2 Fat Loss Drugs On My Radar

[cochino]

It should be for everyone.
However in this case,diet is not applicable.
Cardio can always be done but without being able to diet,you can only go so far.
Also,that's wrong about fat loss drugs.
We could say the same for steroids but hey,you are training your ass off and dieting too.
Drugs alone won't work,full stop.

In his case he just has to ask his psychiatrist,what can be done to make dieting possible. From then on,he will be fine with dieting and cardio alone. No drugs needed to lose weight the same way not drugs are needed to put on muscle(to a point).

We want things sped up,all of us including me and you. Otherwise we wouldn't be here.

Exactly. Nothing wrong with adding in something to help speed up the weightloss a little. Just realize that you still have to put the effort in with diet and cardio.just like steroids, weight-loss drugs aren't going to do all the work for you.

 

[Eman]

Drugs alone won't work,full stop.

Hm... Challenge accepted.

 

[TrennedOutLunatic]

Yeah I have seen that study. The 1996 one?
"fat-free mass was determined by underwater weighing, muscle size was measured by magnetic resonance imaging"
THAT one?

You could try some testosterone at the 600s and just sit on your ass- no training,no dieting at all.
Let's see.
If it's that way,anyone could go on testosterone and EVENTUALLY get a sort of nice physique. Even if that would take 10 years of doing nothing.

If you mean something else,enlighten me.
I am not being ironic,I am really interested.

My argument is that: "fat-free mass was determined by underwater weighing, muscle size was measured by magnetic resonance imaging"

A total joke. That's all they may have had back then.

 

[MFAAS]

After gaining alot of weight from antidepressants due to a big increase in appetite and cravings, I decided to look into fat loss drugs to help me lose weight. I have been lean all my life and in order to bulk I had to force myself to eat so this is not normal for me to be this fat. Now I understood why someone people are overweight as losing weight with a messed up appetite and mental illness and any other health condition can be nearly impossible unless you want to feel hungry for the rest of your life. It just takes more food to feel full and you get hungry much quicker despite eating more than usual.

Now there are alot of great anabolics out there but after doing my research I couldn't find any good fat loss drugs. There's stimulants which obviously have lots of side side effects and arent even weight loss drugs. Dnp which I've looked into but it does cause you to heat up and perhaps makes you not feel well while on it, it's just kind of an iffy drug. Lastly you have FDA approved drugs but they don't show that much weight loss really. In conclusion I don't think there are any good weight loss drugs right now as they are all just very primitive.

However I did find 2 promising drugs on the horizon that are better than the current medication we have.

Tesofensine (Appetite Suppressant): A serotonin neuropinephrin dopamine reuptake inhibitor (raises the levels of these neurotransmitters) originally developed for Alzheimer's but the participants lost alot of weight and was then trialed for fat loss. Currently in stage 3 clinical trials and the company is trying to get FDA approval soon. It showed more weight loss than any current drug on the market. The downside is that I do believe it has a mild stimulating effect but it was well tolerated with only a few people dropping out.
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Bam15 (DNP Derivative/Fat Burner): This drug was only tested in rats but with promising results. Its just like dnp but it doesn't raise body temperature and also it does other chemical stuff healthier than other dnp derivatives. Essentially it makes your mitochondria inefficient at producing energy and other benefits but it seems to preserve muscle tissue and burn fat. One instance was rats with obesety gene treated with bam15 stoped gaining weight while the control continued to pack on fat. Other instance was 3 groups | high fat diet | hfd + bam15 | 15% calorie defecit to lose the same weight as bam15 | bam15 group lost more fat and kept their muscle while eating 15% more than the dieting rats and improved glucose and insulin.

I found a few places from china that sell these and I'm really thinking of taking tesofensine and maybe bam15.

Honestly Tesofensine seems horrible. SNRIs cause horrible physical and mental withdrawal symptoms. You get the BRAIN ZAPS which are pure fucking unadulterated HELL. It is fucking horrible. It's like a mini-seizure and muscle spasm every time you move. It is enough to drive you insane. But once those pass (or if you taper down) you will find crazy mood swings, insane anger outbursts, depression, anxiety. It is awful. Look up effexor withdrawals.

An SNDRI is a tricyclic. Tricyclics are also associated with antidepressants withdrawal syndrome and can cause brain zaps along with a plethora of other symptoms. While taking them, they often cause weight gain/fat deposition, though I don't know if the mechanism behind this is known (if it is increased appetite then obviously that one would not matter, since it suppresses appetite--or if it is actual changes to genetic expression or biological pathways, who knows, I don't feel like digging into it now.

Long story short, I would avoid tesofensine at all costs. It seems fit only for morbidly obese people that can't stop eating, perhaps as an alternative to a gastric sleeve or to help treat a binge eating disorder.

BAM15 sounds reallly interesting though. A DNP analogue/derivative is quite intriguing. This one I would for sure keep my eye on the clinical trials for.

But for real, don't order tesofensine. It is NOT worth it. You do NOT want to fuck around with your neurotransmitters like that, you're just asking for trouble and you WILL get it.

Edit :but in reality all you need to do is take testosterone and eat a deficit and do some cardio and lifting. That's fucking all you need to do. Are you competing to be a pro bodybuilder? I don't even think they take would DNP and shit, why would you? Blast test and add some masteron or anavar or winny or fucking tren ace if you are really struggling to lose weight. Don't resort to research chemical antidepressants that you order from China.

 

[m314]

Why choose an experimental drug that's untested in humans when DNP is available? DNP has been widely tested in humans and shown to be effective and safe at low doses. 100 mg/day can greatly speed up the results from a good diet and training plan.

Diet has to be the first priority. No pill you are taking is forcing you to eat more calories than you burn. If fat loss is a priority, you will make the decision to stop overeating and start making healthier food choices.

 

[TrennedOutLunatic]

Why choose an experimental drug that's untested in humans when DNP is available? DNP has been widely tested in humans and shown to be effective and safe at low doses. 100 mg/day can greatly speed up the results from a good diet and training plan.

Diet has to be the first priority. No pill you are taking is forcing you to eat more calories than you burn. If fat loss is a priority, you will make the decision to stop overeating and start making healthier food choices.

Wrong,regarding the last part.
There are many pills forcing the fuck out of you to eat more than you should and I've been there personally.
You can check the side effects of almost all of the SSRI'S. Not to mention antipsychotics.
All of them except fluoxetine which is the only ssri fda approved for bulimia.

This shit is not just increasing your appetite in some cases. It makes it absolutely unreal.

Discipline is one thing. Discipline when secondary factors such as these,are in the equation,is totally out of question.

Regarding dnp,100mg is all someone needs,as you said.
To the dump it goes if the diet is not in check.

No dnp,nothing. In my opinion.
Do as eman said. Speak with your psychiatrist,then diet diet diet and you will be okay.

 

[TrennedOutLunatic]

Honestly Tesofensine seems horrible. SNRIs cause horrible physical and mental withdrawal symptoms. You get the BRAIN ZAPS which are pure fucking unadulterated HELL. It is fucking horrible. It's like a mini-seizure and muscle spasm every time you move. It is enough to drive you insane. But once those pass (or if you taper down) you will find crazy mood swings, insane anger outbursts, depression, anxiety. It is awful. Look up effexor withdrawals.

An SNDRI is a tricyclic. Tricyclics are also associated with antidepressants withdrawal syndrome and can cause brain zaps along with a plethora of other symptoms. While taking them, they often cause weight gain/fat deposition, though I don't know if the mechanism behind this is known (if it is increased appetite then obviously that one would not matter, since it suppresses appetite--or if it is actual changes to genetic expression or biological pathways, who knows, I don't feel like digging into it now.

Long story short, I would avoid tesofensine at all costs. It seems fit only for morbidly obese people that can't stop eating, perhaps as an alternative to a gastric sleeve or to help treat a binge eating disorder.

BAM15 sounds reallly interesting though. A DNP analogue/derivative is quite intriguing. This one I would for sure keep my eye on the clinical trials for.

But for real, don't order tesofensine. It is NOT worth it. You do NOT want to fuck around with your neurotransmitters like that, you're just asking for trouble and you WILL get it.

Edit :but in reality all you need to do is take testosterone and eat a deficit and do some cardio and lifting. That's fucking all you need to do. Are you competing to be a pro bodybuilder? I don't even think they take would DNP and shit, why would you? Blast test and add some masteron or anavar or winny or fucking tren ace if you are really struggling to lose weight. Don't resort to research chemical antidepressants that you order from China.

Once upon a time I withdrew from ssris. 2 times actually.
As long as you are reading online shit,it only gets worse.
Brain zaps are a joke. I mean it totally exists but I gave zero fucks about it back in the day.
I hear effexor withdrawals are peculiar indeed. Have no personal opinion.
It defers from other antidepressants for reasons I won't go into,withdrawals wise.

 

[TrennedOutLunatic]

Honestly Tesofensine seems horrible. SNRIs cause horrible physical and mental withdrawal symptoms. You get the BRAIN ZAPS which are pure fucking unadulterated HELL. It is fucking horrible. It's like a mini-seizure and muscle spasm every time you move. It is enough to drive you insane. But once those pass (or if you taper down) you will find crazy mood swings, insane anger outbursts, depression, anxiety. It is awful. Look up effexor withdrawals.

An SNDRI is a tricyclic. Tricyclics are also associated with antidepressants withdrawal syndrome and can cause brain zaps along with a plethora of other symptoms. While taking them, they often cause weight gain/fat deposition, though I don't know if the mechanism behind this is known (if it is increased appetite then obviously that one would not matter, since it suppresses appetite--or if it is actual changes to genetic expression or biological pathways, who knows, I don't feel like digging into it now.

Long story short, I would avoid tesofensine at all costs. It seems fit only for morbidly obese people that can't stop eating, perhaps as an alternative to a gastric sleeve or to help treat a binge eating disorder.

BAM15 sounds reallly interesting though. A DNP analogue/derivative is quite intriguing. This one I would for sure keep my eye on the clinical trials for.

But for real, don't order tesofensine. It is NOT worth it. You do NOT want to fuck around with your neurotransmitters like that, you're just asking for trouble and you WILL get it.

Edit :but in reality all you need to do is take testosterone and eat a deficit and do some cardio and lifting. That's fucking all you need to do. Are you competing to be a pro bodybuilder? I don't even think they take would DNP and shit, why would you? Blast test and add some masteron or anavar or winny or fucking tren ace if you are really struggling to lose weight. Don't resort to research chemical antidepressants that you order from China.

And no sndris are not tricyclic.
You are talking about two absolutely different types of antidepressant medications as if it is the same.

Do not spread misinformation.

Correct me if I am wrong.

As for the pros and what they are actually taking...we will never really know. All we can do is speculate.

 

[Eman]

I took an antidepressant years ago to get through an insomnia problem I was struggling with. I've never experienced appetite increase anything close to what that drug caused...

If I tried to muscle through it and get to sleep to avoid the inevitable food gorge, I would sleep walk/sleep eat. Only time I've ever experienced sleepwalking or sleepeating was during that time, no prior history of sleep walking at all. When I started waking up with half eaten steak sandwiches in my bed, I stopped using it.

I had a thing where I'd make nachos in my sleep too for some reason, I never really ever ate them otherwise. I didn't even know I was doing it until I started finding food in my bed when I'd wake up... And even then I thought someone in the house was fucking with me, I had zero recollection of doing anything but going to sleep hungry.

So... Lol at the comments to man up, buckle down on diet and that the drug isn't forcing you to eat. Unless you find a type of drug that works for you, the drug's side effects will either win or you'll be miserable fighting it.

 

[TrennedOutLunatic]

I took an antidepressant years ago to get through an insomnia problem I was struggling with. I've never experienced appetite increase anything close to what that drug caused...

If I tried to muscle through it and get to sleep to avoid the inevitable food gorge, I would sleep walk/sleep eat. Only time I've ever experienced sleepwalking or sleepeating was during that time, no prior history of sleep walking at all. When I started waking up with half eaten steak sandwiches in my bed, I stopped using it.

I had a thing where I'd make nachos in my sleep too for some reason, I never really ever ate them otherwise. I didn't even know I was doing it until I started finding food in my bed when I'd wake up... And even then I thought someone in the house was fucking with me, I had zero recollection of doing anything but going to sleep hungry.

So... Lol at the comments to man up, buckle down on diet and that the drug isn't forcing you to eat. Unless you find a type of drug that works for you, the drug's side effects will either win or you'll be miserable fighting it.

Word.

Mirtazapine has been what you described,for me.
And I am not soft mate,I really am not. This shit overpowered absurd amounts of tren acetate.
It made dnp cravings look like a joke.
Totally unreal. Every appetite suppressant really did jack shit.

 

[Eman]

Word.

Mirtazapine has been what you described,for me.
And I am not soft mate,I really am not. This shit overpowered absurd amounts of tren acetate.
It made dnp cravings look like a joke.
Totally unreal. Every appetite suppressant really did jack shit.

That is exactly what I took. I had to look it up, I took the brand name version, Remeron. Won't forget that RX name.

It also gave me VIVID nightmares that make me shudder to this day, and that was almost 15 years ago now. Vivid as in I wasn't sure if I was really awake when I woke up, I couldn't tell the difference between a dream and reality. It made me completely comatose too... You couldn't shake me awake in the morning. I was told I was moaning in my sleep, and not the kind of moans I wish I had been doing.

This was all over the course of about a week or so? Needless to say, I couldn't take it any longer. You couldn't pay me to take that shit again.

 

[TrennedOutLunatic]

That is exactly what I took. I had to look it up, I took the brand name version, Remeron. Won't forget that RX name.

It also gave me VIVID nightmares that make me shudder to this day, and that was almost 15 years ago now. Vivid as in I wasn't sure if I was really awake when I woke up, I couldn't tell the difference between a dream and reality. It made me completely comatose too... You couldn't shake me awake in the morning. I was told I was moaning in my sleep, and not the kind of moans I wish I had been doing.

This was all over the course of about a week or so? Needless to say, I couldn't take it any longer. You couldn't pay me to take that shit again.

I am not sure if I liked the vivid dreams or not.
I could not tell reality from another dimension each morning I woke up.
The vividness was too much. Man ,my subconscious was hitting me strongly. All my insane dreams made total sense. Things that bothered me,experiences,past experiences all cocktailed together. I was really facing my considerations and bothers every single night in a such vivid manner that had me literally say that if I don't stop this shit I am going straight for the psych ward. And I could fucking remember every detail.

Even if I take it now only for once,I will shit my self in the night from the dreams. Uncomparable to tren dreams. This was a new level.

It was the only drug that literally had me disabled. I couldn't wake up. I couldn't do shit.
I couldn't do the next day no matter what.

 

[MFAAS]

Once upon a time I withdrew from ssris. 2 times actually.
As long as you are reading online shit,it only gets worse.
Brain zaps are a joke. I mean it totally exists but I gave zero fucks about it back in the day.
I hear effexor withdrawals are peculiar indeed. Have no personal opinion.
It defers from other antidepressants for reasons I won't go into,withdrawals wise.

SSRIs don't really cause much brain zaps at all in comparison with drugs that act on norepinephrine.

And no sndris are not tricyclic.
You are talking about two absolutely different types of antidepressant medications as if it is the same.

Do not spread misinformation.

Correct me if I am wrong.

As for the pros and what they are actually taking...we will never really know. All we can do is speculate.

That is correct, I mis-wrote there. Cocaine is an SDNRI (triple-reuptake inhibitor--I confused it with tricyclic). Regardless, I would definitely avoid tesofensine. The DNP analogue is much more interesting, though I wouldn't touch it without really researching it and probably waiting a couple years to see more studies come out.

 

[RebornNez]

I get brain zaps after coming off ssris but luckily they go away for me

 

[MFAAS]

I get brain zaps after coming off ssris but luckily they go away for me

Yeah I did too, just not anywhere near as bad as with SNRIs. It definitely happens with SSRIs as well though.

Long story short, the last thing you want to do is mess with your main neurotransmitters responsible for your mental health just because you want to lose some weight. There are PLENTY of other options out there to lose weight.

 

[TrennedOutLunatic]

Yes. No messing with the neurotransmitters to lose weight.

Tren acetate 350mg per week.
100mg/200mg dnp per day at the end of your cutting for something like 14 days. 20 days max.

If diet and training is not in check and you just jump on these,you will be wasting your time in the long run. Not even in the long run.

You don't need any of the above.
300mg testosterone per week is what I would suggest. Sounds conservative but it isn't. It is effective as fuck if everything else is in check.

 

[Human_backhoe]

Damn. I never knew there was a name for what I was experiencing!!!!!! brain zaps. I have got them off and on for 20 years. A doc put me on ssri's when I was 14 for a while (about the time when fighting in school became "unacceptable " ) I abused them a bit and stopped within months. I have had them irregularly ever since. When I was a bit older (19-20) I always got them from mushrooms when I tried them.

 

[cochino]

Damn. I never knew there was a name for what I was experiencing!!!!!! brain zaps. I have got them off and on for 20 years. A doc put me on ssri's when I was 14 for a while (about the time when fighting in school became "unacceptable " ) I abused them a bit and stopped within months. I have had them irregularly ever since. When I was a bit older (19-20) I always got them from mushrooms when I tried them.

Ah the shroom days. Brings back memories.

 

[Pineapples4Puss]

Nope.
If his appetite is fucked by ssris, that solution is not applicable.

Oh So me being hungry because my appetite is exaggerated by something just throws thermodynamics out the window. Forgot about that one.

 

[TrennedOutLunatic]

Oh So me being hungry because my appetite is exaggerated by something just throws thermodynamics out the window. Forgot about that one.

I am more than aware of the laws of thermodynamics. It is in my field.

Care to apply any of them in this case?

If you manage to, I will do the rest and see if we can reach a reasonable conclusion.

And if you are right, I will admit it without a second thought.

I never expected that I would be challenged in physics here. It is my strongest subject.

I am serious and you are totally welcome to explain what you mean. I will be so happy to be wrong. Honestly,not being ironic. This has triggered my scientific interest.
I am not arguing. Really.