A long term unconventional HRT/TRT regimen with Dianabol

Isochroma

New Member
Just registered after finding the thread: a long term unconventional HRT/TRT regimen with tren and test.

That thread was part of my research project for my own long-term unconvential HRT/TRT protocol with Dianabol :) Below is a short summary of my complete report on how I self-cured my low Testosterone with 7mg oral Dianabol powder combined with 14mg intranasal Dianabol powder, both administered within the first hour of awakening each morning.

Dianabol was developed by Dr. John Bosely Ziegler precisely for the treament of hypogonadism (Testosterone deficiency) and other disorders at low daily doses of 5-10mg.

Combined with careful early-morning administration without other foods to slow absorption, I can say with 100% positivity that not only does Dianabol completely cure all the physical and mental symptoms of low Testosterone but it does this with minimal suppression of existing Testosterone production if the dose is kept at or below 10mg per day and it is timed correctly to co-incide with the natural morning Testosterone spike.

I'm 35 and was tested 1.5 months ago at only 340 ng/dl total Testosterone.

That's the level of an 85-100 year-old man, according to the study of healthy Boston men in 1996 here:

Testosterone Week: What’s a “Normal” Testosterone Level and How to Measure Your T
artofmanliness.com/2013/01/16/normal-testosterone-levels/

Measurements in Conventional Units (ng/dl)

Age # Subj. Total T
--------------------------------
25-34 45 617
35-44 22 668
45-54 23 606
55-64 43 562
65-74 47 524
75-84 48 471
85-100 21 376


My complete report from the start of treatment on August 7th, 2013 when I received ten grams of pure Dianabol powder directly from a Chinese chemical manufacturer until recent days is here:

T-Nation Forum: I titled the thread after my successful and world's first test of the intranasal route to deliver Dianabol directly to the brain for relief of the cognitive symptoms of low Testosterone. It includes my complete report on both intranasal and oral use and also my final program of combining both routes of administratoin for full symptom relief:

http://tnation.t-nation.com/free_online_forum/sports_training_performance_bodybuilding_trt/insufflation_snorting_dbol_trip_report (Insufflation (Snorting) Dbol - Trip Report)
tnation.t-nation.com/free_online_forum/sports_training_performance_bodybuilding_trt/insufflation_snorting_dbol_trip_report

and mirrored on the Longecity Forum here:

Hypogonadotropic Hypogonadism
longecity.org/forum/topic/34666-hypogonadotropic-hypogonadism/

On Longecity I'm known as Isochroma-Reborn and on T-Nation as Isochroma.

After suffering worsening symptoms for the past fifteen years, I finally worked up the guts to have my Testosterone tested by the hated needle - I've had way too many useless blood tests over the decades but none to test for Testosterone. All the tests by uninformed GPs were for the symptomatically-similar Hypothyroid, which I always tested OK for including the most recent test which included a TSH panel.

It's now September 19th and the few small side-effects of Dianabol therapy are gone except for the loose stool which I get from many foods and even Oxiracetam due to a hypersensitive GI tract. Very few others report such a side effect from Dianabol even at a bodybuilder's much higher doses.

I'm shining. Frankly, my life has taken a complete U-turn from suicidal depression, massive physical fatigue with muscle wasting, cognitive and memory dysfunctions to splendid physical health with gained muscle mass from basic regular cycling on hilly roads and a good diet with a range of other supplements.

Be sure to read my ART manifesto which I will post below in its entirety so others who have my condition and those who are just interested in the medical practicalities and moral philosophy behind using alternative androgens and routes of administration besides the disastrous single, medically-approved Testosterone hormone replacement therapy with only two routes of administration - injection and patches:

The ART Manifesto

This is going to sound like a manifesto, and maybe it is.

What this self-experimentation is, is ART - not science.

Androgen Replacement Therapy, rather than Testosterone Replacement Therapy.

ART includes TRT and a whole lot more because it encompasses the entire field of androgens, doses, timings and routes of administration.

ART strives to accomplish the activation of under-activated androgen receptors in both body and brain using the most suitable and appropriate androgen(s), doses, timings and routes of administration that best fit each case.

ART and TRT are not mutually exclusive but one contains the other.

Because of genetic and circumstantial hormonal individuality in each man, personally acceptable route(s) of administration, economic factors and numerous other considerations, the field of options must be kept as wide open as possible to be able to treat so many cases that are simply left in the cold as of today's offical medical practice.

ART is inclusive, not exclusive.

ART is not a fixed practice like TRT seems to have become. Instead it is always trying new options and alternatives because of both the complexity of each individual case and the new types of damages caused by modern technology itself - Xenoestrogens in particular. These chemicals can mangle a man's Leydig cells before he is even born, leaving him with half or less of his full complement of cells. By the time he reaches the age of twenty-five or thirty-five, his circulating Testosterone can be half of normal or less.

ART - unlike so many physicians - recognizes that these victims are now often young men in their twenties and thirties and does not attempt to deny their suffering or assume that they are trying to obtain androgens for other purposes but rather, fully investigates and treats with seriousness their conditions using the full array of therapeutic options.

ART recognizes that these young victims, if exposed to the currently-standard Testosterone replacement therapy, will have their fertility compromised or destroyed. Unlike the older practice of TRT for aging men whose fertility is not so critical, it's crucial that the younger victims of today be given more and better options to live a decent life while still being able to have children.

ART recognizes that these environmental casualties are increasing in both number and percent of the population each year as the planet and food supply become ever more polluted with a growing list of xenobiotic estrogenic molecules - some of which have already been found to kill Leydig cells in the womb. I have the studies.

ART also strives to have minimal negative impact on the patient's own Testosterone production if he still has some, so it steps lightly on his system by using androgens, timings, doses and routes of administration that have the absolute minimum impact on his natural production in a best-effort attempt to function as a complement rather than a suppressor.

Recognizing the normal circadian release of Testosterone, ART tries to imitate it rather than suppress it as current medical HRT practice does by introducing androgens at inappropriate times. The current medical practices of weekly injections or patches that provide continuous-release dosing cause abnormally continuous androgen receptor activation thereby maximizing negative-feedback mediated suppression and causing other issues since the entire body is evolved to receive its androgen receptor activation in a circadian rhythm.

Using supplemental Testosterone - while contained within the definition of ART practice - is in some ways opposed to its fundamental tenets due to supplemental Testosterone's strong suppression of endogenous production. Alternative androgens with less suppressive activity and often having other advantages over supplemental Testosterone - dbol being one among many - are often preferred by ART practitioners.

Nevertheless, since the ART field is inclusive and wide, TRT therapy is included within it as an option - one that is not always the best choice for many men but is always available alone or in combination with other therapeutic agents and modalities.

ART Therapy is a light at the end of the tunnel for the numerous men who are unable to receive Testosterone replacement therapy and others who failed on it or found that its negative effects were not to their liking.

ART Therapy is not perfect or ideal but strives to excel the current and limited therapeutic HRT options while also including them.

Finally, ART Therapy has no respect for and does not recognize the artificial and arbitrary limitations imposed on the treatments available to patients by the law, by corporate profits or by the medical Establishment so it can always perform at its best for the patient without denying options.
 
interesting, thread should probably be in the Health section but that is a whole other argument

one thing off the top of my head as a concern would be that dianabol is liver toxic, but I don't know a lot about that so would be interested to hear more about this as a long term concern (although I am not interested in experimenting with dianabol myself)
 
Dianabol Toxicity

Indeed, Dianabol and other 17a-Methylated anabolics produce a bit of liver damage.

At the low, 7mg ART/HRT dose, and without adding any other liver stressors - I drink zero alcohol (never did drink in my entire life), take zero caffeine, zero aspirin/Tylenol, no other liver-stressing drugs, etc. With no history of liver disease in either side of my family, I expect that my liver will be able to regenerate faster than it's damaged.

Honestly, many people do far, far worse to their livers on a daily basis with alcohol, caffeine and other toxic drugs.

Aspirin and Tylenol combined (these two drugs make up the majority of the NSAID market) - both cheaply and freely available in every pharmacy, killed - in 1998 - 16,500 Americans [http://www.naturalnews.com/027548_swine_flu_vaccines_death_risk.html]. Yet these toxic drugs are still freely available without prescription or any significant regulation and nobody is worrying about their toxicity. They should be. Worse, NSAIDs are often taken daily to treat chronic pain so they often present a constant liver burden.

I have done a bit of research on the liver safety issue and can't find the pile of victims - even the bodybuilders who use much higher doses. Many of them don't take liver support either.

If I need to I can use Milk Thistlle as liver support. My current vitamin regime includes 8000 mg/day of Vitamin C taken shortly after the morning's Dianabol dose. It's quite strongly hepatoprotective on its own.
 
I am concerned about your decision to snort D-bol. Intranasal admininstration of any compound designed to be taken orally is dangerous. You will eventually cause damage to the internal structures of the nose and sinuses.


Just my two cents on the subject.
 
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NSAID Deaths: Correct Link

Thanks for the report. I have no doubt the individual had other concomittant liver issues and/or stressors.

One report in 50+ years of use is more illustrative of Dianabol's safety rather than its hazards.

This year more than 16,500 Americans will die from NSAID-induced toxicity. In fact by the report I linked in my previous post, that body-count is only arthritis sufferers, not the entire American population.

Aplogies to everyone for mangling the link to that report with a trailing ]: here is the correct link:

Aspirin kills 400% more people than H1N1 swine flu
Aspirin kills 400% more people than H1N1 swine flu

"... at least 16,500 NSAID-related deaths occur each year among arthritis patients alone." (Singh Gurkirpal, MD, “Recent Considerations in Nonsteroidal Anti-Inflammatory Drug Gastropathy”, The American Journal of Medicine, July 27, 1998, p. 31S)."
 
HRT Trial Participants Wanted

Strangely enough, true that caffeine by itself has no documented hepatotoxicity, but when I Googled it all the studies showed a significant enhancement of NSAID hepatotoxocity when combined with caffeine.

Considering that most of the population are regular caffeine users, this finding is highly significant:

PubMed: Effect of caffeine on acetaminophen hepatotoxicity in cultured hepatocytes treated with ethanol and isopentanol

"
Pretreatment of cultured rat hepatocytes with ethanol alone or in combination with isopentanol, the major higher chain alcohol in alcoholic beverages, significantly increased CYP3A and acetaminophen (APAP) bioactivation, with no increase in APAP toxicity. Caffeine has previously been shown to activate CYP3A activity in vitro and to increase APAP hepatotoxicity in rodents pretreated with prototypic inducers of CYP3A. Here we found that caffeine enhanced APAP toxicity in cultured rat hepatocytes pretreated with the alcohols. The caffeine-mediated increase in APAP toxicity was similar in cells treated with ethanol or isopentanol alone or in combination. These findings suggest that even small increases in CYP3A are sufficient to support caffeine-enhanced APAP toxicity. Triacetyloleandomycin inhibited CYP3A activity in intact hepatocytes and protected alcohol-pretreated cells from caffeine enhancement of APAP toxicity. This protection was associated with decreased formation of the toxic metabolite of APAP. The results indicate that CYP3A is responsible for the caffeine-mediated stimulation of APAP toxicity. Our results suggest that caffeine may be an additional risk factor for developing alcohol-mediated APAP hepatotoxicity.​
"

---------------------------------------------------

Lest I become sidetracked by the hepatotoxicity non-concern with ART/HRT doses of Dianabol, my next hope is to recruit one man from this forum or another who fits some basic criteria for testing with the low-dose Dianabol morning therapy program for low-Testosterone symptoms.

The idea is to get the pump primed so to speak by showing success in others. This will prove that I'm not crazy, suffering from massive placebo-effects, etc. Once the successful cases begin to pile up then the floodgates will begin to open and the many others who have either failed on medical TRT or who can't obtain it - or who simply don't want to deal with needles, patches or the other often-undesireable effects of this type of treatment will be inspired to give the alternatives a shot so to speak - no pun intended :)

Some basic ideas for qualifying factors:

1. Blood test showing dismally low Total Testosterone: <400 ng/dl. Mine at 340 ng/dl was plenty low enough to bring most if not all of these symptoms on but individuals vary.

2. Blood test showing normal Thyroid function: many of the symptoms overlap so it's important to exclude this confounding factor. My own tests over the years right up until the last test 1.5 months ago showed perfectly normal Thyroid values.

3. Symptoms of low-T: loss of muscle mass with inability to maintain or build it despite regular exercise, chronic fatigue, frequent urination, frequent waking during the night to urinate, poor sleep quality and most specific of all: an increase in the symptoms after sex.

4. Failure of the Clomid challenge to elicit any improvement in symptoms with doses of at least 25mg/day for at least one week. This indicates Primary Hypogonadism. The secondaries have much better options than HRT and should not be involved in it.

5. Low or no libido.

And the disqualifying factor:

1. History of androgen use - particularly the high doses used in non-HRT applications. This can cause the same symptoms and might also indicate a higher probability of deeper dysregulations which could prevent successful ART/HRT therapy. One of these dysregulations in particular concerns me: androgen receptor downregulation due to high doses of androgens.

Hopefully I can expand/enhance this list from the suggestions of others.

As for the protocol itself: presuming my next shipment of Dianbol powder (20g) arrives OK, there will be plenty to send a free, premeasured 14-day supply by untracked lettermail to the recipient.

For now I think that the first tester should live in the USA or Canada. The USPS by Article 4 of the Constitution can't open lettermail without a warrant so it's pretty safe to send there too.

As for the dose form, I'm inclined to implement an idea I've been thinking about for several years: the PrintDrug project. I put up the detailed specs on Longecity Forum here: PrintDrug: Revolutionary, Cheap, Fast Dosing of Drugs.

In short, a couple grams of Dianabol powder will be dissolved in 70% Isopropyl alcohol and poured into a refillable yellow inkjet cartridge and printed out onto an 8.5" x 11" (A4 size) edible rice-paper sheet in the form of two rows of 6 squares.

A few drops of edible tracer-ink - food dye - will be used to make the dosed squares just barely visible with an edible or non-edible black outline, or maybe only the outline will be visible, or maybe there won't be an outline at all, just the squares.

Then the paper is simply folded up and mailed, or cut into squares first then mailed. It's a very precise, quick and stealthy way to send molecules by lettermail. The possibilities are nearly endless with this system and it's super-cheap and ultra-fast and kicks most 1mg digiscales' butts in terms of repeatability and accuracy.

The bubblejet printer's micronozzles are ultra-precise dispensers of drug molecules and the dose in milligrams per square can be adjusted by simply changing the color saturation of the squares in the PNG image.before printing.

Any folks who are interested to try this new ART/HRT program are encouraged to reply to this thread. My PM system isn't working (yet) on this forum so I think there's probably a minimum post-count needed to get it functional and to end the rerequirement for moderator approval of every post.
 
The fact that you think "cherry picking" a single study FROM GOOGLE is justification for any idea means you don't understand how science works. It is almost never about a single paper since papers are constantly publishing contradictory information - you can literally find a paper to support just about ANY idea no matter how crazy. Good science is about what the consensus is in the literature.

Also, with that in mind are you seriously trying to recruit someone to do HUMAN EXPERIMENTATION?!

This is crazy and not how things are done. This why IRBs exist....so some nut job can't decide on day with no supporting evidence it would be good snort some steroids.
 
Late Bed: Dose Skip Day / Intense Morning Woods

Funny you should say these things when 'how things are done' is failing so badly with TRT.

There are plenty of folks using much higher Dianabol doses for no medical reason yet I don't see anyone calling them crazy on this forum or any other bodybuilding site.

It's only me proposing to use the single low morning dose for an actual medical reason that's attacked. Why?

Now for the good news. Due to irresponsibility I went to bed at 3:00a last night. Way too late compared to my usual 1:00a - 3:00a. I slept in and knew it would be too late to take my usual ART dose. And at just before I woke up at 9:30a - around 9:15a while still lightly dreaming some intense dreams I was assaulted by the most intense morning woods I've had in years - excepting my last dose-skip day about 1.2 weeks ago.

It's great verification that my circadian Testosterone release is working dandily and also verification that suppression is minimal if not unexistent from the single tiny morning Dianabol dose. It's also good to have a single break-day once a week to let my HPTA axis recalibrate.
 
IRC Channel: Rizon Network: #ARTTherapy

Today I established a new IRC channel on the rather gigantic Rizon network: #ARTTherapy. All times below are in the Pacific Standard Time zone.

It's for those with hypogonadism and anyone else who wants to chat about alternative low-T therapies, concerns, questions or suggestions.

The channel is a resource for real-time questions/answers/consultations in a private setting for those who prefer to keep their medical concerns confidential and also for anyone who simply has questions, concerns or suggestions and prefers realtime discussion.

I'll be on the channel under the same username as I post with on this forum. My box is booted up each morning around the 7:00a - 8:30a timeframe with me being available to chat for a brief window somewhere in that time range.

After that is usually chores/housework until early afternoon - around 2:00p - 3:00p and sometimes as late as 4:00p. Then I'm active on the channel until about 9:30p.

Exceptions to this rule: I'll be unavailable for realtime chat every Tuesday until either 1:40p or sometimes 4:30p.
 
Is it just me or is this starting to sound like a really elaborate sales pitch. I keep waiting for a post that says "I'll send you a 14 day supply when you buy my new book The Truth About TRT. Plus if you meet my strict qualifications and act within the next 15 minutes I'll let you purchase my secret formula pre workout powder...."
 
So why go through all this crap if you need TRT, and not take a shot of actual testosterone once a week? This makes no sense. And who's going to agree to snort dbols or print dbol squares on rice paper? Lol
 
Hepatic Function Tests

I won't be having hepatic tests performed unless I show symptoms. Reasons:

1. Zero family history of liver disease on either side.

2. Lifetime high Vitamin C dosing: 4000mg/day from the age of 16 and in the last two years 8000mg/day every day.

3. Zero alcohol consumption.

4. Zero prescription drugs / caffeine.

5. No other liver stressors.

6. Low Single Dianabol Dose: 7mg/day maximum. At this dose it's perfectly safe for most anyone. After thousands of hours of searching forum posts and academic papers I could not find one report of verified liver injury at this dose. A poster on this or another forum did point out a single medical case report of a woman's multi-organ failure after taking 5mg:

Death due to Liver Failure Following the Use of Methandrostenolone [PDF]
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1849648/pdf/canmedaj00964-0049.pdf

In contrast, a more recent study:

Anabolic steroid-induced hepatotoxicity: is it overstated?
Anabolic steroid-induced hepatotoxicity: is... [Clin J Sport Med. 1999] - PubMed - NCBI

"Abstract

OBJECTIVE: There have been numerous reports of hepatic dysfunction secondary to anabolic steroid use based on elevated levels of serum aminotransferases. This study was conducted to distinguish between serum aminotransaminase elevations secondary to intense resistance training and anabolic steroid-induced hepatotoxicity in elite bodybuilders.

DESIGN: This was a case-control study of serum chemistry profiles from bodybuilders using and not using anabolic steroids with comparisons to a cohort of medical students and patients with hepatitis.

PARTICIPANTS: The participants were bodybuilders taking self-directed regimens of anabolic steroids (n = 15) and bodybuilders not taking steroids (n = 10). Blood chemistry profiles from patients with viral hepatitis (n = 49) and exercising and nonexercising medical students (592) were used as controls.

MAIN OUTCOME MEASURES: The focus in blood chemistry profiles was aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltranspeptidase (GGT), and creatine kinase (CK) levels.

RESULTS: In both groups of bodybuilders, CK, AST, and ALT were elevated, whereas GGT remained in the normal range. In contrast, patients with hepatitis had elevations of all three enzymes: ALT, AST, and GGT. Creatine kinase (CK) was elevated in all exercising groups. Patients with hepatitis were the only group in which a correlation was found between aminotransferases and GGT.

CONCLUSION: Prior reports of anabolic steroid-induced hepatotoxicity based on elevated aminotransferase levels may have been overstated, because no exercising subjects, including steroid users, demonstrated hepatic dysfunction based on GGT levels. Such reports may have misled the medical community to emphasize steroid-induced hepatotoxicity when interpreting elevated aminotransferase levels and disregard muscle damage. For these reasons, when evaluating hepatic function in cases of anabolic steroid therapy or abuse, CK and GGT levels should be considered in addition to ALT and AST levels as essential elements of the assessment."​
After 50+ years of worldwide, unregulated sale and use - usually at far higher doses - there is no pile of victims. Instead, there is one damn case report. A single one. That single report is much more proof of my low-toxicity contention than the reverse. The paper for your examination:

In comparison, NSAIDs (Aspirin, Tylenol, etc.) kill ridiculous numbers of folks in the USA each year yet they are unregulated and nobody tells their users to get monthly liver panels. Same with good ole' alcohol - not even a medical necessity that one - along with most NSAIDs if the underlying causes of the pain they 'treat' were addressed.

Natural News: Aspirin kills 400% more people than H1N1 swine flu (2009) [Data from CDC: 1998]:

"The July 1998 issue of The American Journal of Medicine explains it as follows:

'Conservative calculations estimate that approximately 107,000 patients are hospitalized annually for nonsteroidal anti-inflammatory drug (NSAID)-related gastrointestinal (GI) complications and at least 16,500 NSAID-related deaths occur each year among arthritis patients alone." (Singh Gurkirpal, MD, “Recent Considerations in Nonsteroidal Anti-Inflammatory Drug Gastropathy”, The American Journal of Medicine, July 27, 1998, p. 31S)'"​
NSAIDs cause both liver and gastric toxicity. Both deaths and illnesses caused by them are in fact due to toxicity targets in those organ systems.

Dianabol's liver toxicity is highly overrated. I can dig up lots more comparisons but the time isn't worth it.

Frankly, I have about a 10,000% higher risk of dying on the road riding my bicycle tomorrow. Or getting stung to death by a swarm of wasps or bees. Or being struck to death by lightning.

Or committing suicide due to my 'natural' Testosterone level that is half of what it should be in a healthy man. A 33% increase in all-cause death among many other morbid and mortal symptoms according to this study:

BBC UK: "Low testosterone 'death risk'"

"A study of 800 men over 50 found that those with low levels had a 33% increased risk of death over an 18-year period than those with higher levels."​
There are many more studies on the sickness and death-risk increases due to low Testosterone. I know all about them because 1.5 months ago I had three well-organized suicide plans all set up with chemical suppliers for each.

Not anymore and never again :)

All risks are relative and death comes for us all sooner or later. I plan to shine until that day and I won't be giving up a single second before I have to.

All these datums lead to my final two reasons to remain untested:

7. Since I've never had my hepatic function tested before beginning the Dianabol ART program - and won't be stopping to establish my 'normal' liver values - the only comparison from a test performed today would be to standard 'average' values. If my values are found to be denormalized (elevated, etc.), this may be reflective of a pre-existing condition or genetics rather than a change since starting the Dianabol ART program. The only way to establish a baseline for such values is to stop the treatment for a period of time and be retested which I have no intention of doing.

8. Findings of denormalized liver values - likely small elevations in certain enzymes - would simply instill fear and might even result in my stopping the Dianabol ART treatment program. Such a stoppage may result in a renormalization of such values - a short-term gain - inevitably followed within weeks by a worsening loss of androgen receptor activation and a resumption of the many highly toxic pretreatment disease processes and lethal risks such as suicide. It is vital that I do not allow short-termism to overcome the long-term value of this program and there is no reason to be burdened by information that - without context and perspective relative to the results of allowing my body to regress back to its previous dying state - are tiny in comparison.
 
I must also agree those whom use anything but test, except perhaps Var in it is stead, are indeed cycling and seem to justify this form of "therapy" as TRT. I also suspect the reasoning is relatively straightforward, they don't want to be eschewed because they have morphed into the dreaded AAS "abuser". To that I say, guys this TRT notion seems silly since your on Meso an anonymous AAS forum, where no judgment is passed for what should be legal.
 
I saw this thread on t-nation and it piqued my interest, I was hoping you might migrate over to here and receive better reception as these are usually more accomodating and mature forms.

looks like I was wrong in assuming that.

For fucks sake what is with some of you dudes, you freak out about a guy experimenting with low dose dianabol, but you're MORE than happy to stick a needle in your body and inject a substances that you dont even know what it contains (and please, dont try and argue with me on that, 90% of you use UGL gear and you know it, half the fucking pharma gear you get is probably relabelled UGL gear too) or whether its sterile or what.

so this guy snorting 5mg of dbol a day is horrifying, but swallowing 100s of mgs of anadrols, winstrol, injecting multiple grams of testosterone and trenbolone and whatever else you please is responsible steroid use?

Give me a break.

Go ahead mate, be nice to see someone document their experiences and bloodwork rather than relying on the parrot mentality that so many steroid forums operate under.
 
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