MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
is it possible that one has reached a "upper ceiling" with one of these drugs? Basically going higher with the dose doesn't give more effect? I tried 12.5 Tirz and it made no difference compared to 10mg. I'm just staying at 10 because I feel as if I reached maximal GIP receptor saturation (if that is even a thing?).
Not sure but same here 7.5 vs 15 had almost no differnece for me
yeah. At first 5mg was potent af. then after loosing a bunch of weight and having to go up, going from 5 to 10mg only resulted in a TINY difference in appetite suppression, and more than 10 seems to not do anything. Heavily diminishing results basically.
I was thinking of stacking Cagri or Sema since they work trough a different receptor.
I might be completely wrong but to me it would make sense for there to be an upper ceiling with these drugs. Like you only have a certain number of GLP1/GIP receptors. lile if you have 1million GIP receptors then injecting 2million Tirzepatide particles would be just a waste? I'm probably horribly butchering the actual science but still almost every drug had diminishing returns as you increase the dose
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From what i seen here ghoul write About Stacking i would stay away from it as far as possible but always better to do your own reaserch + mby worth a try a think he said sema should be safe up to 7mg mby try to increase that but dont want to misqoute him
I don't think it's that dangerous. many people do it and seems fine. Going higher Tirz seems like a waste so might as well stack at this point
Ghoul
Member
Why does going higher seem like a waste?
Low and Non-responders to 2.4mg Semaglutide saw significant weight loss in the trials that raised dosages up to 7.2mg. That tells us some people need significantly more GLP1 receptor agonism to respond.
As far as “stacking being safe” because you don’t “see harm” with your eyes, by that logic drinking lead contaminated water, smoking, or living in a house filled with radon gas is perfectly safe too.
At least explain why it’s perfectly safe, given the number of carefully designed GLP drugs that never make it out of Phase 1 trials for safety reasons but somehow, randomly throwing molecules together creates a safe drug.
Pharma hasn’t been successful getting one multi-peptide drug to market, despite multiple attempts. They’ve all failed.
Cagri-Sema, long delayed, would be the first, when and if it’s approved.
If you must stack, at least limit risk. Keep it simple with GLP-1 by using Sema, and inject on a different day. Don’t get GIP or glucagon receptors involved. Pharma clearly struggled to balance those in relation to each other to find a safe balance. GLP-1 via Sema is almost identical to the endogenously produced hormone, and doesn’t have the “special” characteristics of the GIP and Glucagon found in Tirz/Reta.
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I explained in another post that I see no point going higher than 10mg because of the diminishing returns. I tried 12.5 and it made no difference. Also the increase is suppression from 5 mg to 10mg was very minimal. Many people here stack GLPs and I don't see many experiencing issues.
I'll try to add Cagri since many serm to have used it in combination with all other GLPs with little issues. if Cagri is not enough I'll try Sema, many here and on other platforms have done tirz + sema and it seems relativly benign.
like if I didn't respond to low doses I'd get just raising the Tirzepatide, but the opposite happened. I responded well at first to 5mg, but as I raised it the difference was minimal to non-existant
Ghoul
Member
What issues would you expect in the short period of time these drugs have been around?
You know health.damage doesn’t necessarily manifest quickly or obviously right?
Fen-Phen was prescribed to millions of people as a weight loss drug, and it took nearly 7 years before it was discovered it was causing fibrosis that destroyed heart valves leading to countless disabilities and deaths.
Ironic that damage that destroyed heart valves was caused by 5-HT₂B receptor stimulation on cardiac cells, causing fibrosis, since Glucagon receptor stimulation, unless carefully managed, also triggers cardiac fibrosis, and that danger was the reason numerous GLP / Glucagon drugs in development were canceled.
why are you so up in arms on this? you yourself use GLPs. I tried going higher than 10mg and it hasn't worked so I was asking about stacking.
We're on a steroid forum, I think we'd understand that any of us experimenting on themselves with drugs has already made their risk-assesment considerations?
If we wanna be so risk adverse let's just live like a hermit and not do anything. I'll take my responsability.
Just try the higher dose sema first sema is cheapest and probably safer then stacking so why not give it a shot before trowing everything together
I had tried sema before tirz, 0.25mg had no appetite suppresion but if I overate after like 10-12 hours I'd get sick af.
So I'm not too keen on going to Sema alone. Tirz did well but no longer enough, so stacking makes more sense to me
I tried once a week and twice a week. once a week dosing also works best for me. Sema alone was terrible with both, I had no appetite suppression but if I overate I'd get incredibly sick the next day, not even right away.
Tirz I always did once weekly, I tried to split the dose last week to see if it made a difference but I didn't like it. so I'm going back to the usual once weekly
sorry didn't want to be rude. You're always incredibly helpfull on here I didn't mean to offend.
I just mean it's not like I randomly decided to put a bunch of drugs togheter.
I tried sema like 2 years ago and 0.25mg was awful. only side effects and no benefits so I stopped after 4 weeks.
Then a year later I tried Tirz and went great. first week 2.5 felt nothing, second week 5mg worked and I stayed on 5mg for 4 months. Then did 1 week on 7.5, made no difference so I went to 10 and stayed on 10 for another 3 months.
I wanted to still go higher so I did 1 week on 12.5 with no difference and 1 week on 15 with still no difference.
So I went back to 10mg and decided to try stacking (since 12.5 or 15 was just a waste of product)
I'll try Cagrilintide first since it's a different receptor. if Cagri doesn't work for whatever reason I'll give Sema another shot to stack on Tirz.
Reta, UGL, tritate up from 1mg to 5mg\weekly, split M/TH 2.5 mg.
Taking Since August, It's doing a terrific job, lost so far 22 libs/10kg with a strict diet and last 3-week added DNP 400 mg ED.
So far, no side effect, I'm amazed how it completely removed food noise, no more days when I would have eaten tons of carbs and sweets.
I reached weight target, could lose few kg as well, I'd be skinny
I'm thinking to reduce dose to 2.5mg every 5 days and see how I'll react
in terms of craving sweets and junk food.
Reading different source, Tirz. seems a safer option in a long run, would try to switch to Tirz. start with a lower dose and see how it works.
Raww
Member
Did you do any labwork to see where you were sodium and other mineral-wise prior to supplementing? Just curious as I've had some hypotension as well, but my bloodwork is fine.
@Ghoul
These things have me concerned about reta long term. I'm trying to be wise about my heart with family history there.
Do you have any link to data supporting the lvh claim or is it just a synthesis of data on your part?
I've tried finding some data myself and seem to find the opposite. See attached. I know the real data on reta is scant so maybe that's the issue?
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