Boldenone & trestolone

[bigdaddyandfriends]

Curious if anyone has trestolone with boldenone?

Started boldenone beginning of the month at ‘low dose’ of 30mg/day, no front loading. So I will take a long time to reach steady state. And of course a lot of the mg is ester.

I prefer to use trestolone with a tiny bit of testosterone over TRT. I tried primobolan with treat but didn’t really get any estrogen control.. it’s been a disappointment every time I’ve used it now.

I use Aromasin prn, so should know if EQ starts dropping my e2/7α-me-e2 by needing less of it.

My trest dose is only 6mg/day along with 5mg/day tren, both ace. I use mast too and recently replaced primo with half he dose of DHB… noticed a major strength boost after just a week, even without the front loading.

 

[Sampei]

So you are doing rainbow unicorn cycle, I see

 

[bigdaddyandfriends]

Yes I like the exotic stuff! Part because it works, and part because I enjoy experimenting.

Seriously though I am one of those that doesn’t handle typical testosterone doses well. If I done a typical bro cycle of 500test I’d be covered in acne, bald, and have a grapefruit sized prostate. And have bitch tits to go with it all.

It may be because of my age, I was natty until my early 50’s…

 

[Slowww]

i do this every off season. If test is bread and eq is butter ment is the cup of coffee. can’t go wrong with a cup of coffee. Just have to watch out for water, methylated estradiol and hematocrit mainly. Keeping the ment conservative and other ones moderate and I have no issues.

 

[Sampei]

My current cycle is a little bit of everything xD

Test
MENT
TREN
Npp
EQ
Mast

All at low dosages
I'm curious to see how it will end

 

[bigdaddyandfriends]

keep me please, that's basically what I'm doing. Just replaced primo with EQ + DHB, and have noticed a big difference in strength after just a couple weeks (obviously not from the EQ).

NPP is the one thing I'm not using. figured it doesn't serve much purpose with tren + ment already there, and I'm gyno prone too.

 

[Sampei]

keep me please, that's basically what I'm doing. Just replaced primo with EQ + DHB, and have noticed a big difference in strength after just a couple weeks (obviously not from the EQ).

NPP is the one thing I'm not using. figured it doesn't serve much purpose with tren + ment already there, and I'm gyno prone too.

I don't use DHB but I do love nandrolone, great for joint and just gives me a great look.

But dosages are low
100mg tren
200mg NPP
70mg trest
500mg EQ
300mg test
400mg mast

 

[krvuxn]

My current cycle is a little bit of everything xD

Test
MENT
TREN
Npp
EQ
Mast

All at low dosages
I'm curious to see how it will end

This is the same as what I’m running just without the NPP.

Test 625
Mast 600
EQ 600
Trest A 175
Tren 100

 

[sliderke]

This is the same as what I’m running just without the NPP.

Test 625
Mast 600
EQ 600
Trest A 175
Tren 100

Trest and tren together. Damn you must be a very relax guy off cycle to handle them together.

 

[Ruru_Teh_seks]

I'm also trying DHB at the moment and I'll probably add a little Ment to try it out.

 

[sionnach]

Curious if anyone has trestolone with boldenone?

Started boldenone beginning of the month at ‘low dose’ of 30mg/day, no front loading. So I will take a long time to reach steady state. And of course a lot of the mg is ester.

I prefer to use trestolone with a tiny bit of testosterone over TRT. I tried primobolan with treat but didn’t really get any estrogen control.. it’s been a disappointment every time I’ve used it now.

I use Aromasin prn, so should know if EQ starts dropping my e2/7α-me-e2 by needing less of it.

My trest dose is only 6mg/day along with 5mg/day tren, both ace. I use mast too and recently replaced primo with half he dose of DHB… noticed a major strength boost after just a week, even without the front loading.

I may have missed it in another thread, but how often are you doing labs? And did you do a draw right before starting the trest?

 

[krvuxn]

Trest and tren together. Damn you must be a very relax guy off cycle to handle them together.

I recently dropped the tren from 300 to 100 and increased the eq from 400 to 600 because I was getting too worked up all the time. I’ve not noticed trest cause any kind of negative mental sides, except for the usual 19nor laziness that I get. Nothing compared to deca though. All I want to do is train, everything else is a bit of a chore.

But yeah I’d say I’m pretty relaxed in general.

 

[ChemBB]

My trest dose is only 6mg/day

You might know this already, but that's roughly the equivalent of ~9mg Test in terms of E2 activity

I was running 200-300mg Trest D last blast, great stuff

5mg/day tren

Homeopathic, LaCroix tren dose, what's the rationale?

I'd say something like 50-75mg Tren/wk is the lowest that'd "do" anything within reason.

 

[sliderke]

You might know this already, but that's roughly the equivalent of ~9mg Test in terms of E2 activity

I was running 200-300mg Trest D last blast, great stuff


Homeopathic, LaCroix tren dose, what's the rationale?

I'd say something like 50-75mg Tren/wk is the lowest that'd "do" anything within reason.

TrestD maybe less side effects as acetate?

 

[ChemBB]

TrestD maybe less side effects as acetate?

Only difference is rate of release/blood concentration curve shape
Once the ester is cleaved in the body it's all Trestolone at the end of the day

I've run Trest E, Trest D, and Trest Ace and it all felt the same to me ¯\_(ツ)_/¯

 

[bigdaddyandfriends]

You might know this already, but that's roughly the equivalent of ~9mg Test in terms of E2 activity

I was running 200-300mg Trest D last blast, great stuff


Homeopathic, LaCroix tren dose, what's the rationale?

I'd say something like 50-75mg Tren/wk is the lowest that'd "do" anything within reason.

I've found even 5mg/day tren to make a difference in nutrient partitioning, feed efficiency and metabolic enhancement.

Trest I consider 1mg = 2mg test in terms of E2 production. That's factoring in aromatase conversion rate about 35% of testosterone, binding affinity 102% of estradiol, 400% transactivation of ER⍺/ERβ, and inability to be bound bye SHBG. Only the binding affinity is fairly certain (102%, so quite close to estradiol)... everything else is interpolated from other compounds, and the 4x transactivation was derived from T47Dco cells - a breast cancer cell line with resistance to estrogen because of a mutated ER and tetraploidy; possibly not the ideal cell line model to test transactivation of 7⍺-methylestradiol ?! So transaction in normal male calls maybe far closer to 1:1. But that 2x estrogenicity seems to be about right overall based on my MENT dosage and aromasin needs.

Primbobolan does not really affect my E2, so wanted to try EQ as it is also known for that. I still don't think EQ converts to estrone directly, or that any DHT-like androgen truly acts as an AI. But DHT and similar AAS do interact with 17β-HSD1/2 which might explain everything, as those enzymes control balance of estrone and estradiol; it is highly unnusual for one compound to be both a metabolite and a precursor to another, but that's exactly what we have here. A strong inhibitor of 17β-HSD1 could explain normal ECLIA estrogen but LC/MS high estrone + low estradiol readings some guys have received on EQ.

There is one 17-HSD1 inhibitor under investigation for endometriosis and breast/uterine cancer, called Linustedastat / FOR-6219. This drug should act as analogous to an AI by raising estrone and decreasing estradiol levels. Estrone is a week ER agonist, so is somewhat analogous to a SERM by occupying binding sites that could be used by estradiol.

 

[LGOP528]

I've found even 5mg/day tren to make a difference in nutrient partitioning, feed efficiency and metabolic enhancement.

Trest I consider 1mg = 2mg test in terms of E2 production. That's factoring in aromatase conversion rate about 35% of testosterone, binding affinity 102% of estradiol, 400% transactivation of ER⍺/ERβ, and inability to be bound bye SHBG. Only the binding affinity is fairly certain (102%, so quite close to estradiol)... everything else is interpolated from other compounds, and the 4x transactivation was derived from T47Dco cells - a breast cancer cell line with resistance to estrogen because of a mutated ER and tetraploidy; possibly not the ideal cell line model to test transactivation of 7⍺-methylestradiol ?! So transaction in normal male calls maybe far closer to 1:1. But that 2x estrogenicity seems to be about right overall based on my MENT dosage and aromasin needs.

Primbobolan does not really affect my E2, so wanted to try EQ as it is also known for that. I still don't think EQ converts to estrone directly, or that any DHT-like androgen truly acts as an AI. But DHT and similar AAS do interact with 17β-HSD1/2 which might explain everything, as those enzymes control balance of estrone and estradiol; it is highly unnusual for one compound to be both a metabolite and a precursor to another, but that's exactly what we have here. A strong inhibitor of 17β-HSD1 could explain normal ECLIA estrogen but LC/MS high estrone + low estradiol readings some guys have received on EQ.

There is one 17-HSD1 inhibitor under investigation for endometriosis and breast/uterine cancer, called Linustedastat / FOR-6219. This drug should act as analogous to an AI by raising estrone and decreasing estradiol levels. Estrone is a week ER agonist, so is somewhat analogous to a SERM by occupying binding sites that could be used by estradiol.

You still don’t want high E1 with lower E2. What you are describing is what happens in women when they go through menopause. They stop producing E2 and produce more E1. This is why osteoporosis, cardiovascular issues and a whole host of other problems happen with women during this time.

My understanding is that the ratio of E2:E1 is what matters.

 

[cap’nboldenone]

This is the same as what I’m running just without the NPP.

Test 625
Mast 600
EQ 600
Trest A 175
Tren 100

I’m not sure there’s enough telmisartan in the world for me to run this same cycle without developing stage 2 hypertension

 

[krvuxn]

I’m not sure there’s enough telmisartan in the world for me to run this same cycle without developing stage 2 hypertension

I was taking 40mg and it was in range, but now I’ve run out so I’m taking 80mg. Which one of those apart from ment raises your blood pressure so much?

I’ve had far more issues with a simple test, deca and dbol cycle in the past than I’ve had with this one! No headaches, no reflux. Especially now that I’ve lowered the tren to 100 I’m a lot less tightly wound.

 

[cap’nboldenone]

I was taking 40mg and it was in range, but now I’ve run out so I’m taking 80mg. Which one of those apart from ment raises your blood pressure so much?

I’ve had far more issues with a simple test, deca and dbol cycle in the past than I’ve had with this one! No headaches, no reflux. Especially now that I’ve lowered the tren to 100 I’m a lot less tightly wound.

Tren sends my bp to the moon, especially with higher test, and as much as I love EQ I’ll admit that it raises it a smidge too.