 12 weeks, twice a year, and wondering why they don’t experience acromegaly symptoms, only anabolism, and then it clicked. They have very low appetites, high inflammation, dropping Leptin to very low levels.

That signals the liver you’re starving so don’t waste energy on growth, ie, slow down IGF production.

So 18iu rHGH is used to overcome this liver “GH resistance” and results in normal IGF levels. That’s why they don’t develop acromegaly.

But what about all the free GH floating around that’s not converted to IGF? Doesn’t that have some major effect on tissues that respond to GH?

And where did all the GH he injected just an hour before the test go?

I learned the body deals with excess GH in low Leptin induced IGF suppressed states (like starvation) by increasing growth hormone binding hormone production to quickly clear GH out of the body.

So low Leptin gives you very low IGF, is anti-anabolic, lower GH direct effects (skin, hair), but MORE SIDES because it increases GH receptor sensitivity in the kidneys increasing edema and carpel. High Leptin levels, signaling nutrient abundance, does the opposite of all this.

Mystery solved.

Now I’m going to start checking Leptin levels when I get IGF-1, since that seems to be the major regulator of how much IGF the liver produces per unit of GH.

There are also a number of drugs that can raise Leptin despite being in a caloric deficit or low body fat, which drop Leptin levels. I’m going to check them out.

Keeping Leptin elevated may be a way of preventing the elimination of GH by keeping GH binding hormone levels low, so that GH isn’t eliminated and enhanced fat lipolysis doesn’t slow down as body fat gets lower, which is what normally happens, and IGF should also stay higher, possibly maintaining the full GH anabolic effect even while cutting fat.

View attachment 358401

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This actually sounds very similar to T3/4 whereby T3 usually drops when you're on a cut.

Is there any point in regularly monitoring leptin similar to thyroid? -- to be more specific, can we increase or decrease it (should we?), because monitoring wouldn't be as useful if we cant do anything about it? i believe someone was talking about metreleptin?

(Cheapest is GL 23$?)
 
Ghoul said:
Less effective, yes. Less IGF produced per unit of GH.

Once fasting leptin dips below roughly 2 ng/mL, corresponding to ~8–10 % body fat in men, the hypothalamus reads “starvation,” suppressing hepatic GH receptor sensitivity and IGF-1 synthesis. Up to 60% drop in IGF.

12-15%, leptin 6-8 ng / ml, maximum IGF production per unit of GH.

Above 20%, leptin 10 ng+ , leptin resistance develops, IGF per unit of GH drops as body fat increases
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A guess a reason not to stay ultra lean and single digit bf%? I'm 41 though and only care about anti-aging, so maybe I can take enough GH to offset the decreased IGF-1.
 
RocketSurge0n said:
Wait what? All he ever asks for is transaction ID and maybe a screen shot of the competed transaction. Nothing more.
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Not with me. I asked my banks chat and they're like "that doesn't exist, would you like a statement? Or report fraud?". I've not reported for fraud yet. I'm going to go in person to my bank, see if I can get anything, if not, I'll report fraud to get my money back. I think I've sent more than enough evidence at this point.
 
Itsthejuice said:
Not with me. I asked my banks chat and they're like "that doesn't exist, would you like a statement? Or report fraud?". I've not reported for fraud yet. I'm going to go in person to my bank, see if I can get anything, if not, I'll report fraud to get my money back. I think I've sent more than enough evidence at this point.
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Are you serious?
You hardly think someone is going to send the good BEFORE they get payment? You can't be that naïve... surely...
 
explodingHeart said:
A guess a reason not to stay ultra lean and single digit bf%? I'm 41 though and only care about anti-aging, so maybe I can take enough GH to offset the decreased IGF-1.
Click to expand...

A high enough dose can absolutely overcome GH resistance and increase IGF.

As BF % goes down suppressing IGF is the body’s way of pushing back against using nutrients for growth, reserving them strictly for fuel.

Exogenous Leptin would be very effective, it’s like a “SuperGLP” that cuts appetite, melts fat, boosts muscle growth, fewer side effects than GLP, but at the standard daily 10mg dose a little cost prohibitive lol

IMG_3255.webp

This is something China UGL should be producing. It’d be a bigger seller than rHGH.
 
Ghoul said:
A high enough dose can absolutely overcome GH resistance and increase IGF.

As BF % goes down suppressing IGF is the body’s way of pushing back against using nutrients for growth, reserving them strictly for fuel.

Exogenous Leptin would be very effective, it’s like a “SuperGLP” that cuts appetite, melts fat, boosts muscle growth, fewer side effects than GLP, but at the standard daily 10mg dose a little cost prohibitive lol

View attachment 358725

This is something China UGL should be producing. It’d be a bigger seller than rHGH.
Click to expand...

India pharma seems to have it, havnt tried asking for a quote tho.
 
Itsthejuice said:
Not with me. I asked my banks chat and they're like "that doesn't exist, would you like a statement? Or report fraud?". I've not reported for fraud yet. I'm going to go in person to my bank, see if I can get anything, if not, I'll report fraud to get my money back. I think I've sent more than enough evidence at this point.
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Why on earth wouldn't you choose to use crypto. As you've chosen the most archaic and slowest method of payment, it's on you to be patient now. Complaining about fraud if there hasn't been any will ruin the possibility of the payment channel for others. Don't be that guy.
 
Itsthejuice said:
Not with me. I asked my banks chat and they're like "that doesn't exist, would you like a statement? Or report fraud?". I've not reported for fraud yet. I'm going to go in person to my bank, see if I can get anything, if not, I'll report fraud to get my money back. I think I've sent more than enough evidence at this point.
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The simple fact that you think that this is "OK" behavior truly blows my fucking mind.. Not even as someone who's purchasing illegal shit from across the globe using the most prehistoric method 2nd only to carrier pigeon, not as someone who is a fellow Meso member but just as a fuckin man in general shines a huge spotlight on the caliber of individual you are irl.. Diabolical to say the least, I feel for those who actually know you cause u convinced me you sucked in 3 minutes, imagine dealing with u for 30 years ... Fuckin ☠️
 
SmiggySmigs said:
The simple fact that you think that this is "OK" behavior truly blows my fucking mind.. Not even as someone who's purchasing illegal shit from across the globe using the most prehistoric method 2nd only to carrier pigeon, not as someone who is a fellow Meso member but just as a fuckin man in general shines a huge spotlight on the caliber of individual you are irl.. Diabolical to say the least, I feel for those who actually know you cause u convinced me you sucked in 3 minutes, imagine dealing with u for 30 years ... Fuckin ☠️
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Seems more naive than an asshat
 
Itsthejuice said:
Not with me. I asked my banks chat and they're like "that doesn't exist, would you like a statement? Or report fraud?". I've not reported for fraud yet. I'm going to go in person to my bank, see if I can get anything, if not, I'll report fraud to get my money back. I think I've sent more than enough evidence at this point.
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You boomers need stop buying gear online if you don't know how payment processors work! Stick with buying gear from your buddy in the gym or better yet just get off gear altogether and start focusing on longevity.
 
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