The state of medicine is worse than that of total ignorance. Could we divest ourselves of every thing we suppose we know in it, we should start from a higher ground [and] with fairer prospects. Thomas Jefferson
I presume nobody will question the existence of a widespread popular delusion that every doctor is a man of science. . .. As a matter of fact, the rank and file of doctors are no more scientific than their tailors. George Bernard Shaw
Below I have listed AAS belief systems for BodyBuilders; Physicians/Academics; & the evdidence from Research. Too often we attempt to see things as we wish or desire rather than the facts glaring us in the face. "You always hurt the one you love." We have such a strong desire to see caretakers in the best light possible. This is natural. However, how many times does someone have to be wrong, completely wrong (whacked) before we realize that they are seriously disturbed. The medcial community has forsaken the health of individuals for the safety of political and financial gain. You, unfortunately, are the recipients of this medical care. I apologize.
In the practice of medicine, uncertainty is both inevitable and disquieting. At least two things account for this endemic uncertainty: "first, defects in the knowledge of the individual physician and, second, the inadequacies of the profession's knowledge." Traditionally, physicians relied heavily on personal experience and anecdotal information.
Evidence-based medicine (EBM) is concept that practice of medicine should be based on firm data rather than anecdote, tradition, intuition, or belief. The conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients. The practice of EBM means integrating individual clinical expertise with the best available external clinical evidence from systematic research.
Evidence based health care is the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients. We already have evidence-based medicines, but we most certainly do not yet enjoy fully evidence-based health care.
Beliefs Held by the Athletic and the Academic Communities About the Effects of Androgenic Steroids in the 1970s and 1980s
BodyBuilders
Research
Physicians/Academics
Beliefs held by recreational body- builders and athletic community about AAS
What have recent studies revealed?
The physician/ academic view and belief.
AAS increase muscle mass, strength, and athletic performance.
---Replacement doses of testosterone when administered to hypogonadal men and supraphysiological doses when administered to eugonadal men increase fat-free mass, muscle size, and strength.
Only replacement doses of testosterone when given to hypogonadal men and prepubertal boys have anabolic effects. Supra- physiological doses of testosterone do not further increase muscle mass.
Higher doses of AAS promote greater increases in muscle mass and strength than lower doses; administering more than one androgenic steroid simultaneously (stacking) produces greater increases in muscle mass and strength than any single agent alone.
---A linear dose?response relationship exists between testosterone dose and its anabolic effects over a wide range of concentrations extending from subphysiologic to supraphysiologic range.
Beyond the physiologic range, further increases in the dose of AAS would produce no further gains in fat-free mass and muscle strength.
The anabolic and androgenic activities of AAS can be dissociated, so that some derivatives of testosterone have preferentially greater anabolic activity than androgenic activity.
---Different androgen- dependent processes have different dose? response relationships.
The anabolic and androgenic activity cannot be dissociated; they are described by the same dose?response relationship.
The anabolic and androgenic effects are mediated through separate mechanisms and thus can be dissociated.
---The anabolic effects are likely mediated through an androgen-receptor- mediated mechanism that involves recruitment of tissue- specific coactivators and corepressors.
The anabolic effects are mediated through an androgen-receptor- mediated mechanism.
The effects of AAS administration cause an up-regulation of the skeletal muscle androgen receptor (AR).
---AAS administration causes a upregulation of the skeletal muscle and bone androgen receptor (AR).
The effects of AAS administration cause a down-regulation of the skeletal muscle androgen receptor (AR).
HPTA Normalization after AAS cessation is variable and sometimes may never occur.
---The severity and duration of ASIH after AAS cessation is unknown and has been reported to take over 2+years.
AAS cessation uniformly results in HPTA normalization within 2 weeks to several months.
Signs & symptoms after AAS cessation are due inadequate gonadal function.
---There is no medical or scientific literature that supports AAS dependency/ addiction. AAS dependency/addiction is not a recognized disease within the ICD-10 or the DSM-IV.
AAS use is associated with adverse health consequences that include chemical dependency/addiction.
SCORECARD:
BodyBuilders ? 7
Physicians/Academics - 0
I presume nobody will question the existence of a widespread popular delusion that every doctor is a man of science. . .. As a matter of fact, the rank and file of doctors are no more scientific than their tailors. George Bernard Shaw
Below I have listed AAS belief systems for BodyBuilders; Physicians/Academics; & the evdidence from Research. Too often we attempt to see things as we wish or desire rather than the facts glaring us in the face. "You always hurt the one you love." We have such a strong desire to see caretakers in the best light possible. This is natural. However, how many times does someone have to be wrong, completely wrong (whacked) before we realize that they are seriously disturbed. The medcial community has forsaken the health of individuals for the safety of political and financial gain. You, unfortunately, are the recipients of this medical care. I apologize.
In the practice of medicine, uncertainty is both inevitable and disquieting. At least two things account for this endemic uncertainty: "first, defects in the knowledge of the individual physician and, second, the inadequacies of the profession's knowledge." Traditionally, physicians relied heavily on personal experience and anecdotal information.
Evidence-based medicine (EBM) is concept that practice of medicine should be based on firm data rather than anecdote, tradition, intuition, or belief. The conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients. The practice of EBM means integrating individual clinical expertise with the best available external clinical evidence from systematic research.
Evidence based health care is the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients. We already have evidence-based medicines, but we most certainly do not yet enjoy fully evidence-based health care.
Beliefs Held by the Athletic and the Academic Communities About the Effects of Androgenic Steroids in the 1970s and 1980s
BodyBuilders
Research
Physicians/Academics
Beliefs held by recreational body- builders and athletic community about AAS
What have recent studies revealed?
The physician/ academic view and belief.
AAS increase muscle mass, strength, and athletic performance.---Replacement doses of testosterone when administered to hypogonadal men and supraphysiological doses when administered to eugonadal men increase fat-free mass, muscle size, and strength.
Only replacement doses of testosterone when given to hypogonadal men and prepubertal boys have anabolic effects. Supra- physiological doses of testosterone do not further increase muscle mass.
Higher doses of AAS promote greater increases in muscle mass and strength than lower doses; administering more than one androgenic steroid simultaneously (stacking) produces greater increases in muscle mass and strength than any single agent alone.---A linear dose?response relationship exists between testosterone dose and its anabolic effects over a wide range of concentrations extending from subphysiologic to supraphysiologic range.
Beyond the physiologic range, further increases in the dose of AAS would produce no further gains in fat-free mass and muscle strength.
The anabolic and androgenic activities of AAS can be dissociated, so that some derivatives of testosterone have preferentially greater anabolic activity than androgenic activity.---Different androgen- dependent processes have different dose? response relationships.
The anabolic and androgenic activity cannot be dissociated; they are described by the same dose?response relationship.
The anabolic and androgenic effects are mediated through separate mechanisms and thus can be dissociated.---The anabolic effects are likely mediated through an androgen-receptor- mediated mechanism that involves recruitment of tissue- specific coactivators and corepressors.
The anabolic effects are mediated through an androgen-receptor- mediated mechanism.
The effects of AAS administration cause an up-regulation of the skeletal muscle androgen receptor (AR). ---AAS administration causes a upregulation of the skeletal muscle and bone androgen receptor (AR).
The effects of AAS administration cause a down-regulation of the skeletal muscle androgen receptor (AR).
HPTA Normalization after AAS cessation is variable and sometimes may never occur.---The severity and duration of ASIH after AAS cessation is unknown and has been reported to take over 2+years.
AAS cessation uniformly results in HPTA normalization within 2 weeks to several months.
Signs & symptoms after AAS cessation are due inadequate gonadal function. ---There is no medical or scientific literature that supports AAS dependency/ addiction. AAS dependency/addiction is not a recognized disease within the ICD-10 or the DSM-IV.
AAS use is associated with adverse health consequences that include chemical dependency/addiction.
SCORECARD:
BodyBuilders ? 7
Physicians/Academics - 0
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