Reta helps with ADHD symptoms?

[2lanes]

I've seen a few of such posts, is there something to it? If so, what possibly makes reta work better than semaglutide or tirzepatide?

I did Tirz for 2 months it made me sleepy and low energy, unmotivated. Also had a hard time getting through the work day and nodding off around 3 pm. Started reading up on Reta and found many describing the energy and focus they were experiencing on Reta. As well as saying it helped with ADHD. I do have ADHD managed my whole life by myself and honestly it wasn't a thing when I was younger. I actually didn't have a clue until my oldest son was diagnosed. We never did medication, used a lot of organization practices and self awareness technics to manage. Anyway after reading all the info I decided to switch. There really is something to it. I've been on for 4 weeks, uping my dosage to 4 mg today. I've gotten so much done in the past 3 weeks. Like started and finished to completion. My energy level has been great as well. Not sleepy at all during work. It's not like hyper, just awake and not feeling sleepy and getting things done. I am having a hard time shutting down at night. Again it's not like I'm hyper, I'm just awake. However if I make myself go to bed I do fall asleep. So I am practicing getting in the habit. When I wake up, I'm not tired. I have actually noticed I barely drink a half a cup of coffee now.

I've also tried tirz and it only made me sleepy as fuck, not even being in a big calorie deficit. Wondering if it's different with reta or semaglutide.

 

[lilhawk]

I have heard the same about the ADHD symptom relief with Reta. I can say I felt like complete shit on Tirz at just 1.25mg per week. On Reta I feel great at 2mg per week, and have more energy than before I took it. Reta is a blockbuster drug and I don't see any reason to stop taking it ever.

 

[Ghoul]

Most here are using sub clinical doses of these GLPs.

There is a ton of observational evidence regarding psychological benefits from all these GLPs, Reta doesn’t stand out in particular.

The most likely mechanism for improved brain function is a reduction in inflammation. Tirz and Reta are roughly equivalent in that regard. But if you have significant visceral fat, a literal inflammation engine, something like Tesamorelin or rHGH would be even more helpful in reducing inflammation.

How old are you? Are you already at ideal weight / trim, or do you have visceral (deep abdominal) fat, like most men 30+?

Have you ever had HS-CRP checked? That’s not the only marker reflecting brain inflammation, but the easiest one and can often give a good indication of where systemic inflammation stands.

 

[Ghoul]

Coincidentally was reading this yesterday.

In layman’s terms, it’s becoming increasingly apparent inflammation drives a TON of neurological / psychological problems. From mild brain fog, to severe depression, and addiction. When you reduce systemic inflammation, brain function and mood always seem to improve.

From Harvard Medical School’s 10 most important medical developments of 2025
Inflammation and the Brain: How Immune Activity Can Alter Mood and Fuel Anxiety

 

[osqe]

When it comes to ADD, I have read anecdotal claims that Reta may “extend” or “amplify” the effects of amphetamines but it did the opposite for me. Even though there isn't any science to back me up and I could just be retarded, I stopped Reta because I lost the focusing effects of Adderall. I take 30 IR and 25 XR daily and 2mg of Reta made my XR feel useless. I even took a two-week break from Adderall and upon starting it again it felt the same. A few weeks after stopping Reta my Adderall did what it was supposed to.

 

[Getleanordie]

Agree on the inflammation part.
Just freestyling here, but it could also be about the stable energy and the glucagon piece. On Reta glucagon pushes body to release more fuel and makes energy from it. From liver glucose and lipolysis if i have understood correctly. People have also reported elevated ketone levels on Reta. Maybe once glucose is empty from liver, glucaon keeps signaling to make more energy and then it produces ketones even though one would be on a normal carb based diet?

ADHD symptoms go down for people in ketosis and also when there is a stable form of energy for the body to use. Probably dopamine relates to this also in some manner.

 

[2lanes]

The most likely mechanism for improved brain function is a reduction in inflammation. Tirz and Reta are roughly equivalent in that regard. But if you have significant visceral fat, a literal inflammation engine, something like Tesamorelin or rHGH would be even more helpful in reducing inflammation.

How old are you? Are you already at ideal weight / trim, or do you have visceral (deep abdominal) fat, like most men 30+?

Have you ever had HS-CRP checked? That’s not the only marker reflecting brain inflammation, but the easiest one and can often give a good indication of where systemic inflammation stands.

30s with around 17% bodyfat. Losing weight is actually not the main reason for me to take it. I also found many reports suggesting that GLPs help with IBS a lot, that's also a big reason for me to try it.

I've tried HGH but it didn't do anything for my ADHD. Never tested HS-CRP, i will consider it though.

 

[WinnerTakesAll]

Yes, I've been a lot more disciplined and focused since I started taking it

 

[2lanes]

I have heard the same about the ADHD symptom relief with Reta. I can say I felt like complete shit on Tirz at just 1.25mg per week. On Reta I feel great at 2mg per week, and have more energy than before I took it. Reta is a blockbuster drug and I don't see any reason to stop taking it ever.

Yes, I've been a lot more disciplined and focused since I started taking it

You dose once per week?

 

[WinnerTakesAll]

You dose once per week?

I dose whenever I start feeling hungry. Sometimes it's after 5 days sometimes 7 days

 

[any-name-you-wish]

30s with around 17% bodyfat. Losing weight is actually not the main reason for me to take it. I also found many reports suggesting that GLPs help with IBS a lot, that's also a big reason for me to try it.

I've tried HGH but it didn't do anything for my ADHD. Never tested HS-CRP, i will consider it though.

Both reta and tirz have made a huge difference to my IBS.