Androgenic or Anabolic

[cathex]

Can anyone explain what it is that makes a particular steroid more androgenic or anabolic? For example, why is cyp more androgenic than say, primo or nandrolone? Surely, test is test if it all ends up as test in your body after it has been absorbed, whether from an injectable (ester) or an oral. Please explain.

 

[einstein1905]

It doesn't all end up as test....I don't know what gave you that impression. The androgenicity of a particular AAS is directly correlated with its affinity for the androgen receptor. 5a reduced compounds are more androgenic than others. There are also nonAR-mediated actions of AAS, but they don't determine androgenicity.

 

[cathex]

It doesn't all end up as test....I don't know what gave you that impression. The androgenicity of a particular AAS is directly correlated with its affinity for the androgen receptor. 5a reduced compounds are more androgenic than others. There are also nonAR-mediated actions of AAS, but they don't determine androgenicity.

Okay fine, so what you're saying is that the higher the affinity for the andrgen receptor, the more the adrogenic effects of the drug, so the more potent right.

Well here goes, (you new this was coming) what is it that determines the level of affinity between the drug and the receptor?

 

[Adogg4]

bro who cares about that shit...lol

 

[jayce]

A quick biochem lesson.

Think of a cast and mold. All receptors are made out of one or more proteins pieced together to form a certain shape (the mold). Molecules that bind to those receptors have a shape of their own that mirrors that of the receptor (the cast). The molecule is held in place by bonds of varying strength. If the shape of the molecule and receptor are matched in a way where there are many areas of strong bonding, you have high affinity. If the molecule fits in place but doesn't match in a way that results in many areas of strong bonding, you have low affinity.

It is very oversimplified in this presentation, but it has to be. That is the basic concept though.

Jayce

 

[MaxRep]

"Okay fine, so what you're saying is that the higher the affinity for the andrgen receptor, the more the adrogenic effects of the drug, so the more potent right."


Cathex, you're getting a little off base here.
For example, DHT has a significantly higher affinity for the AR than Testosterone but no one would say it's "more potent."

Proviron has a strong affinity for the AR but no one wants to do a Proviron cycle.

Deca is another good example of a product that binds to the AR better than does Testosterone. Yet most would agree that it is less androgenic than Test and less effective than Test, mg for mg.

There are various ways, directly through the AR and indirect, that AAS exert their effects.

Cathex, this is a huge and complicated topic and one you could spend years researching.

Good luck,
MaxRep

 

[cathex]

"Okay fine, so what you're saying is that the higher the affinity for the andrgen receptor, the more the adrogenic effects of the drug, so the more potent right."


Cathex, you're getting a little off base here.
For example, DHT has a significantly higher affinity for the AR than Testosterone but no one would say it's "more potent."

Proviron has a strong affinity for the AR but no one wants to do a Proviron cycle.

Deca is another good example of a product that binds to the AR better than does Testosterone. Yet most would agree that it is less androgenic than Test and less effective than Test, mg for mg.

There are various ways, directly through the AR and indirect, that AAS exert their effects.

Cathex, this is a huge and complicated topic and one you could spend years researching.

Good luck,
MaxRep

Okay not that simple to understand via a question through a message board then huh! Thought as much! Thanks anyway guys.

 

[BoogerSnax]

Okay not that simple to understand via a question through a message board then huh! Thought as much! Thanks anyway guys.

BRO, don't go away mad...

VISIT: http://www.sportsci.org/encyc/anabster/anabster.html

You can consider this a primer to biochemistry.

PEACE

 

[MaxRep]

Keep in mind that link is a very basic primer and there are a large number of factual inaccuracies. Enough that no one should go around quoting the guy.

Notice also the references he uses are all about 15 + years old.

Typical of the nonsense spouted by researchers in the 1980's is this gem from the guy:

Psychological Effects
Some researchers have speculated that the real effect of anabolic steroids is the creation of a "psychosomatic state" characterized by sensations of well being, euphoria, increased aggressiveness and tolerance to stress, allowing the athlete to train harder. Such a psychosomatic state would be more beneficial to experienced weight lifters who have developed the motor skills to exert maximal force during strength training. Diets high in protein and calories may also be important in maximizing the effectiveness of anabolic steroids.

I could go on and on but I don't want to tear up the poor guy's entire article so I'll leave by saying more recent research and information would be much more beneficial to today's readers.

MaxRep

 

[BoogerSnax]

Keep in mind that link is a very basic primer and there are a large number of factual inaccuracies. Enough that no one should go around quoting the guy.

Notice also the references he uses are all about 15 + years old.

Typical of the nonsense spouted by researchers in the 1980's is this gem from the guy:

Psychological Effects
Some researchers have speculated that the real effect of anabolic steroids is the creation of a "psychosomatic state" characterized by sensations of well being, euphoria, increased aggressiveness and tolerance to stress, allowing the athlete to train harder. Such a psychosomatic state would be more beneficial to experienced weight lifters who have developed the motor skills to exert maximal force during strength training. Diets high in protein and calories may also be important in maximizing the effectiveness of anabolic steroids.

I could go on and on but I don't want to tear up the poor guy's entire article so I'll leave by saying more recent research and information would be much more beneficial to today's readers.

MaxRep

MR, point conceeded. I should have told hime to buy:
Anabolics 2004 by William Llewellyn

from MESO...LOL

PEACE