Nested
Member
For those who have tried both Cagrilintide and Semaglutide. If you had to pick just one, which would you say is better for fat loss and overall results?
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Cagrilintide vs. Semaglutide – Which One Would You Choose?
- Thread starter Nested
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AlexDavis43
Member
Is that you in the avatar? Doesn't look like you have a lot of body fat.
Trying to go from visible abs to shredded ab veins? Or trying to improve other health markers? etc
primojuju
Member
I have used all of them, in different combinations and solo. Cagri solo is my favorite by far.
In my opinion and experience if you are already relativly lean (not obese) they all offer about the same amount of weight loss potential. In my case its all about just sticking to the pre planned prepped meals and maintaining the calorie deficit, and they all work. It's just a matter of finding which one fits you best.
Sema works just fine when you find the adequate dose, but gives me miserable side effects no matter how much btane hcl and metamucil i take. Significantly slows the gut so you can't eat, but food noise and desire to eat is still there. Cant push myself super hard in the gym without feeling sick. Not for me
Cagri works just fine when you find the adequate dose, for me it was .6mg a week. For me it seems to ONLY supress the mental drive to eat, and supress the type of food i care to eat. I literally feel like im just fueling a machine and i care about macros but i could be eating Soylent and it wouldn't bother me. It gives me no undesirable effects, has no slowing of the gut i can notice at this dose, and allows me to go as hard as i can muster in the gym.
Tirz,maz,reta,survo. These all will be a combo of glp and either gip and or glucagon. Between them having varying "strengths" of glp and the additional other actions they definitely seems to lessen the sides but i still experience drops in cardiovascular endurance and not feeling like i can push as hard as I want on all of them. I know people on the highest dose of tirz (15mg i believe) and they have none of the issues i have experienced.
You might just have to try and see for yourself.
It might seem like your getting dogged on about the intro post, but please understand, its with the best of intentions for the forum.
Nested
Member
Yes, that’s me in the avatar. I always keep my abs fully visible since I don’t let myself get fat while bulking or cutting—I stay within a 250 to 500 calorie surplus or deficit depending on my goal, so my body fat never gets out of control.
I take Retatrutide mainly to help with food noise and for the focus and clarity it brings. It makes it a lot easier to stay locked in and consistent without constantly thinking about food.
Nested
Member
My diet and training are always on point, and I use Retatrutide primarily to help with food noise and energy levels. I’ve tried Tirz before and loved the appetite suppression it provided, but I noticed that Retatrutide feels better overall and is much more effective at burning fat.
That’s actually why I was considering adding a very small dose of either Semaglutide or Cagrilintide—to enhance the appetite suppression aspect. While Retatrutide does help me feel satiated and get full quicker, it doesn’t suppress my appetite in the same way Tirz did. I still find myself thinking about food throughout the day, especially sweets, which wasn’t an issue when I was on Tirz.
So, I’m exploring ways to get that same level of appetite control without sacrificing the benefits I’m getting from Retatrutide
Nested
Member
You mentioned a 0.6 mg dose for your Cagri—what was your Sema dose? I’m trying to compare the ratio between the two and see which one was stronger. Since I’ll be adding it to Reta, I doubt I’ll need a full dose, just a very small amount.
Ghoul suggested starting with 0.1 mg of Sema alongside Reta and working up to 0.25 mg per week if needed. I just want to get an idea of what a good starting dose for Cagri would be so I can avoid any unwanted side effects while stacking it with Reta.
primojuju
Member
I don't think i can recommend anybody start stacking them just because there isn't much data. But if I wanted to add cagri I would start at .1-.3mg, pretty much the same dose as if you were adding sema. Novos cagrisema is a 1:1 ratio, so they are probably on to something there. As for strength im not sure you can compare them. To me they feel very different.
Nested
Member
This is exactly the information I was looking for. Really appreciate you sharing your experience—this helps a lot. Thanks.
Nested
Member
@Ghoul
I don’t have access to CagriSema, so I need to mix Cagrilintide and Semaglutide separately. My question is, can I combine them in the same syringe, or is it better to inject them separately? I remember you mentioning something about this in another thread, and I just wanted to double-check with you.
Also, since I’ll be using such low doses (around 0.1-0.25 mg of each) and the vials come in no less than 5 mg for Semaglutide and 10 mg for Cagrilintide, I’m a bit concerned about potential degradation since it’ll take a long time to go through them. How long would you wait before discarding an open vial and starting a new one to avoid any loss of potency?
I don’t have access to CagriSema, so I need to mix Cagrilintide and Semaglutide separately. My question is, can I combine them in the same syringe, or is it better to inject them separately? I remember you mentioning something about this in another thread, and I just wanted to double-check with you.
Also, since I’ll be using such low doses (around 0.1-0.25 mg of each) and the vials come in no less than 5 mg for Semaglutide and 10 mg for Cagrilintide, I’m a bit concerned about potential degradation since it’ll take a long time to go through them. How long would you wait before discarding an open vial and starting a new one to avoid any loss of potency?
Ghoul
Member
Peptides ≤ 40 amino acids go through the standard drug approval process. Much faster and simpler than the "biologics" route required for larger proteins.
LMAO........ So in reality these drugs could probably be made much more effective if not for this stupidity
Ghoul
Member
There are a few other nuances (exclusive marketing time limits etc), but yes, because of the law, drug companies have a strong financial incentive to not exceed 40 amino acids.
Totally artificial limit preventing protein drugs from being much better than they would otherwise be.
Cagri-Sema was an attempt to get around this, since its two seperate peptides, but that's created all sorts of manufacturing complications and additional expense since you can't just mix two peptides in the same vial without numerous technical issues that have to be dealt with.
Thoughts on cagri stability/ph, fibrils, etc.
Figured you'd have an opinion since you seem to read up a bit.
I dont use it but it's always funny to watch the back and forth on the topic.
Ghoul
Member
Mixing peptides is unwise. It's a demonstrable fact that they can merge, creating random new drug molecules with completely unknown effects. 99.999% of these modified proteins may become inert and useless (a waste of peptide at the least), and the other .001% may do something very undesirable not noticeable for a long time, by which point no connection could possibly be made to the cause. How often is the root cause of brain or prostate cancer established? Parkinson's or any other neurodegenerative disease?
Here's Semaglutide that's been in contact with BPC-157. The points changed on the Sema amino chain (chemically) and (on the 3d molecule) structure are marked in red. This isn't Sema anymore. It's a completely different peptide. What does it do? What are the long term consequences of exposure to this randomly created peptide?
Who the hell knows. Do we need a trial that injects 1000 people with this every week for a year or two to establish whether it's risky or not?
But if the user gets the expected effect to some degree, if they don't have to rush to the hospital "it's fine".
It's impossible to reason with the "I did it and it's fine" crowd who insist that harms must either be noticeable immediately, or that impossible to conduct studies that intentionally expose humans to something potentially harmful must be done to establish "proof" of harm.
That's not at all how harm reduction is approached by medical science. Safety needs to be demonstrated, not harm.
Hypothesis and signals are more than enough to warrant avoiding potential risks. Especially when it'd be nearly impossible to connect some slow developing disease to the something you injected a few dozen times years before.
It's simple. To minimize the inherent risks of injecting unregulated, largely untested substances, you should do everything reasonable to ensure you're only injecting the compound you want, with as little "other random shit" as possible.
I don't need "proof" that injecting glass particles, frankenpeptides, or protein aggregates on a daily basis is best avoided for long term health.
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Was more so alluding to cagri unstability based on novos trials and the fact they had to have the ph at 4. Less on the combination of peptides. Has been debated for a long time in peptide communities. Fibrils. Blood brain barrier. The like.
I stay away from it period because I firmly believe I can get a little supression from more well known peptides. Why risk it period. I'm already taking a risk with injecting bathtub peps from CN.
Ghoul
Member
Cagri missed the mark tanking Novo's stock. They have to look ahead at what's coming, which in GLPs is a lot from many directions.
May make the most business sense to go with the higher dose Sema they've already trialed for a more effective weight loss option where needed, and targeting the low price option of the market for which there's a huge unmet demand and a fortune to be made in, put Cagri back on the shelf and invest in developing longer shot options, like the "glp+muscle preservation" golden ring drugs being worked on, for the "high priced high margin" premium market.
Because as it stands, they've got a difficult (and therefore costly) to produce product that isn't going to compete well with Tirz or Reta.
Ghoul
Member
Looks like Sema doses up to 7.2mg are going to hit the market later this year.
Caremark, the 2nd largest pharmacy benefits manager service in the US, covering meds for 103 million patients in the US recently announced they're dropping Zepbound (Tirz) coverage and transitioning those patients to Wegovy (Sema).
That's huge (in a shit way for patients) but a clear indicator Novo Nordisk has decided to offer Sema as the cheaper alternative to Tirz, and going to max doses of 7.2mg for Sema significantly closes the gap between the two.
Still, a lot of metabolic benefits are lost vs Tirz, and a terrible development for future patients with Caremark.
This also brings into question just how willing insurance will be to cover newer, presumably more expensive GLPs like Reta or CagriSema, if they're willing to boot millions of people off Zepbound (which had dropped significantly in price already).
*I say "future" because existing patients with a sharp doctor may be able to fight to keep them on Zepbound, especially if they're on maintenance doses of 12.5mg+ which 7.2mg Sema can't match in terms of weight loss.
Caremark, the 2nd largest pharmacy benefits manager service in the US, covering meds for 103 million patients in the US recently announced they're dropping Zepbound (Tirz) coverage and transitioning those patients to Wegovy (Sema).
That's huge (in a shit way for patients) but a clear indicator Novo Nordisk has decided to offer Sema as the cheaper alternative to Tirz, and going to max doses of 7.2mg for Sema significantly closes the gap between the two.
Still, a lot of metabolic benefits are lost vs Tirz, and a terrible development for future patients with Caremark.
This also brings into question just how willing insurance will be to cover newer, presumably more expensive GLPs like Reta or CagriSema, if they're willing to boot millions of people off Zepbound (which had dropped significantly in price already).
*I say "future" because existing patients with a sharp doctor may be able to fight to keep them on Zepbound, especially if they're on maintenance doses of 12.5mg+ which 7.2mg Sema can't match in terms of weight loss.
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