Testosterone for Women: Green Light for Sex, Amber Light for Health?
In 1950, Greenblatt and colleagues published findings of a randomised clinical trial of androgen therapy to manage menopausal symptoms. After removal of the ovaries, postmenopausal women reported improved wellbeing, enhanced libido, decreased hot flushes, and amelioration of other symptoms when treated with methyltestosterone and diethylstilbestrol, versus either hormone alone or a placebo.
Since then, androgen replacement for women—using effective and safe compounds—has been considered by health-care providers struggling to manage hypoandrogenic symptoms in women and to prevent medical conditions linked to hypoandrogenicity.
Many testosterone formulations are available to improve measures of sexual wellbeing including low sex drive and poor sexual function. However, currently, these compounds are available only as male formulations and their safety or adverse events, as well as their effect on general aspects of women's health, remain controversial because of scant published data.
Nappi RE. Testosterone for women: green light for sex, amber light for health? The Lancet Diabetes & Endocrinology. https://doi.org/10.1016/S2213-8587(19)30251-7
In 1950, Greenblatt and colleagues published findings of a randomised clinical trial of androgen therapy to manage menopausal symptoms. After removal of the ovaries, postmenopausal women reported improved wellbeing, enhanced libido, decreased hot flushes, and amelioration of other symptoms when treated with methyltestosterone and diethylstilbestrol, versus either hormone alone or a placebo.
Since then, androgen replacement for women—using effective and safe compounds—has been considered by health-care providers struggling to manage hypoandrogenic symptoms in women and to prevent medical conditions linked to hypoandrogenicity.
Many testosterone formulations are available to improve measures of sexual wellbeing including low sex drive and poor sexual function. However, currently, these compounds are available only as male formulations and their safety or adverse events, as well as their effect on general aspects of women's health, remain controversial because of scant published data.
Nappi RE. Testosterone for women: green light for sex, amber light for health? The Lancet Diabetes & Endocrinology. https://doi.org/10.1016/S2213-8587(19)30251-7