I’m 36 years old with no known health issues. After your reply I just checked my bloodwork prior to rHGH. 56* was the original number and the number since starting is actually 106 not 159. I was confusing the number with something else. So still not good even on 4iu.
I never even considered I may actually be deficient. Pharma GH script would be awesome either way tho right? Feeling run down and lethargic was the whole reason I started rHGH and test a couple months ago.
36 makes that level even worse:
I’m in a rush so going to cheat and let this sum it up. Make sure you stop rHGH asap. You’ll need 4 weeks, 5 is better, to return to baseline so it’s not elevated when they test. I wouldn’t mention you used rHGH. Complain like the symptoms have been increasing for a year or more, and a buddy recommended a hormone workup. (When they order the tests, “suggest” IGF-1 since “Dr Google” suggested that might cause
your symptoms. If they don’t order it, you may want to get it on your own (just IGF-1), tell the doc your buddy pressured you to do it, and give him the results (make sure he can’t see previous ones), otherwise you may be fucking around for months before they finally test it.
Whatever’s going on, even if not AGHD (but it does look likely), you still need to get to the bottom of it, since none of the causes can be ignored.
——
IGF-1 of 56 in a 36-year-old: Clinical Context
1. Typical IGF-1 levels:
• For adults around 36 years old: roughly 100–300 ng/mL (lab-dependent).
• 56 is significantly below normal, suggesting low GH activity.
2. Possible causes of low IGF-1:
• Adult Growth Hormone Deficiency (AGHD) – pituitary not producing enough GH.
• Other hormonal issues – low thyroid (hypothyroidism), low sex hormones, or adrenal problems.
• Chronic illness or malnutrition – liver disease, kidney disease, severe illness..
3. Symptoms often associated with low IGF-1 / GH deficiency:
• Fatigue, low energy
• Decreased muscle mass / strength
• Increased body fat (especially around abdomen)
• Poor exercise tolerance
• Thinning skin, decreased bone density
• Mood changes, low motivation
4. Next steps typically recommended by specialists:
• Confirm the low IGF-1: repeat test to rule out lab error.
• Full pituitary hormone panel: TSH, free T4, cortisol, LH/FSH, testosterone/estradiol as applicable.
• GH stimulation testing: e.g., insulin tolerance test, arginine-GHRH, or glucagon test to confirm AGHD.
• Evaluate for underlying conditions like liver/kidney disease or malnutrition.
• Imaging: MRI of the pituitary if a deficiency is confirmed, to check for structural causes.
5. Treatment considerations:
• If AGHD is confirmed, GH replacement therapy can improve:
• Body composition (more muscle, less fat)
• Bone density
• Energy and quality of life
• Cardiovascular risk markers
Important: GH therapy is prescription-only and carefully monitored with IGF-1 levels to avoid side effects (like swelling, joint pain, insulin resistance).