Who here has used andractim and been suppressed from it? I used it or a couple weeks and I definitely am feeling the bad affects being off of it the past few days. Although now on my 3rd day off I'm starting to feel a bit better. Do you think I'll be able to recover without the help of a serm or hcg?
MESO-Rx
Anabolic Steroids
Andractim and suppression
- Thread starter jonnyboy
- Start date
What gave you the impression that DHT is NOT suppressive? It most definitely is HPTA suppressive. You will recover quickly. Give it a little while, no more than a few weeks, if that.
https://thinksteroids.com/community/posts/733665
Cailleux-Bounacer A, Rohmer V, Lahlou N, Lefebvre H, Roger M, Kuhn JM. Impact level of dihydrotestosterone on the hypothalamic-pituitary-leydig cell axis in men. International Journal of Andrology 2009;32(1):57-65. Impact level of dihydrotestosterone on the hypothalamic-pituitary-leydig cell axis in men - Cailleux-Bounacer - 2007 - International Journal of Andrology - Wiley Online Library
Summary Dihydrotestosterone (DHT) the physiologically most potent androgen cannot be aromatised into oestrogen. DHT is used as a treatment for idiopathic gynaecomastia. In order to investigate the different sites of action of DHT on the hypothalamic-pituitary-testicular axis, two groups of adult men were studied.
Group I included 10 gonadotropin-releasing hormone (GnRH)-deficient men who were evaluated before and during a pulsatile infusion of GnRH alone for 2 weeks and then in association with DHT given transdermally at doses used in the treatment of gynaecomastia for further two weeks. Luteinizing hormone (LH) pulsatility was assessed at the end of each step of the study. Plasma LH levels were measured every 15 min. Plasma testosterone (T), DHT, oestradiol (E2), free alpha-subunit (FAS) of glycoproteic hormones and LH bioactivity were measured on pooled plasma samples. Group II included 12 healthy men in whom plasma T, DHT and E2 were measured before and then 24, 48 and 72 h after the injection of 5000 IU hCG alone or in combination with either DHT or the pure anti-androgen nilutamide. Two weeks separated each of the 3 hCG testing.
In group I, except for bioactive/immunoreactive (B/I) LH ratio which was unchanged, GnRH treatment induced significant rises (p < 0.01) in all plasma hormone levels, LH pulse amplitude and frequency. During treatment with GnRH+DHT, plasma DHT levels increased up to 16.8 ± 2.5 nm, while plasma hormone levels, B/I LH ratio, LH pulse amplitude and frequency were similar to those obtained with GnRH alone. In group II, the peak of hCG-induced T rise was not modified by either DHT or nilutamide. In contrast, DHT reduced by 50% (p < 0.01) the E2 peak in response to hCG.
These data show that DHT exerts no direct action on the pituitary to retroregulate LH secretion and to modify either B/I LH ratio or FAS secretion. Its reducing effect on LH secretion is likely mediated at the hypothalamic level. DHT does not appear to have a physiological influence on Leydig cells steroidogenesis. Administered at therapeutic doses, DHT directly reduces testicular aromatase activity that combined with its antigonadotropic effect leads to the gain in the symptomatic treatment of gynaecomastia.
Cailleux-Bounacer A, Rohmer V, Lahlou N, Lefebvre H, Roger M, Kuhn JM. Impact level of dihydrotestosterone on the hypothalamic-pituitary-leydig cell axis in men. International Journal of Andrology 2009;32(1):57-65. Impact level of dihydrotestosterone on the hypothalamic-pituitary-leydig cell axis in men - Cailleux-Bounacer - 2007 - International Journal of Andrology - Wiley Online Library
Summary Dihydrotestosterone (DHT) the physiologically most potent androgen cannot be aromatised into oestrogen. DHT is used as a treatment for idiopathic gynaecomastia. In order to investigate the different sites of action of DHT on the hypothalamic-pituitary-testicular axis, two groups of adult men were studied.
Group I included 10 gonadotropin-releasing hormone (GnRH)-deficient men who were evaluated before and during a pulsatile infusion of GnRH alone for 2 weeks and then in association with DHT given transdermally at doses used in the treatment of gynaecomastia for further two weeks. Luteinizing hormone (LH) pulsatility was assessed at the end of each step of the study. Plasma LH levels were measured every 15 min. Plasma testosterone (T), DHT, oestradiol (E2), free alpha-subunit (FAS) of glycoproteic hormones and LH bioactivity were measured on pooled plasma samples. Group II included 12 healthy men in whom plasma T, DHT and E2 were measured before and then 24, 48 and 72 h after the injection of 5000 IU hCG alone or in combination with either DHT or the pure anti-androgen nilutamide. Two weeks separated each of the 3 hCG testing.
In group I, except for bioactive/immunoreactive (B/I) LH ratio which was unchanged, GnRH treatment induced significant rises (p < 0.01) in all plasma hormone levels, LH pulse amplitude and frequency. During treatment with GnRH+DHT, plasma DHT levels increased up to 16.8 ± 2.5 nm, while plasma hormone levels, B/I LH ratio, LH pulse amplitude and frequency were similar to those obtained with GnRH alone. In group II, the peak of hCG-induced T rise was not modified by either DHT or nilutamide. In contrast, DHT reduced by 50% (p < 0.01) the E2 peak in response to hCG.
These data show that DHT exerts no direct action on the pituitary to retroregulate LH secretion and to modify either B/I LH ratio or FAS secretion. Its reducing effect on LH secretion is likely mediated at the hypothalamic level. DHT does not appear to have a physiological influence on Leydig cells steroidogenesis. Administered at therapeutic doses, DHT directly reduces testicular aromatase activity that combined with its antigonadotropic effect leads to the gain in the symptomatic treatment of gynaecomastia.
Thank ya very much. I never thought that it wouldnt suppress me but I have seen one guy post before saying that he used low dose andractim to help his low dht, and he found a dose to work that wouldnt suppress him. He was using something really small. I'd imagine 1/16th of the recommended dose.
Im still able to have sex right. Ow even though I'm clearly suppressed. I'm gettin the puffy red eyes in the morning and the dark bags under my eyes which is the most obvious symptom for me besides muscle ache. Testicles are still full though
Im still able to have sex right. Ow even though I'm clearly suppressed. I'm gettin the puffy red eyes in the morning and the dark bags under my eyes which is the most obvious symptom for me besides muscle ache. Testicles are still full though
Effeminate_builder
Banned
I have applied 5g of Andractim per day for one week and my balls did not shrink
I have applied 5g of Andractim per day for one week and my balls did not shrink
It won't shut you down if you have AIS. We are in the minority.
Effeminate_builder
Banned
Wow sade something new.
In case you have know any papers that mention the absence of HPTA shutdown in AIS guys abusing androgens kindly give me the links.
Because if what you are saying is 100 percent true then
noticing lack of testicular shrinkage on abusing androgens could be kind of a test for MAIS
In case you have know any papers that mention the absence of HPTA shutdown in AIS guys abusing androgens kindly give me the links.
Because if what you are saying is 100 percent true then
noticing lack of testicular shrinkage on abusing androgens could be kind of a test for MAIS
High bodybuilding doses will shut any guy down, AIS or not. Low doses should lower pituitarys demand on testicles and drop LH levels so that T production is satisfactory.
Effeminate_builder
Banned
is this taken from wiedermans paper, if not which one.??
I have a bad habit of not reading in between the lines and miss out on some real important stuff
is this taken from wiedermans paper, if not which one.??
I have a bad habit of not reading in between the lines and miss out on some real important stuff
It's taken from the MAIS wiki article page!!
