Anyone tried Mirabegron?

deeoeraclea · 2024-07-31T13:02:10-0400

Vigorous Steve has been singing the praises of Mirabegron (brand name Betmiga) on a few of his recent Q&A's. He says he will dedicate a video to it soon, but has yet to do so. Has anyone tried it? If so, what were your doses, results and side-effects? How does it compare to clenbuterol (in terms of fat loss and side effects)?

buzzingonaas · 2024-07-31T13:06:21-0400

curious about anecdotal reports too

Eddie. · 2024-07-31T13:09:07-0400

I thought of trying this for my minicut, but the idea of excess urination is horrible. Especially if it wakes you up at night. It's a drug to empty your bladder faster, right?

deeoeraclea · 2024-07-31T13:15:04-0400

Eddie. said:
I thought of trying this for my minicut, but the idea of excess urination is horrible. Especially if it wakes you up at night. It's a drug to empty your bladder faster, right?

The clinical use is to treat overactive bladder. So, I think it would actually reduce the urge to urinate.

Eddie. · 2024-07-31T13:53:57-0400

deeoeraclea said:
The clinical use is to treat overactive bladder. So, I think it would actually reduce the urge to urinate.

Oh yes, you're right i believed it was the opposite lol. That's great.. I'll wait for a couple anecdotal reports because until now i've heard it only from Steve and another guy on his livestream.

roofer22 · 2024-07-31T14:51:47-0400

I was just prescribed Solifenacin for this. Maybe when I go back I'll ask for that instead.

Eddie. · 2024-07-31T15:00:21-0400

roofer22 said:
I was just prescribed Solifenacin for this. Maybe when I go back I'll ask for that instead.

Solifenacin appears to have a similar action but it's not a beta 3 agonist. Let us know if it works in case you try it.

bighunanballs · 2024-07-31T15:15:30-0400

I had recently looked at a study showing the beta 3 receptor action of Mira targeted brown adipose fat (BAT) only. I can't for the life of me find that study now. Would be curious to see what @Ghoul can dig up, im a lazy researcher.

mochul · 2024-07-31T15:17:16-0400

bighunanballs said:
I had recently looked at a study showing the beta 3 receptor action of Mira targeted brown adipose fat (BAT) only. I can't for the life of me find that study now. Would be curious to see what @Ghoul can dig up, im a lazy researcher.

Brown adipose fat has mainly beta 3 receptors. Since Mira is beta 3 receptor agonist, it will hit the BAT.

29trt · 2024-07-31T15:24:47-0400

one prob with Mirabegron is the price...maybe some raws are available but haven't looked yet

Ghoul · 2024-07-31T15:28:35-0400

bighunanballs said:
I had recently looked at a study showing the beta 3 receptor action of Mira targeted brown adipose fat (BAT) only. I can't for the life of me find that study now. Would be curious to see what @Ghoul can dig up, im a lazy researcher.

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

Increasing energy expenditure through activation of endogenous brown adipose tissue (BAT) is a potential approach to treat obesity and diabetes. The class of β3-adrenergic receptor (AR) agonists stimulates rodent BAT, but this activity has never ...

www.ncbi.nlm.nih.gov

bighunanballs · 2024-07-31T15:30:09-0400

mochul said:
Brown adipose fat has mainly beta 3 receptors. Since Mira is beta 3 receptor agonist, it will hit the BAT.

I would be willing to bet bat only makes up maybe 1% of the fat most adults carry around

bighunanballs · 2024-07-31T15:31:36-0400

"The amount of brown adipose tissue (BAT) in adults can vary widely, ranging from 0.02% to 300 grams, or less than 0.5% of total body mass. A 2020 systematic review of 22 peer-reviewed papers estimated the pooled prevalence of BAT in adults to be 6.97%. However, a 2021 study of 52,000 patients found BAT in nearly 10% of individuals, though the researchers noted that this number may be an underestimate."

mochul · 2024-07-31T15:37:14-0400

bighunanballs said:
I would be willing to bet bat only makes up maybe 1% of the fat most adults carry around

Yea it’s not effective to target BAT imo. Dnp works in the same mechanism as bat does.
But i am curious in the development of new drugs that can convert white fat to either beige or brown. Since brown fat is metabolically more active

Liter O' Test · 2024-07-31T16:45:23-0400

i dont know if we even want to target brown fat or what?
Im sure bodybuilders are looking for DNP alternatives to get rid of visceral fat

Ghoul · 2024-07-31T16:55:51-0400

Liter O' Test said:
i dont know if we even want to target brown fat or what?
Im sure bodybuilders are looking for DNP alternatives to get rid of visceral fat

Is Tesa not good enough for the task?

bighunanballs · 2024-07-31T17:07:41-0400

Liter O' Test said:
i dont know if we even want to target brown fat or what?
Im sure bodybuilders are looking for DNP alternatives to get rid of visceral fat

Ya that's what I'm thinking. Mira seems pointless to me from a bodybuilding persepctive and certainly not a replacement for Clen+ketotifen

bighunanballs · 2024-07-31T17:08:51-0400

mochul said:
Yea it’s not effective to target BAT imo. Dnp works in the same mechanism as bat does.
But i am curious in the development of new drugs that can convert white fat to either beige or brown. Since brown fat is metabolically more active

Ya that does sound intriguing. As far as Mira goes I don't see it being beneficial for us, certainly not the claims by Vig Steve I think he needs to do a little more deep diving on this one

Anyone tried Mirabegron?

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