4 week bloods test/boldenone/HGH cycle, high hs-CRP

Anything crashed does increase CRP.
Quite easy to test.

Pull hsCRP, pin like 200mg of TNE, it'll crash, then pull hsCRP the next day.
You think running PQO water based Test base would reflect elevated hsCRP? First time trying and had delated PIP at site. Read anecdotally water based with more complications compared to oil-based TNE.
 
You think running PQO water based Test base would reflect elevated hsCRP? First time trying and had delated PIP at site. Read anecdotally water based with more complications compared to oil-based TNE.

Yea pip=hscrp increase.
Id used oil based instead.

Water based usually results in PIP.
 
You mentioned you filter your gear. Is any of it Chinese? If so EO may not agree with you.
No Chinese gear, Test C is from Opti and Bold C is from Defiant. TNE from Arail. I just filter everything to reduce the number of unknown variables.
 
Seems like there’s a host of things here that could be the culprit. If you really want to find out what’s going on the most reasonable option is to go to TRT for a month, let all this other shit clear out, and get a baseline hsCRP. If it’s normal at that time you can start systematically adding things back. Any other approach is likely to result in you chasing your tail. Remember even hsCRP is nonspecific. If you drop the TNE and the number goes down that doesn’t necessarily mean it was the TNE. However, if you clear out everything, get a baseline, then add the TNE back in and then it’s elevated, tou can attribute it to the TNE. But even then you don’t know if it’s the api, or if it’s crashing post injection. As far as MiG 840, it’s designed specifically to be anti/non inflammatory. I think a lot of guys reporting issues with mig840 really have issues with what is dissolved (or not fully dissolved in the case of stuff like injectable Anadrol, TNE, etc
C) in it. I didn’t check my CRP at the time but I spent a few weeks fighting with crashed Anadrol only to realize that the reactions I was having was likely due to it crashing in the tissue post injection. That is, the vials I had that were crashed then heated were not heated long / high enough. The vials I have that were not crashed had no issues. I’ve since come up with a heating protocol for the crashed vials, which is at a higher temp and for a longer time than I thought was necessary, and now I have no issues. But I can only imagine my CRP was likely very elevated during the times of pip, redness, swelling etc.
 
Seems like there’s a host of things here that could be the culprit. If you really want to find out what’s going on the most reasonable option is to go to TRT for a month, let all this other shit clear out, and get a baseline hsCRP. If it’s normal at that time you can start systematically adding things back. Any other approach is likely to result in you chasing your tail. Remember even hsCRP is nonspecific. If you drop the TNE and the number goes down that doesn’t necessarily mean it was the TNE. However, if you clear out everything, get a baseline, then add the TNE back in and then it’s elevated, tou can attribute it to the TNE. But even then you don’t know if it’s the api, or if it’s crashing post injection. As far as MiG 840, it’s designed specifically to be anti/non inflammatory. I think a lot of guys reporting issues with mig840 really have issues with what is dissolved (or not fully dissolved in the case of stuff like injectable Anadrol, TNE, etc
C) in it. I didn’t check my CRP at the time but I spent a few weeks fighting with crashed Anadrol only to realize that the reactions I was having was likely due to it crashing in the tissue post injection. That is, the vials I had that were crashed then heated were not heated long / high enough. The vials I have that were not crashed had no issues. I’ve since come up with a heating protocol for the crashed vials, which is at a higher temp and for a longer time than I thought was necessary, and now I have no issues. But I can only imagine my CRP was likely very elevated during the times of pip, redness, swelling etc.
 
Seems like there’s a host of things here that could be the culprit. If you really want to find out what’s going on the most reasonable option is to go to TRT for a month, let all this other shit clear out, and get a baseline hsCRP. If it’s normal at that time you can start systematically adding things back. Any other approach is likely to result in you chasing your tail. Remember even hsCRP is nonspecific. If you drop the TNE and the number goes down that doesn’t necessarily mean it was the TNE. However, if you clear out everything, get a baseline, then add the TNE back in and then it’s elevated, tou can attribute it to the TNE. But even then you don’t know if it’s the api, or if it’s crashing post injection. As far as MiG 840, it’s designed specifically to be anti/non inflammatory. I think a lot of guys reporting issues with mig840 really have issues with what is dissolved (or not fully dissolved in the case of stuff like injectable Anadrol, TNE, etc
C) in it. I didn’t check my CRP at the time but I spent a few weeks fighting with crashed Anadrol only to realize that the reactions I was having was likely due to it crashing in the tissue post injection. That is, the vials I had that were crashed then heated were not heated long / high enough. The vials I have that were not crashed had no issues. I’ve since come up with a heating protocol for the crashed vials, which is at a higher temp and for a longer time than I thought was necessary, and now I have no issues. But I can only imagine my CRP was likely very elevated during the times of pip, redness, swelling etc.
 
You wipe the top of your vial but not the skin? This is an abscess waiting to happen. You're already wiping the vial, just sit the alcohol swab next to the vial and then wipe your skin with it before injection.

Bold cyp is known to cause pip which could lead to elevated crp. Mig840 can do the same
 
Yeah I'm a fucking dumbass for not wiping the injection site, I did start doing that after making this post and feeling embarrassed about it lol, but I had to mention it since it seemed relevant. I'd rather embarrass myself publicly if it helps someone else not make the same mistake.

The Bold C has been almost pipless. Not 100% but enough that I don't notice it most sites and didn't realize I had it at all at first.

Since my CRP was elevated before I even started the cycle. Another possibility that occurred to me was that it was related to the Test U I'd been taking. That was Chinese. I stopped at the start of the cycle as I switched over to a shorter ester. The oil and solvents from an injection don't stick around as long as the esterified testosterone do they? I should still have some Test U in my body now, but none of the other stuff that was in it. Another stupid thing is that I didn't have my vials stored upright for years so I could have been injecting dissolved stopper for years at this point. I learned the error of my ways from Meso last year. I just had them loosely sitting in a drawer. Now I have a whole ass toolchest for gear and have been 3d printing gridfinity stuff to organize it, and everything has been sitting upright for months, but I still wonder if I've just been permenently inflamed for years since I didn't start testing hs-CRP until a coupe months ago.
 
I had been taking glutathione in varying dosages for a few months leading up to the start of the cycle, and still am. When I started off and up until a couple weeks ago, I'd basically always feel some kind of relief from the glutathione that was hard to put my finger on. Like a low-level spiky fuzzy feeling would get washed away. Kinda wondering if that's inflammation. That has basically ceased for the last couple weeks. I'm still injecting 500mg glutathione EOD from the same kits bought at the same time from the same vendor, but I don't feel anything from it anymore. Really curious to see if my hs-CRP has dropped and if there's a connection there. Monday (plus the wait for the results...) can't come soon enough! Sketchy Chinese Test U stored on its side, likely made with EO, stopper leaching into the oil, seems like a great potential candidate for a source of high hs-CRP and 8 weeks is enough time for most that to get out of my system.
 
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CRP is down! Hooray for extremely broad markers that leave me with little clue of exactly what caused it. But I'm gonna guess it was the crashed TNE and/or the sketchy chinese Test U.
 
Meso,

I started my first cycle in ~6 years a little over 4 weeks ago. I'm a mid 30's male, 5'10" 195 lbs. My hs-CRP score came out quite high (5.17) and I'm hoping to get some possible explanations. I have some of my own guesses, too. It's really annoying that its such a nonspecific marker. I think the rest of the bloodwork is fine, but I'd appreciate comments on it.

First, here's my stack. I'll spare you the explanation for the change in protocol, its in my cycle thread.

Drugs:
- I started off at 400 Test C/300 Bold C, but after 2 weeks switched to 250 Test C/400 Bold C
- 5iu HGH (had been running 4 for months)
- 2mg Reta every 5 days
- Using TNE preworkout in Migloyl 840 1-2x per week
- Anavar 20mg for the first 10 days until I decided kickstarts were stupid. Was taking 1g TUDCA/day with it.

Ancillaries:
- Combination of aromasin, HCG, and low dose dbol as I figured out what bold did to my E2 (never ran it before). Started on E2 Cyp now.
- Telm 40/Ciln 10
- pitavastatin 2mg, 10 mg Ezet/180mg bemp
- cialis 5 mg, minoxidil 2.5 mg
- 600mg glutathione EOD
- accutane 80mg-120mg (been taking for several months)
- Ivabradine 10mg
- Fish oil, taurine, magnesium, potassium, creatine, collagen, psyllium husk, cissus quandrangularis, berberine, astragalus root

Bloods were taken ~72 hours after last workout (though I did 30 mins LISS a couple hours beforehand).

My best guess is the elevated hs-CRP is related to the TNE. I think it was slightly crashed the first few times I injected it, with pretty bad PIP in my leg on one of them that lasted 5-6 days with the limb stiff, only getting better like 5 or so days before blood was drawn. I had a lesser amount of PIP for other ones. Maybe it could have had a subq leak, too. Subsequently I heated it up in a baby wipe warmer and made sure to inject deep, and I haven't had any issues, so I don't think I'm allergic to Migloyl 840.

I refilter all my oils into ALK vials. I always wipe the stoppers before drawing, though I'll admit I never use an alcohol wipe on the injection site. Seems worth mentioning? Could improper technique here raise hs-CRP? Unfortunately this is one blood marker I never got done in any of my previous cycles, so I have nothing to compare it to.

My previous hs-CRP taken the day the cycle started was also elevated, at 4.28. At that point I had already tried the TNE a few times and experienced PIP. Which leads me to believe this is the most likely culprit.

BP has been around 110/65 in the morning and 120/70 in the evening.

Fasting blood glucose has been mostly in the 80's, with a few in the 90's and once over 100.

I guess the next mildly concerning one is Cystatin-C, at 1.02. Puts me at a eGFR of 83. But if I put my height+weight into eGFR Calculator it gives me a eGFR of around 100. I've had Cystatin-C run at this level while just on TRT, though its usually closer to 0.9, so I figure its fine. My BP is great. I upped my astragalus root dose to ~20g/day anyways (didn't realize it needed to be run so high) and will test it again in a few weeks.

IGF-1 of 411 is too high. I was aiming for a Z-score between 2.5 and 3. I was at a Z-score of 2.0 running 4iu of the exact same HGH, so I guess something about the changed hormone profile made 5iu explode my IGF-1. Think I'll go back to 4iu and see where that lands me. Not worried about this one but would like to better understand the biology.

Obvious missing things: testosterone, E1, E2, SHBG. Since I switched my AAS doses weeks in it didn't seem relevant yet, but this morning after a few days of low E2 symptoms while piling on HCG and Dbol I was absolutely convinced I had low E2 so I got them taken, hopefully have numbers in the next week.

Anyways, I appreciate y'all for taking the time to read this and go through my bloods. I'm making several other changes to my habits that I suspect might be contributing. Once I'm off cycle I've been thinking about doing a long and annoying elimination experiment to try to get my hs-CRP below 1.
Mirin that lipid panel, The lipid stack really does work. albeit youre not on an even remotely high dose
 
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