A sober look at HGH

[bananafeet]

Skeletal muscle is a metabolically active tissue, which accounts for more than 80% of the variation in oxygen consumption during rest. The role of the GH-IGF axis for protein anabolism including muscle growth is also obvious when considering the phenotypes of GH deficiency and acromegaly. Growth hormone substitution in GHDA is associated with a 5–10% increase in muscle volume as assessed by either computed tomography (CT) or dual-energy X-ray absorptiometry (DEXA) scanning [24]. This GH action involves increased protein synthesis and reduced protein breakdown and is mediated both by GH itself and IGF-1. It should, however, be considered that part of this increase includes rehydration. Another important interaction between muscle metabolism and GH is insulin-stimulated glucose disposal. Administration of GH into the brachial artery acutely suppresses insulin-stimulated glucose uptake across the forearm [5].This is accompanied by a concomitant increase in FFA uptake compatible with the lipolytic effects of GH [2]. This is noteworthy, as FFA for many years have been implicated in the development of insulin resistance. It was originally suggested by Randle et al. that increased FFA flux into muscle inhibited glycolysis by means of simple substrate competition [32]. More recent studies in humans suggest that FFA may interfere with insulin signaling and in particular may suppress PI3 kinase activity, which is considered essential for the recruitment and functioning of GLUT4 [8]. By contrast, Jessen et al. did not record any impact of GH on insulin-stimulated PI3 kinase activity in healthy individuals despite the fact that GH was associated with increased FFA levels as well as insulin resistance [9]. It has, however, been shown that GH-induced insulin resistance is associated with accumulation of intramyocellular fat [6] in resemblance with more common conditions of insulin resistance, such as the metabolic syndrome. Moreover, we have been unable to document evidence of crosstalk between the signaling pathways of insulin and GH, respectively [10, 18]. The molecular mechanisms whereby GH causes insulin resistance in muscle therefore remain to be explained.

Source: Effects of GH in human muscle and fat (attached)

 

[strixsir]

From: Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment


Still inconclusive. 6 fold doesn't sound good tho lol

People simply are coping that HGH does didly dick for actual contractile tissue unless you mix in insulin with copious amount of AAS load and have the genetics for grow from anything.

decade long facade.

 

[Billbo98]

People simply are coping that HGH does didly dick for actual contractile tissue unless you mix in insulin with copious amount of AAS load and have the genetics for grow from anything.

decade long facade.

Bro you have a big mouth for a guy who suggests test prop as a 1st cycle to a noob. You sound quite autistic if I may say so myself.

 

[bananafeet]

Bro you have a big mouth for a guy who suggests test prop as a 1st cycle to a noob. You sound quite autistic if I may say so myself.

Fight fight fight!

I need my entertainment.

 

[Billbo98]

Fight fight fight!

I need my entertainment.

Pretty sure hes some Indian kid who stays watching Kurt havens and Vig Steve and Tanner Faggad and spews that bs here in his posts

 

[bananafeet]

Pretty sure hes some Indian kid who stays watching Kurt havens and Vig Steve and Tanner Faggad and spews that bs here in his posts

My current cycle is sponsored by that subcontinent haha

It's good to see people passionate about a subject.

I'm just trying to figure out how I can run all this HGH safely. Couldn't care less about who's right/wrong etc

Youtube was the worst thing to happen to bodybuilding

 

[Billbo98]

My current cycle is sponsored by that subcontinent haha

It's good to see people passionate about a subject.

I'm just trying to figure out how I can run all this HGH safely. Couldn't care less about who's right/wrong etc

Youtube was the worst thing to happen to bodybuilding

My brotha. Carb cycle with 2 low days a week and use Metformin ER 500AM & PM and do 30mins cardio 5-7 days a week. Always keeps me anywhere from 70-90 on the glucometer depending how late I ate and took my bolus night before.

 

[bananafeet]

Goal: lose fat and gain muscle

Me:

 

[strixsir]

Pretty sure hes some Indian kid who stays watching Kurt havens and Vig Steve and Tanner Faggad and spews that bs here in his posts

we are the same age.

Bro you have a big mouth for a guy who suggests test prop as a 1st cycle to a noob. You sound quite autistic if I may say so myself.

i am actually somewhat autistic ( no joke)

 

[Billbo98]

Goal: lose fat and gain muscle

Me:
View attachment 380520

Hahahahaha I love Charlie bro! My wife was joking around saying I can’t do the dishes because that’s her Charlie work hahahahaha

 

[Billbo98]

we are the same age.


i am actually somewhat autistic ( no joke)

Who is the same age? And yeah that’s why I said it I can def tell the spectrum is strong with this one.