I ran it at .3mg 2x daily a while back and I noticed that stimulants didn't work as well. They just didn't pick me up, but I didn't feel depressed or down. Not sure if real or imagined but that was the only negative side I had. Wasn't close to 2mg/day though that seems super high.I read some reports of mild depressive episodes from high dose bpc (2 mg/day and high). When I personally used it I found nothing mentally but everyone reacts differently