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Study Unveils Newest Front in Doping Fight
[SIZE=-1]Bicycling [/SIZE]
[SIZE=-1]In early 2008, scientists at Columbia University built on previous research and tested an emerging thesis for muscle fatigue: the culprit, they wrote, was calcium. As it flows between cells in muscle, it controls contraction and relaxation. But over time, the channels that calcium flows through begin to leak, weakening the muscle contractions and activating an enzyme that destroys muscle fiber. [...][/SIZE]
[SIZE=-1]The test focuses on a class of drugs called benzothiazepines, the same type as the rycals that Dr. Marks is experimenting with. (Thevis thinks the term rycal may be Dr. Marks shorthand for the ryanodine-calstabin1 receptor complex the drugs target.) Similar benzothiazepines are already widely available as anti-angina drugs, but Thevis points to a crucial difference: the drugs already on the market, like Cardizem, block calcium channels rather than modify or control the gating. Thats good for a heart drug designed to treat chest pain or arrythmia, but not for the demands of exercise. The benzothiazepines he and Dr. Marks worked with were chemically altered to modify calcium channel gating rather than block it.[/SIZE][SIZE=-1] [...][/SIZE]
[SIZE=-1]Aside from performance enhancement, theres also the dark possibility of the health effects of abusing calcium-channel modulators. As Dr. Steven Liggett, a heart researcher at the University of Maryland pointed out to the New York Times last February, fatigue exists for a reason; without it, we might literally run ourselves to death. Given elite sport's track record with doping-related deaths, that becomes more than just a theoretical possibility. [/SIZE]
[SIZE=-1]...[/SIZE]
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[SIZE=-1]Bicycling [/SIZE]
[SIZE=-1]In early 2008, scientists at Columbia University built on previous research and tested an emerging thesis for muscle fatigue: the culprit, they wrote, was calcium. As it flows between cells in muscle, it controls contraction and relaxation. But over time, the channels that calcium flows through begin to leak, weakening the muscle contractions and activating an enzyme that destroys muscle fiber. [...][/SIZE]
[SIZE=-1]The test focuses on a class of drugs called benzothiazepines, the same type as the rycals that Dr. Marks is experimenting with. (Thevis thinks the term rycal may be Dr. Marks shorthand for the ryanodine-calstabin1 receptor complex the drugs target.) Similar benzothiazepines are already widely available as anti-angina drugs, but Thevis points to a crucial difference: the drugs already on the market, like Cardizem, block calcium channels rather than modify or control the gating. Thats good for a heart drug designed to treat chest pain or arrythmia, but not for the demands of exercise. The benzothiazepines he and Dr. Marks worked with were chemically altered to modify calcium channel gating rather than block it.[/SIZE][SIZE=-1] [...][/SIZE]
[SIZE=-1]Aside from performance enhancement, theres also the dark possibility of the health effects of abusing calcium-channel modulators. As Dr. Steven Liggett, a heart researcher at the University of Maryland pointed out to the New York Times last February, fatigue exists for a reason; without it, we might literally run ourselves to death. Given elite sport's track record with doping-related deaths, that becomes more than just a theoretical possibility. [/SIZE]
[SIZE=-1]...[/SIZE]
More...
