lowest LDL without using a PCSK9 inhibitor?

[BigChungusRX]

Lp(a) additive risk is linear with Lp(a) level (higher levels = higher risk). The hazard ratio at 140 nmol/L is 1.3-1.5 (30-50% increased risk) depending on what study we're looking at. The researchers gave us a handy dandy table to tell us how much we need to lower LDL to mitigate the risk of elevated Lp(a):

Lp(a) (nmol/L)	Δ Lp(a) vs median (nmol/L)	Lp(a) percentile	HR for MCVE due to ↑Lp(a)	LDL‑C reduction starting age 30 y (mg/dL)	40 y (mg/dL)	50 y (mg/dL)	60 y (mg/dL)
320	300	99	2.56	≈46	≈54	≈66	≈89
270	250	97.5	2.19	≈39	≈46	≈58	≈73
220	200	93.5	1.87	≈31	≈35	≈46	≈58
170	150	90	1.60	≈23	≈27	≈35	≈43
120	100	82.5	1.37	≈15	≈19	≈23	≈31
70	50	75	1.17	≈8	≈8	≈12	≈15
20	ref.	50	ref.	ref.	ref.	ref.	ref.

If I’m reading this right, my LPA is 144 nmol/l. This chart is saying I should be at 15mg/dL LDL? Or am I reading this wrong?

 

[deadbeef]

If I’m reading this right, my LPA is 144 nmol/l. This chart is saying I should be at 15mg/dL LDL? Or am I reading this wrong?

15 reduction. If you normally have ldl of 100, you'd need to lower to 85 to make up for your lp(a).