Aromasin question

[guardianactual]

If sourcings OK I'll tell u were to buy HCG.

During PCT I use torem asin & Ostarine MK2866 w.e u wish to call it. I keep damn near everything & strength is still good... I'm adding IGF1 this time round.

 

[TheronB]

From my experience, people near their natural weight with body fat around 15% or lower usually need 6.25mg Aromasin daily per 400mg aromatizing compound. Dose should be divided, half in the morning and half at night. I think this is a good place to start and adjust as needed, preferably with blood work.

Examples:
400mg test/week - 3.125mg twice daily
800mg test/week - 6.25mg twice daily
1.2g test/week - 9.375mg twice daily
1.6g test/week - 12.25mg twice daily

 

[Nitrobuste]

I want to cycle test and tren enanthat . Which aromasin is the best to prevent gyno ? Will letro do what it should ?

 

[TheronB]

Exemestane is exemestane, so it's all the same if dosed correctly. I do find some of the liquid research chem versions are dosed slightly higher than the Pfizer Aromasin tabs. I can feel my knee joints get dry when switching from the tabs to the liquid sometimes and need to lower the dose.

Letrozole would work fine, but it is much, much harder to dose correctly. It's best saved for emergency gyno IMO.

 

[Michael Scally MD]

Aromatase is saturable, thus there is NO need to have an ever increasing AI dose. It will be of no use.

Further, by stating to take an AI twice per day only demonstrates one absence of knowledge. This will serve no purpose.

 

[TheronB]

So you are saying the aromstase levels are always produced at a set level per individual regardless of total androgen levels?

If that is true, why do I need to increase my AI dose when I increase my aromatizing compounds dose? I notice immediate bloating and higher blood pressure until I increase my AI dose to compensate. Is 400-800mg of aromatizing compound too little too notice these symptoms? If so, what might be the cause of the dry joints I feel when running higher doses of Aromasin with test cyp in the 800mg/week range?

Please explain where my thinking had gone wrong.

Thanks!

 

[Michael Scally MD]

Lakshman KM, Kaplan B, Travison TG, et al. The Effects of Injected Testosterone Dose and Age on the Conversion of Testosterone to Estradiol and Dihydrotestosterone in Young and Older Men. J Clin Endocrinol Metab:jc.2010-0102. http://press.endocrine.org/doi/full/10.1210/jc.2010-0102

Background: During testosterone (T) therapy, T is partly converted to 17{beta}-estradiol (E2) and 5{alpha}-dihydrotestosterone (DHT). Effects of age, testosterone dose, and body composition on total and free E2 and DHT levels are unknown.

Objective: We evaluated age and dose-related differences in E2 and DHT levels in response to graded doses of testosterone enanthate in young and older men.

Methods: Fifty-one young (aged 19-35 yr) and 52 older (aged 59-75 yr) men completed treatment with monthly injections of a GnRH agonist plus randomly assigned weekly doses of testosterone enanthate (25, 50, 125, 300, or 600 mg) for 5 months.

Results: During testosterone administration, total and free E2 levels increased dose-dependently (dose effect, P < 0.001) in both young and older men. Total and free E2 levels and E2:T ratios during T administration were higher in older than young men, but age-related differences in free E2 and free E2:T ratios were not significant after adjusting for testosterone levels, percentage fat mass, and SHBG. DHT levels and DHT:T ratios were dose-related but did not differ between young and older men. Mechanistic modeling of free hormone data revealed that the conversions of T to E2 and DHT were both consistent with saturable Michaelis-Menten kinetics. The in vivo Km values were estimated to be 1.83 nM for aromatase and 3.35 nM for 5{alpha}-reductase, independent of age. The Vmax parameter for E2 was 40% higher in older men than younger men, but Vmax for DHT was not significantly different between age groups.

Conclusions: During im testosterone administration, E2 and DHT levels exhibit saturable increases with dose. The rate of whole body aromatization is higher in older men, partly related to their higher percentage fat mass, SHBG, and testosterone levels.

 

[TheronB]

I thought the half life of Aromasin is approximately 8 hours in men. Wouldn't twelve hour spacing of doses keep plasma levels most consistent. Am I correct that it takes the body approximately five days to produce more aromatase? I think consistent blood levels would be best to ensure that once the aromstase is replenished, the AI is waiting to neutralize a significant share, thus maintaining consistent values and reducing the chances of unwanted side effects. Please help me understand where I have gone wrong in my thinking.

Thanks!

Aromatase is saturable, thus there is NO need to have an ever increasing AI dose. It will be of no use.

Further, by stating to take an AI twice per day only demonstrates one absence of knowledge. This will serve no purpose.

 

[Michael Scally MD]

While this is in females, the data are consistent in males. See: AROMASIN (exemestane) http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=cf066b7a-032a-416c-8d40-15ba581423e3