Accutane permanent cure?

[AllbrandNew]

For you guys that were (or still are) at a high-ish dose for a while, does staying at the exact same dose eventually make all of the uncomfortable dryness sides go away? Does the body get used to a certain dose with time and adjust?

For me, the sides calmed down some from their peak after titrating up to my next dose each time, but the overall effect seemed to be dose dependent. Overall higher dose= more/more severe sides, but in my exp was not linear, if that makes sense. Like a 50% bump in dosage netted like ~15-20% more severe sides.

The only oddity for me was coming back down and not getting relief.

 

[bigforyouben]

For you guys that were (or still are) at a high-ish dose for a while, does staying at the exact same dose eventually make all of the uncomfortable dryness sides go away? Does the body get used to a certain dose with time and adjust?

I'm at 160 mg/day and starting week 6 of my 23,000 mg run. I was thinking if just staying at 160 mg for the remainder of my run if the uncomfortable dryness goes away or, at least, noticeably reduces.

I dropped from 160 to 120 (at about 90kg bodyweight). Sides at 120 have gotten better than when I started 120, but I'm putting Aquaphor lip repair on my lips every hour or two and swabbing my nostrils with Aquaphor healing ointment every night. My lips still crack but not terribly any more. My skin has also got a little less sensitive.

I'm getting US pharma isotretinoin through a dermatology nurse, and he says 120mg is the highest dose he's ever put somebody on, but my bloodwork looks good. I'm at 10k of a 20k cumulative dose and should be done in 3 more months, which I think is manageable with the current sides.

 

[oldage]

I dropped from 160 to 120 (at about 90kg bodyweight). Sides at 120 have gotten better than when I started 120, but I'm putting Aquaphor lip repair on my lips every hour or two and swabbing my nostrils with Aquaphor healing ointment every night. My lips still crack but not terribly any more. My skin has also got a little less sensitive.

I'm getting US pharma isotretinoin through a dermatology nurse, and he says 120mg is the highest dose he's ever put somebody on, but my bloodwork looks good. I'm at 10k of a 20k cumulative dose and should be done in 3 more months, which I think is manageable with the current sides.

1% hydrocortisone lip balm off Amazon is a miracle.

 

[synthetic_juggernaut]

For you guys that were (or still are) at a high-ish dose for a while, does staying at the exact same dose eventually make all of the uncomfortable dryness sides go away? Does the body get used to a certain dose with time and adjust?

I'm at 160 mg/day and starting week 6 of my 23,000 mg run. I was thinking if just staying at 160 mg for the remainder of my run if the uncomfortable dryness goes away or, at least, noticeably reduces.

For me the sides (dry lips, dry eyes) haven't totally gone away, but have gotten much better over a few weeks at the fixed high dose. So yeah, I'd recommend riding it out and running the high dose until you hit the target. I'm still deciding if I go on a long-term microdose after the high dose course to make sure I don't get a recurrence around Test blast/cruise transitions