Accutane, How much to take???

[brutalbuilt]

Dunno if you're covered by insurance or this is out of pocket, but you may want to ask if you can switch to one of the types of Accutane that doesn't require fat to absorb, like Absorica (or a generic equivalent). That way you can be sure you're getting the full dose, Not enough fat can mean as much as an 80% reduction in effective dose.

The LD Difference | ABSORICA LD™ (isotretinoin)

Learn more about ABSORICA LD™. See full prescribing information, including boxed warning, and medication guide.

www.absoricald-hcp.com

yeah i did some research and came across that brand and i have insurance so its cheap

ill ask my derm about it tho on my next follow up appointment

 

[Ghoul]

i

yeah i did some research and came across that brand and i have insurance so its cheap

ill ask my derm about it tho on my next follow up appointment

If I was doing it all over again, even with Indian pharma, I would've just gotten one of the nano-particle isotretinoins so I didn't have to bother with taking it with good, adding fats, etc, like Sun Pharma Sotret NF.

 

[brutalbuilt]

i

If I was doing it all over again, even with Indian pharma, I would've just gotten one of the nano-particle isotretinoins so I didn't have to bother with taking it with good, adding fats, etc, like Sun Pharma Sotret NF.

yeah im on a strict diet plan year round so its hard cause im not doing high fats at all just 1 meal with added fats the rest come from meat and fish oil

ima deff ask my derm about it

 

[RaddishPork]

The prescribed doses are abusrd in America. it's 0.5-1mg mg per kg of body weight. That is ridiculous seeing how it puts most people in the 60+ mg daily range.

There have been studies showing that a fraction of that yielded nearly the same results with FAR less side effects.

I used accutane about 3 years ago. 15mg a day for a few months and it certainly did the job without harming my liver values in the slightest, no nosebleeds, etc. Only side effects I got were dry lips and occasional headaches if I wasn't properly hydrated.

Safety and Efficacy of Low-Dose Isotretinoin in the Treatment of Moderate to Severe Acne Vulgaris - PMC

Isotretinoin is indicated for moderate to severe cases of acne which are unresponsive to conventional therapy. The classical recommended dose is 0.5 to 1.0 mg/kg/day. As the side effects are dose related, low-dose isotretinoin therapy for acne is an ...

pmc.ncbi.nlm.nih.gov

Systematic review of low-dose isotretinoin for treatment of acne vulgaris: Focus on indication, dosage, regimen, efficacy, safety, satisfaction, and follow up, based on clinical studies - PubMed

Oral isotretinoin is the most effective treatment for moderate to severe acne and its side effects are mostly dose-dependent. Low dose isotretinoin (0.5 mg/kg/day for 1 week every 4 weeks for 6-months) could be effective and even in its end result, comparable with high or optimal doses. In this...

pubmed.ncbi.nlm.nih.gov

 

[Anonymous35]

the dose can also depend on the amount of acne you had
When i was 18 i took it around 185lbs
I used 30mg/day and it was more then enough to clear the skin

 

[Ghoul]

The prescribed doses are abusrd in America. it's 0.5-1mg mg per kg of body weight. That is ridiculous seeing how it puts most people in the 60+ mg daily range.

There have been studies showing that a fraction of that yielded nearly the same results with FAR less side effects.

I used accutane about 3 years ago. 15mg a day for a few months and it certainly did the job without harming my liver values in the slightest, no nosebleeds, etc. Only side effects I got were dry lips and occasional headaches if I wasn't properly hydrated.

Safety and Efficacy of Low-Dose Isotretinoin in the Treatment of Moderate to Severe Acne Vulgaris - PMC

Isotretinoin is indicated for moderate to severe cases of acne which are unresponsive to conventional therapy. The classical recommended dose is 0.5 to 1.0 mg/kg/day. As the side effects are dose related, low-dose isotretinoin therapy for acne is an ...

pmc.ncbi.nlm.nih.gov

Systematic review of low-dose isotretinoin for treatment of acne vulgaris: Focus on indication, dosage, regimen, efficacy, safety, satisfaction, and follow up, based on clinical studies - PubMed

Oral isotretinoin is the most effective treatment for moderate to severe acne and its side effects are mostly dose-dependent. Low dose isotretinoin (0.5 mg/kg/day for 1 week every 4 weeks for 6-months) could be effective and even in its end result, comparable with high or optimal doses. In this...

pubmed.ncbi.nlm.nih.gov

I appreciate the low dose protocol, advised people try it, to get over their (and my) fear of side effects. Its popularity began in New Zealand as a government instituted protocol, but its motivator was saving money.

The reason I shifted away from it, is:

1: Body acne requires higher doses to be successfully dealt with than facial acne, where most of the focus is.

2. Recent research analyzing large numbers of patient outcomes using many different protocols. from low dose to extremely high, have clearly shown the best long term outcomes, that is, acne not returning, come from cumulative doses of at least 220mg/kg AND treatment continuing for at least 51 days post clearance. It didn't matter how long it took to hit 220mg/kg, but it's such a large amount, if you don't want to be on for years, it makes sense to use the highest daily dose you can tolerate.

Also, this can be an expensive cumulative dose to reach in the EU and US, and insurance won't typically cover it. However, at India Pharma prices, it's a couple hundred dollars at most.

 

[zpped]

i

If I was doing it all over again, even with Indian pharma, I would've just gotten one of the nano-particle isotretinoins so I didn't have to bother with taking it with good, adding fats, etc, like Sun Pharma Sotret NF.

Have you identified any other brands of that style? I've been searching all week and I've only found 1 supplier with it so far.

 

[Ghoul]

Have you identified any other brands of that style? I've been searching all week and I've only found 1 supplier with it so far.

My advice is come up with your intended cumulative dose, ie, 20,000mg, figure out how to split that up, favoring the largest (40mg) for savings, while including some smaller (ie 10mg) for flexibility of dosing, and submit to all of them for a quote (24, zone, and cosmic) on the total package.

Accufine is excellent and you'll save quite a bit using it and just ensuring you take with food, tbh.

Keep in mind Sotret Nf and similar use lower equivalent doses:

10mg=8mg
20mg=16mg
30mg=24mg

Something like:

40 strips Accufine 40mg
40 strips Accufine 10mg

equaling 20,000mg total

 

[RaddishPork]

I appreciate the low dose protocol, advised people try it, to get over their (and my) fear of side effects. Its popularity began in New Zealand as a government instituted protocol, but its motivator was saving money.

The reason I shifted away from it, is:

1: Body acne requires higher doses to be successfully dealt with than facial acne, where most of the focus is.

2. Recent research analyzing large numbers of patient outcomes using many different protocols. from low dose to extremely high, have clearly shown the best long term outcomes, that is, acne not returning, come from cumulative doses of at least 220mg/kg AND treatment continuing for at least 51 days post clearance. It didn't matter how long it took to hit 220mg/kg, but it's such a large amount, if you don't want to be on for years, it makes sense to use the highest daily dose you can tolerate.

Also, this can be an expensive cumulative dose to reach in the EU and US, and insurance won't typically cover it. However, at India Pharma prices, it's a couple hundred dollars at most.

I can understand that. Low dose was great during cycle to minimize sides and keep the acne away. Now that I'm off and a few years have passed, I do get the occasional shoulder or back acne. I've always been blessed that my breakouts are a couple of pimples at most. and rarely on my face The only reason I started was because I shaved my chest one day and spread folliculitis across my torso. Looked like a teenage boys pepperoni face in what was probably 8x8 inches on my body. I was taking azithromycin and tretinoin creams from my job to try and clear it up. The only thing that ended up working was a full detox and then accutane. Quit vaping, dropped the gear, cut out sodas, etc. and it finally cleared up after a few months.

I get more acne than people who ran a full protocol with normal doses, but I definitely get less than most gym guys or gear users who haven't used it. So for what it's worth, IMO, low dose does "work" it just won't give you the ability to say you never had a breakout again.

 

[Ghoul]

I can understand that. Low dose was great during cycle to minimize sides and keep the acne away. Now that I'm off and a few years have passed, I do get the occasional shoulder or back acne. I've always been blessed that my breakouts are a couple of pimples at most. and rarely on my face The only reason I started was because I shaved my chest one day and spread folliculitis across my torso. Looked like a teenage boys pepperoni face in what was probably 8x8 inches on my body. I was taking azithromycin and tretinoin creams from my job to try and clear it up. The only thing that ended up working was a full detox and then accutane. Quit vaping, dropped the gear, cut out sodas, etc. and it finally cleared up after a few months.

I get more acne than people who ran a full protocol with normal doses, but I definitely get less than most gym guys or gear users who haven't used it. So for what it's worth, IMO, low dose does "work" it just won't give you the ability to say you never had a breakout again.

To be fair, when retreatment has been necessary, it's noted that the return of acne isn't as severe as it was before the first course.

 

[brutalbuilt]

The prescribed doses are abusrd in America. it's 0.5-1mg mg per kg of body weight. That is ridiculous seeing how it puts most people in the 60+ mg daily range.

There have been studies showing that a fraction of that yielded nearly the same results with FAR less side effects.

I used accutane about 3 years ago. 15mg a day for a few months and it certainly did the job without harming my liver values in the slightest, no nosebleeds, etc. Only side effects I got were dry lips and occasional headaches if I wasn't properly hydrated.

Safety and Efficacy of Low-Dose Isotretinoin in the Treatment of Moderate to Severe Acne Vulgaris - PMC

Isotretinoin is indicated for moderate to severe cases of acne which are unresponsive to conventional therapy. The classical recommended dose is 0.5 to 1.0 mg/kg/day. As the side effects are dose related, low-dose isotretinoin therapy for acne is an ...

pmc.ncbi.nlm.nih.gov

Systematic review of low-dose isotretinoin for treatment of acne vulgaris: Focus on indication, dosage, regimen, efficacy, safety, satisfaction, and follow up, based on clinical studies - PubMed

Oral isotretinoin is the most effective treatment for moderate to severe acne and its side effects are mostly dose-dependent. Low dose isotretinoin (0.5 mg/kg/day for 1 week every 4 weeks for 6-months) could be effective and even in its end result, comparable with high or optimal doses. In this...

pubmed.ncbi.nlm.nih.gov

low dose protocol is stupid

there's a reason why dermatologist prescribe it the way they do

you wanna hit hard and fast and get off that shit
you dont wanna be staying on accutane for long periods of time

 

[OldmemberNewcuenta]

i

If I was doing it all over again, even with Indian pharma, I would've just gotten one of the nano-particle isotretinoins so I didn't have to bother with taking it with good, adding fats, etc, like Sun Pharma Sotret NF.

healing pharma isotretinoin capsules IP 20mg
need to be taken with fat?

 

[RonaldRt]

I have IP 20mg Accutane tabs. What is the correct dosage?

1 tab/day or more??

It’s very weight dependent, yes you could microdose but even at the appropriate mg/kg it takes months to clear your skin.

 

[Ghoul]

healing pharma isotretinoin capsules IP 20mg
need to be taken with fat?

Absorption can be 80% lower on an empty stomach with standard isotretinoin.

FDA recommends it's ideally taken with a meal that's at least 50% fat. The data I've seen shows that the main thing is to take with food, with at least a little fat.

Mayo clinic recently said once a day dosing with highest fat meal of the day is preferable to split dosing if one dose is not being taken with food. (something they find was common with their patients). But if you do take with food both times, splitting lowers side effects.

The problem with micronized isotretinoin from India is that it's not a fast selling product, and freshness really impacts the potency of isotretinoin since it degrades in heat. It's better to get 3-4 month old accufine, probobly the biggest selling Indian brand with high turnover, than 8-12 month old Sotret NF (which is what people seem to be getting). I'd only buy that if the vendor can guarantee it won't be more than 3-4 months from date of production.

If you're buying a large supply it's not unreasonable to make freshness a condition regardless of the type. I bought 500 5mg Accufine (ie 5 boxes) a few months ago and the vendor had no problem making sure it fresh stock. IE, produced 1/25, I received it 5/25 and I keep it refrigerated to maintain potency,

 

[brutalbuilt]

Absorption can be 80% lower on an empty stomach with standard isotretinoin.

FDA recommends it's ideally taken with a meal that's at least 50% fat. The data I've seen shows that the main thing is to take with food, with at least a little fat.

Mayo clinic recently said once a day dosing with highest fat meal of the day is preferable to split dosing if one dose is not being taken with food. (something they find was common with their patients). But if you do take with food both times, splitting lowers side effects.

The problem with micronized isotretinoin from India is that it's not a fast selling product, and freshness really impacts the potency of isotretinoin since it degrades in heat. It's better to get 3-4 month old accufine, probobly the biggest selling Indian brand with high turnover, than 8-12 month old Sotret NF (which is what people seem to be getting). I'd only buy that if the vendor can guarantee it won't be more than 3-4 months from date of production.

If you're buying a large supply it's not unreasonable to make freshness a condition regardless of the type. I bought 500 5mg Accufine (ie 5 boxes) a few months ago and the vendor had no problem making sure it fresh stock. IE, produced 1/25, I received it 5/25 and I keep it refrigerated to maintain potency,

talked to my derm and found out he was in the actual studies for absorica and he said regular accutane is fine it just needs to be taken with a good amount of food is the main thing

 

[Ghoul]

talked to my derm and found out he was in the actual studies for absorica and he said regular accutane is fine it just needs to be taken with a good amount of food is the main thing

Yeah I always took dose 1 with breakfast and 2 with dinner. Apparently that's not something a lot of teenagers can manage to do reliably so their treatment often fails.

 

[brutalbuilt]

Yeah I always took dose 1 with breakfast and 2 with dinner. Apparently that's not something a lot of teenagers can manage to do reliably so their treatment often fails.

yeah my derm said the amount of food is more important than the actual fat content cause i told him im on a low fat diet atm

 

[quarter]

Accutane ranks as one of the worst things I've ever taken. I was 220 lbs and they wanted me on 120mg a day, I got up to 80 and felt like a dead man walking with gravel in my joints. 60mg a day made life more bearable, but took me 11 months to get through the treatment. Felt cold all the time, constantly red-faced (which hasn't gone away 2 years later, wtf), and I can't understate the joint pain holy moly

Shit worked tho

 

[VidMc]

I thought its fat solutable because its an vitamin a derivat. Am I wrong?