Came off everything - high progesterone (almost trippled), E2 not detected

[Fxxy]

Hello guys,

I am looking for a little advice from you or any tip. After year of blasting/cruising I came off everything because I am trying to get fertile. I started PCT 2 weeks after my last test E shot (62,5mg). Did 10 000 IU of HCG in these 2 weeks.

I finished PCT ( 5 weeks of clomid, nolva, exe) and then 1 and half week after PCT end I went for blood test. Everything was fine and went as expected.
My testosterone levels are super low - 1,80 nmol/l (8-29 range) - this was expected I felt like I did not recover. LH and FSH are both super low also so I am going to use 1000IU of HCG 3 times per week and combined with HMG later on which should help me to get fertile and rise the levels.
My concern is the high progesterone - what can be the cause? My progesterone levels are 1,5 nmol/l which is tripple the high range (0,159 - 0,474).
My E2 levels are not detected <20 (41 - 159) and prolactin levels are a bit above the range - 419 mU/l (86-324) So I took a little bit of caber when I saw the result.
Is there anything I can do to lower the progesterone or what can be the cause of this? I know I can solve the E2 low levels with HCG which should also raise my testosterone levels but I really have trouble finding anything about the high progesterone levels)

 

[Evom1]

Are you saying you took exemestane during pct?

 

[Fxxy]

Yes I did because I had some high E2 related symptoms. But does it have anything to do with high progesterone?

 

[Evom1]

Yes I did because I had some high E2 related symptoms. But does it have anything to do with high progesterone?

I'm asking because you stated that as well as the fact your e2 is crashed and those would be connected

 

[Fxxy]

Ye but that's kinda obvious and also connected with low T but my question is about the high progesterone.

 

[Zeus45]

a lot of steroid users have high progesterone. it's not something i try to lower.

 

[Type-IIx]

hCG/LH increases side-chain cleavage of cholesterol via cyt. P450 (20-hydroxylase, 22-hydroxylase, 20,22-lyase activity), thereby increasing pregnenolone that via 3B-HSD yields progesterone - so in this case I'd be looking at hCG.

A secondary factor includes some potential cross-reactivity with exemestane if it's still circulating. Exemestane has weak-very weak (0.09%) cross-reactivity with the Progesterone II immunoassay.

 

[Fxxy]

hCG/LH increases side-chain cleavage of cholesterol via cyt. P450 (20-hydroxylase, 22-hydroxylase, 20,22-lyase activity), thereby increasing pregnenolone that via 3B-HSD yields progesterone - so in this case I'd be looking at hCG.

A secondary factor includes some potential cross-reactivity with exemestane if it's still circulating. Exemestane has weak-very weak (0.09%) cross-reactivity with the Progesterone II immunoassay.

Thank you very much for this answer. But it is still very weird for me because the bloodwork was done like 5 weeks after stopping hCG and last exemestane was taken like 2 weeks before bloodwork.
Anyways should I care about high progesterone level or just let it be?

 

[Type-IIx]

Thank you very much for this answer. But it is still very weird for me because the bloodwork was done like 5 weeks after stopping hCG and last exemestane was taken like 2 weeks before bloodwork.
Anyways should I care about high progesterone level or just let it be?

I'd have some concern for potential adrenal hyperplasia.

 

[Detroitmonster]

hCG/LH increases side-chain cleavage of cholesterol via cyt. P450 (20-hydroxylase, 22-hydroxylase, 20,22-lyase activity), thereby increasing pregnenolone that via 3B-HSD yields progesterone - so in this case I'd be looking at hCG.

A secondary factor includes some potential cross-reactivity with exemestane if it's still circulating. Exemestane has weak-very weak (0.09%) cross-reactivity with the Progesterone II immunoassay.

What is the best way to lower or combat high progesterone? Type-IIX

 

[Type-IIx]

What is the best way to lower or combat high progesterone? Type-IIX

I'd start first by looking at whether our progesterone is truly elevated and if so to what degree, or if we're actually seeing cross-reactivity with some drug that we're using (e.g., nandrolone). If so, I'm not really concerned. Then, I'd next look at whether some drug we're using is actually causing an increase to progesterone (e.g., hCG) and remove it if the cost/benefit supports its removal versus the purpose of its use for us. Then, depending on the degree of elevation - if substantial, I might drop all hormonal drug preparations and if a substantial elevation persists, go to an endocrinologist. If not substantial, I might weigh the knowledge of this apparent elevation versus actual symptomology (do I actually have any symptoms?) If I am not symptomatic, I just won't really care and just keep an eye to symptoms developing. If I am symptomatic, after having dropped all hormonal drug preparations, if symptoms persist (even insubstantial elevation), I'd go see a general practitioner.

 

[Zeus45]

I'd start first by looking at whether our progesterone is truly elevated and if so to what degree, or if we're actually seeing cross-reactivity with some drug that we're using (e.g., nandrolone). If so, I'm not really concerned. Then, I'd next look at whether some drug we're using is actually causing an increase to progesterone (e.g., hCG) and remove it if the cost/benefit supports its removal versus the purpose of its use for us. Then, depending on the degree of elevation - if substantial, I might drop all hormonal drug preparations and if a substantial elevation persists, go to an endocrinologist. If not substantial, I might weigh the knowledge of this apparent elevation versus actual symptomology (do I actually have any symptoms?) If I am not symptomatic, I just won't really care and just keep an eye to symptoms developing. If I am symptomatic, after having dropped all hormonal drug preparations, if symptoms persist (even insubstantial elevation), I'd go see a general practitioner.

Hey Type-IIx, you ever see this study? Nandrolone activates the ER like E2?

Synthetic 19-nortestosterone derivatives as estrogen receptor alpha subtype-selective ligands induce similar receptor conformational changes and steroid receptor coactivator recruitment than natural estrogens - PubMed​

 

[Type-IIx]

Hey Type-IIx, you ever see this study? Nandrolone activates the ER like E2?

Synthetic 19-nortestosterone derivatives as estrogen receptor alpha subtype-selective ligands induce similar receptor conformational changes and steroid receptor coactivator recruitment than natural estrogens - PubMed​

I have not read this study, I will take a look at this though - thank you. I use Houtman's mammalian reporter bioluminescence data as my standard for a large sample of AAS and their potencies to transactivate the nuclear family receptors.

 

[Type-IIx]

@Zeus45 according to Houtman's bioluminescence data, nandrolone activates ERα with five thousandths (0.0050X) the relative potency of E2. It is a very weak ligand for this receptor. @PeterBond at what doses of nandrolone in an 80 kg adult man might we start seeing biological activity as an estrogen?

 

[Zeus45]

@Zeus45 according to Houtman's bioluminescence data, nandrolone activates ERα with five thousandths (0.0050X) the relative potency of E2. It is a very weak ligand for this receptor. @PeterBond at what doses of nandrolone in an 80 kg adult man might we start seeing biological activity as an estrogen?

i have a lot of studies id like to send you if thats cool with you.

 

[Type-IIx]

i have a lot of studies id like to send you if thats cool with you.

Though appreciated, I am all set with focusing on the papers that I can get to already with limited time. I still have unread papers that I intend to read through, and adding more to the stack will just add stress and become unmanageable.

However, if you are able to acquire difficult to obtain papers if I were to request them, it would be amazingly useful if you could become a resource for that!

 

[Aeons]

a lot of steroid users have high progesterone. it's not something i try to lower.

Do you know why?