Accutane permanent cure?

[just some dude]

probably individual like everything else but my LDL actually dropped on accutane. I think the worries are overblown and I believe Ghoul said as much at least once.

take 5mg accutane often - but i just mean generally speaking i wouldn’t have researched:
- repatha
- ezetimibe
- berberine
- pitavastatin
- tirzepatide
- retatrutide
- cildinipine
- oral minoxidil
- ivermectin
- bempedoic acid
- citrus bergamot
- micro dosing accutane
- ldl, hba1c, bp, & hs-crp

 

[imthankful]

Just got first bloods in, about 3 weeks. On 500TC 150NPP. LDL jumped to 160, Triglycerides up from 60 to 100, HDL 43, AST 22 ALT 24 GGT 28. PT/inr is unremarkable. All liver values went down from baseline, I stay on Tudca nac milk thistle and 200mg gluta 2x a week year round. Only increased NAC since starting.

Edit: Most importantly, in my opinion doubled my EPA/DHA from 2g to 4g daily. Triglyceride form fish oil, using sport research from costco currently.

Feels - dryer than a bitch. Have just about resolved the side of mouth cracking, neglected my nose for a couple days and the point where my nostril connects with cheek cracked open. That was a fun one.

Currently 6 40mg a a day split dose. These were manufactured 9/25. Three days left and the remaining 20ish grams all are 11/25mfg. Will be interesting to see if there is noticeable difference. After a week of the newer ones, may dabble up to 260-280 for a few weeks.

Day 1-3 80mg
Day 4/6 120mg
Day 7-9 160mg
Day 10-12 200mg
Day 13-22(current) 240mg

Nothing shocking or unexpected, hopefully this gives some information to anyone currently on or thinking about it.

 

[adrenalytic]

LDL jumped to 160, Triglycerides up from 60 to 100,

Nothing shocking or unexpected

this would shock me. those values are terrible for such a moderate stack. I'm cruising on 300 TC, 150 deca and 100 tren and my LDL is 76, trigs 30.

Your LDL should qualify you for at least prescription fishoil. Talk to your doctor. Get on a statin and ezetimibe. You're headed down a terrible path if you don't find those numbers concerning.

 

[imthankful]

this would shock me. those values are terrible for such a moderate stack. I'm cruising on 300 TC, 150 deca and 100 tren and my LDL is 76, trigs 30.

Your LDL should qualify you for at least prescription fishoil. Talk to your doctor. Get on a statin and ezetimibe. You're headed down a terrible path if you don't find those numbers concerning.

Yep, starting ezetimibe tomorrow. More so meant, overall results were better than I was expecting. Already have another panel set to run 3 weeks time

 

[ekim]

Just got first bloods in, about 3 weeks. On 500TC 150NPP. LDL jumped to 160, Triglycerides up from 60 to 100, HDL 43, AST 22 ALT 24 GGT 28. PT/inr is unremarkable. All liver values went down from baseline, I stay on Tudca nac milk thistle and 200mg gluta 2x a week year round. Only increased NAC since starting.

Edit: Most importantly, in my opinion doubled my EPA/DHA from 2g to 4g daily. Triglyceride form fish oil, using sport research from costco currently.

Feels - dryer than a bitch. Have just about resolved the side of mouth cracking, neglected my nose for a couple days and the point where my nostril connects with cheek cracked open. That was a fun one.

Currently 6 40mg a a day split dose. These were manufactured 9/25. Three days left and the remaining 20ish grams all are 11/25mfg. Will be interesting to see if there is noticeable difference. After a week of the newer ones, may dabble up to 260-280 for a few weeks.

Day 1-3 80mg
Day 4/6 120mg
Day 7-9 160mg
Day 10-12 200mg
Day 13-22(current) 240mg

Nothing shocking or unexpected, hopefully this gives some information to anyone currently on or thinking about it.

Damn, dude. Based on what I've seen in this thread (and what I've experienced so far (ending week 5 right now at 160mg/day)), you seem to be going all-in with that dosage schedule. Are you concerned at all about lag and dryness level catching up to your dose and being too much to handle?

 

[synthetic_juggernaut]

Day 13-22(current) 240mg

Damn, you are really speedrunning it! Gotta respect having the balls to go all in and get it done quick

 

[adrenalytic]

is that even effective to dose that high? I mean there's gotta be a limit somewhere otherwise why not just do 20k mg over a weekend and get it over with?

 

[BendigoShafter]

Day 1-3 80mg
Day 4/6 120mg
Day 7-9 160mg
Day 10-12 200mg
Day 13-22(current) 240mg

How much do you weigh, what's your cumulative goal?

Wishing you success and please report back because I'm also the type of guy who prefers to suffer through things if it gets it over with quicker.

 

[BendigoShafter]

is that even effective to dose that high? I mean there's gotta be a limit somewhere otherwise why not just do 20k mg over a weekend and get it over with?

It'll be a spectrum where there's an ideal dose and then effectiveness tapers on either side of that.

For a 100kg (220 pound) dude who's shooting for 220mg/kg total, it'll still take three months at 240mg/day. That's going to still be somewhere in the effective range.

The big question is: does that person get better overall results than someone who took 120mg/day for six months. What about the monster who takes 480mg for six weeks?

I don't know the answer and am basically just talking to hear myself talk.

 

[adrenalytic]

The big question is: does that person get better overall results than someone who took 120mg/day for six months. What about the monster who takes 480mg for six weeks?

Ya, that's kinda what I was driving at, obviously I was being hyperbolic with finishing it in a weekend haha. There's gotta be a toxicity limit somewhere.

 

[imthankful]

How much do you weigh, what's your cumulative goal?

94kg

is that even effective to dose that high?

I can’t image it the effectiveness starts to slide too much at 2.5mg/kg (i hope) But yeah, who honestly knows.

 

[Terraform]

I've read one or two 6 month courses of Accutane can permanently cure acne in a lot of cases.

Has this worked permanently for anyone with steroid induced acne?

I suspect a permanent cure isn't for the steroid induced type, but I'd like to know if it's worth a try given the nasty sides or just stick to Doxycycline, which is effective and no sides but temporary.

microdose 10 mg eod or 5mg daily forever. basically 0 side effects

 

[adrenalytic]

microdose 10 mg eod or 5mg daily forever. basically 0 side effects

you'll never reach full clearance that way which is what most guys here are after.

 

[BendigoShafter]

microdose 10 mg eod or 5mg daily forever. basically 0 side effects

"Forever" is probably right. This is the opposite of the 24000mg in a weekend dose and will probably help while you're on it but I wouldn't expect to have the same lasting effects as someone who completed a full cycle at 80mg/day and then stops at the cumulative goal.

 

[adrenalytic]

"Forever" is probably right. This is the opposite of the 24000mg in a weekend dose and will probably help while you're on it but I wouldn't expect to have the same lasting effects as someone who completed a full cycle at 80mg/day and then stops at the cumulative goal.

Ya, that's the maintenance dose post clearance. It's supposed to be great for keeping your skin glow but you could never reach clearance on it.

 

[2ndchancesNK]

Hey brothers, just checking back in with an update.

@AlexDavis43 Exactly. I’m running a bit over a gram AAS right now, and while doing that, I definitely don’t want to be hammering high doses of accutane, even with a good polypharma protocol in place. Nick’s back is wild to me — the fact he is able to cover that up pretty well on stage is impressive. Still, going to message him a link to this thread and see if he’s getting on board lmao

@imthankful @BendigoShafter @adrenalytic
So I think there’s definitely a point of no return in dosing protocols. There’s definitely a sweet spot. The study where participants dosed between 1.3-2.0mg/kg for a period of 6 months straight had impressive results. I just refuse to believe you can take 300-400mg of this stuff per day. Yes, obviously it will work, and while I think the drugs effect on lipids and liver values is overblown by gen pop and spaz dermatologists, there’s no way that dose is not going to have a significant effect of doing more harm than good in relation to blood work.

At least in the 100-200mg range you get the right balance of a high dose and a good amount of time on the drug when going for 220mg/kg.

I’ve been happy with my approach of high dosing for about 3 months to get a good chunk of cumulative dosage in and now dropping to 40mg per day. After a few days, it’s like I’m not even taking anything. The dryness is so much better and manageable. However, I stand by high dosing throughout to reach that high cumulative dose, and think if you’re planning to reach it at 20mg a day, well, good luck. With those maths, at 250lbs, I would need to do that for 3.5 years and 7 years at 10mg a day lol I’m good.

 

[AlexDavis43]

@AlexDavis43 Exactly. I’m running a bit over a gram AAS right now, and while doing that, I definitely don’t want to be hammering high doses of accutane, even with a good polypharma protocol in place. Nick’s back is wild to me — the fact he is able to cover that up pretty well on stage is impressive. Still, going to message him a link to this thread and see if he’s getting on board lmao

This is not medical advice

I think the liver toxicity risk of accutane is overblown

I don't recall if I was running any orals at the time, but I was running gear, had a few drinks per week (usual for me), and liver values never budged

I was taking NAC and TUDCA, if that matters (Idk)

 

[AllbrandNew]

This is not medical advice

I think the liver toxicity risk of accutane is overblown

I don't recall if I was running any orals at the time, but I was running gear, had a few drinks per week (usual for me), and liver values never budged

I was taking NAC and TUDCA, if that matters (Idk)

I think that if it moves the liver values at all, some drs would raise a flag. Given what we're also doing on the AAS+ancillary (or should be I suppose) front, I think it's far less of an issue.

My liver values were elevated a bit roughly 2 months into when I started vs before I started the course, but marginally, and I was running oral occasionally as well as NAC and TUDCA. I added lower dose gluta before during and after the orals later on, but no bloodwork since to see what changed if anything.

The dryness is so much better and manageable.

That's awesome. I'm glad pulling back helped. I am down to 40mgs/day and starting to get some relief from that bump in sides after coming down to 80. Few more days and I will be on 5mg, so expecting more relief soon.

 

[macmac]

You won’t regret it! I have suffered in the past with the malassezia overgrowth and gotten the nasty ass crusties around my nose and eyebrows.

I remember blasting Test with Primo on my second cycle and having the physique that would make the ladies want to slob on my wiener, but dealt with the Seb Derm bullshit.

You will not need tretinoin if you are taking iso. Just let the drug do its job and you will be amazed.

What would you do as a treatment? I'm using the nizoral shampoo, taking itraconazol en using a nizoral lotion alle prescribed by a dermatologist but they don't really seem to help much. It all got way worse when i started my first cycle of 350 mg test e/week. Beforehand I had some spots but nothing like I have now. Thanks!