all hormones inhibited by steroids. take pregnenolone

[Dead]

Yep


Thyroid hormones and insulin are not really related at all to that pathway, tho.

(although this guys claim, interpreted literally would include those as well, which is even more ridiculous)


The word that you are looking for is "luteinizing" and you are wrong.

The fact that you are not the only one wrong doesn't change the reality.

Oh thank you for correcting my typo to give ur self more credibility.

Thyroid comes from the pituitary gland from TSH insulin comes from the pancreas I’m talking about every hormone that doensteos from cholesterols and ends in testosterone and dht who the FUCK said anything about skin or thyroid god you’re ducking stupid besides doesn’t this board hate u for faking test results?

 

[Dead]

Let me RENAME THE TITLE


THESE ARE ALL OF THE HORMONES THAT ARE INHIBITED TO A DEGREE OR FULLY WHEN ON EXOGENOUS TESTOSTERONE

 

[Dead]

http://www.aging.wisc.edu/pdfs/38.pdf
Here’s the fucking evidence

Why are all these forums full of so many brick headed people I am amazed at how dumb some people are. If u inhibit LH u inhibit more than just testosterone. That’s what I’m saying I would bang my head on a wall for anyone who disagrees with this link but by that point is know they’re trolling

 

[Dead]

Pregnenolone: What You Need to Know About this Precursor Hormone - Testosterone Wisdom

 

[Dead]

-all hormones inhibited by testosterone should make sense if ur not s god damn idiot I put the fuckin chart right underneath

But ya I should have sai d “ all precursor steroids derived from cholesterol are inhibited by taking exogenous testosterone”

 

[Michael Scally MD]

This has no clinical significance at all. In addition to being wrong. Crisler [RIP] pushed this false narrative calling it backfilling.

See: Dr. wants to add DHEA to regimen

 

[Michael Scally MD]

http://www.aging.wisc.edu/pdfs/38.pdf
Here’s the fucking evidence

Why are all these forums full of so many brick headed people I am amazed at how dumb some people are. If u inhibit LH u inhibit more than just testosterone. That’s what I’m saying I would bang my head on a wall for anyone who disagrees with this link but by that point is know they’re trolling

I suspect you bang your head against the wall often. It is apparent from your posts.

More ... What is wrong with daily low dose HCG with TRT?

There is NO, NADA, ZIP, ZERO evidence for functional Extragonadal Luteinizing Hormone / Chorionic Gonadotropin Receptors [LH/hCG-R] within the CNS and more especially in males.

A few years back, I wrote the author for an update on the 2007 review wrt any functional significance for the "Extragonadal LH/hCG action." He has not changed his opinion.

Pakarainen T, Ahtiainen P, Zhang F-P, Rulli S, Poutanen M, Huhtaniemi I. Extragonadal LH/hCG action—Not yet time to rewrite textbooks. Molecular and Cellular Endocrinology 2007;269(1-2):9-16. https://www.sciencedirect.com/science/article/pii/S0303720707000391

Gonadotropins are indispensable in both sexes in the regulation of gonadal sex steroid production and gametogenesis. In addition to their well-established classical actions, numerous recent publications have indicated the presence and function of luteinizing hormone/chorionic gonadotropin receptors (LH/hCG-R) in a variety of extragonadal tissues. However, the physiological significance of such effects has remained unclear. We have generated two genetically modified mouse models, one with excessive production of hCG and the other with targeted disruption of LH/hCG-R gene, and used them to address the functions of LH and hCG. Numerous gonadal and extragonadal phenotypes were found in the models with the two extremes of LH/hCG action. However, when the extragonadal effects were scrutinized in greater detail, they all appeared to arise through modification of gonadal function, either through enhanced or inhibited response to LH/hCG stimulation. Hence, further evidence is needed before the extragonadal LH/hCG-R expression can be considered functionally significant.

 

[Eman]

I suspect you bang your head against the wall often. It is apparent from your posts.

Lol.

Scally doesn't flame often... But when he does, it burns.

 

[LeoTC]

So much wrong with this post. Was waiting for the good Doc to lay it all out just so I could drop the lulz.

 

[Dead]

This has no clinical significance at all. In addition to being wrong. Crisler [RIP] pushed this false narrative calling it backfilling.

See: Dr. wants to add DHEA to regimen

DHEA is responsible for much much more than fucking testosterone . Doc

 

[Dead]

DHEA is responsible for much much more than fucking testosterone . Doc

Secondly I take back my original post. These are mainly adrenal hormones so inhibitiuion of the pituitary should likely not have effect . I knew DHEA came from the adrenals but not pregenenolone. Learned something new.

However if preg did come from the pituitary I would have been entirely correct

 

[LeoTC]

So you would have been right, if only you hadn't been wrong...

 

[janoshik]

So you would have been right, if only you hadn't been wrong...

A misunderstood genius indeed.

 

[mindgame1516]

What a fun and exciting thread to read!!!

 

[Chuck Spears]

So taking testosterone inhibits estrogen?
Good to know.

 

[AbstractMind]

@Type-IIx

 

[Type-IIx]

@Type-IIx

The claim in the OP is wrong (that exogenous steroids inhibit all hormones), & it does not follow from the biosynthesis flowchart posted that there is any therapeutic indication for exogenous neurosteroids arising out of AAS use.

 

[Deleted member 59947]

Everyone should be just as mindful of how they feel as they are of scientific studies.

Any time I take any dose of pregnenolone, it puts me in a state of depression and hate against the world.

Any time I take transdermal DHEA, it makes me sharp intellectually, alert physically, avid to have sex with any remotely average girl, and confident as a bull.

Experiment, assess, draw conclusions.
Read forums, don't listen too much to wannabe endocrinologists telling you there is such a thing as "backfilling the pathways".

If you feel good adding pregnenolone, you were probably just as deficient in pregnenolone to begin with as you were deficient in testosterone. AAS most likely didn't aggravate that.

 

[Type-IIx]

Everyone should be just as mindful of how they feel as they are of scientific studies.

Any time I take any dose of pregnenolone, it puts me in a state of depression and hate against the world.

Any time I take transdermal DHEA, it makes me sharp intellectually, alert physically, avid to have sex with any remotely average girl, and confident as a bull.

Experiment, assess, draw conclusions.
Read forums, don't listen too much to wannabe endocrinologists telling you there is such a thing as "backfilling the pathways".

If you feel good adding pregnenolone, you were probably just as deficient in pregnenolone to begin with as you were deficient in testosterone. AAS most likely didn't aggravate that.

It doesn't follow that if you take an exogenous neurosteroid, and it makes you feel good, that you were deficient.

Progesterone (P4) & allopregnanolone are positive allosteric modulators of GABA-A receptors: they are potently anxiolytic & antidepressant, on par with benzodiazepines and barbiturates (drug-like efficacy). DHEA is another, though less potent; and with broader spectrum action. GABA-A positive allosteric modulators are subject to reinforcement (addiction) and withdrawal symptoms.

Pregnenolone, conversely, is a negative allosteric modulator of GABA-A receptor; it would follow that it would tend to promote anxiety and depression-like symptoms.

 

[Deleted member 59947]

It doesn't follow that if you take an exogenous neurosteroid, and it makes you feel good, that you were deficient.

The natural state of every human being and animal in perfect health is a slight feeling of euphoria and relaxation (Raymond Peat, PhD).

If taking a neurosteroid makes you reach that state, which you were not experimenting before, you were deficient.
No matter what your blood test says, which wouldn't even be relevant in that case.

That only goes for bio identical hormones.

Not saying that if Tren makes you feel good you were Tren-deficient ...