High E2 shit

1) No
2) No

depends on person's response to the treatment and if they are taking too much test to convert e2 if the first place.

If you use TRT then stabilize on T levels first along with e2 then if need be add in HCG
depends on the shbg where e2 should fall.
 
I told you.You didnt listen me.It is about estrogen and estrogen receptors.You need Femara.half tab per 3 days for 2 or 3 months.Last week of Femara >start Nolvadex and continue nolvadex 3 more weeks after Femara.Totally 4 weeks Nolvadex.This will save you from estrogenic side effects.And femara will refresh your estrogen receptors.But you may lose some hair and can break your tendoms cuz of Femara.Be careful about this.Femara is your answer,arimidex should help too but Femara will %100 refresh you
 
I told you.You didnt listen me.It is about estrogen and estrogen receptors.You need Femara.half tab per 3 days for 2 or 3 months.Last week of Femara >start Nolvadex and continue nolvadex 3 more weeks after Femara.Totally 4 weeks Nolvadex.This will save you from estrogenic side effects.And femara will refresh your estrogen receptors.But you may lose some hair and can break your tendoms cuz of Femara.Be careful about this.Femara is your answer,arimidex should help too but Femara will %100 refresh you

[quoteDiagnosisMain article: Diagnosis of Androgen Insensitivity Syndrome
MAIS is only diagnosed in normal phenotypic males, and is not typically investigated except in cases of male infertility [18]. MAIS has a mild presentation that often goes unnoticed and untreated [15]; even with semenological, clinical and laboratory data, it can be difficult to distinguish between men with and without MAIS, and thus a diagnosis of MAIS is not usually made without confirmation of an AR gene mutation [5]. The androgen sensitivity index (ASI), defined as the product of luteinizing hormone (LH) and testosterone (T), is frequently raised in individuals with all forms of AIS, including MAIS, although many individuals with MAIS have an ASI in the normal range [5]. Testosterone levels may be elevated despite normal levels of luteinizing hormone [15][20][24]. Conversion of testosterone (T) to dihydrotestosterone (DHT) may be impaired, although to a lesser extent than is seen in 5?-reductase deficiency [3]. A high ASI in a normal phenotypic male [45], especially when combined with azoospermia or oligospermia [5][7], decreased secondary terminal hair [26], and / or impaired conversion of T to DHT [3], can be indicative of MAIS, and may warrant genetic testing
][/quote]

[ame=http://en.wikipedia.org/wiki/Mild_androgen_insensitivity_syndrome]Mild androgen insensitivity syndrome - Wikipedia, the free encyclopedia[/ame]
 
Maybe your situation with high E2 is analogous to those who have experienced big E2 spikes from using HCG.

All of that HCG stimulation ramps up testicular aromatase activity and you end up with high E2. The same thing could happen with high LH.

Just sayin'.

Exogenous T might not spike E2 like driving the testicles hard with HCG/LH

Nah mean?
 
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Maybe your situation with high E2 is analogous to those who have experienced big E2 spikes from using HCG.

All of that HCG stimulation ramps up testicular aromatase activity and you end up with high E2. The same thing could happen with high LH.

Just sayin'.

Exogenous T might not spike E2 like driving the testicles hard with HCG/LH

Nah mean?

I'm not using hcg. Not using anything. My E2 is now normal and I feel no different. It's not an E2 issue.

When I first came her last year I was looking on advice of my hormones because I came off a Test E cycle and became limp. My dick wouldn't work. I did a 9 month enanthate cycle and became like this after coming off.

My Test levels were good. In the upper range but in November I was given a complete hormonal panel and found out my LH was high. High LH means that my pituitary thinks my T is low. I always said from the beginning that I thought I had downregulated my androgen receptors and this high LH level kind of confirmed it but things didn't make sense. It's not heard of right?

Structure (a member of this forum) came on here, saw my bloodwork and that I had symptoms of low T. He said to me, "I think you could have MAIS" At first I didn't believe it but then started reading up more and more on it and this totally defines me 100%. I have LH and High T nothing else can explain it but this:

MAIS is only diagnosed in normal phenotypic males, and is not typically investigated except in cases of male infertility [18]. MAIS has a mild presentation that often goes unnoticed and untreated [15]; even with semenological, clinical and laboratory data, it can be difficult to distinguish between men with and without MAIS, and thus a diagnosis of MAIS is not usually made without confirmation of an AR gene mutation [5]. The androgen sensitivity index (ASI), defined as the product of luteinizing hormone (LH) and testosterone (T), is frequently raised in individuals with all forms of AIS, including MAIS, although many individuals with MAIS have an ASI in the normal range [5]. Testosterone levels may be elevated despite normal levels of luteinizing hormone [15][20][24]. Conversion of testosterone (T) to dihydrotestosterone (DHT) may be impaired, although to a lesser extent than is seen in 5?-reductase deficiency [3]. A high ASI in a normal phenotypic male [45], especially when combined with azoospermia or oligospermia [5][7], decreased secondary terminal hair [26], and / or impaired conversion of T to DHT [3], can be indicative of MAIS, and may warrant genetic testing

[ame=http://en.wikipedia.org/wiki/Mild_androgen_insensitivity_syndrome]Mild androgen insensitivity syndrome - Wikipedia, the free encyclopedia[/ame]
 
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I told you.You didnt listen me.It is about estrogen and estrogen receptors.You need Femara.half tab per 3 days for 2 or 3 months.Last week of Femara >start Nolvadex and continue nolvadex 3 more weeks after Femara.Totally 4 weeks Nolvadex.This will save you from estrogenic side effects.And femara will refresh your estrogen receptors.But you may lose some hair and can break your tendoms cuz of Femara.Be careful about this.Femara is your answer,arimidex should help too but Femara will %100 refresh you

I didn't want to have to bump this thread but it's stayed in my head as if they know me, LTFOL. I've now been diagnosed with MAIS. Is it all about estrogen and estrogen receptors now? You sound just like my old doctors, lol.

No one had a clue but Structure and if it wasn't for him I'd have never visited Dr Gerard Conway and got that diagnosis. You, and them including my docs just looked at my T levels and thought I was normal. Like fuck I'm normal. I always said from the beginning that I had downregulated my androgen receptors and I kind of proved it.
 
I always said from the beginning that I had downregulated my androgen receptors and I kind of proved it.

So, you downregulated receptors by AAS and it caused MAIS?

I just don't understand, were you overall normal before AAS? If yes (your problems started after cycle?), then seems steroids CAN cause MAIS symptoms in some form (no congenital, whatever)? Or you will be treating the wrong thing? :confused:

Are you going to get genetic testing or you just need diagnosis to start testosterone shots? Dr. Scally mentioned that only T, LH results are not enough.
 
So, you downregulated receptors by AAS and it caused MAIS?

I just don't understand, were you overall normal before AAS? If yes (your problems started after cycle?), then seems steroids CAN cause MAIS symptoms in some form (no congenital, whatever)? Or you will be treating the wrong thing? :confused:

Are you going to get genetic testing or you just need diagnosis to start testosterone shots? Dr. Scally mentioned that only T, LH results are not enough.

I said I wasn't normal before steroids and I only gained like 5 pounds from a 9 month test cycle. Dr Conway said that I could get the test on the NHS and look at scans of my mutant androgen receptor. he IS AN ASI SPECIALIST AND WAS 100% CONFIDENT THAT I HAVE MAIS OTHERWISE HE WOULDN't HAVE DIAGNNOSED ME. What can explain my persistently my elevated T and LH levels? You tell me that.

I always had symtpoms of low T before roids it's just the ED hit me after the cycle. My levels were in the 1000's before roids and then that cycle lowered them but they were still elevated.

I don't need that Test.. Read what it says here. DR Conway is no douchebag .[quoteMAIS is only diagnosed in normal phenotypic males, and is not typically investigated except in cases of male infertility [18]. MAIS has a mild presentation that often goes unnoticed and untreated [15]; even with semenological, clinical and laboratory data, it can be difficult to distinguish between men with and without MAIS, and thus a diagnosis of MAIS is not usually made without confirmation of an AR gene mutation [5]. The androgen sensitivity index (ASI), defined as the product of luteinizing hormone (LH) and testosterone (T), is frequently raised in individuals with all forms of AIS, including MAIS, although many individuals with MAIS have an ASI in the normal range [5]. Testosterone levels may be elevated despite normal levels of luteinizing hormone [15][20][24]. Conversion of testosterone (T) to dihydrotestosterone (DHT) may be impaired, although to a lesser extent than is seen in 5?-reductase deficiency [3]. A high ASI in a normal phenotypic male [45], especially when combined with azoospermia or oligospermia [5][7], decreased secondary terminal hair [26], and / or impaired conversion of T to DHT [3], can be indicative of MAIS, and may warrant genetic testing.

[edit] Management][/quote]

That is all he needed to see. My persistently high LH and T and my persistently high ASI. Nuff said.
 
I don't want to sound redundant but I found this very interesting and want to clarify some things. So before you ever touched testosterone, naturally you were at 1000ng/dL of testosterone and still exhibited symptoms of low testosterone?
 
I never have in 3+ years of TRT. In fact, after reading this forum and ATM for those same 3+ years, dicking with my estrogen scares the shit out of me. No thanks.

What have you heard about AI's that scare you? I've heard of scary stuff with those hair loss prescriptions but I haven't heard really anything negative about AI's.
 
I don't want to sound redundant but I found this very interesting and want to clarify some things. So before you ever touched testosterone, naturally you were at 1000ng/dL of testosterone and still exhibited symptoms of low testosterone?

I never checked what my levels were before touching Testosterone Enanthate but I suspect that they were very high, like 1200+. These are the levels that men with MAIS have and I took Test E for 9 months which is extreme abuse and they must have lowered them to where they are now. 879, 844 etc... I always had symptoms of Low T such as depression, difficulty concentrating, lower libido than most males etc... I could always get erections on demand but sometimes lost them upon penetration.

I always lacked confidence with women because I was skinny build and couldn't gain muscle by working out and eating 3000+ calories a day which is the reason I took 500mg Testosterone Enanthate for 9 months. I only gained a few pounds from that cycle even though I was working out 3 - 4 times a week and eating plenty clean foods, around 2 gram protein per pound of bodyweight and like I said earlier; 3000+ calories every day. I was surprised when I didn't put much mass on like other guys and my training partner and best friend.

I always knew that something was wrong.
 
What have you heard about AI's that scare you? I've heard of scary stuff with those hair loss prescriptions but I haven't heard really anything negative about AI's.

AIs don't scare me per se, it's dicking with my estrogen that scares me. Too high and you turn into a limpdick emotional pussy who cries when your wife raises her voice, too low and you turn into a limpdick apathetic eunuch who couldn't give a shit about sex or anything else. And the tolerance between too high and too low is not only tight in men, it's likely to be as individual as testosterone levels in women. I appreciate their value for those who need to use them professionally (bodybuilders and other athletes looking for supraphysiological levels of testosterone for performance enhancement which will almost invariably result in too high levels of estrogen), but that ain't me. I'll stick to just Androgel (at least as long as it keeps working for me) and let my body do whatever the hell it feels it needs to do with the downstream metabolites. Everything's good at 475 ng/dl 24 hours post-application, why would I dick with something that ain't broke?
 
I'm not using hcg. Not using anything. My E2 is now normal and I feel no different. It's not an E2 issue.

When I first came her last year I was looking on advice of my hormones because I came off a Test E cycle and became limp. My dick wouldn't work. I did a 9 month enanthate cycle and became like this after coming off.

My Test levels were good. In the upper range but in November I was given a complete hormonal panel and found out my LH was high. High LH means that my pituitary thinks my T is low. I always said from the beginning that I thought I had downregulated my androgen receptors and this high LH level kind of confirmed it but things didn't make sense. It's not heard of right?

Structure (a member of this forum) came on here, saw my bloodwork and that I had symptoms of low T. He said to me, "I think you could have MAIS" At first I didn't believe it but then started reading up more and more on it and this totally defines me 100%. I have LH and High T nothing else can explain it but this:



Mild androgen insensitivity syndrome - Wikipedia, the free encyclopedia

The problem with your theory as to the cause of your condition is that androgen receptors dont down regulate. There is a post, with studies, where Dr. Scally convinces me that this is the case.
 

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