cvictorg
New Member
A Natural Approach to Erectile Dysfunction that Improves Vascular Health - Life Extension
Researchers have developed a unique natural strategy for management of erectile dysfunction that includes a blend of Pycnogenol® (French maritime pine bark extract) and L-arginine aspartate, an amino acid chelate; combined with icariin, a flavonoid compound used in Chinese herbal medicine.
The interaction of these three ingredients creates a unique strategy that promises to tackle erectile dysfunction from multiple angles.
The nutrients’ underlying mechanisms of action are innovative yet elegantly simple. Here’s how it works: to get an erection, you need adequate blood flow. This requires the relaxation of the smooth muscle in the arteries of the penis. The chemical compound nitric oxide triggers this process of relaxation, increasing the blood flow to the penis required for an erection.
Endothelial cells are responsible for nitric oxide production. They release nitric oxide synthase, an enzyme that catalyzes the production of nitric oxide from L-arginine. This process is essential to maintaining an erection. Dysfunctional endothelial cells, disabled by plaque buildup, can no longer produce enough of this enzyme.
Pycnogenol® stimulates endothelial nitric oxide synthase to produce nitric oxide in the artery linings from the amino acid L-arginine, yielding sufficient bioactive nitric oxide to maintain an erection. At the same time, icariin acts to block the enzyme responsible for causing erections to subside, known as phosphodiesterase-5 (PDE5).
Interestingly, these nutrients not only promote erections, but also enhance male fertility and endo-thelial health. In other words, numerous distinct modes of action work together to produce a broad array of clinically proven health benefits. Meanwhile, prescription erectile dysfunction drugs such as Viagra® support penile erection primarily by blocking the action of PDE5, without delivering any other benefit.
Icariin: Sustaining Erectile Function
Icariin is a flavonoid compound extracted from plants in the Epimedium family, which are also known as Yin Yang Huo. Chinese medicine practitioners claim that these plants produce aphrodisiac effects and help restore erectile function.
Researchers agree there is good evidence that icariin is the primary active component of Epimedium extracts. Like Viagra®, Cialis®, and Levitra®, icariin blocks the action of PDE5, the enzyme that causes erections to subside.
Icariin enhances the production of nitric oxide in human endothelial cell culture and in animal models. Additionally, scientists have noted that icariin behaves similarly to testosterone—a significant feature, since testosterone is crucial for healthy sexual function. Animal research has shown that administration of Epimedium extracts improves erectile function in aged rats.
Together, these multiple mechanisms of action suggest that icariin can help support healthy erectile function.
http://multivu.prnewswire.com/mnr/p...cs/42406-stanislavov_erectile_dysfunction.pdf
The first clinical trial to report successful treatment of erectile dysfunction with Pycnogenol® and L-arginine aspartate involved 40 men between 25 and 45 years of age suffering from mild ED. After treatment with arginyl aspartate (which provided the equivalent of 1.7 g L-arginine per day) for one month, only 2 patients (5% of all patients) experienced normal erections. During a second month of treatment, 80 mg Pycnogenol® per day was added to the arginine regimen and yielded a significant improvement, with 32 patients (80%) enjoying normal erections. A third month’s treatment with L-arginine, together with an increased amount of Pycnogenol® (120 mg per day), further increased the number of patients with restored normal erectile function. At the end of the trial, 37 patients, equivalent to 92.5% of all participants, achieved normal erectile function.
A second clinical study examined 50 middle-aged men with low testosterone levels who suffered from ED as well as from poor fertility due to impaired sperm motility and morphology. Men were given 3 g L-arginine aspartate and 120 mg Pycnogenol® plus 120 mg testosterone undecanoate over a period of 11 months. A statistically significant 76% of men achieved normal sexual function and this effect was sustained during the entire treatment period. The researchers found that this treatment improved sperm quality and quantity at the end of the 1-year treatment and an astounding 40% (20 of 50 patients) achieved fertilization.
Researchers have developed a unique natural strategy for management of erectile dysfunction that includes a blend of Pycnogenol® (French maritime pine bark extract) and L-arginine aspartate, an amino acid chelate; combined with icariin, a flavonoid compound used in Chinese herbal medicine.
The interaction of these three ingredients creates a unique strategy that promises to tackle erectile dysfunction from multiple angles.
The nutrients’ underlying mechanisms of action are innovative yet elegantly simple. Here’s how it works: to get an erection, you need adequate blood flow. This requires the relaxation of the smooth muscle in the arteries of the penis. The chemical compound nitric oxide triggers this process of relaxation, increasing the blood flow to the penis required for an erection.
Endothelial cells are responsible for nitric oxide production. They release nitric oxide synthase, an enzyme that catalyzes the production of nitric oxide from L-arginine. This process is essential to maintaining an erection. Dysfunctional endothelial cells, disabled by plaque buildup, can no longer produce enough of this enzyme.
Pycnogenol® stimulates endothelial nitric oxide synthase to produce nitric oxide in the artery linings from the amino acid L-arginine, yielding sufficient bioactive nitric oxide to maintain an erection. At the same time, icariin acts to block the enzyme responsible for causing erections to subside, known as phosphodiesterase-5 (PDE5).
Interestingly, these nutrients not only promote erections, but also enhance male fertility and endo-thelial health. In other words, numerous distinct modes of action work together to produce a broad array of clinically proven health benefits. Meanwhile, prescription erectile dysfunction drugs such as Viagra® support penile erection primarily by blocking the action of PDE5, without delivering any other benefit.
Icariin: Sustaining Erectile Function
Icariin is a flavonoid compound extracted from plants in the Epimedium family, which are also known as Yin Yang Huo. Chinese medicine practitioners claim that these plants produce aphrodisiac effects and help restore erectile function.
Researchers agree there is good evidence that icariin is the primary active component of Epimedium extracts. Like Viagra®, Cialis®, and Levitra®, icariin blocks the action of PDE5, the enzyme that causes erections to subside.
Icariin enhances the production of nitric oxide in human endothelial cell culture and in animal models. Additionally, scientists have noted that icariin behaves similarly to testosterone—a significant feature, since testosterone is crucial for healthy sexual function. Animal research has shown that administration of Epimedium extracts improves erectile function in aged rats.
Together, these multiple mechanisms of action suggest that icariin can help support healthy erectile function.
http://multivu.prnewswire.com/mnr/p...cs/42406-stanislavov_erectile_dysfunction.pdf
The first clinical trial to report successful treatment of erectile dysfunction with Pycnogenol® and L-arginine aspartate involved 40 men between 25 and 45 years of age suffering from mild ED. After treatment with arginyl aspartate (which provided the equivalent of 1.7 g L-arginine per day) for one month, only 2 patients (5% of all patients) experienced normal erections. During a second month of treatment, 80 mg Pycnogenol® per day was added to the arginine regimen and yielded a significant improvement, with 32 patients (80%) enjoying normal erections. A third month’s treatment with L-arginine, together with an increased amount of Pycnogenol® (120 mg per day), further increased the number of patients with restored normal erectile function. At the end of the trial, 37 patients, equivalent to 92.5% of all participants, achieved normal erectile function.
A second clinical study examined 50 middle-aged men with low testosterone levels who suffered from ED as well as from poor fertility due to impaired sperm motility and morphology. Men were given 3 g L-arginine aspartate and 120 mg Pycnogenol® plus 120 mg testosterone undecanoate over a period of 11 months. A statistically significant 76% of men achieved normal sexual function and this effect was sustained during the entire treatment period. The researchers found that this treatment improved sperm quality and quantity at the end of the 1-year treatment and an astounding 40% (20 of 50 patients) achieved fertilization.
