Cabergoline

[foreveryoung]

How is it "evil" ?
Now this, this is interesting.

[popcorn]

have you tried it? maybe my choice of word evil was dramatic, but for me that is an accurate feeling. gave it a chance a few runs and it is really good at making me feel really bad with no upside, I'm flushing the rest down the toilet

 

[corageon]

The correct word is "those" you moron. Go back to using your spell and grammar check.

Using the word "those" would be more objective actually, as if we knew what eye glasses you were buying, it's too formal. "Them" is more sarcastic and common form, it's only a technical mistake, not an utter grammatical incorrectness.

 

[toolman]

Using the word "those" would be more objective actually, as if we knew what eye glasses you were buying, it's too formal. "Them" is more sarcastic and common form, it's only a technical mistake, not an utter grammatical incorrectness.[/QUOTE]

Once again, an excuse for your idiocy. I pity your poor parents. I won't even get started on how you ended this sentence. I think we have all seen what an idiot you are in your previous posts regarding your lack of verbal skills.

 

[corageon]

Using the word "those" would be more objective actually, as if we knew what eye glasses you were buying, it's too formal. "Them" is more sarcastic and common form, it's only a technical mistake, not an utter grammatical incorrectness.[/QUOTE]

Once again, an excuse for your idiocy. I pity your poor parents. I won't even get started on how you ended this sentence. I think we have all seen what an idiot you are in your previous posts regarding your lack of verbal skills.

You are certainly spending ALOT of time on here in the Afternoon. Glad you are having a good lunch break, or can you not afford lunch Today?

 

[toolman]

You are certainly spending ALOT of time on here in the Afternoon. Glad you are having a good lunch break, or can you not afford lunch Today?

I'm retired little man. As I worked hard all my life and actually studied at a real college and law school, some are fortunate such as myself to do that early in life. What about you blogger to millions, successful real estate magnate and oracle of nothing?

I am guessing that since you refer to lunch as a "lunch break", you are not familiar with life in the professional world. Do not worry, your lack of vocabulary and grammatical skills has already indicated that long ago.

 

[corageon]

I'm retired little man. As I worked hard all my life and actually studied at a real college and law school, some are fortunate such as myself to do that early in life. What about you blogger to millions, successful real estate magnate and oracle of nothing?

I am guessing that since you refer to lunch as a "lunch break", you are not familiar with life in the professional world. Do not worry, your lack of vocabulary and grammatical skills has already indicated that long ago.

Yeah, you certainly are retired. What you don't know though, is how much I know about you. Just by the way you talk, and the paralegal comments, I have found out quite a bit of information on you.

It's amazing how much a few sentences can reveal.
Law Firms may have some reach, but not as much reach as some people...

 

[toolman]

Yeah, you certainly are retired. What you don't know though, is how much I know about you. Just by the way you talk, and the paralegal comments, I have found out quite a bit of information on you.

It's amazing how much a few sentences can reveal.
Law Firms may have some reach, but not as much reach as some people...

Lol...not even original. You are quoting me you moron...but clearly forgot your source. Like I said, I have grown bored and I am sure the rest are weary of your stupidity.

 

[ehudxx]

Hey Toolman and Corageon , this topic is important to me so please make peace by ignoring each other. Toolman, I respect your opinion and any scammer needs to be exposed. I'm just looking for as much hands on Cabergoline usage I can get. I've read all your stuff on both the Steroid forum
and here. I understand. Even Dr. Jim trashes his viewpoints, as well as several others. But, the guy has not done anything to me.

 

[CensoredBoardsSuck]

Hey Toolman and Corageon , this topic is important to me so please make peace by ignoring each other. Toolman, I respect your opinion and any scammer needs to be exposed. I'm just looking for as much hands on Cabergoline usage I can get. I've read all your stuff on both the Steroid forum
and here. I understand. Even Dr. Jim trashes his viewpoints, as well as several others. But, the guy has not done anything to me.

Actually, he has done something to you. He's "done something" to everybody in Men's Health by wreaking havoc in every thread that he's infected with his nonsense.

Regardless, vermin like Contagion cannot be ignored because the result will be noobs getting scammed and an infestation of shills and snake oil salesmen that render Men's Health useless for any serious evidence based discussion. These shills need to be stamped out. People like Contagion destroyed usenet and with the advent of Tor and hide your ass ISP's, it's now happening to web based forums too.

If you don't like it, complain to Millard and get this clown banned.

 

[ehudxx]

I guess I never looked at it that way. Thanks for setting me straight.

 

[toolman]

Actually, he has done something to you. He's "done something" to everybody in Men's Health by wreaking havoc in every thread that he's infected with his nonsense.

Regardless, vermin like Contagion cannot be ignored because the result will be noobs getting scammed and an infestation of shills and snake oil salesmen that render Men's Health useless for any serious evidence based discussion. These shills need to be stamped out. People like Contagion destroyed usenet and with the advent of Tor and hide your ass ISP's, it's now happening to web based forums too.

If you don't like it, complain to Millard and get this clown banned.

That is the nice part about invite only forums where everyone is vetted. You never have to deal with these clowns. However that is of no help to the new guys who are truly in here with serious questions that they want answered by someone in the know...not community college dropouts that are playing Dr. and may sound like they know what they are doing, but are truly clueless.

 

[Dr JIM]

Definitely, but Caber is worth the go, its half life is impeccable. There are also research chemical sites for the Prami as well (aka liquid prami).

RUI products used to have some good ones,
=== How do you know they are GOOD have you had this RESEARCH LAB products analyzed. ==========F NO!!!
=====Gabergoline is a DOPAMINE AGONIST with potentially serious side effects (including the possibility of valvular heart disease) that are DOSE related and for that reason I wouldn't even consider using a non-pharm grade product =====

What in the hell you referring to Gaber is worth a go?
==== Damn fool! "Worth a go" for what indication or does that matter? ===

Because of it's "an impeccable half life"?
====So your now defining the quality, efficacy, bioavailability or cost of a drug based on it's "half life" Conatgion! LMFAO=====
===Oh that's right its impeccable because it's half life approximate THREE DAYS so when someone OD's on that crap from RUI products that you RECOMMENDED their in it for the long haul. ========

====== THREE DAY half life impeccable WTF, DAMN your one ignorant and dangerous fuck =====================

 

[Dr JIM]

Thanks Forever.
I'm at my wits end with my libido. Its been almost 5 years without one.
AAS does not help at any dosage. I've read some great things about
Caber and very little against using it.
Thanks for your opinion, its important to me.

More BS has been contrived, conceived or has convinced mates to use Gabergoline, (which is designed to treat Parkinson's or Prolactinoma patients) than ONE UNCONTROLLED STUDY involving roughly 20 patients. The authors conclusion, Gaber may aid those with "ANORGASMIA", period!

Those remaining comments touting Gaber as the next Viagra are absolute BULLSHIT, since they are derived from rat studies, bro science, blogs, forums, or from a "placebo effect" which approximates 30% in many ED studies!

Finally I've had at least FIFTY PATIENTS use Gaber for the SD you (the OP) seems to be referring to, and NONE noted any benefit yet several developed intolerable side effects!

jim

 

[Dr JIM]

I should state there is no ABSOLUTE proof that AAS will ensure a healthy or enhanced libido as some people would like to think, although often it is the case.
But which AAS are you referring to?
Test E + Cyp + Proviron + Masteron is usually a solid cocktail for such an androgenic effect.

Caber is pretty effective, keep in mind it also has a positive modulating effect on Serotonin though, Prami however does NOT have affinity for serotonin receptors.

So paradoxically, even despite the dopaminergic effect, with the serotonin effect you may actually have a lowered libido as so many have complained with Caber.

There are other tactics though. For example, you could use a serotonin blocking agent such as Remeron, and have Caber to go along with that. That is an option.
If You wanna go further than that, I would say add some Forskolin to those two.

DAMN HOW DO YOU CONCOCT SUCH HORSE SHIT!!


Finally, the fourth thing you can attempt, is to ensure the Glutamatergic Pathway is activated, specifically through the NMDA's and AMPA - Piracetam works for this.

OVERVIEW FOR ENSURING NEURAL NETWORKS.

1.) Caber (D(2)(3)(4) Agonist) (Dopaminergic)
2.) Remeron (5-HT2(A/C) Blocker + 5-HT3 Blocker)
3.) Forskolin (Adenylyl Cyclase Activator)
4.) Piracetam (AMPA / NMDA Modulator)

"Neuronal networks" LMFAO
DAMN HOW DO YOU CONCOCT SUCH HORSESHIT?
[)]
[)][)]
[)][)][)]

 

[ehudxx]

I hope you guys know I really appreciate your feedback. I will continue to pursue my quest for my lost libido, but not with Cabergoline or corageon's
posts. After nearly 5 years I guess I was getting desperate.

 

[CensoredBoardsSuck]

Because of it's "an impeccable half life"?
====So your now defining the quality, efficacy, bioavailability or cost of a drug based on it's "half life" Conatgion! LMFAO=====
===Oh that's right its impeccable because it's half life approximate THREE DAYS so when someone OD's on that crap from RUI products that you RECOMMENDED their in it for the long haul. ========

====== THREE DAY half life impeccable WTF, DAMN your one ignorant and dangerous fuck =====================

So, would you say its adverse events are impeccable too? Perhaps its bioavailabilty is impeccable?

I think its pharmacokinetic interaction with L-dopa is both nefarious and perceptive. Do you agree?

 

[corageon]

I hope you guys know I really appreciate your feedback. I will continue to pursue my quest for my lost libido, but not with Cabergoline or corageon's
posts. After nearly 5 years I guess I was getting desperate.

Be careful there who you listen to, but Caber can be effective if you have an elevated PRL (Prolactin) level.

As I said, dopamine agonists can paradoxically have an adverse effect.
Dr.Jim wasn't lying about the effects on the heart, but he didn't go too much into detail. Specifically, because they are dopaminergic agonists with only affinity (affecting) only type (2) (3) (4) receptors, they will depress the nervous system, and lower heart and BP. Some people also will wake up extremely fatigued the next morning because of this, they also can decrease thyroid function due to the same mechanism.

 

[Dr JIM]

Be careful there who you listen to, but Caber can be effective if you have an elevated PRL (Prolactin) level.

As I said, dopamine agonists can paradoxically have an adverse effect.
Dr.Jim wasn't lying about the effects on the heart, but he didn't go too much into detail.

===== Enough "detail" do you know what valvular heart disease is Clown? Nope - of course and that's why Bozo's like you can be dangerous
===== ever heard of Mitral or Aortic Valve incompetence? Nope Hmm ever heard of THE DRUG COMBO FENPHEN DUMB ASS ==========

Specifically, because they are dopaminergic agonists with only affinity (affecting) only type (2) (3) (4) receptors, they will depress the nervous system, and lower heart and BP. ===== WRONG dopamine agonists MAY lower BP because of vasodilation ===== the heart rate actually INCREASES Clown! ====

Some people also will wake up extremely fatigued the next morning because of this,

======= because of WHAT? ====== Exclusive of orthostasis some patients develop upon assuming an erect posture from a supine position, the "fatigue" experienced is caused by the effects of dopamine on the CNS =====

they also can decrease thyroid function due to the same mechanism.

====Can you provide any evidence GABERGOLINE causes thyroid dysfunction simply because Dopamine receptors are involved in the pituitary release of TSH===== HELL NO/ ===== WHY IS THAT? BECUAE THERE IS NO SUCH EVIDENCE

. What's become clear to me and probably every one else on Meso, you don't give a shit wether your comments are evidence based as long as they 'increase your post count" and your snake oil sales.

 

[corageon]

====Can you provide any evidence GABERGOLINE causes thyroid dysfunction simply because Dopamine receptors are involved in the pituitary release of TSH===== HELL NO/ ===== WHY IS THAT? BECUAE THERE IS NO SUCH EVIDENCE

. What's become clear to me and probably every one else on Meso, you don't give a shit wether your comments are evidence based as long as they 'increase your post count" and your snake oil sales.

D(2)(3)(4) Agonists decrease adenylyl cyclase - leading to a DECREASE in cyclic AMP, which results in lessened T4 conversion! (1) (2) (3)
So no, TSH itself isn't disrupted, but the overall thyroid EFFICIENCY is.

Imbalance between thyroid hormones and the dopaminergic system might be central to the pathophysiology of restless legs syndrome: a hypothesis

TH levels follow DA levels14–16 Thus, the depressing effects of DA on TH are a concern in certain clinical settings.27–29 Thyroid-releasing hormone (TRH) regulates TSH synthesis by stimulating the transcription and translation of the TSH ?-subunit gene; dopamine inhibits this process.30 Anti-DA drugs such as metoclopramide aggravate the symptoms of RLS,17 while DA agonists diminish RLS symptoms.31–35 Reduced levels of iron diminish the DA system, which in turn aggravates RLS.10–12, 22 TH axis heightens during sleep deprivation, as demonstrated in voluntary sleep deprivation. 23 Sleep deprivation, in turn, is well known to aggravate RLS symptoms.5 Some of the effects of increased TH, such as hyperthyroidism, resemble some symptoms of RLS patients.21, 22

Possible Influence of Dopaminergic Receptor in Maintenance of Thyroid Hormone Homeostasis: A Study in Adult Rat Brain | Kundu | Journal of Endocrinology and Metabolism


DRUGS THAT SUPPRESS TSH OR CAUSE CENTRAL HYPOTHYROIDISM



Cabergoline. A review of its pharmacological propertie... [Drugs. 1995] - PubMed - NCBI


Abstract
Cabergoline is a synthetic ergoline which shows high specificity and affinity for the dopamine D2 receptor. It is a potent and very long-acting inhibitor of prolactin secretion. Prolactin-lowering effects occur rapidly and, after a single dose, were evident at the end of follow up (21 days) in puerperal women, and up to 14 days in patients with hyperprolactinaemia. In the only comparative study to date, cabergoline 0.5 to 1.0 mg twice weekly was more effective than bromocriptine 2.5 to 5.0 mg twice daily in the treatment of hyperprolactinaemic amenorrhoea, restoring ovulatory cycles in 72% of women and normalising plasma prolactin levels in 83%, compared with 52 and 58%, respectively, for bromocriptine. In the prevention of puerperal lactation, a single dose of cabergoline 1.0mg was as effective as bromocriptine 2.5mg twice daily for 14 days. A significantly lower incidence of rebound lactation in the third postpartum week was seen with cabergoline. Unpublished data suggest cabergoline 0.25mg twice daily for 2 days is effective in suppressing established puerperal lactation in about 85% of women. Nausea, vomiting, headache and dizziness are characteristic adverse events of the dopaminergic ergot derivatives. Cabergoline appears to be better tolerated than bromocriptine in both patients with hyperprolactinaemia and postpartum women. Most patients intolerant of other ergot derivatives can tolerate cabergoline. Bromocriptine use in the puerperium has been associated with an increased risk of serious thromboembolic events. However, there are no such reports with cabergoline and whether these events will become associated with other dopaminergic agents is unknown. The teratogenic potential of cabergoline has not been extensively investigated in humans. Ten congenital abnormalities have been reported in 199 cabergoline-associated pregnancies. Although there is no pattern to these abnormalities, the limited experience with cabergoline in pregnancy means the drug cannot be considered as a first-line therapy for the treatment of infertility associated with hyperprolactinaemia. At this stage of its development, cabergoline will prove useful in patients with hyperprolactinaemia who have failed treatment with, or are intolerant of, other dopamine agonists such as bromocriptine. If drug treatment is required for the prevention or suppression of puerperal lactation, cabergoline offers significant advantages over bromocriptine and should become the drug treatment of first choice for this indication.
PMID: 7729332 [PubMed - indexed for ME

 

[CensoredBoardsSuck]

D(2)(3)(4) Agonists decrease adenylyl cyclase - leading to a DECREASE in cyclic AMP, which results in lessened T4 conversion! (1) (2) (3)
So no, TSH itself isn't disrupted, but the overall thyroid EFFICIENCY is.

Imbalance between thyroid hormones and the dopaminergic system might be central to the pathophysiology of restless legs syndrome: a hypothesis




Possible Influence of Dopaminergic Receptor in Maintenance of Thyroid Hormone Homeostasis: A Study in Adult Rat Brain | Kundu | Journal of Endocrinology and Metabolism


DRUGS THAT SUPPRESS TSH OR CAUSE CENTRAL HYPOTHYROIDISM



Cabergoline. A review of its pharmacological propertie... [Drugs. 1995] - PubMed - NCBI


Abstract
Cabergoline is a synthetic ergoline which shows high specificity and affinity for the dopamine D2 receptor. It is a potent and very long-acting inhibitor of prolactin secretion. Prolactin-lowering effects occur rapidly and, after a single dose, were evident at the end of follow up (21 days) in puerperal women, and up to 14 days in patients with hyperprolactinaemia. In the only comparative study to date, cabergoline 0.5 to 1.0 mg twice weekly was more effective than bromocriptine 2.5 to 5.0 mg twice daily in the treatment of hyperprolactinaemic amenorrhoea, restoring ovulatory cycles in 72% of women and normalising plasma prolactin levels in 83%, compared with 52 and 58%, respectively, for bromocriptine. In the prevention of puerperal lactation, a single dose of cabergoline 1.0mg was as effective as bromocriptine 2.5mg twice daily for 14 days. A significantly lower incidence of rebound lactation in the third postpartum week was seen with cabergoline. Unpublished data suggest cabergoline 0.25mg twice daily for 2 days is effective in suppressing established puerperal lactation in about 85% of women. Nausea, vomiting, headache and dizziness are characteristic adverse events of the dopaminergic ergot derivatives. Cabergoline appears to be better tolerated than bromocriptine in both patients with hyperprolactinaemia and postpartum women. Most patients intolerant of other ergot derivatives can tolerate cabergoline. Bromocriptine use in the puerperium has been associated with an increased risk of serious thromboembolic events. However, there are no such reports with cabergoline and whether these events will become associated with other dopaminergic agents is unknown. The teratogenic potential of cabergoline has not been extensively investigated in humans. Ten congenital abnormalities have been reported in 199 cabergoline-associated pregnancies. Although there is no pattern to these abnormalities, the limited experience with cabergoline in pregnancy means the drug cannot be considered as a first-line therapy for the treatment of infertility associated with hyperprolactinaemia. At this stage of its development, cabergoline will prove useful in patients with hyperprolactinaemia who have failed treatment with, or are intolerant of, other dopamine agonists such as bromocriptine. If drug treatment is required for the prevention or suppression of puerperal lactation, cabergoline offers significant advantages over bromocriptine and should become the drug treatment of first choice for this indication.
PMID: 7729332 [PubMed - indexed for ME

More bullshit.


Your citations don't support your bullshit, Contagion. The thyroid isn't even mentioned in most of these studies. You would have to commit every logical fallacy known to man to reach your conclusions.

By citing the study below, you show you don't even know the difference between thyroid dysfunction associated with NTIS and real hypothyroidism.

Fortunately, most of these medications do not cause clinically evident central hypothyroidism. A newer class of nuclear hormone receptors agonists, called rexinoids, cause clinically significant central hypothyroidism in most patients and dopamine agonists may exacerbate ‘hypothyroidism’ in patients with nonthyroidal illness. In this review, we explore mechanisms governing TSH suppression of these drugs and the clinical relevance of these effects.

Imbalance between thyroid hormones and the dopaminergic system might be central to the pathophysiology of restless legs syndrome: a hypothesis

I don't know if you're just obtuse and really believe this nonsense or if you're very skillful at being deceptive in order to make a sale. I'm almost inclined to think you don't know any better and really believe in this crap. Either way, you are still FOS!