The average man produces about 4-7 mg of testosterone per day in a circadian pattern

cvictorg

New Member
http://www.prostatehealthnaturally....tosterone_supplementation_T-03.html#_ednref21

1) If this is a true statement then isn't the best delivery method transdermal? Injections do not mimic the circadian pattern.

2) Normal testosterone levels can usually be reached within a few weeks by using a low dose transdermal cream mixed by a compounding pharmacy to contain about 25 to 50 mg of testosterone per dose. Typically, only about ten percent of the dose is absorbed into the blood, so this will yield about 2.5 to 5 mg of testosterone per day.

3) The normal range for total testosterone for a male is about 280-1100 ng/dl with the higher limit for young men. Reference ranges for testosterone are often grouped by age and can vary slightly between laboratories. A normal level for free testosterone is between 1.5 to 2.9 percent of the total value, again with the higher limit for young men. Consider supplementing if your free testosterone is on the low side and you are having symptoms, even if your total testosterone level is normal. This is particularly true if you are older than sixty. The determinant should be how you feel—not just the laboratory value.

One interesting thing about testosterone values is that the high limit of normal for a man over sixty is more than 30 percent below that of a forty year old. This may be obsolete. Many experts consider that values for young men are also valid for older men.
 
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Re: The average man produces about 4-7 mg of testosterone per day in a circadian patt

Here are two (of many) criticisms of such an approach: (1) where is the evidence that a circadian rhythm of T is needed for benefit? and (2) transdermals, particularly commercial, as approved do not deliver amounts to bring T to the upper range of normal (800-1000 mg/dL) as advocated by your link. Where is the evidence these levels are needed and how high a transdermal dose will be needed to provide these levels. [The last point goes directly to the BS link since it is really nothing more than a sales push for their product(s)!]
 
Re: The average man produces about 4-7 mg of testosterone per day in a circadian patt

Here are two (of many) criticisms of such an approach: (1) where is the evidence that a circadian rhythm of T is needed for benefit? and (2) transdermals, particularly commercial, as approved do not deliver amounts to bring T to the upper range of normal (800-1000 mg/dL) as advocated by your link. Where is the evidence these levels are needed and how high a transdermal dose will be needed to provide these levels. [The last point goes directly to the BS link since it is really nothing more than a sales push for their product(s)!]


Circadian variation in testosterone, sex hormone-binding globulin, and calculated non-sex hormone-binding globulin bound testosterone in healthy young and elderly men -- Plymate et al. 10 (5): 366 -- Journal of Andrology

Disruption of the Nocturnal Testosterone Rhythm by Sleep Fragmentation in Normal Men -- Luboshitzky et al. 86 (3): 1134 -- Journal of Clinical Endocrinology & Metabolism
 
Re: The average man produces about 4-7 mg of testosterone per day in a circadian patt



I am aware of those publication, but they do NOT answer the question posed. The circadian rhythm of T as well as other hormones are well-known and well-described. Is a circadian administration of T needed for its benefits? [Even along these lines there are many other questions regarding a circadian administration but can you answer just this one?]
 
Re: The average man produces about 4-7 mg of testosterone per day in a circadian patt

I am aware of those publication, but they do NOT answer the question posed. The circadian rhythm of T as well as other hormones are well-known and well-described. Is a circadian administration of T needed for its benefits? [Even along these lines there are many other questions regarding a circadian administration but can you answer just this one?]

How is using test cream or gel "a circadian administration of T"? I was under the impression that creams or gels mimic the circadian pattern as opposed to shots which create peaks and troughs.
 
Re: The average man produces about 4-7 mg of testosterone per day in a circadian patt

Well, Using a trasndermal T cream, once a day in the morning that gives you a daily dose of T....thats circadian. It mimics the approximate way the our bodies naturally produce T...Higher in the morning when we wake then it trials off....A dose of T Once A week-every other Gives A large dose at once that brings you to supra physiological levels...then the trough level should be "normal"

Thats not Circadian...

So youre right. T gels/creams mimic our Circadian Rhythm, where as Shots do not.
Doc was just saying that there doesnt seem to be any study showing the benefits

I would say that anecdotal most guys on it who can get the levels high enough (me being one) find it much more convenient and without and side effects RE mood
 
Re: The average man produces about 4-7 mg of testosterone per day in a circadian patt

And sorry for the double post, but and adequately dosed cream will get you within those levels within 3-5 days.
 
Re: The average man produces about 4-7 mg of testosterone per day in a circadian patt

Well, Using a trasndermal T cream, once a day in the morning that gives you a daily dose of T....thats circadian. It mimics the approximate way the our bodies naturally produce T...Higher in the morning when we wake then it trials off....A dose of T Once A week-every other Gives A large dose at once that brings you to supra physiological levels...then the trough level should be "normal"

Thats not Circadian...

So youre right. T gels/creams mimic our Circadian Rhythm, where as Shots do not.
Doc was just saying that there doesnt seem to be any study showing the benefits

I would say that anecdotal most guys on it who can get the levels high enough (me being one) find it much more convenient and without and side effects RE mood


Thank you.
 
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