Aromasin vs arimidex

[Northern Nutrition]

It hasn't affected my lipids and for most I think it doesn't affect them enough to worry about.

The number is roughly 50%, I forget exactly what the studies mentioned, but I'll see if I can find them and post them up for you.

http://press.endocrine.org/doi/abs/10.1210/jc.2003-031279

Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males.

To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects (14–26 yr of age) were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg Aromasin daily, orally, for 10 days with a 14 day washout period. Blood was withdrawn before and 24 hours after the last dose of each treatment period. A PK study was performed using a 25mg dose. Aromasin suppressed plasma estradiol comparably with either dose [25 mg, 38%; 50 mg, 32%], with a reciprocal increase in testosterone concentrations (60% and 56%; for both).

 

[ThE SiCkNeSs]

32-38% decrease? Damn that's not a whole lot if it gets up there. I guess it's nice that it doesn't seem to crash it though. I read adex can cause severe estrogen rebound when it is stopped. Has anyone heard of or experienced this?

 

[Burrr]

. I read adex can cause severe estrogen rebound when it is stopped. Has anyone heard of or experienced this?

I know a few posters on meso believe it's a myth that there is a rebound when stopping Adex, as in that all the temporarily bound aromatase enzymes are released at once. I don't know if it's a myth or not, but last cycle I stopped my E3d adex dose and switched to 5mg of aromasin daily and had a huge gain ( 10 pounds) in water weight in 24 hours.
The weight dropped back off after a few days of aromasin. Seemed like a E2 rebound to me.

 

[Northern Nutrition]

There's no such thing as estrogen rebound. Hormones aren't made of rubber. And if estrogen rebound exists, what about testosterone rebound? And how about the rest of the entire metabolic panel? Do these rebound too? Or is this simply an anomaly that only occurs with estrogen? There just isn't any reliable medical information (or medical professionals) anywhere supporting this parroted phenomenon.

Sorry guys. It's 100% pure grade A bro science served up with a healthy side dish of BS.

 

[Docd187123]

32-38% decrease? Damn that's not a whole lot if it gets up there. I guess it's nice that it doesn't seem to crash it though. I read adex can cause severe estrogen rebound when it is stopped. Has anyone heard of or experienced this?

I've yet to see bloodwork or any sort of proof of an estrogen rebound. It was probably coined after exemestane came out lol.

 

[double-leg]

I've only ever used aromasin. It was the only thing available on my first cycle

 

[Mayne]

Kinda weird how more exemestane reduced estradiol less. Now do you think all this is incorrect also: The suggested use of Aromasin /Exemestane is 25mg to see the20% decrease in SHBG, 65% decrease in estradiol, and60% increase in total/ 117% in free testosterone.

 

[ThE SiCkNeSs]

There's no such thing as estrogen rebound. Hormones aren't made of rubber. And if estrogen rebound exists, what about testosterone rebound? And how about the rest of the entire metabolic panel? Do these rebound too? Or is this simply an anomaly that only occurs with estrogen? There just isn't any reliable medical information (or medical professionals) anywhere supporting this parroted phenomenon.

Sorry guys. It's 100% pure grade A bro science served up with a healthy side dish of BS.

Just some shit I read, that's why I'm asking you guys. I appreciate the help you given me.

 

[Burrr]

There's no such thing as estrogen rebound.

What about aromatase enzyme rebound? If the adex bond to the enzyme is only temporary wouldn't the enzymes become available again?

 

[Northern Nutrition]

What about aromatase enzyme rebound? If the adex bond the enzyme is only temporary wouldn't the enzymes become available again?

Yes they would. Your body continues to convert testosterone via aromatase enzyme into estrogen regardless of which AI you choose (suicide/blocker). But your E2 levels will not return higher levels than what you initially started with. However, the rate at which each person converts can perhaps be discussed. Currently im not aware of any undertakings or studys that have measured this conversion rate in terms of a scientific timeline.

 

[Northern Nutrition]

Just to clear above; my comments are omitting the idea of perpetual conversion via prolonged/continued exogenous testosterone administration. Bare in mind that if you continue exogenous testosterone, then yes of course your E2 will continue to rise if left unchecked. But this is NOT rebound.

 

[Jimmyinkedup]

There's no such thing as estrogen rebound. Hormones aren't made of rubber. And if estrogen rebound exists, what about testosterone rebound? And how about the rest of the entire metabolic panel? Do these rebound too? Or is this simply an anomaly that only occurs with estrogen? There just isn't any reliable medical information (or medical professionals) anywhere supporting this parroted phenomenon.

Sorry guys. It's 100% pure grade A bro science served up with a healthy side dish of BS.

Yeah I pretty much tend to agree. While there would be a spike in e2, there would not be a rebound where levels are going to magically bounce back higher so to speak. While it can be speculated (and probably accurately) the spike in e2 would be more pronounced with a type 2 ai over a type 1, I dont think it is of clinical significance. It is good however to be aware of how the different ai's work and the possible effects so you can understand what is happening in your body while it is taking place.

 

[bigtyivier2k2]

Figured id give this thread a bump after 7 years lol.

Now lets retry this in 2022..

Adex vs Aromasin. Which and why?

 

[narta]

Figured id give this thread a bump after 7 years lol.

Now lets retry this in 2022..

Adex vs Aromasin. Which and why?

Adex for quick control Aromasin for stabilized

 

[bigtyivier2k2]

Adex for quick control Aromasin for stabilized

Which would you prefer on a test dose of 200mg a week? How about 400mg? Im assuming if Aromasin then 25mg E3D?

 

[narta]

Which would you prefer on a test dose of 200mg a week? How about 400mg? Im assuming if Aromasin then 25mg E3D?

I would get e2 bloodwork and go from there

 

[lukiss96]

Adex for quick control Aromasin for stabilized

Finally someone said it like it is. With arimidex I just can't take it regularly like ed/eod or 2-3x week, no, I have to take it based on when I feel like taking it. There are some people like me who just can't dial in with arimidex and have to use it when needed, otherwise it's unwanted classic high estro symptoms. I guess some people like me are very estrogen sensitive.

Although, I feel fine doing it this way. It just took a lot of time to figure it out and listening to my body.

 

[narta]

Finally someone said it like it is. With arimidex I just can't take it regularly like ed/eod or 2-3x week, no, I have to take it based on when I feel like taking it. There are some people like me who just can't dial in with arimidex and have to use it when needed, otherwise it's unwanted classic high estro symptoms. I guess some people like me are very estrogen sensitive.

Although, I feel fine doing it this way. It just took a lot of time to figure it out and listening to my body.

People tend to choose adex cause it's cheaper and acts quicker. But for individuals that are estrogen sensitive or aromatize heavily aromasin is better if you can dial down the dosage. On the plus, less impact on lipids.

But it needs bloods before you can dial the dosage and it get expensive fast

 

[Henchus maximus98736]

Aromas in all de way IME

 

[FortyFiveLbs]

Figured id give this thread a bump after 7 years lol.

Now lets retry this in 2022..

Adex vs Aromasin. Which and why?

After going the safe route in choosing Adex for my first blast, I learned real quick that I aromatize like a cunt and that I'm a low responder to Adex. Nips on fire, bloated af, E2 at 130 pg/ml on 500mg Test-E/week when I ran bloods and it wasn't until I got up to 1.5mg of Adex daily to notice everything begin to subside (it was pharma grade Anastrozole). Also ran 20mg of Nolva for the final 6 weeks of said blast to keep gyno under control as well.

Switched to Aromasin for my next blast and had a way better experience keeping everything stable at 12.5mg e3d. I take it if I begin to notice any flare ups through my cruise as well being that I start to experience sides once E2 pushes over 60 pg/ml (currently running 175mg Test E/week).