nervousness causing loss of erection

[corageon]

Yea what it tells me is your implying neurochemical bench research has direct clinical applications. Really!

Let's see the CLINICAL TRIALS first fella.

How about a trial where oxytocin was used to modify "nervousness", LOL!

How many supplements have not went through "CLINICAL TRIALS" and yet have great reviews. Oh but, maybe that's ALL 100% PLACEBO-EFFECT.


Oxytocin has been reported by many to have an effect, but again, OP and others curious...your genes may be different, so let's see once you get it going (if you choose to), how it works for you.

Then we can have a report when you come back to the forum for *some others*
to not be convinced by.

 

[Dr JIM]

Oh that's the ticket plead the "supplement issue" to justify your own ignorance.

You tell me who is preventing the "supplement manufactures" from performing and then publishing their own studies on efficacy, LMAO!

Those companies know better because probably less than ONE PERCENT (my estimate based on meta-analysis) of what is sold as an OTC supplement is anything but BUNK.

So purchasing that junk lines the pockets of supplement producers just like the Pharm companies BUT at least what the latter sells has proven benefit albeit not without risks.

Fact is of the few supplements which have undergone formal clinical trials VERY FEW have proven to be better than placebo.

So FY your better off using placebo because at least it won't cause HARM, nuts!

 

[CensoredBoardsSuck]

This is the first evidence that OT can be anxiogenic in humans. The partial dissociation in the effect of OT on defensive responses to predictable and unpredictable shocks can be explained by evidence in rodents that OT facilitates excitatory signaling in a structure that underlies sustained anxiety-like behavior to uncertainty, the BNST, by directly activating corticotrophin releasing factor neurons. Several reasons might explain the failure to detect any AVP effect. The AVP dose may have been too low. Alternatively, OT effects may be mediated by the OT receptor as opposed to AVP receptors (for example, V1a and V1b). Finally, OT and AVP may affect differentially the brainstem pathways that mediate the various components of anxiety, suggesting that startle potentiation is selectively sensitive to OT but not AVP.


Molecular Psychiatry 18, 958-960 (September 2013)
Oxytocin increases anxiety to unpredictable threat http://www.nature.com/mp/journal/v18/n9/full/mp2012156a.html
C Grillon, M Krimsky, D R Charney, K Vytal, M Ernst and B Cornwell

Abstract

The nonapeptide oxytocin (OT), dubbed by the media as the ‘moral’ or ‘love’ molecule, has a variety of pro-social effects across species. A relatively simple explanation for these complex effects is that OT alleviates anxiety,1 thereby indirectly promoting trust, cooperation and other affiliative behaviors. Indeed, OT can reduce anxiety-like behavior in animals, via its neuromodulatory influence on the amygdala, a core hub mediating fear and anxiety. Surprisingly, OT also promotes territoriality, aggression and other defensive behaviors toward out-group members,2 complicating any straightforward interpretation of OT’s socio-emotional effects. Here, we show that OT does not reduce but rather increases defensive responding to unpredictable threat in humans, suggesting that OT enhances anxiety.

 

[Dr JIM]

But, but, but, but,, wha, wha, wha, I'm, I'm, I'm, kkkkfused

 

[corageon]

Oh that's the ticket plead the "supplement issue" to justify your own ignorance.

You tell me who is preventing the "supplement manufactures" from performing and then publishing their own studies on efficacy, LMAO!

Those companies know better because probably less than ONE PERCENT (my estimate based on meta-analysis) of what is sold as an OTC supplement is anything but BUNK.

So purchasing that junk lines the pockets of supplement producers just like the Pharm companies BUT at least what the latter sells has proven benefit albeit not without risks.

Fact is of the few supplements which have undergone formal clinical trials VERY FEW have proven to be better than placebo.

So FY your better off using placebo because at least it won't cause HARM, nuts!

Studies have been published on various chemicals found in supplements.
Many are still un-studied. I don't advocate pharmaceuticals over supplements, I am merely saying since you stand so much for "CLINICAL STUDIES", and now with this response, you have directly contradicted yourself.

Btw, your terminology is terrible. "Nervousness" is hardly a scientific term, anxiety is used much more frequently.

Now let me get to the oxytocin study that was just posted in attempt to counter what I've said. Prepare to get shot down.

 

[corageon]

This is the first evidence that OT can be anxiogenic in humans. The partial dissociation in the effect of OT on defensive responses to predictable and unpredictable shocks can be explained by evidence in rodents that OT facilitates excitatory signaling in a structure that underlies sustained anxiety-like behavior to uncertainty, the BNST, by directly activating corticotrophin releasing factor neurons. Several reasons might explain the failure to detect any AVP effect. The AVP dose may have been too low. Alternatively, OT effects may be mediated by the OT receptor as opposed to AVP receptors (for example, V1a and V1b). Finally, OT and AVP may affect differentially the brainstem pathways that mediate the various components of anxiety, suggesting that startle potentiation is selectively sensitive to OT but not AVP.


Molecular Psychiatry 18, 958-960 (September 2013)
Oxytocin increases anxiety to unpredictable threat http://www.nature.com/mp/journal/v18/n9/full/mp2012156a.html
C Grillon, M Krimsky, D R Charney, K Vytal, M Ernst and B Cornwell

Abstract

The nonapeptide oxytocin (OT), dubbed by the media as the ‘moral’ or ‘love’ molecule, has a variety of pro-social effects across species. A relatively simple explanation for these complex effects is that OT alleviates anxiety,1 thereby indirectly promoting trust, cooperation and other affiliative behaviors. Indeed, OT can reduce anxiety-like behavior in animals, via its neuromodulatory influence on the amygdala, a core hub mediating fear and anxiety. Surprisingly, OT also promotes territoriality, aggression and other defensive behaviors toward out-group members,2 complicating any straightforward interpretation of OT’s socio-emotional effects. Here, we show that OT does not reduce but rather increases defensive responding to unpredictable threat in humans, suggesting that OT enhances anxiety.

The context of this statement suggests its all hype. First of all it wasn't "dubbed by the media", technically it was first defined as that in a bit of medical literature, also studies like (1) (2).

"The BioChemistry of Love" - An Oxytocin Hypothesis​

LINK (TOO LONG)


Now before you even shape hypothesis vs suggestion. As "CensoredBoardsSuck" has posted a study, that among the majority of, are indeed "suggestive" rather than affirmative, you can see that there is an even ground. Common sense really.

Now I am going to point out some numbers. That's ONE study that shows that oxytocin has an anxiogenic effect,.. can you find more?

Also this is in the context of facing an unpredictable threat, which one should understand, who would be in a calm state of mind in such a situation anyway?
Anyone with a moderate awareness of what's going on (including animals) would have an "anxiogenic" effect to such stimuli. It's not saying it induced a panic attack, is it?

Therefore your argument just got hit and nullified.


Come at me again with more relevance. Then maybe you might have a chance.

[)]​

 

[MR10X]

I once took cialis 20mg during the day and then took some viagra that night before sex and felt real light headed so it ook my BP and it was really low,i dont remember the readingsbut it was super low...........

 

[Dr JIM]

I've nothing to prove, since your the clown attempting to justify unconventional treatment for the OPs complaint of; "NERVOUSNESS".

Therefore until you provide evidence of CLINICAL benefit for your non-traditional therapies your FOS, lol!

 

[corageon]

I've nothing to prove, since your the clown attempting to justify unconventional treatment for the OPs complaint of; "NERVOUSNESS".

Therefore until you provide evidence of CLINICAL benefit for your non-traditional therapies your FOS, lol!

Your making a fool of yourself; my points that I've made are perfectly sensible, and are far more backed then your irrelevant and misplaced rhetoric. I don't see any significant army on either side. Let's stand and wait for someone to come forth with a testimonial of oxytocin's effects.

For now... OP should be either doing his own research in addition to what he has seen, or experimenting.

 

[corageon]

I once took cialis 20mg during the day and then took some viagra that night before sex and felt real light headed so it ook my BP and it was really low,i dont remember the readingsbut it was super low...........

Why would you take Viagra + Cialis in the same night?
Cialis is still in your system at that point, thats why you only need to dose it once a day. It's got quite long of a half-life. Adding Viagra to that makes really no sense.
If anything, add a nitric oxide booster, not another PDE-5 inhibitor.

Also it should be noted that too MUCH nitric oxide can take your erections off the board or weaken them as well.

 

[Dr JIM]

The points you have made are nothing more than esoteric garbage and awaiting anecdotal reports from oxytocin "users" is no substitute for evidence based applied clinical research.

Of course your pleadings for the latter are no surprise since you have offered zip, ziltch, zero to support your molecular biology based suggestions from a clinical perspective.

Oh yea people like you prance onto Meso about once every six months, believing a theory is the equivalent of a practice.

And indeed many are no different than yourself, since their arguments may be compelling for the uninformed or unwitting reader. That is, they know just enough to be dangerous!!!

 

[corageon]

The points you have made are nothing more than esoteric garbage and awaiting anecdotal reports from oxytocin "users" is no substitute for evidence based applied clinical research.

Of course your pleadings for the latter are no surprise since you have offered zip, ziltch, zero to support your molecular biology based suggestions from a clinical perspective.

Oh yea people like you prance onto Meso about once every six months, believing a theory is the equivalent of a practice.

And indeed many are no different than yourself, since their arguments may be compelling for the uninformed or unwitting reader. That is, they know just enough to be dangerous!!!

You have made no valid points either other than trying to avert a suggestion, yet you side with a suggestion stating the opposite, I have pointed out studies, you have not made one significant counter-argument with scientific backing.
I am not saying oxytocin is a cure all, it was suggested because many on here *may* benefit for it. I am offering a suggestion as Anything else would be considered on here.

If you were to go over every *clinically approved* "remedy", does that guarantee it will work for everybody? No.
Therefore the same for other things that have some studies, it may actually work for some people. So why not make a suggestion, why not attempt to expand someone's "horizons". Let all see the vast knowledgebase.

People use "research chemicals" all the time, many of which haven't been approved, and yet see benefit for it.


So again, my statements speak for themselves, because they actually have logic.


Don't insure the closed-mindedness of others, indeed, everybody should become more open-minded...

 

[CensoredBoardsSuck]

That's ONE study that shows that oxytocin has an anxiogenic effect,.. can you find more?

Nat Neurosci. 2013 Sep;16(9):1185-7.
Fear-enhancing effects of septal oxytocin receptors. Fear-enhancing effects of septal oxytocin recep... [Nat Neurosci. 2013] - PubMed - NCBI
Guzmán YF1, Tronson NC, Jovasevic V, Sato K, Guedea AL, Mizukami H, Nishimori K, Radulovic J.

Abstract

The nonapeptide oxytocin is considered beneficial to mental health due to its anxiolytic, prosocial and antistress effects, but evidence for anxiogenic actions of oxytocin in humans has recently emerged. Using region-specific manipulations of the mouse oxytocin receptor (Oxtr) gene (Oxtr), we identified the lateral septum as the brain region mediating fear-enhancing effects of Oxtr. These effects emerge after social defeat and require Oxtr specifically coupled to the extracellular signal-regulated protein kinase pathway.




Psychopharmacology (Berl). 2013 Nov 28. [Epub ahead of print]
Role of oxytocin receptors in modulation of fear by social memory. Role of oxytocin receptors in modu... [Psychopharmacology (Berl). 2013] - PubMed - NCBI
Guzmán YF1, Tronson NC, Sato K, Mesic I, Guedea AL, Nishimori K, Radulovic J.


Abstract

RATIONALE: Oxytocin receptors (Oxtr) are important mediators of social learning and emotion, with bidirectional effects on fear and anxiety. Contrary to the anxiolytic actions of Oxtr in the amygdala, we recently showed that Oxtr in the lateral septum mediate the enhancement of fear conditioning by social defeat in mice.

OBJECTIVES: Using positive social interactions, which impair fear conditioning, here we attempted to delineate whether the role of septal Oxtr in fear regulation depends on the valence of the social memory.

METHODS: Pharmacological and genetic manipulations of lateral septal Oxtr were combined with the social buffering of fear paradigm, in which pre-exposure to nonfearful conspecifics reduces subsequent contextual fear conditioning, as revealed by decreased freezing behavior.

RESULTS: Antagonism and down-regulation of Oxtr in the lateral septum abolished, while oxytocin (Oxt) administration before pre-exposure to nonfearful conspecifics facilitated the decrease of freezing behavior.

CONCLUSIONS: The septal oxytocin system enhances memory of social interactions regardless of their valence, reducing fear after positive and enhancing fear after negative social encounters. These findings explain, at least in part, the seemingly bidirectional role of Oxt in fear regulation.




Psychopharmacology (Berl). 2012 Sep;223(2):149-58.
Central administration of oxytocin receptor ligands affects cued fear extinction in rats and mice in a timepoint-dependent manner. Central administration of oxytocin... [Psychopharmacology (Berl). 2012] - PubMed - NCBI
Toth I1, Neumann ID, Slattery DA.

Abstract

RATIONALE: Oxytocin (OXT) has been proposed as a potential therapeutic agent for post-traumatic stress disorder (PTSD).

OBJECTIVES: We aimed to verify whether pharmacological manipulation of the brain OXT system affects cued fear conditioning and fear extinction.

METHODS: Male rats and mice were intracerebroventricularly administered synthetic OXT (rats, 0.1 or 1.0 ?g/5 ?l; mice, 0.1 or 0.5 ?g/2 ?l) and/or an OXT receptor antagonist (OXTR-A; rats, 0.75 ?g/5 ?l) either prior to fear conditioning or extinction training.

RESULTS: Preconditioning administration of OXT did not affect fear conditioning in rats, but decreased fear expression and facilitated fear extinction. In contrast, preconditioning blockade of OXT neurotransmission by OXTR-A did not affect fear conditioning or fear expression, but impaired fear extinction. When administered before extinction training, OXT impaired fear extinction in both rats and mice, indicating that the effects of OXT on fear extinction are conserved across species. This impairment was OXTR-mediated, as the inhibitory effect of OXT on fear extinction was abolished by prior treatment with OXTR-A. The impaired fear extinction was not a result of reduced locomotion in rats, whereas an apparent decrease in fear expression and facilitation of fear extinction with the higher OXT dose in mice was the result of behavioral hyperactivity.

CONCLUSIONS: These results suggest that increasing OXT neurotransmission during traumatic events is likely to prevent the formation of aversive memories. In contrast, OXT treatment before fear extinction training, which would be the comparable timepoint for psychotherapy in PTSD patients, rather delays fear extinction and, therefore, caution is needed before recommending OXT for the treatment of PTSD.

 

[corageon]

Nat Neurosci. 2013 Sep;16(9):1185-7.
Fear-enhancing effects of septal oxytocin receptors. Fear-enhancing effects of septal oxytocin recep... [Nat Neurosci. 2013] - PubMed - NCBI
Guzmán YF1, Tronson NC, Jovasevic V, Sato K, Guedea AL, Mizukami H, Nishimori K, Radulovic J.

Abstract

The nonapeptide oxytocin is considered beneficial to mental health due to its anxiolytic, prosocial and antistress effects, but evidence for anxiogenic actions of oxytocin in humans has recently emerged. Using region-specific manipulations of the mouse oxytocin receptor (Oxtr) gene (Oxtr), we identified the lateral septum as the brain region mediating fear-enhancing effects of Oxtr. These effects emerge after social defeat and require Oxtr specifically coupled to the extracellular signal-regulated protein kinase pathway.




Psychopharmacology (Berl). 2013 Nov 28. [Epub ahead of print]
Role of oxytocin receptors in modulation of fear by social memory. Role of oxytocin receptors in modu... [Psychopharmacology (Berl). 2013] - PubMed - NCBI
Guzmán YF1, Tronson NC, Sato K, Mesic I, Guedea AL, Nishimori K, Radulovic J.


Abstract

RATIONALE: Oxytocin receptors (Oxtr) are important mediators of social learning and emotion, with bidirectional effects on fear and anxiety. Contrary to the anxiolytic actions of Oxtr in the amygdala, we recently showed that Oxtr in the lateral septum mediate the enhancement of fear conditioning by social defeat in mice.

OBJECTIVES: Using positive social interactions, which impair fear conditioning, here we attempted to delineate whether the role of septal Oxtr in fear regulation depends on the valence of the social memory.

METHODS: Pharmacological and genetic manipulations of lateral septal Oxtr were combined with the social buffering of fear paradigm, in which pre-exposure to nonfearful conspecifics reduces subsequent contextual fear conditioning, as revealed by decreased freezing behavior.

RESULTS: Antagonism and down-regulation of Oxtr in the lateral septum abolished, while oxytocin (Oxt) administration before pre-exposure to nonfearful conspecifics facilitated the decrease of freezing behavior.

CONCLUSIONS: The septal oxytocin system enhances memory of social interactions regardless of their valence, reducing fear after positive and enhancing fear after negative social encounters. These findings explain, at least in part, the seemingly bidirectional role of Oxt in fear regulation.




Psychopharmacology (Berl). 2012 Sep;223(2):149-58.
Central administration of oxytocin receptor ligands affects cued fear extinction in rats and mice in a timepoint-dependent manner. Central administration of oxytocin... [Psychopharmacology (Berl). 2012] - PubMed - NCBI
Toth I1, Neumann ID, Slattery DA.

Abstract

RATIONALE: Oxytocin (OXT) has been proposed as a potential therapeutic agent for post-traumatic stress disorder (PTSD).

OBJECTIVES: We aimed to verify whether pharmacological manipulation of the brain OXT system affects cued fear conditioning and fear extinction.

METHODS: Male rats and mice were intracerebroventricularly administered synthetic OXT (rats, 0.1 or 1.0 ?g/5 ?l; mice, 0.1 or 0.5 ?g/2 ?l) and/or an OXT receptor antagonist (OXTR-A; rats, 0.75 ?g/5 ?l) either prior to fear conditioning or extinction training.

RESULTS: Preconditioning administration of OXT did not affect fear conditioning in rats, but decreased fear expression and facilitated fear extinction. In contrast, preconditioning blockade of OXT neurotransmission by OXTR-A did not affect fear conditioning or fear expression, but impaired fear extinction. When administered before extinction training, OXT impaired fear extinction in both rats and mice, indicating that the effects of OXT on fear extinction are conserved across species. This impairment was OXTR-mediated, as the inhibitory effect of OXT on fear extinction was abolished by prior treatment with OXTR-A. The impaired fear extinction was not a result of reduced locomotion in rats, whereas an apparent decrease in fear expression and facilitation of fear extinction with the higher OXT dose in mice was the result of behavioral hyperactivity.

CONCLUSIONS: These results suggest that increasing OXT neurotransmission during traumatic events is likely to prevent the formation of aversive memories. In contrast, OXT treatment before fear extinction training, which would be the comparable timepoint for psychotherapy in PTSD patients, rather delays fear extinction and, therefore, caution is needed before recommending OXT for the treatment of PTSD.

Interesting. Most of these justify that oxytocin has an anxiolytic role, but in dismissal of fears, and a type of confidence or memory evoked response.
It has a "bidirectional role", but not a generally anxiogenic action. Rather, a generally anxiolytic action, other than in specialized situations that would normally incite a territorial or fearful response.

So again, still, its generally anxiolytic.

We can still conclude it has some degree of pro-social effect, but perhaps "too social" in certain situations.

 

[toolman]

The points you have made are nothing more than esoteric garbage and awaiting anecdotal reports from oxytocin "users" is no substitute for evidence based applied clinical research.

Of course your pleadings for the latter are no surprise since you have offered zip, ziltch, zero to support your molecular biology based suggestions from a clinical perspective.

Oh yea people like you prance onto Meso about once every six months, believing a theory is the equivalent of a practice.

And indeed many are no different than yourself, since their arguments may be compelling for the uninformed or unwitting reader. That is, they know just enough to be dangerous!!!

Ignore him Jim, as you said, these types show up every 6 months. Another wannabe that couldn't make it through undergrad or score high enough on their MCATS. The grammatical errors throughout are the tell as to the lack of a quality education. They think pontification is intelligent discussion.

 

[Dr JIM]

So again, my statements speak for themselves, because they actually are FOS!!!

Your garbage may work on an infomercial, an advertisement to sell supplements or some other lame AAS forum where anything goes BUT on Meso, rest assured, your BULLSHIT will be challenged to no end!

You are correct TM and as long as no one on Meso is openly following or believing this bozo I'm good and have achieved my goal, ensuring this clown or those numb nuts of similar ilk do no harm to Meso members.

jim

 

[corageon]

Ignore him Jim, as you said, these types show up every 6 months. Another wannabe that couldn't make it through undergrad or score high enough on their MCATS. The grammatical errors throughout are the tell as to the lack of a quality education. They think pontification is intelligent discussion.

Grammatical errors? Where? Do show?!
Btw, I have a H.Regents Diploma and an Associate's Degree, and am currently attending other programs. Good one. Not quite though. Your assumptions have spoken of your blindness to what is going on. I bet ya didn't even read through most of the discussion.

You also, look like a blind idiot.
[)]

 

[corageon]

So again, my statements speak for themselves, because they actually are FOS!!!

Your garbage may work on an infomercial, an advertisement to sell supplements or some other lame AAS forum where anything goes BUT on Meso, rest assured, your BULLSHIT will be challenged to no end!

You are correct TM and as long as no one on Meso is openly following or believing this bozo I'm good and have achieved my goal, ensuring this clown or those numb nuts of similar ilk do no harm to Meso members.

jim

You use a hella lotta acronyms and abbreviations...too lazy to write a full word out?
Also, I am sure MANY who are reading what I have wrote, have more than considered what I have said; they've acted on it.
Some will achieve good results, some may not. But what I have said, again, makes perfect sense, your simply challenging an argument that you know is correct, and you can't find anything else to counter with, so you automatically think your rep will take care of your ass.

But in reality, intelligent people read science, and logic, your reputation can't be used to save your ignorant remarks from the soon to be coming further criticism.

Your not gonna convince people to be closed-minded like you, when they insist on being open-minded and curious. I will not stop informing people, and I am glad there is feedback on my statements. We should all test our minds more often.

 

[toolman]

Grammatical errors? Where? Do show?!
Btw, I have a H.Regents Diploma and an Associate's Degree, and am currently attending other programs. Good one. Not quite though. Your assumptions have spoken of your blindness to what is going on. I bet ya didn't even read through most of the discussion.

You also, look like a blind idiot.
[)]

Like I said, your lack of education is indicated in your grammar. I hope you plan on attending other programs with only your associates degree. With that little education, you are clearly unqualified to give any medical advice and this is typical of your ilk. I won't have to pour over your dribble for any examples, you make some typical ones right in this post. Your first three sentences as punctuated are not sentences.

Morons like you come and go. You have been identified and called out for the ignorant "wannabe" you are. Reading your responses reminds me of my favorite line from Macbeth.

"It is a tale. Told by an idiot, full of sound and fury, signifying nothing."

Now go get a job or apply yourself and finish a real degree! as attending "some programs" as you say, isn't working for you.

 

[toolman]

You use a hella lotta acronyms and abbreviations...too lazy to write a full word out?
Also, I am sure MANY who are reading what I have wrotehave written, have more than considered what I have said; they've acted on it.
Some will achieve good results, some may not. But what I have said, again, makes perfect sense, your simply challenging an argument that you know is correct, and you can't find anything else to counter with, so you automatically think your rep will take care of your ass.major run on sentence also contraction errors such as using your instead of you are or you're

But in reality, intelligent people read science, and logic, your reputation can't be used to save your ignorant remarks from the soon to be comingSoon to be coming?!? Don't even know where to begin with that. Also another major run on sentence further criticism.

Your not gonna3rd use of the wrong word your instead of You're clearly indicating it wasn't a typo, but ignorance..gonna..What are you writing in, English or Ebonics? convince people to be closed-minded like you, when they insist on being open-minded and curious. I will not stop informing people, and I am glad there is feedback on my statements. We should all test our minds more often.

So what is your pitch to people? I have no command of the English language or writing skills, but I went to a local community college (which shows) and because I can use PubMed and pontificate, you should follow what I say. Fortunately for you, P.T. Barnum was right and you will get a sucker here and there. But among those that have a far superior knowledge and education than you, you will be exposed for what you are....nothing much. Now go find another site where we don't have to read your dribble. Or, be respectful of those that clearly know far more than you. Those of us that are in here to learn, prefer to hear from those that are properly trained, vetted and actually know what they are talking about.