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Well-known Member
Just a summary (unedited from my notes) for your reflection on just how poor this combination of a secretagogue (the Ghrelin mimetic MK-0677; Ibutamoren) and SARM (Ligandrol; LGD-4033) was. This is based on the data from Cardaci, T. D., Machek, S. B., W ilburn, D. T., Heileson, J. L., Harris, D. R., Cintineo, H. P., & Willoughby, D. S. (2022). LGD-4033 and MK-677 use impacts body composition, circulating biomarkers, and skeletal muscle androgenic hormone and receptor content: a case report. Experimental Physiology, 00, 00– 00. https://doi.org/10.1113/EP090741:
A case report of combined LGD‐4033 and MK‐677 use on body composition...muscle androgenic hormone and receptor content (abysmal results):
Overview
25.3 y male, 178 cm, training age 8.8 y
10 mg/d LGD-4033 & 15 mg/d MK-0677 x 5 w
blood-work drawn pre-, on- (@ 5 w), & post- (+4 w) cycle
on-cycle excision of skeletal muscle tissue & strength testing (1RM leg press & 1RM bench press), cross-sectional (vs. recreationally resistance trained men)
body comp. metrics & biospecimens collection taken upon waking, 48 h post-training & rested, fasted, euhydrated state
Results:
- body comp.: pre- to on- cycle - body mass +6.0%, LBM +3.1%, trunk LBM +6.6%, appendicular LBM +4.3%, total fat mass (FM) +15.4%, trunk FM +2.8%, appendicular FM +14.8%
- serum lipids: chol. +14.8%, trig. +39.2%, LDL-chol. +40.0%, HDL-chol -36.4%
- liver: AST +95.8%, ALT +205%
- androgen-associated: free T (fT) -85.7%, total T (TT) -62.3%, SHBG -79.6%
- "...all variables returned to pre- cycle values post-cycle, apart from total FM, appendicular FM, bone area, total chol. & LDL-chol."
- gonadotropins: FSH sub-clinical (low) both on- (1.2 IU/L) & post- (1.3 IU/L) cycle [not assessed pre-]
- in case subject vs. non-users: intramuscular (i.m.) AR -44.6%, T +47.8%, HT +34.4%, 1RM leg press +39.2%, 1RM bench press +32.0%
"...A decrease from on- to post- cycle was observed in BM (-5.7%), total LBM (-2.8%), trunk LBM (-6.7%), appendicular LBM (-2.9%) & total body water (-2.1%), while trunk FM increased further (+1.9%) & total FM (-6.7%) & appendicular FM (-1.0%) decreased, albeit not to pre- cycle levels. The bone mineral content (-3.6%), bone area (-1.1%) & BMD (-2.1%) decreased from pre- to on-cycle. From on- to post- cycle, BM content (+3.02%) & BMD (+2.9%) returned to near pre-cycle values, whereas bone area (+0.1%) did not. Visceral adipose tissue (AT) area increased from pre- to on- cycle (+4.0%) & increased further from on- to post- cycle (+13.6%)."
TT decreased on-cycle from 639 to 241 ng/dL, back to 659 post-cycle & fT decreased on-cycle from 48 to 85.7 pg/mL, back to 148.1 post-cycle.
Conclusion
Versus recreationally trained population, SARM use saw ↓AR content, i.m. DHT & i.m. T, but strength (leg press & bench press 1RM) was > average for recreationally resistance trained population; co-administration of LGD-4033 & MK-0677 ↑body mass, LBM & FM, while negatively impacting bone, lipids, liver enzymes, T (T & f) & LH.
A case report of combined LGD‐4033 and MK‐677 use on body composition...muscle androgenic hormone and receptor content (abysmal results):
Overview
25.3 y male, 178 cm, training age 8.8 y
10 mg/d LGD-4033 & 15 mg/d MK-0677 x 5 w
blood-work drawn pre-, on- (@ 5 w), & post- (+4 w) cycle
on-cycle excision of skeletal muscle tissue & strength testing (1RM leg press & 1RM bench press), cross-sectional (vs. recreationally resistance trained men)
body comp. metrics & biospecimens collection taken upon waking, 48 h post-training & rested, fasted, euhydrated state
Results:
- body comp.: pre- to on- cycle - body mass +6.0%, LBM +3.1%, trunk LBM +6.6%, appendicular LBM +4.3%, total fat mass (FM) +15.4%, trunk FM +2.8%, appendicular FM +14.8%
- serum lipids: chol. +14.8%, trig. +39.2%, LDL-chol. +40.0%, HDL-chol -36.4%
- liver: AST +95.8%, ALT +205%
- androgen-associated: free T (fT) -85.7%, total T (TT) -62.3%, SHBG -79.6%
- "...all variables returned to pre- cycle values post-cycle, apart from total FM, appendicular FM, bone area, total chol. & LDL-chol."
- gonadotropins: FSH sub-clinical (low) both on- (1.2 IU/L) & post- (1.3 IU/L) cycle [not assessed pre-]
- in case subject vs. non-users: intramuscular (i.m.) AR -44.6%, T +47.8%, HT +34.4%, 1RM leg press +39.2%, 1RM bench press +32.0%
"...A decrease from on- to post- cycle was observed in BM (-5.7%), total LBM (-2.8%), trunk LBM (-6.7%), appendicular LBM (-2.9%) & total body water (-2.1%), while trunk FM increased further (+1.9%) & total FM (-6.7%) & appendicular FM (-1.0%) decreased, albeit not to pre- cycle levels. The bone mineral content (-3.6%), bone area (-1.1%) & BMD (-2.1%) decreased from pre- to on-cycle. From on- to post- cycle, BM content (+3.02%) & BMD (+2.9%) returned to near pre-cycle values, whereas bone area (+0.1%) did not. Visceral adipose tissue (AT) area increased from pre- to on- cycle (+4.0%) & increased further from on- to post- cycle (+13.6%)."
TT decreased on-cycle from 639 to 241 ng/dL, back to 659 post-cycle & fT decreased on-cycle from 48 to 85.7 pg/mL, back to 148.1 post-cycle.
Conclusion
Versus recreationally trained population, SARM use saw ↓AR content, i.m. DHT & i.m. T, but strength (leg press & bench press 1RM) was > average for recreationally resistance trained population; co-administration of LGD-4033 & MK-0677 ↑body mass, LBM & FM, while negatively impacting bone, lipids, liver enzymes, T (T & f) & LH.
