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Anabolic Steroids

Anyone heard of Trevogrumab and Garetosmab?

L

Luke391

Member
So they're drugs developed by Regen Pharmaceuticals and they seem quite promising. A study monkeys of these 2 drugs paired with semaglutide showed impressive results.
Trevogrumab is a myostatin antibody amd Garetosmab is a activin-A antagonist.
They made the apes diet for 20weeks.
group 1 dieted naturally and lost 400g of fat and 20g if muscle (I am going off memory tyeae numbers might be a bit off)
group 2 dieted with semaglutide and lost 700g of fat and 100g of muscle
group 3 was sema + trevogrumab and lost 1300g of fat and lost 15g of muscle
Group 4 was sema + trevogrumab + garetosmab and lost 1600g of fat while gaining 400g of muscle.

Obviously the side effects and log term efficacy aren't clear yet.
You guys think it'll be the next big breaktrough or another fluke like Folliatatin344?

I found them online by pharmaceutical research companies but they insanely expensive. If I found a legit one at an acceptable price I was thinking of being a lab rat for these 2 drugs
 
CorgisOnTren said:
Please, no more
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why? Yall act like old guys cursing at technology. Imagine if people refused to use the lightbulb because it was new.
There will be failures but you can't just dismiss anything new just because it's new.
Imagine if people gave up on trying to build cars because "horses is how it's always been done".
Afterall muscle mass amd bodycomposition is just chemistry. Some people have "better genetics" for bodybuilding because of their biochemistry. That means it can be artificially replicated.
Sure these 2 drugs might not be "the ones" but it's progress
 
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Wizbang said:
Man I can't wait for the UGL monoclonal antibodies and the clusterfuck of issues.
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well if these drugs work it's inevitable. Surely there were issues when synthetic testosterone was intruduced but you still love test.
There was a clusterfuck of issues when cars amd planes were invented but you can still agree that those were good inventions.
Not saying these drugs will work but people here are hyppcritical. If I wanted to listed to old people hate anything that came about after the 90's I'd go visit my grandparents
 
Wizbang said:
Oh I'm referencing the difference in production methods, storage requirements and such needed to make biologics, this isn't bathtub hormone production. Is it doable? Sure anything is possible.
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yeahI know they are a completely different thing. Trevogrumab is made from genetically modified mice. not something you can just make. But if these drugs are found to not be harfull they might become pretty easy to get a hold of
 
Luke391 said:
yeahI know they are a completely different thing. Trevogrumab is made from genetically modified mice. not something you can just make. But if these drugs are found to not be harfull they might become pretty easy to get a hold of
Click to expand...
Doubtful, the cost of production for these drugs is very high due to their complex production methods (cell culture, isolation, scale up, purification), which lead to their price tag, and while that price tag will reduce over time its a volume game, big pharma can produce this stuff at volume and control the overall price while providing something that maintains a refrigerated supply chain and you wont end up with immunogenicity issues from a bunch of mis-made antibodies. While I wont disagree that on the minimal research released on these drugs it shows some promise this is often the case and then they do not make it past phase 2/3 trials due to something like ineffectiveness, or horrific sides or downstream issues that need resolution, cancer potential, etc. Right now this is all a bunch of hype being pumped by some influencers that saw a new study come out on something novel. nothing more.
 
Wizbang said:
Doubtful, the cost of production for these drugs is very high due to their complex production methods (cell culture, isolation, scale up, purification), which lead to their price tag, and while that price tag will reduce over time its a volume game, big pharma can produce this stuff at volume and control the overall price while providing something that maintains a refrigerated supply chain and you wont end up with immunogenicity issues from a bunch of mis-made antibodies. While I wont disagree that on the minimal research released on these drugs it shows some promise this is often the case and then they do not make it past phase 2/3 trials due to something like ineffectiveness, or horrific sides or downstream issues that need resolution, cancer potential, etc. Right now this is all a bunch of hype being pumped by some influencers that saw a new study come out on something novel. nothing more.
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That's how I feel about many peptides, they died on the vine and are now touted as the new thing. I've tried many of them and tirz and pt141, mots c and NAD were the only ones that really worked like they were touted, the rest not so much. jmho
 
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It's definitely interesting, I'm curious to see what becomes of it.
For now I can see it being shelved until technology catches up so big pharma can produce it at a good price.
 
Luke391 said:
So they're drugs developed by Regen Pharmaceuticals and they seem quite promising. A study monkeys of these 2 drugs paired with semaglutide showed impressive results.
Trevogrumab is a myostatin antibody amd Garetosmab is a activin-A antagonist.
They made the apes diet for 20weeks.
group 1 dieted naturally and lost 400g of fat and 20g if muscle (I am going off memory tyeae numbers might be a bit off)
group 2 dieted with semaglutide and lost 700g of fat and 100g of muscle
group 3 was sema + trevogrumab and lost 1300g of fat and lost 15g of muscle
Group 4 was sema + trevogrumab + garetosmab and lost 1600g of fat while gaining 400g of muscle.

Obviously the side effects and log term efficacy aren't clear yet.
You guys think it'll be the next big breaktrough or another fluke like Folliatatin344?

I found them online by pharmaceutical research companies but they insanely expensive. If I found a legit one at an acceptable price I was thinking of being a lab rat for these 2 drugs
Click to expand...
ik where to get it from some sources. the cheapest u can find it for is like 700k for 10 week cycle right now lol.
 
Realistically, the effects that are touted as oh so great gains could be replicated with a generous application of AAS for a fraction of a price. In an untrained population even TRT doses (starting from hypogonadal) lead to significant changes in body composition, somewhat comparable to the changes seen in the studies on those thingamajigs Regeneron is testing right now.
Hell, even the first few waves of SARMs seemed equally promising.

might go crazy in combination with AAS and HGH tho, but we will have to wait and see.
 
IndividualMan said:
Realistically, the effects that are touted as oh so great gains could be replicated with a generous application of AAS for a fraction of a price. In an untrained population even TRT doses (starting from hypogonadal) lead to significant changes in body composition, somewhat comparable to the changes seen in the studies on those thingamajigs Regeneron is testing right now.
Hell, even the first few waves of SARMs seemed equally promising.

might go crazy in combination with AAS and HGH tho, but we will have to wait and see.
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yeah obviously AAS are still the most effective thing we have. The point of research like this would be to create a drug that creates Steroid-like results with minimal to no side effects.
It will take a long time but I think it's possible, the drugs we have today were absolutely unthinkable 70years ago
 
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