HCG induced Leydig Cell desensitization

[maxx1]

I asked my HRT doctor about this again a couple of days ago and he said: " Yes it could happend BUT only if you use hcg for 10-15 years , so only long term usage so dont worry

 

[HeadDoc]

There are many errors in the above analysis. It is far too lengthy to put them in a post. One will demonstrate: a hCG dose of 300 IU will not normalize T serum T. If you are taking this from the ITT article, you are misinterpreting the article.

If i understand the post, the rational for the hCG two days in a row on Friday and Saturday before the Sunday injection is to assist in the lowest part of the week. If you read the literature on hCG effects, they come about 48-72 hours after injection. This schedule dosing is nonsense. I have a better question: produce literature that supports the use in this manner! Instead, we have theoretical and hypothetical baloney. And even that is based on imagined science.

For all practical purposes, hCG Leydig Cell desensitization does not exist within the clinical framework .

Why can I say this with absolute confidence? Because I have treated with success males with AIH, TRT, & hypogonadism. As above, this supposed problem is not seen in clinical care. Why do people continue to debate this point? This is a rumor that refuses to die. I wish to thank you for bringing this topic up since many who have been told this falsity will learn from the thread. Thanks.

does this imply that if the TRT protocol combines the use of Test Cyp with hcg for purposes of covering a trough period in weekly injections would it make sense to inject the hcg more towards the middle of the week?

 

[superone]

So would 500IU every other day while on TRT keep the testicals functioning and not cause desensitization of the leydig cells?

 

[Michael Scally MD]

So would 500IU every other day while on TRT keep the testicals functioning and not cause desensitization of the leydig cells?

Why would anyone use such a dose? And there is ample literature using this dose for extended periods without problems. However, these are older studies and the need for this dose is not necessary.

 

[superone]

Why would anyone use such a dose? And there is ample literature using this dose for extended periods without problems. However, these are older studies and the need for this dose is not necessary.

So are you saying this is too much? My natural T levels are mid range but I was haivng depression and other problems so I was put on TRT and feel way way better. So while on TRT I want to keep my teste's from atrophying and keep them as fully functional as possible. I also think HCG raises my libido and well being on the days I use it. I've read that you do not need to take it every day, and that EOD is best. So is 500IU too much EOD? Or would 350IU be better?



Also, I've been using 250IU twice per week, mon and thurs, and my balls are still shrinking or have gotton smaller while on TRT, so it seems this isnt enough for me possibly.

 

[Michael Scally MD]

So are you saying this is too much? My natural T levels are mid range but I was haivng depression and other problems so I was put on TRT and feel way way better. So while on TRT I want to keep my teste's from atrophying and keep them as fully functional as possible. I also think HCG raises my libido and well being on the days I use it. I've read that you do not need to take it every day, and that EOD is best. So is 500IU too much EOD? Or would 350IU be better?


Also, I've been using 250IU twice per week, mon and thurs, and my balls are still shrinking or have gotton smaller while on TRT, so it seems this isnt enough for me possibly.

I misread!!! I was reading 5,000. My error. I would do 500 IU Q3D (every third day). You will probably be able to back off the T dose.

 

[superone]

I misread!!! I was reading 5,000. My error. I would do 500 IU Q3D (every third day). You will probably be able to back off the T dose.

Awesome, thanks a lot for the help, I really appreciate it.

 

[saru]

I misread!!! I was reading 5,000. My error. I would do 500 IU Q3D (every third day). You will probably be able to back off the T dose.

I am on TU (Testosterone Undeconate), which raises my Total T to about 700 [my levels prior to TU were sub 200 (insulin resistance related hypogonadotrophic hypogonadism)]

I am thinking of adding a bit of HCG to the TRT so that
(1) Total T is raised to sub-900 is achieved and
(2) Testes are exercised

Should I, instead, use HCG as my primary treatment and supplement it with TU (if required)?

Thanks in advance

 

[swifto]

I misread!!! I was reading 5,000. My error. I would do 500 IU Q3D (every third day). You will probably be able to back off the T dose.

How long would you use this dose for TRT before stopping because of E2 and Progesterone build up?

 

[TBG]

If one were to use too much HCG for too long, to the point that it no longer resulted in an increase in T, how long would it take for the desensitization to reverse naturally? Furthermore, is there anything that can be done to accelerate re-sensitization?

 

[InfoFront]

If one were to use too much HCG for too long, to the point that it no longer resulted in an increase in T, how long would it take for the desensitization to reverse naturally? Furthermore, is there anything that can be done to accelerate re-sensitization?

There is little to no evidence to have any idea, AFAIK.

 

[Michael Scally MD]

If one were to use too much HCG for too long, to the point that it no longer resulted in an increase in T, how long would it take for the desensitization to reverse naturally? Furthermore, is there anything that can be done to accelerate re-sensitization?

This has never been described clinically!